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The map label for this gene is htrA [H]

Identifier: 89898038

GI number: 89898038

Start: 273236

End: 274702

Strand: Direct

Name: htrA [H]

Synonym: CF0231

Alternate gene names: 89898038

Gene position: 273236-274702 (Clockwise)

Preceding gene: 89898037

Following gene: 89898040

Centisome position: 23.43

GC content: 40.42

Gene sequence:

>1467_bases
ATGACAAAGAAGCCAATATATTTATTATTAGCCACAGTGATGTTTTTAAGTGTTTCTATATTTCATCCTGTAGGATTCGC
CGCTGTGAAAAAAGATGCGCGGATGGCAGAAGTGCCTCAAGAGACGCTTTTAAAGGAGATTTCTGGAGGGTTTTCTAAAG
TCGCAGAACAGGCAACTCCTGGTGTTGTTTATATCGAAAGCTTTCCAAAATGTAATCGTCCTGTAAATCCTGCTCCGGGA
CGTCGAGGACCTTATGACAATCCTTTTGATTATTTTAATGACGAGTTCTTTAATCGCTTTTTTGGTTTGCCTTCGCAAAA
AGAACGTCCCATGTCTAAAGAGGCTGTTCGTGGTACAGGATTTATAGTTTCTCCAGACGGTTATGTCGTTACTAATAATC
ACGTTGTTGAAGATGCTGGAAAGATTCATGTGACCCTACATGATGGTCAGAAATATCCTGCTAAGGTTATCGGCCTAGAT
CCTAAAACTGATTTAGCCGTTATTAAAATCAATGCGAATAAGCTTCCCCACCTTACTTTTGGGAATTCTGATAATTTGAA
AGTCGGGGATTGGGCAATAGCTATCGGGAATCCTTTTGGGCTGCAAGCTACAGTTACCGTAGGGGTAATTAGTGCAAAAG
GTAGAAATCAGTTGCATATTGCCGATTTCGAAGATTTTATTCAGACAGATGCAGCTATTAACCCAGGAAACTCCGGGGGG
CCCCTTCTCAATATCGATGGAGAAGTTATAGGAGTGAATACTGCTATCGTAAGTGGTAGTGGAGGTTATATTGGTATCGG
ATTTGCTATTCCTAGTTTAATGGCTAAGAGAATCATAGATCAGCTTATTAGCGATGGTCAGGTAATTCGTGGATTTTTAG
GCGTGACTCTACAACCCATAGATGCTGAGCTCGCTGCTTGCTATAAACTAGACAAGGTATACGGAGCTCTAGTAACAGAT
GTTGTTAAAGGGTCTCCTGCACATAAAGCAGGATTAAAACAAGAAGATGTAATTATTGCCTATAATGGTAGGGAAGTAGA
ATCCCTCAGTGCTTTCCGTAACGCTATTTCTTTAATGAATCCTAATACTCGTGTGTTGCTTAAAGTAGTTCGAGAAGGAC
AAGTTTTAGAAATTCCTGTTATTGTTTCTCAAGCACCCCAAGATGATGGAGTCTCTGCTTTACAGCGTGTGGGTATTCGT
GTACAAAATCTTAATGCAGAAACTGCTAAGAAATTAGGAATGGCGCCGGATAGTAAAGGCGTACTGATTGTTTCTGTTGA
AGCCGGCTCTGTAGCTGGCTCTTCAGGAGTGGCTCCGGGACAACTTATCTTGGCCGTAAATAGACAGAAAGTATCCTCAG
TAGAAGAGTTAAATTCTGTTTTAAAAGATGGAAATAACGAAAATATTCTTCTCATGGTCTCTCAAGGAGAGGTTATTCGC
TTTATAGTGTTAAAACCAGAAGAATAA

Upstream 100 bases:

>100_bases
TATAAAACGCATATTTAAAAAGTATTAGGATTCACAGGCTTTCAAAAATGTGAGCACGAGATCAAGAAAGAATTTAGCGC
TTGCCTATAGGGAAAAAAGT

Downstream 100 bases:

>100_bases
ACTGAAATTTTTCAGCAGGTTTATCTTATAAAAGCACTCTTTTCAAGAGTGCTTTTTTTATGCTTTTCCTAATCTATCAA
GAAGAAGACAAATAGAAATA

Product: DO serine protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 488; Mature: 487

