Click here to switch to the map view.

The map label for this gene is ribD [H]

Identifier: 89897925

GI number: 89897925

Start: 135704

End: 136837

Strand: Direct

Name: ribD [H]

Synonym: CF0118

Alternate gene names: 89897925

Gene position: 135704-136837 (Clockwise)

Preceding gene: 89897921

Following gene: 89897926

Centisome position: 11.64

GC content: 40.21

Gene sequence:

>1134_bases
ATGGAAGATTTCTCTGAGCAACAACTATTTTTTATGCGGAGAGCTATAGAATTAGGAGAAAATGGAAGACTTTCTGCTCC
ACCTAACCCCTGGGTTGGTTGTGTAATCGTAAAAAATGGACGGATTATAGGGGAAGGGTATCACAAGAAAAAAGGCCAAC
CACATGCAGAAGAAGAGGCCGTAAACTCTACAACCGAGTCTATAGAGGGTTGTGATGTGTATGTGACTTTAGAGCCATGC
TGTCATTATGGAAGTACGCCGCCATGTGTGAACTTATTAATCAAACATAAAGTCTCTACTGTTTATGTGGCTTTACTAGA
TCCTGATGGTCGTGTTTCTGGTAAGGGAATTGCTGCATTAAGAAATGCGGGTATACGTGTTTATGTGGGGTTGGGAAAAG
AGGAGGCTGAGTCTTCTTTAAAATCTTATATATACCAGAGAACCTATGGGAAACCCTGGATTGTTATTAAAAGTGCTGCA
ACTTTAGACGGACAGGTTGCGGATAGCGATGGGCAATCTCAATGGATCACTTGTCCGGAAGCACGAGCTGATGTGGGGAA
AATTCGTGCAAGTTCTCAAGCTATTGTTATAGGTTCTAAAACTGTTTTGCAAGATGATCCCCTATTAACAGCTAGAAAGC
CTTCCGGAGAGCTGTATTCTAATCAACCTTTACGTGTAGTTGTGGATAGTTCTGGAATAGTGCCTCCTCAAGCAAAAGTT
TTTCATGTTCCTGGAAAATCTCTCTATGTAACCACAACGCGATCCTCAAGCGAGCATATCAAAAATATAGAAGATCTTGG
TGTGGAAGTTTTGGTTACTCAACCCAGAGAATCTAAAGTAGATTTGCATGAATTAGTGGCATATTTATCTAACAAAACAG
TGCTACAAGTTCTTGTTGAAGGCGGATCTATTTTACATACTTCTTTTTTGAAAGAACGTTTGGCGAATGCTCTAGTCCTT
TACCTAGGTCCAAAAATTTTTGGAGATCAACGAAAACCTCTTTTTGGAGATCTAGGACTACGTTTGCACTCTGCTCAAGA
AATTATTCCTAAGTTTTCTGTAGTGCTAGGAAATTCTTTAAAAACCTCTTGGGAAATCCTTGGAGAGAGGAAAGAGGGTA
AGAGATTGAAGTGA

Upstream 100 bases:

>100_bases
ACGAAGACGAGTTTCACATTCTTCAGGTGCCTTGCGTATTAATTTTATATCCAACATCCTCGTATCTCTTTAATTACCTT
TTCTTATAACGGCAAAGTAT

Downstream 100 bases:

>100_bases
ATAGGTGGTTTCTATTAGCATTCCTAAGAGAGAAGCAATCAGTAATTGGGGGCTCCAGTGTTAACATCTAGTGATGGTGC
ACGTGCATCGTGTTTTGTCC

Product: riboflavin biosynthesis protein

Products: NA

Alternate protein names: Diaminohydroxyphosphoribosylaminopyrimidine deaminase; DRAP deaminase; Riboflavin-specific deaminase; 5-amino-6-(5-phosphoribosylamino)uracil reductase; HTP reductase [H]

Number of amino acids: Translated: 377; Mature: 377

Protein sequence:

>377_residues
MEDFSEQQLFFMRRAIELGENGRLSAPPNPWVGCVIVKNGRIIGEGYHKKKGQPHAEEEAVNSTTESIEGCDVYVTLEPC
CHYGSTPPCVNLLIKHKVSTVYVALLDPDGRVSGKGIAALRNAGIRVYVGLGKEEAESSLKSYIYQRTYGKPWIVIKSAA
TLDGQVADSDGQSQWITCPEARADVGKIRASSQAIVIGSKTVLQDDPLLTARKPSGELYSNQPLRVVVDSSGIVPPQAKV
FHVPGKSLYVTTTRSSSEHIKNIEDLGVEVLVTQPRESKVDLHELVAYLSNKTVLQVLVEGGSILHTSFLKERLANALVL
YLGPKIFGDQRKPLFGDLGLRLHSAQEIIPKFSVVLGNSLKTSWEILGERKEGKRLK

Sequences:

