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The map label for this gene is mrdB [H]

Identifier: 89056140

GI number: 89056140

Start: 3723158

End: 3724297

Strand: Direct

Name: mrdB [H]

Synonym: Jann_3649

Alternate gene names: 89056140

Gene position: 3723158-3724297 (Clockwise)

Preceding gene: 89056139

Following gene: 89056141

Centisome position: 86.22

GC content: 60.88

Gene sequence:

>1140_bases
ATGAGTTTTCTGGAATACAACGTCAAGTCCACACCGACCGGATGGCGCAAGTTTTTGCACCTGAACTGGGCGCTTGCGAT
GTTGCTGGCCGCCGTGGCCTGCGTGGGCTTCCTGATGCTGTATTCCGTCGCCGGAGGATCGTTCGACCCCTGGGCGGAGC
AGCAGATGCAGCGCTTCGTGGTGGGTTTCGTCGCCATGCTGATCATCGCAATGGTGCCGATCTGGTTCTGGCGCAACATG
TCGGTGCTGGCCTACATCGTGGGGATCGTGCTGCTGGTCTGGGTGGAGTTCTTCGGCGTCACGCGCGGTGGCGCACAGCG
CTGGATTGATCTTGGGTTCATGGGTCTTCAACCCTCGGAACTGGCCAAGATCACCGTCGTCATGATGCTGGCGGCCTATT
ACGACTGGCTTGATCTTGGGAAGGTCTCGCACCCGCTATTCGTGGCCATTCCGCTTGTGCTGATTGGCCTGCCCGTGGGG
CTGACATTCATTCAGCCCGATCTGGGAACGTCGTTGCTGATCCTGATGGGGGGCGGTGCGGTCATGTTCCTGGCAGGCGT
GCATTGGCTGTATTTCGTGACCGTCATTGCCATGGGCATCGGTGCCATAAGCGCAGTCTTTGCCAGCCGCGGCACCGGGT
GGCAGCTGCTGGCGGACTACCAATATGGGCGGATTGATACCTTCCTTGATCCCTCCTCGGATCCGCTTGGCGACGGCTAC
CACATTACCCAAAGCCAGATCGCCCTCGGCTCCGGCGGTTGGACGGGACGCGGCTTCATGCAGGGCACCCAGATCCAGGG
GGATTTCCTGCCCGAGAGCCATACGGACTTCATCTTCCCCACCCTGGCCGAGGAATTCGGCTTTGTTGGCGGCGCATCGC
TGCTGCTGCTGTATGTGTTGATCCTGGTTTTCTGCATCGCCACGGCCATGCTGTCGCGCGACCGCTATGCCTCGCTGATG
GTTATGGGCGTCGCGGTCACCTTCTTTCTCTACTTCGCGCTGAATATGGCGATGGTCATGGGCCTCGCGCCGGTGGTGGG
CGTACCCCTGCCGCTGGTCAGCTATGGCGGGTCGGCCATGTTGGTGCTGTTGGCCGCATTCGGTCTTGTCCAATCGGCGC
ATGTTCATCGGGCCCGGTAG

Upstream 100 bases:

>100_bases
TCTACCCCGTCAGCCAGCGCCGGGCCATTCAGGAGATGCACGAGAACCTCCCGATCCTTGAAAGTCCCCCGGTGCCTTCA
GGGCGGGAGCCGCGGCGCGC

Downstream 100 bases:

>100_bases
CGGGTCCGCGCGTCTCCCAAGCAAGGTAGCCCAGATGACAGCCCCCACGATCCTATTCGCTGCCAAGCCCGAGCGGTGGA
TTACGTATGAGCCGCACCTG

Product: rod shape-determining protein RodA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 378

Protein sequence:

>379_residues
MSFLEYNVKSTPTGWRKFLHLNWALAMLLAAVACVGFLMLYSVAGGSFDPWAEQQMQRFVVGFVAMLIIAMVPIWFWRNM
SVLAYIVGIVLLVWVEFFGVTRGGAQRWIDLGFMGLQPSELAKITVVMMLAAYYDWLDLGKVSHPLFVAIPLVLIGLPVG
LTFIQPDLGTSLLILMGGGAVMFLAGVHWLYFVTVIAMGIGAISAVFASRGTGWQLLADYQYGRIDTFLDPSSDPLGDGY
HITQSQIALGSGGWTGRGFMQGTQIQGDFLPESHTDFIFPTLAEEFGFVGGASLLLLYVLILVFCIATAMLSRDRYASLM
VMGVAVTFFLYFALNMAMVMGLAPVVGVPLPLVSYGGSAMLVLLAAFGLVQSAHVHRAR

