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The map label for this gene is mrdA [H]

Identifier: 89056139

GI number: 89056139

Start: 3721212

End: 3723161

Strand: Direct

Name: mrdA [H]

Synonym: Jann_3648

Alternate gene names: 89056139

Gene position: 3721212-3723161 (Clockwise)

Preceding gene: 89056138

Following gene: 89056140

Centisome position: 86.18

GC content: 64.67

Gene sequence:

>1950_bases
ATGAAACGCACCGCCAAAGAGATTGAGGACAGCACGCGCCAGATCGGCCGCCGCAGCCTTATCGTGGGCGGCCTCTTTGG
GGGCACCGCGGCGGTTCTGGCCGGACGGATGCGGTATTTGCAGGTGGAGCGGGCCGATGATTTTCGGCTTCTGGCCGAGG
ACAACCGCATCTCTATCCGGCTTCTGCCGCCTGAGCGTGGACTGATCTTTGACCGCACGGGTGTGCTTCTGGCGGGCAAT
GAGCCGGTCTACCGGATCACCTTCGTGCGCGAGGACGCAGATGACGTGGACGCGGTGTTGGAGCGGCTCAGCCAGATCGT
GACGCTCGACATGGCATCCCTTGAGCGGACCCGCGAAGAAATATTCGCGCGCCGTCCCTGGGTGCCTGTTACCATCGCCG
ACCGCATTTCGTGGGAAGAGATGTCGTCGGTCGCCGTCAACGCCCCCGCCCTTCCGGGTGTGAACCCCGAGGTTGGCCTG
TCGCGCGCCTATCCCATGGGCGCGGATTTCGCCCACGTTGTGGGCTATGTGCGCAATGTCCCGGAGAGCTATCAGGAGCG
GACGGGCGACACGGACCCTGTCCTCAGCATCCCCGATTTTCAGGTCGGCCTTCTGAACGTGGAAGAGGGGCTGGAGACGA
CGCTAAGGGGCCAGGCCGGCACCAAACGCGTGGAGGTCAATGCCAATGGCCGCGTGATGCGGGAGCTGGATCGCGACCCG
GCGGTGCCCGGCGGCGATGTGCAGCTGACAGTGGATGCAGGCCTACAGAATTACGTCGAGGCGCGGCTGACCGGCGAAAG
CGCGGGCGCTGTGGTGATGGATTGCCAGACGGGCGATATCGTGGCGCTGGCGTCTGCGCCGACCTATGACCCCTCGATCT
TCACACGGCCTTTGTCGGCCACGATCTACAATGGGCTGCTCAACGATCCGTACCGGCCCCTCTCGAACAAATCGACGCAA
GGCCTCTACCCGCCCGGATCAACCTACAAGATGATTGTGGCCCTGGCCGCGCTGGAAGGTGGCTTTGTCACCCCCGACGA
GACGGTCAATTGCCCCGGTCATATGGAAATCGGCAACCGCCGCTTCCATTGCTGGCGGCGGGGCGGGCATGGGCGGATGA
ACCTGTCTGAAAGCATCTCGCAATCGTGCGACGTCTACTATTACGAACTCGCCCAGCGGGTCGGGATCGAGAATATCTCG
GCCATGGCACGGCGTCTGGGCTGTGGGGTGCGTCATGATCTGCCGCTGTCGAGCATCGCCCAAGGCCTTGCGCCAACGAT
GGAATGGAAGCGGCAGAGATTTGAGCAGGACTGGGTCGTGGGCGACACGCTGAATGCCTCCATCGGGCAAGGCTTCGTGC
TGTCCTCACCCCTGCATCTGGCGGTGATGACCGCCCGGATCGCAAGCGGCAAGGCGTTGGAGCCGTCGCTGATCCGGTCG
CTTGGGGGTGTGCCGCAGCGGCGCGGGGAGGCCCCGGATCTGGGAATCGACCCGGCCAATCTGGCGCTGGTCCATCAGGG
CATGTGGCGAGTGAACAATCATGCGCGCGGCACGGCCTATCGCAGCCGCGTCATGGGAGACGAATTCACCATCGCAGGCA
AAACCGGCACCAGCCAGGTCCGCAACATCACTGCGGCAGAGCGCGCCGCAGGTGTGATCCGCAATGAGGATTTGCCCTGG
GAACGGCGCGACCATGCGCTGTTCGTGGGCTTTGCACCGTTCGATAACCCGCGCTACGCCGTCTCGGTCATCGTGGAACA
TGGCGGCGGTGGGTCGGCGGCTGCCGCCCCCATCGGCCGCGATGTGCTGCTACGCGCACAAGTCGGCGATGTGCCCCCGC
CGGAACTCTACCCCGTCAGCCAGCGCCGGGCCATTCAGGAGATGCACGAGAACCTCCCGATCCTTGAAAGTCCCCCGGTG
CCTTCAGGGCGGGAGCCGCGGCGCGCATGA

