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The map label for this gene is liaR [H]

Identifier: 91786900

GI number: 91786900

Start: 1015979

End: 1016512

Strand: Reverse

Name: liaR [H]

Synonym: Bpro_1000

Alternate gene names: 91786900

Gene position: 1016512-1015979 (Counterclockwise)

Preceding gene: 91786901

Following gene: 91786897

Centisome position: 19.55

GC content: 61.24

Gene sequence:

>534_bases
ATGCTGATACGCCGTTTGAGCAGCAAGGCCACTGTGACCGAGCTGGACCGGCTGGCTGCTGTCATGCCCGCCGTAGAACA
GCATGGCGTGCCGGAGTTGATCTGCCTGGATCTGAAGCTGCCCGACACCAATGGCGTGTCCGGGGTGCGCGAACTCAAAC
GGCAGTTTCCGGATGTTCCGCTGGTGGTCCTCTCGGCTGCACCGGCCCAGGACTATGAAGACCTTTCGATCGAAGCCGGT
GCCGACGCCTATATTCAAAAATCCGCAGGCGCCACCGAGATCTCCAATGTGCTGCGCGTCTTCCTGAACGAGGAGCTGGA
GCCCGAATCCGCCACGCCGACAGAAAAGCTCTCCAAGCGCCAGAAGCAGCTGCTGGTCATGCTCGACAAGGGCATGAGTA
ACCGCGACATCGCAGAAGAGCTTCAAATCAGCGAGCACACGGTCAAGGTGCATCTGTGGCGCCTGTTCCGGCGCCTGAAC
GTCAAGAGCCGCTCGCAGGCCAGTCATCTCGCCCGGACCCAGGGCCTGCTGTAG

Upstream 100 bases:

>100_bases
CACCAGTTATGCTCAGTAACCATCGAGTCGATACTTCAACCCTGAATTAATGAGCATTTTTGTAATAGACGACCATCCCC
TGATGCGGGAAGCGGTTGTC

Downstream 100 bases:

>100_bases
CCGCCGGGCTCGCACCTCCGGCGTCATCGCCAGGACTCGTCAGCGCCACCCAGAACACACTGCCCCGGCCCGCCCGGGAT
GACATGCCCACCGGGTGGTT

Product: two component LuxR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 177; Mature: 177

Protein sequence:

>177_residues
MLIRRLSSKATVTELDRLAAVMPAVEQHGVPELICLDLKLPDTNGVSGVRELKRQFPDVPLVVLSAAPAQDYEDLSIEAG
ADAYIQKSAGATEISNVLRVFLNEELEPESATPTEKLSKRQKQLLVMLDKGMSNRDIAEELQISEHTVKVHLWRLFRRLN
VKSRSQASHLARTQGLL

Sequences:

>Translated_177_residues
MLIRRLSSKATVTELDRLAAVMPAVEQHGVPELICLDLKLPDTNGVSGVRELKRQFPDVPLVVLSAAPAQDYEDLSIEAG
ADAYIQKSAGATEISNVLRVFLNEELEPESATPTEKLSKRQKQLLVMLDKGMSNRDIAEELQISEHTVKVHLWRLFRRLN
VKSRSQASHLARTQGLL
>Mature_177_residues
MLIRRLSSKATVTELDRLAAVMPAVEQHGVPELICLDLKLPDTNGVSGVRELKRQFPDVPLVVLSAAPAQDYEDLSIEAG
ADAYIQKSAGATEISNVLRVFLNEELEPESATPTEKLSKRQKQLLVMLDKGMSNRDIAEELQISEHTVKVHLWRLFRRLN
VKSRSQASHLARTQGLL

Specific function: Member of the two-component regulatory system liaS/liaR probably involved in response to a subset of cell wall-active antibiotics that interfere with the lipid II cycle in the cytoplasmic membrane (bacitracin, nisin, ramoplanin and vancomycin). Seems also

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=161, Percent_Identity=26.0869565217391, Blast_Score=77, Evalue=4e-16,
Organism=Escherichia coli, GI1788521, Length=154, Percent_Identity=31.8181818181818, Blast_Score=70, Evalue=8e-14,
Organism=Escherichia coli, GI1786911, Length=88, Percent_Identity=39.7727272727273, Blast_Score=61, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 19720; Mature: 19720

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIRRLSSKATVTELDRLAAVMPAVEQHGVPELICLDLKLPDTNGVSGVRELKRQFPDVP
CCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCC
LVVLSAAPAQDYEDLSIEAGADAYIQKSAGATEISNVLRVFLNEELEPESATPTEKLSKR
EEEEECCCCCCCCCCEECCCCCHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
QKQLLVMLDKGMSNRDIAEELQISEHTVKVHLWRLFRRLNVKSRSQASHLARTQGLL
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MLIRRLSSKATVTELDRLAAVMPAVEQHGVPELICLDLKLPDTNGVSGVRELKRQFPDVP
CCHHHHCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHHHCCCCC
LVVLSAAPAQDYEDLSIEAGADAYIQKSAGATEISNVLRVFLNEELEPESATPTEKLSKR
EEEEECCCCCCCCCCEECCCCCHHHHCCCCHHHHHHHHHHHHCCCCCCCCCCCHHHHHHH
QKQLLVMLDKGMSNRDIAEELQISEHTVKVHLWRLFRRLNVKSRSQASHLARTQGLL
HHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9639930; 9384377 [H]