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The map label for this gene is ribA [H]

Identifier: 89897926

GI number: 89897926

Start: 136895

End: 138154

Strand: Direct

Name: ribA [H]

Synonym: CF0119

Alternate gene names: 89897926

Gene position: 136895-138154 (Clockwise)

Preceding gene: 89897925

Following gene: 89897927

Centisome position: 11.74

GC content: 43.17

Gene sequence:

>1260_bases
GTGTTAACATCTAGTGATGGTGCACGTGCATCGTGTTTTGTCCCAATAGAAAAAGCTATAGCAGATATTTCTGAAGGGAA
ATTTGTTATTGTTGTCGATGAAGCTTCGAGAGAAGACGAAGGGGATCTGGTCATAGCAGGTGAGAAGATGACCGTCGAAA
AGATGACTTTTCTTCTTAAATATACGACGGGGATTATTTGCGCTTCTTTAGAACCTGAAAGAGCAAAAGCCTTAGAATTC
CCTCCTATGGTTAAAGATAATTGTTGTCGTTACCACACAGCATTTACTGTATCCGTGGATGCAGCGCAAGGTATAACAAC
CGGAGTATCTGCAGCAGATCGAACTAAAGTAGTGGAGCTATTGTCAAATCCTAACAGCAGCCCTGAGGATTTTGTCCGTC
CGGGGCATTTTTTCCCCCTAGTGGGGACTCCTGGAGGCGTATTAAAACGTGCAGGACATACAGAGGCTGCTTTAGATCTT
ATGCGTTTGGCAAATATGCAACCTTGTGGGGTTCTTTCTGAGCTTGTTAACGAAGACCACACTATGATGCGCCTTCCTCA
AATTATAGAATTTGCTAATCAGCATGGTCTCTCAGTGATCTCTATTTCTGACTTGATAGCCTATCGGAGGTTATCCGAAA
GGCTGGTAGTTCCAGTTTCCTCCGCGCGCCTTCCTACAGAATATGGAGATTTTAATATTCATGTTTACGAATCTCTCCTC
GACGGTATTCAACATATCGCTTTGGTAAAAGGTGATGTGAGAGGTGAGGAGAATGTTCTTGTTCGTGTGCACTCTGAATG
TCTCACAGGAGATGTTATGGGATCCATTCGTTGTGATTGTGGACATCAGTTGCGCTCAGCTATGGAATATATCGGATTAG
AAGGTAGGGGAGTCATTGTTTACTTACGTGGACAAGAGGGACGGGGAATCGGATTGGGTCATAAGGTCCGTGCTTATGCT
TTACAAGATTGTGGGTACGATACTGTAGACGCGAACTTAGAAATTGGCTTCCCTGTAGATTCTAGGGAGTACGGGATAGG
GGCTCAGATTCTAGCTGATCTAGGATTGACAAAGATCAAATTGATTACCCATAATCCCCATAAATATTTTGGTCTTCAGG
GATTTGGATTGGAAATTGTAGATCGAATAGCTCTTCCGGTCAATGTCTCTGAGGAAAATGAAAATTACCTACGCACAAAA
AAAGAGCGTATGGGGCATTGGATAGACCTCTCTTTCGTTAGGGAAGTAAACACAAGATAA

Upstream 100 bases:

>100_bases
GGAAATCCTTGGAGAGAGGAAAGAGGGTAAGAGATTGAAGTGAATAGGTGGTTTCTATTAGCATTCCTAAGAGAGAAGCA
ATCAGTAATTGGGGGCTCCA

Downstream 100 bases:

>100_bases
TTCAAGGATTATATGAAAATATTGAAAGGGACGGCATCAGCAAGAGGCATGAGAGTTGCTATTGTTGGCGCTTGTTTTAA
TGGACCTATAGCAGACGCAT

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein

Products: NA

Alternate protein names: 3,4-dihydroxy-2-butanone 4-phosphate synthase; DHBP synthase; GTP cyclohydrolase-2; GTP cyclohydrolase II [H]