Protein sequence:

>488_residues
MTKKPIYLLLATVMFLSVSIFHPVGFAAVKKDARMAEVPQETLLKEISGGFSKVAEQATPGVVYIESFPKCNRPVNPAPG
RRGPYDNPFDYFNDEFFNRFFGLPSQKERPMSKEAVRGTGFIVSPDGYVVTNNHVVEDAGKIHVTLHDGQKYPAKVIGLD
PKTDLAVIKINANKLPHLTFGNSDNLKVGDWAIAIGNPFGLQATVTVGVISAKGRNQLHIADFEDFIQTDAAINPGNSGG
PLLNIDGEVIGVNTAIVSGSGGYIGIGFAIPSLMAKRIIDQLISDGQVIRGFLGVTLQPIDAELAACYKLDKVYGALVTD
VVKGSPAHKAGLKQEDVIIAYNGREVESLSAFRNAISLMNPNTRVLLKVVREGQVLEIPVIVSQAPQDDGVSALQRVGIR
VQNLNAETAKKLGMAPDSKGVLIVSVEAGSVAGSSGVAPGQLILAVNRQKVSSVEELNSVLKDGNNENILLMVSQGEVIR
FIVLKPEE

Sequences:

>Translated_488_residues
MTKKPIYLLLATVMFLSVSIFHPVGFAAVKKDARMAEVPQETLLKEISGGFSKVAEQATPGVVYIESFPKCNRPVNPAPG
RRGPYDNPFDYFNDEFFNRFFGLPSQKERPMSKEAVRGTGFIVSPDGYVVTNNHVVEDAGKIHVTLHDGQKYPAKVIGLD
PKTDLAVIKINANKLPHLTFGNSDNLKVGDWAIAIGNPFGLQATVTVGVISAKGRNQLHIADFEDFIQTDAAINPGNSGG
PLLNIDGEVIGVNTAIVSGSGGYIGIGFAIPSLMAKRIIDQLISDGQVIRGFLGVTLQPIDAELAACYKLDKVYGALVTD
VVKGSPAHKAGLKQEDVIIAYNGREVESLSAFRNAISLMNPNTRVLLKVVREGQVLEIPVIVSQAPQDDGVSALQRVGIR
VQNLNAETAKKLGMAPDSKGVLIVSVEAGSVAGSSGVAPGQLILAVNRQKVSSVEELNSVLKDGNNENILLMVSQGEVIR
FIVLKPEE
>Mature_487_residues
TKKPIYLLLATVMFLSVSIFHPVGFAAVKKDARMAEVPQETLLKEISGGFSKVAEQATPGVVYIESFPKCNRPVNPAPGR
RGPYDNPFDYFNDEFFNRFFGLPSQKERPMSKEAVRGTGFIVSPDGYVVTNNHVVEDAGKIHVTLHDGQKYPAKVIGLDP
KTDLAVIKINANKLPHLTFGNSDNLKVGDWAIAIGNPFGLQATVTVGVISAKGRNQLHIADFEDFIQTDAAINPGNSGGP
LLNIDGEVIGVNTAIVSGSGGYIGIGFAIPSLMAKRIIDQLISDGQVIRGFLGVTLQPIDAELAACYKLDKVYGALVTDV
VKGSPAHKAGLKQEDVIIAYNGREVESLSAFRNAISLMNPNTRVLLKVVREGQVLEIPVIVSQAPQDDGVSALQRVGIRV
QNLNAETAKKLGMAPDSKGVLIVSVEAGSVAGSSGVAPGQLILAVNRQKVSSVEELNSVLKDGNNENILLMVSQGEVIRF
IVLKPEE

Specific function: Protease With A Shared Specificity With Degp. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=290, Percent_Identity=40.3448275862069, Blast_Score=174, Evalue=1e-43,
Organism=Homo sapiens, GI24308541, Length=277, Percent_Identity=38.9891696750903, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI22129776, Length=276, Percent_Identity=38.4057971014493, Blast_Score=158, Evalue=1e-38,
Organism=Homo sapiens, GI7019477, Length=316, Percent_Identity=35.126582278481, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1789629, Length=371, Percent_Identity=41.7789757412399, Blast_Score=274, Evalue=1e-74,
Organism=Escherichia coli, GI1786356, Length=370, Percent_Identity=41.6216216216216, Blast_Score=271, Evalue=6e-74,
Organism=Escherichia coli, GI1789630, Length=273, Percent_Identity=39.1941391941392, Blast_Score=177, Evalue=2e-45,
Organism=Drosophila melanogaster, GI24646839, Length=321, Percent_Identity=32.7102803738318, Blast_Score=152, Evalue=6e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 52213; Mature: 52082