Upstream 100 bases:

>100_bases
TGACAATCGCAATCTATCCGATCGTCGTCGCCGTCTCGAAATTCGTGTTCGGAGTCCGTAAACTGGGCCCGACCGAGCTG
GAAGCCCTGTAAGAGCCGCT

Downstream 100 bases:

>100_bases
GTTTTCTGGAATACAACGTCAAGTCCACACCGACCGGATGGCGCAAGTTTTTGCACCTGAACTGGGCGCTTGCGATGTTG
CTGGCCGCCGTGGCCTGCGT

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 649; Mature: 649

Protein sequence:

>649_residues
MKRTAKEIEDSTRQIGRRSLIVGGLFGGTAAVLAGRMRYLQVERADDFRLLAEDNRISIRLLPPERGLIFDRTGVLLAGN
EPVYRITFVREDADDVDAVLERLSQIVTLDMASLERTREEIFARRPWVPVTIADRISWEEMSSVAVNAPALPGVNPEVGL
SRAYPMGADFAHVVGYVRNVPESYQERTGDTDPVLSIPDFQVGLLNVEEGLETTLRGQAGTKRVEVNANGRVMRELDRDP
AVPGGDVQLTVDAGLQNYVEARLTGESAGAVVMDCQTGDIVALASAPTYDPSIFTRPLSATIYNGLLNDPYRPLSNKSTQ
GLYPPGSTYKMIVALAALEGGFVTPDETVNCPGHMEIGNRRFHCWRRGGHGRMNLSESISQSCDVYYYELAQRVGIENIS
AMARRLGCGVRHDLPLSSIAQGLAPTMEWKRQRFEQDWVVGDTLNASIGQGFVLSSPLHLAVMTARIASGKALEPSLIRS
LGGVPQRRGEAPDLGIDPANLALVHQGMWRVNNHARGTAYRSRVMGDEFTIAGKTGTSQVRNITAAERAAGVIRNEDLPW
ERRDHALFVGFAPFDNPRYAVSVIVEHGGGGSAAAAPIGRDVLLRAQVGDVPPPELYPVSQRRAIQEMHENLPILESPPV
PSGREPRRA

Sequences:

>Translated_649_residues
MKRTAKEIEDSTRQIGRRSLIVGGLFGGTAAVLAGRMRYLQVERADDFRLLAEDNRISIRLLPPERGLIFDRTGVLLAGN
EPVYRITFVREDADDVDAVLERLSQIVTLDMASLERTREEIFARRPWVPVTIADRISWEEMSSVAVNAPALPGVNPEVGL
SRAYPMGADFAHVVGYVRNVPESYQERTGDTDPVLSIPDFQVGLLNVEEGLETTLRGQAGTKRVEVNANGRVMRELDRDP
AVPGGDVQLTVDAGLQNYVEARLTGESAGAVVMDCQTGDIVALASAPTYDPSIFTRPLSATIYNGLLNDPYRPLSNKSTQ
GLYPPGSTYKMIVALAALEGGFVTPDETVNCPGHMEIGNRRFHCWRRGGHGRMNLSESISQSCDVYYYELAQRVGIENIS
AMARRLGCGVRHDLPLSSIAQGLAPTMEWKRQRFEQDWVVGDTLNASIGQGFVLSSPLHLAVMTARIASGKALEPSLIRS
LGGVPQRRGEAPDLGIDPANLALVHQGMWRVNNHARGTAYRSRVMGDEFTIAGKTGTSQVRNITAAERAAGVIRNEDLPW
ERRDHALFVGFAPFDNPRYAVSVIVEHGGGGSAAAAPIGRDVLLRAQVGDVPPPELYPVSQRRAIQEMHENLPILESPPV
PSGREPRRA
>Mature_649_residues
MKRTAKEIEDSTRQIGRRSLIVGGLFGGTAAVLAGRMRYLQVERADDFRLLAEDNRISIRLLPPERGLIFDRTGVLLAGN
EPVYRITFVREDADDVDAVLERLSQIVTLDMASLERTREEIFARRPWVPVTIADRISWEEMSSVAVNAPALPGVNPEVGL
SRAYPMGADFAHVVGYVRNVPESYQERTGDTDPVLSIPDFQVGLLNVEEGLETTLRGQAGTKRVEVNANGRVMRELDRDP
AVPGGDVQLTVDAGLQNYVEARLTGESAGAVVMDCQTGDIVALASAPTYDPSIFTRPLSATIYNGLLNDPYRPLSNKSTQ
GLYPPGSTYKMIVALAALEGGFVTPDETVNCPGHMEIGNRRFHCWRRGGHGRMNLSESISQSCDVYYYELAQRVGIENIS
AMARRLGCGVRHDLPLSSIAQGLAPTMEWKRQRFEQDWVVGDTLNASIGQGFVLSSPLHLAVMTARIASGKALEPSLIRS
LGGVPQRRGEAPDLGIDPANLALVHQGMWRVNNHARGTAYRSRVMGDEFTIAGKTGTSQVRNITAAERAAGVIRNEDLPW
ERRDHALFVGFAPFDNPRYAVSVIVEHGGGGSAAAAPIGRDVLLRAQVGDVPPPELYPVSQRRAIQEMHENLPILESPPV
PSGREPRRA

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=608, Percent_Identity=34.703947368421, Blast_Score=347, Evalue=1e-96,
Organism=Escherichia coli, GI1786272, Length=609, Percent_Identity=24.4663382594417, Blast_Score=102, Evalue=9e-23,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 70920; Mature: 70920