Number of amino acids: Translated: 419; Mature: 419

Protein sequence:

>419_residues
MLTSSDGARASCFVPIEKAIADISEGKFVIVVDEASREDEGDLVIAGEKMTVEKMTFLLKYTTGIICASLEPERAKALEF
PPMVKDNCCRYHTAFTVSVDAAQGITTGVSAADRTKVVELLSNPNSSPEDFVRPGHFFPLVGTPGGVLKRAGHTEAALDL
MRLANMQPCGVLSELVNEDHTMMRLPQIIEFANQHGLSVISISDLIAYRRLSERLVVPVSSARLPTEYGDFNIHVYESLL
DGIQHIALVKGDVRGEENVLVRVHSECLTGDVMGSIRCDCGHQLRSAMEYIGLEGRGVIVYLRGQEGRGIGLGHKVRAYA
LQDCGYDTVDANLEIGFPVDSREYGIGAQILADLGLTKIKLITHNPHKYFGLQGFGLEIVDRIALPVNVSEENENYLRTK
KERMGHWIDLSFVREVNTR

Sequences:

>Translated_419_residues
MLTSSDGARASCFVPIEKAIADISEGKFVIVVDEASREDEGDLVIAGEKMTVEKMTFLLKYTTGIICASLEPERAKALEF
PPMVKDNCCRYHTAFTVSVDAAQGITTGVSAADRTKVVELLSNPNSSPEDFVRPGHFFPLVGTPGGVLKRAGHTEAALDL
MRLANMQPCGVLSELVNEDHTMMRLPQIIEFANQHGLSVISISDLIAYRRLSERLVVPVSSARLPTEYGDFNIHVYESLL
DGIQHIALVKGDVRGEENVLVRVHSECLTGDVMGSIRCDCGHQLRSAMEYIGLEGRGVIVYLRGQEGRGIGLGHKVRAYA
LQDCGYDTVDANLEIGFPVDSREYGIGAQILADLGLTKIKLITHNPHKYFGLQGFGLEIVDRIALPVNVSEENENYLRTK
KERMGHWIDLSFVREVNTR
>Mature_419_residues
MLTSSDGARASCFVPIEKAIADISEGKFVIVVDEASREDEGDLVIAGEKMTVEKMTFLLKYTTGIICASLEPERAKALEF
PPMVKDNCCRYHTAFTVSVDAAQGITTGVSAADRTKVVELLSNPNSSPEDFVRPGHFFPLVGTPGGVLKRAGHTEAALDL
MRLANMQPCGVLSELVNEDHTMMRLPQIIEFANQHGLSVISISDLIAYRRLSERLVVPVSSARLPTEYGDFNIHVYESLL
DGIQHIALVKGDVRGEENVLVRVHSECLTGDVMGSIRCDCGHQLRSAMEYIGLEGRGVIVYLRGQEGRGIGLGHKVRAYA
LQDCGYDTVDANLEIGFPVDSREYGIGAQILADLGLTKIKLITHNPHKYFGLQGFGLEIVDRIALPVNVSEENENYLRTK
KERMGHWIDLSFVREVNTR

Specific function: Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate [H]

COG id: COG0807

COG function: function code H; GTP cyclohydrolase II

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=202, Percent_Identity=48.5148514851485, Blast_Score=211, Evalue=5e-56,
Organism=Escherichia coli, GI1787533, Length=191, Percent_Identity=50.7853403141361, Blast_Score=194, Evalue=7e-51,
Organism=Saccharomyces cerevisiae, GI6320695, Length=206, Percent_Identity=42.7184466019417, Blast_Score=180, Evalue=4e-46,
Organism=Saccharomyces cerevisiae, GI6319438, Length=172, Percent_Identity=47.093023255814, Blast_Score=137, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12; =3.5.4.25 [H]