>Translated_377_residues
MEDFSEQQLFFMRRAIELGENGRLSAPPNPWVGCVIVKNGRIIGEGYHKKKGQPHAEEEAVNSTTESIEGCDVYVTLEPC
CHYGSTPPCVNLLIKHKVSTVYVALLDPDGRVSGKGIAALRNAGIRVYVGLGKEEAESSLKSYIYQRTYGKPWIVIKSAA
TLDGQVADSDGQSQWITCPEARADVGKIRASSQAIVIGSKTVLQDDPLLTARKPSGELYSNQPLRVVVDSSGIVPPQAKV
FHVPGKSLYVTTTRSSSEHIKNIEDLGVEVLVTQPRESKVDLHELVAYLSNKTVLQVLVEGGSILHTSFLKERLANALVL
YLGPKIFGDQRKPLFGDLGLRLHSAQEIIPKFSVVLGNSLKTSWEILGERKEGKRLK
>Mature_377_residues
MEDFSEQQLFFMRRAIELGENGRLSAPPNPWVGCVIVKNGRIIGEGYHKKKGQPHAEEEAVNSTTESIEGCDVYVTLEPC
CHYGSTPPCVNLLIKHKVSTVYVALLDPDGRVSGKGIAALRNAGIRVYVGLGKEEAESSLKSYIYQRTYGKPWIVIKSAA
TLDGQVADSDGQSQWITCPEARADVGKIRASSQAIVIGSKTVLQDDPLLTARKPSGELYSNQPLRVVVDSSGIVPPQAKV
FHVPGKSLYVTTTRSSSEHIKNIEDLGVEVLVTQPRESKVDLHELVAYLSNKTVLQVLVEGGSILHTSFLKERLANALVL
YLGPKIFGDQRKPLFGDLGLRLHSAQEIIPKFSVVLGNSLKTSWEILGERKEGKRLK

Specific function: Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate [H]

COG id: COG1985

COG function: function code H; Pyrimidine reductase, riboflavin biosynthesis

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the HTP reductase family [H]

Homologues:

Organism=Escherichia coli, GI1786616, Length=343, Percent_Identity=39.3586005830904, Blast_Score=248, Evalue=3e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016192
- InterPro:   IPR002125
- InterPro:   IPR016193
- InterPro:   IPR004794
- InterPro:   IPR011549
- InterPro:   IPR002734 [H]

Pfam domain/function: PF00383 dCMP_cyt_deam_1; PF01872 RibD_C [H]

EC number: =3.5.4.26; =1.1.1.193 [H]

Molecular weight: Translated: 41311; Mature: 41311

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: PS00903 CYT_DCMP_DEAMINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
0.5 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDFSEQQLFFMRRAIELGENGRLSAPPNPWVGCVIVKNGRIIGEGYHKKKGQPHAEEEA
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCEEEECCCCCCCCCCCHHHHH
VNSTTESIEGCDVYVTLEPCCHYGSTPPCVNLLIKHKVSTVYVALLDPDGRVSGKGIAAL
HHHHHHCCCCCEEEEEECHHHCCCCCCHHHHHHHHCCEEEEEEEEECCCCCCCCCCHHHH
RNAGIRVYVGLGKEEAESSLKSYIYQRTYGKPWIVIKSAATLDGQVADSDGQSQWITCPE
HCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEECCCCCCCEEECCH
ARADVGKIRASSQAIVIGSKTVLQDDPLLTARKPSGELYSNQPLRVVVDSSGIVPPQAKV
HHCCHHHHCCCCCEEEEECCEEECCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCEE
FHVPGKSLYVTTTRSSSEHIKNIEDLGVEVLVTQPRESKVDLHELVAYLSNKTVLQVLVE
EECCCCEEEEEEECCCHHHHCCHHHCCEEEEEECCCCCCCCHHHHHHHHCCCCEEEEECC
GGSILHTSFLKERLANALVLYLGPKIFGDQRKPLFGDLGLRLHSAQEIIPKFSVVLGNSL
CCCEEHHHHHHHHHHHEEEEEECCHHCCCCCCCCCHHCCCEEHHHHHHHHHHHHHHCCCC
KTSWEILGERKEGKRLK
CCHHHHHCCCCCCCCCC
>Mature Secondary Structure
MEDFSEQQLFFMRRAIELGENGRLSAPPNPWVGCVIVKNGRIIGEGYHKKKGQPHAEEEA
CCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEEECCEEEECCCCCCCCCCCHHHHH
VNSTTESIEGCDVYVTLEPCCHYGSTPPCVNLLIKHKVSTVYVALLDPDGRVSGKGIAAL
HHHHHHCCCCCEEEEEECHHHCCCCCCHHHHHHHHCCEEEEEEEEECCCCCCCCCCHHHH
RNAGIRVYVGLGKEEAESSLKSYIYQRTYGKPWIVIKSAATLDGQVADSDGQSQWITCPE
HCCCEEEEEECCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCEEECCCCCCCEEECCH
ARADVGKIRASSQAIVIGSKTVLQDDPLLTARKPSGELYSNQPLRVVVDSSGIVPPQAKV
HHCCHHHHCCCCCEEEEECCEEECCCCCEEEECCCCCCCCCCCEEEEECCCCCCCCCCEE
FHVPGKSLYVTTTRSSSEHIKNIEDLGVEVLVTQPRESKVDLHELVAYLSNKTVLQVLVE
EECCCCEEEEEEECCCHHHHCCHHHCCEEEEEECCCCCCCCHHHHHHHHCCCCEEEEECC
GGSILHTSFLKERLANALVLYLGPKIFGDQRKPLFGDLGLRLHSAQEIIPKFSVVLGNSL
CCCEEHHHHHHHHHHHEEEEEECCHHCCCCCCCCCHHCCCEEHHHHHHHHHHHHHHCCCC
KTSWEILGERKEGKRLK
CCHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]