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The map label for this gene is sucD [H]

Identifier: 89898037

GI number: 89898037

Start: 272023

End: 272898

Strand: Direct

Name: sucD [H]

Synonym: CF0230

Alternate gene names: 89898037

Gene position: 272023-272898 (Clockwise)

Preceding gene: 89898036

Following gene: 89898038

Centisome position: 23.32

GC content: 42.58

Gene sequence:

>876_bases
ATGTTTTGCTCATTAAGTAAAAAAATACCAATAATTACTCAAGGTATCACAGGAAAAGCAGGATCATTTCATACAGAGAA
ATGCCTAGAGTATGGATCGAATTTTGTTGCAGGAGTTACTCCTGGAAAGGGAGGAACGAAGCACTTGAATCTTCCAGTGT
ACGATTCCGTATTAGAAGCAAAACAAGCAACCAACTGTCAAATAACAATGATTTTTGTTCCTCCTGCTTATGCAGCAGAA
GCTATTCTCGAAGCTGAGGATGCAGGAATTGAACTGATTGTCTGCATTACAGAAGGTATCCCAATAAAAGATATGCTCGA
AGTGAGCCATGTTATGCAGCACAGTGCCTCTAGATTAATAGGCCCTAATTGTCCAGGAATTATTAAACCTGGAGCTTGTA
AAATTGGCATCATGCCAGGGTATATCCATCTTCCCGGGAATGTTGGCGTAGTATCAAGATCGGGGACATTAACTTATGAA
GCCGTTTGGCAGCTAACGCAACGCAGCATAGGACAAAGCGTATGCCTAGGTATAGGAGGAGATCCTTTAAACGGAACCTC
GTTTATTGATGTGTTGGAAGAATTCCAGAACGACCCTCAAACAGAACTTATCTTGATGATTGGAGAAATCGGAGGTAGTG
CTGAAGAAGAGGCCGCAGAATGGATTCAATCTTACTGTACAAAACCTGTTGTAGCGTTTATCGCGGGAGAAACAGCTCCT
AAAGGGAAACGTATGGGGCACGCTGGAGCGATTATCTCTGGGAATTCTGGAGATGCGAAAAGCAAAAAAAAAGCTTTGAA
AAGAGCGGGGGTGTCCGTTGTTGAATCTCCAGCTTTAATTGGAGAAGCTGTAGAAACTGTGTTTCGCTCGCTATAG

Upstream 100 bases:

>100_bases
AAATCGTGCAACGTTCGGGAATCCCCTGCCAATTTACAGATTCCTTAAATGAAGGCGCACGTCTTGCTGTAGCGCTGAGT
AAACAAGTTTAAGGGGCTTT

Downstream 100 bases:

>100_bases
TGAACAAGGCATTGGGGTATAAATATTTCCAGATATATTTACTACTATGTTTTATAAGCATAGAGATTTATATGTCGGGA
AAATAGACCTCTATTTCTTC

Product: succinyl-CoA synthetase subunit alpha

Products: NA

Alternate protein names: Succinyl-CoA synthetase subunit alpha; SCS-alpha [H]

Number of amino acids: Translated: 291; Mature: 291

Protein sequence:

>291_residues
MFCSLSKKIPIITQGITGKAGSFHTEKCLEYGSNFVAGVTPGKGGTKHLNLPVYDSVLEAKQATNCQITMIFVPPAYAAE
AILEAEDAGIELIVCITEGIPIKDMLEVSHVMQHSASRLIGPNCPGIIKPGACKIGIMPGYIHLPGNVGVVSRSGTLTYE
AVWQLTQRSIGQSVCLGIGGDPLNGTSFIDVLEEFQNDPQTELILMIGEIGGSAEEEAAEWIQSYCTKPVVAFIAGETAP
KGKRMGHAGAIISGNSGDAKSKKKALKRAGVSVVESPALIGEAVETVFRSL

Sequences:

>Translated_291_residues
MFCSLSKKIPIITQGITGKAGSFHTEKCLEYGSNFVAGVTPGKGGTKHLNLPVYDSVLEAKQATNCQITMIFVPPAYAAE
AILEAEDAGIELIVCITEGIPIKDMLEVSHVMQHSASRLIGPNCPGIIKPGACKIGIMPGYIHLPGNVGVVSRSGTLTYE
AVWQLTQRSIGQSVCLGIGGDPLNGTSFIDVLEEFQNDPQTELILMIGEIGGSAEEEAAEWIQSYCTKPVVAFIAGETAP
KGKRMGHAGAIISGNSGDAKSKKKALKRAGVSVVESPALIGEAVETVFRSL
>Mature_291_residues
MFCSLSKKIPIITQGITGKAGSFHTEKCLEYGSNFVAGVTPGKGGTKHLNLPVYDSVLEAKQATNCQITMIFVPPAYAAE
AILEAEDAGIELIVCITEGIPIKDMLEVSHVMQHSASRLIGPNCPGIIKPGACKIGIMPGYIHLPGNVGVVSRSGTLTYE
AVWQLTQRSIGQSVCLGIGGDPLNGTSFIDVLEEFQNDPQTELILMIGEIGGSAEEEAAEWIQSYCTKPVVAFIAGETAP
KGKRMGHAGAIISGNSGDAKSKKKALKRAGVSVVESPALIGEAVETVFRSL