Molecular weight: Translated: 46104; Mature: 46104

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: PS00430 TONB_DEPENDENT_REC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLTSSDGARASCFVPIEKAIADISEGKFVIVVDEASREDEGDLVIAGEKMTVEKMTFLLK
CCCCCCCCCEEEEEEHHHHHHHCCCCCEEEEEECCCCCCCCCEEEECCCEEHHHHHHHHH
YTTGIICASLEPERAKALEFPPMVKDNCCRYHTAFTVSVDAAQGITTGVSAADRTKVVEL
HHCCEEEECCCCHHHHHCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCHHHHHHHHH
LSNPNSSPEDFVRPGHFFPLVGTPGGVLKRAGHTEAALDLMRLANMQPCGVLSELVNEDH
HHCCCCCHHHHCCCCCEEEEECCCHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCH
TMMRLPQIIEFANQHGLSVISISDLIAYRRLSERLVVPVSSARLPTEYGDFNIHVYESLL
HHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCEEEEEECCCCCCCCCCCEEEEEHHHHH
DGIQHIALVKGDVRGEENVLVRVHSECLTGDVMGSIRCDCGHQLRSAMEYIGLEGRGVIV
HHHHHEEEEECCCCCCCCEEEEEECHHHCCCCCCCEECCCCHHHHHHHHHHCCCCCEEEE
YLRGQEGRGIGLGHKVRAYALQDCGYDTVDANLEIGFPVDSREYGIGAQILADLGLTKIK
EEECCCCCCCCCCCCEEEEEECCCCCCEECCCEEEECCCCCCCCCCHHHHHHHCCCEEEE
LITHNPHKYFGLQGFGLEIVDRIALPVNVSEENENYLRTKKERMGHWIDLSFVREVNTR
EEEECCCCEECCCCCCHHHHHHEECCEEECCCCCHHHHHHHHHCCCEEEHHHHHHCCCC
>Mature Secondary Structure
MLTSSDGARASCFVPIEKAIADISEGKFVIVVDEASREDEGDLVIAGEKMTVEKMTFLLK
CCCCCCCCCEEEEEEHHHHHHHCCCCCEEEEEECCCCCCCCCEEEECCCEEHHHHHHHHH
YTTGIICASLEPERAKALEFPPMVKDNCCRYHTAFTVSVDAAQGITTGVSAADRTKVVEL
HHCCEEEECCCCHHHHHCCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCCHHHHHHHHH
LSNPNSSPEDFVRPGHFFPLVGTPGGVLKRAGHTEAALDLMRLANMQPCGVLSELVNEDH
HHCCCCCHHHHCCCCCEEEEECCCHHHHHCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCH
TMMRLPQIIEFANQHGLSVISISDLIAYRRLSERLVVPVSSARLPTEYGDFNIHVYESLL
HHHHHHHHHHHHHHCCCEEEEHHHHHHHHHHHCEEEEEECCCCCCCCCCCEEEEEHHHHH
DGIQHIALVKGDVRGEENVLVRVHSECLTGDVMGSIRCDCGHQLRSAMEYIGLEGRGVIV
HHHHHEEEEECCCCCCCCEEEEEECHHHCCCCCCCEECCCCHHHHHHHHHHCCCCCEEEE
YLRGQEGRGIGLGHKVRAYALQDCGYDTVDANLEIGFPVDSREYGIGAQILADLGLTKIK
EEECCCCCCCCCCCCEEEEEECCCCCCEECCCEEEECCCCCCCCCCHHHHHHHCCCEEEE
LITHNPHKYFGLQGFGLEIVDRIALPVNVSEENENYLRTKKERMGHWIDLSFVREVNTR
EEEECCCCEECCCCCCHHHHHHEECCEEECCCCCHHHHHHHHHCCCEEEHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10192388; 10684935; 10871362 [H]