Theoretical pI: Translated: 6.89; Mature: 6.89

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKKPIYLLLATVMFLSVSIFHPVGFAAVKKDARMAEVPQETLLKEISGGFSKVAEQATP
CCCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHCCHHHHHHHHCCHHHHHHHHCCC
GVVYIESFPKCNRPVNPAPGRRGPYDNPFDYFNDEFFNRFFGLPSQKERPMSKEAVRGTG
CEEEEECCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHCCCCCCCCCCCHHHHCCCC
FIVSPDGYVVTNNHVVEDAGKIHVTLHDGQKYPAKVIGLDPKTDLAVIKINANKLPHLTF
EEECCCCEEEECCEEEECCCEEEEEEECCCCCCEEEEECCCCCCEEEEEEECCCCCEEEE
GNSDNLKVGDWAIAIGNPFGLQATVTVGVISAKGRNQLHIADFEDFIQTDAAINPGNSGG
CCCCCEEECCEEEEECCCCCCEEEEEEEEEECCCCCEEEECCHHHHHHHCCCCCCCCCCC
PLLNIDGEVIGVNTAIVSGSGGYIGIGFAIPSLMAKRIIDQLISDGQVIRGFLGVTLQPI
CEEEECCEEEEEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCEECCC
DAELAACYKLDKVYGALVTDVVKGSPAHKAGLKQEDVIIAYNGREVESLSAFRNAISLMN
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHCC
PNTRVLLKVVREGQVLEIPVIVSQAPQDDGVSALQRVGIRVQNLNAETAKKLGMAPDSKG
CCHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHCCEEEECCHHHHHHHCCCCCCCC
VLIVSVEAGSVAGSSGVAPGQLILAVNRQKVSSVEELNSVLKDGNNENILLMVSQGEVIR
EEEEEEECCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEE
FIVLKPEE
EEEECCCC
>Mature Secondary Structure 
TKKPIYLLLATVMFLSVSIFHPVGFAAVKKDARMAEVPQETLLKEISGGFSKVAEQATP
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHCCHHHHHHHHCCHHHHHHHHCCC
GVVYIESFPKCNRPVNPAPGRRGPYDNPFDYFNDEFFNRFFGLPSQKERPMSKEAVRGTG
CEEEEECCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHCCCCCCCCCCCHHHHCCCC
FIVSPDGYVVTNNHVVEDAGKIHVTLHDGQKYPAKVIGLDPKTDLAVIKINANKLPHLTF
EEECCCCEEEECCEEEECCCEEEEEEECCCCCCEEEEECCCCCCEEEEEEECCCCCEEEE
GNSDNLKVGDWAIAIGNPFGLQATVTVGVISAKGRNQLHIADFEDFIQTDAAINPGNSGG
CCCCCEEECCEEEEECCCCCCEEEEEEEEEECCCCCEEEECCHHHHHHHCCCCCCCCCCC
PLLNIDGEVIGVNTAIVSGSGGYIGIGFAIPSLMAKRIIDQLISDGQVIRGFLGVTLQPI
CEEEECCEEEEEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCEECCC
DAELAACYKLDKVYGALVTDVVKGSPAHKAGLKQEDVIIAYNGREVESLSAFRNAISLMN
CHHHHHHHHHHHHHHHHHHHHHCCCCCHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHCC
PNTRVLLKVVREGQVLEIPVIVSQAPQDDGVSALQRVGIRVQNLNAETAKKLGMAPDSKG
CCHHHHHHHHHCCCEEEEEEEEECCCCCCHHHHHHHHCCEEEECCHHHHHHHCCCCCCCC
VLIVSVEAGSVAGSSGVAPGQLILAVNRQKVSSVEELNSVLKDGNNENILLMVSQGEVIR
EEEEEEECCCCCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHCCCCCEEEEEEECCCEEE
FIVLKPEE
EEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]