Specific function: Unknown

COG id: COG0074

COG function: function code C; Succinyl-CoA synthetase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the succinate/malate CoA ligase alpha subunit family [H]

Homologues:

Organism=Homo sapiens, GI109452591, Length=289, Percent_Identity=58.8235294117647, Blast_Score=285, Evalue=3e-77,
Organism=Homo sapiens, GI38569423, Length=261, Percent_Identity=31.0344827586207, Blast_Score=105, Evalue=4e-23,
Organism=Homo sapiens, GI38569421, Length=261, Percent_Identity=31.0344827586207, Blast_Score=105, Evalue=5e-23,
Organism=Escherichia coli, GI1786949, Length=289, Percent_Identity=59.8615916955017, Blast_Score=350, Evalue=7e-98,
Organism=Caenorhabditis elegans, GI17553126, Length=289, Percent_Identity=56.7474048442907, Blast_Score=304, Evalue=4e-83,
Organism=Caenorhabditis elegans, GI17550194, Length=289, Percent_Identity=55.7093425605536, Blast_Score=303, Evalue=5e-83,
Organism=Caenorhabditis elegans, GI17557344, Length=286, Percent_Identity=29.020979020979, Blast_Score=108, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17551266, Length=286, Percent_Identity=29.7202797202797, Blast_Score=106, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6324716, Length=293, Percent_Identity=50.5119453924915, Blast_Score=272, Evalue=4e-74,
Organism=Drosophila melanogaster, GI21356559, Length=289, Percent_Identity=55.0173010380623, Blast_Score=308, Evalue=4e-84,
Organism=Drosophila melanogaster, GI28574296, Length=286, Percent_Identity=58.7412587412587, Blast_Score=300, Evalue=6e-82,
Organism=Drosophila melanogaster, GI281363477, Length=261, Percent_Identity=30.6513409961686, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI281363475, Length=261, Percent_Identity=30.6513409961686, Blast_Score=105, Evalue=3e-23,
Organism=Drosophila melanogaster, GI281363473, Length=261, Percent_Identity=30.6513409961686, Blast_Score=105, Evalue=3e-23,

Paralogues:

None

Copy number: 900 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017440
- InterPro:   IPR003781
- InterPro:   IPR005810
- InterPro:   IPR005811
- InterPro:   IPR016040
- InterPro:   IPR016102 [H]

Pfam domain/function: PF02629 CoA_binding; PF00549 Ligase_CoA [H]

EC number: =6.2.1.5 [H]

Molecular weight: Translated: 30613; Mature: 30613

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS01216 SUCCINYL_COA_LIG_1 ; PS00399 SUCCINYL_COA_LIG_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFCSLSKKIPIITQGITGKAGSFHTEKCLEYGSNFVAGVTPGKGGTKHLNLPVYDSVLEA
CCCCCCCCCCEEECCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCCEEECCCHHHHHHHH
KQATNCQITMIFVPPAYAAEAILEAEDAGIELIVCITEGIPIKDMLEVSHVMQHSASRLI
HHCCCCEEEEEEECCHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCC
GPNCPGIIKPGACKIGIMPGYIHLPGNVGVVSRSGTLTYEAVWQLTQRSIGQSVCLGIGG
CCCCCCCCCCCCEEEEECCCEEECCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEECCC
DPLNGTSFIDVLEEFQNDPQTELILMIGEIGGSAEEEAAEWIQSYCTKPVVAFIAGETAP
CCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCC
KGKRMGHAGAIISGNSGDAKSKKKALKRAGVSVVESPALIGEAVETVFRSL
CCCCCCCCCEEEECCCCCHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFCSLSKKIPIITQGITGKAGSFHTEKCLEYGSNFVAGVTPGKGGTKHLNLPVYDSVLEA
CCCCCCCCCCEEECCCCCCCCCCHHHHHHHHCCCEEEEECCCCCCCEEECCCHHHHHHHH
KQATNCQITMIFVPPAYAAEAILEAEDAGIELIVCITEGIPIKDMLEVSHVMQHSASRLI
HHCCCCEEEEEEECCHHHHHHHHHHCCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCC
GPNCPGIIKPGACKIGIMPGYIHLPGNVGVVSRSGTLTYEAVWQLTQRSIGQSVCLGIGG
CCCCCCCCCCCCEEEEECCCEEECCCCCEEEECCCCCHHHHHHHHHHHHCCCEEEEECCC
DPLNGTSFIDVLEEFQNDPQTELILMIGEIGGSAEEEAAEWIQSYCTKPVVAFIAGETAP
CCCCCHHHHHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCEEEEEECCCCC
KGKRMGHAGAIISGNSGDAKSKKKALKRAGVSVVESPALIGEAVETVFRSL
CCCCCCCCCEEEECCCCCHHHHHHHHHHHCCHHHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12704232 [H]