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRTAKEIEDSTRQIGRRSLIVGGLFGGTAAVLAGRMRYLQVERADDFRLLAEDNRISIR
CCCHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHEEEEECCCCEEEEECCCEEEEE
LLPPERGLIFDRTGVLLAGNEPVYRITFVREDADDVDAVLERLSQIVTLDMASLERTREE
EECCCCCEEEECCCEEEECCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFARRPWVPVTIADRISWEEMSSVAVNAPALPGVNPEVGLSRAYPMGADFAHVVGYVRNV
HHHCCCCCEEEECCCCCHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
PESYQERTGDTDPVLSIPDFQVGLLNVEEGLETTLRGQAGTKRVEVNANGRVMRELDRDP
CHHHHHHCCCCCCEEECCCCEEEEEEHHHHHHHHHCCCCCCEEEEECCCCHHHHHHCCCC
AVPGGDVQLTVDAGLQNYVEARLTGESAGAVVMDCQTGDIVALASAPTYDPSIFTRPLSA
CCCCCCEEEEECCCHHHHHHHEECCCCCCEEEEEECCCCEEEEECCCCCCCHHHCCCHHH
TIYNGLLNDPYRPLSNKSTQGLYPPGSTYKMIVALAALEGGFVTPDETVNCPGHMEIGNR
HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
RFHCWRRGGHGRMNLSESISQSCDVYYYELAQRVGIENISAMARRLGCGVRHDLPLSSIA
EEEEEECCCCCCCCHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCHHHHH
QGLAPTMEWKRQRFEQDWVVGDTLNASIGQGFVLSSPLHLAVMTARIASGKALEPSLIRS
HHCCHHHHHHHHHHCCCCEECCCCCCCCCCCEEECCCHHEEHHHHHHCCCCCCCHHHHHH
LGGVPQRRGEAPDLGIDPANLALVHQGMWRVNNHARGTAYRSRVMGDEFTIAGKTGTSQV
HCCCCCCCCCCCCCCCCCHHHHHHHHCHHHCCCCCCCHHHHHHHCCCCEEEECCCCHHHH
RNITAAERAAGVIRNEDLPWERRDHALFVGFAPFDNPRYAVSVIVEHGGGGSAAAAPIGR
HHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEEECCCCCCCCCCCCC
DVLLRAQVGDVPPPELYPVSQRRAIQEMHENLPILESPPVPSGREPRRA
CEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKRTAKEIEDSTRQIGRRSLIVGGLFGGTAAVLAGRMRYLQVERADDFRLLAEDNRISIR
CCCHHHHHHHHHHHHCCCEEEEEECHHHHHHHHHHHHHEEEEECCCCEEEEECCCEEEEE
LLPPERGLIFDRTGVLLAGNEPVYRITFVREDADDVDAVLERLSQIVTLDMASLERTREE
EECCCCCEEEECCCEEEECCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
IFARRPWVPVTIADRISWEEMSSVAVNAPALPGVNPEVGLSRAYPMGADFAHVVGYVRNV
HHHCCCCCEEEECCCCCHHHHHHEEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHC
PESYQERTGDTDPVLSIPDFQVGLLNVEEGLETTLRGQAGTKRVEVNANGRVMRELDRDP
CHHHHHHCCCCCCEEECCCCEEEEEEHHHHHHHHHCCCCCCEEEEECCCCHHHHHHCCCC
AVPGGDVQLTVDAGLQNYVEARLTGESAGAVVMDCQTGDIVALASAPTYDPSIFTRPLSA
CCCCCCEEEEECCCHHHHHHHEECCCCCCEEEEEECCCCEEEEECCCCCCCHHHCCCHHH
TIYNGLLNDPYRPLSNKSTQGLYPPGSTYKMIVALAALEGGFVTPDETVNCPGHMEIGNR
HHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
RFHCWRRGGHGRMNLSESISQSCDVYYYELAQRVGIENISAMARRLGCGVRHDLPLSSIA
EEEEEECCCCCCCCHHHHHHHCCCHHHHHHHHHHCHHHHHHHHHHHCCCCCCCCCHHHHH
QGLAPTMEWKRQRFEQDWVVGDTLNASIGQGFVLSSPLHLAVMTARIASGKALEPSLIRS
HHCCHHHHHHHHHHCCCCEECCCCCCCCCCCEEECCCHHEEHHHHHHCCCCCCCHHHHHH
LGGVPQRRGEAPDLGIDPANLALVHQGMWRVNNHARGTAYRSRVMGDEFTIAGKTGTSQV
HCCCCCCCCCCCCCCCCCHHHHHHHHCHHHCCCCCCCHHHHHHHCCCCEEEECCCCHHHH
RNITAAERAAGVIRNEDLPWERRDHALFVGFAPFDNPRYAVSVIVEHGGGGSAAAAPIGR
HHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCEEEEEEEEECCCCCCCCCCCCC
DVLLRAQVGDVPPPELYPVSQRRAIQEMHENLPILESPPVPSGREPRRA
CEEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]