Sequences:

>Translated_379_residues
MSFLEYNVKSTPTGWRKFLHLNWALAMLLAAVACVGFLMLYSVAGGSFDPWAEQQMQRFVVGFVAMLIIAMVPIWFWRNM
SVLAYIVGIVLLVWVEFFGVTRGGAQRWIDLGFMGLQPSELAKITVVMMLAAYYDWLDLGKVSHPLFVAIPLVLIGLPVG
LTFIQPDLGTSLLILMGGGAVMFLAGVHWLYFVTVIAMGIGAISAVFASRGTGWQLLADYQYGRIDTFLDPSSDPLGDGY
HITQSQIALGSGGWTGRGFMQGTQIQGDFLPESHTDFIFPTLAEEFGFVGGASLLLLYVLILVFCIATAMLSRDRYASLM
VMGVAVTFFLYFALNMAMVMGLAPVVGVPLPLVSYGGSAMLVLLAAFGLVQSAHVHRAR
>Mature_378_residues
SFLEYNVKSTPTGWRKFLHLNWALAMLLAAVACVGFLMLYSVAGGSFDPWAEQQMQRFVVGFVAMLIIAMVPIWFWRNMS
VLAYIVGIVLLVWVEFFGVTRGGAQRWIDLGFMGLQPSELAKITVVMMLAAYYDWLDLGKVSHPLFVAIPLVLIGLPVGL
TFIQPDLGTSLLILMGGGAVMFLAGVHWLYFVTVIAMGIGAISAVFASRGTGWQLLADYQYGRIDTFLDPSSDPLGDGYH
ITQSQIALGSGGWTGRGFMQGTQIQGDFLPESHTDFIFPTLAEEFGFVGGASLLLLYVLILVFCIATAMLSRDRYASLMV
MGVAVTFFLYFALNMAMVMGLAPVVGVPLPLVSYGGSAMLVLLAAFGLVQSAHVHRAR

Specific function: This is one of the proteins responsible for the rod shape of the cell. It is required for the expression of the enzymatic activity of PBP2, which is thought to synthesize peptidoglycan in the step of initiation of cell elongation [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786853, Length=371, Percent_Identity=41.7789757412399, Blast_Score=237, Evalue=7e-64,
Organism=Escherichia coli, GI1786277, Length=345, Percent_Identity=31.5942028985507, Blast_Score=159, Evalue=3e-40,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR011923 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 41290; Mature: 41158

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00428 FTSW_RODA_SPOVE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
5.5 %Met     (Translated Protein)
6.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFLEYNVKSTPTGWRKFLHLNWALAMLLAAVACVGFLMLYSVAGGSFDPWAEQQMQRFV
CCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
VGFVAMLIIAMVPIWFWRNMSVLAYIVGIVLLVWVEFFGVTRGGAQRWIDLGFMGLQPSE
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHH
LAKITVVMMLAAYYDWLDLGKVSHPLFVAIPLVLIGLPVGLTFIQPDLGTSLLILMGGGA
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCEEEEEECCCH
VMFLAGVHWLYFVTVIAMGIGAISAVFASRGTGWQLLADYQYGRIDTFLDPSSDPLGDGY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCE
HITQSQIALGSGGWTGRGFMQGTQIQGDFLPESHTDFIFPTLAEEFGFVGGASLLLLYVL
EECHHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHH
ILVFCIATAMLSRDRYASLMVMGVAVTFFLYFALNMAMVMGLAPVVGVPLPLVSYGGSAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHH
LVLLAAFGLVQSAHVHRAR
HHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SFLEYNVKSTPTGWRKFLHLNWALAMLLAAVACVGFLMLYSVAGGSFDPWAEQQMQRFV
CCEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHH
VGFVAMLIIAMVPIWFWRNMSVLAYIVGIVLLVWVEFFGVTRGGAQRWIDLGFMGLQPSE
HHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCHHH
LAKITVVMMLAAYYDWLDLGKVSHPLFVAIPLVLIGLPVGLTFIQPDLGTSLLILMGGGA
HHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCEEEEEECCCH
VMFLAGVHWLYFVTVIAMGIGAISAVFASRGTGWQLLADYQYGRIDTFLDPSSDPLGDGY
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCE
HITQSQIALGSGGWTGRGFMQGTQIQGDFLPESHTDFIFPTLAEEFGFVGGASLLLLYVL
EECHHHEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHH
ILVFCIATAMLSRDRYASLMVMGVAVTFFLYFALNMAMVMGLAPVVGVPLPLVSYGGSAM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHH
LVLLAAFGLVQSAHVHRAR
HHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]