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The map label for this gene is norM [H]

Identifier: 89056074

GI number: 89056074

Start: 3661652

End: 3662968

Strand: Direct

Name: norM [H]

Synonym: Jann_3583

Alternate gene names: 89056074

Gene position: 3661652-3662968 (Clockwise)

Preceding gene: 89056072

Following gene: 89056075

Centisome position: 84.8

GC content: 65.68

Gene sequence:

>1317_bases
ATGACGACCGCCATTCTCCCCTCCGCAAAGGCCGAACTCGCGCCTCTGATCCGTCTGTCGGTGCCCCTGATGGTCGGCCT
GACGGCTGCGCTTTTGATCGGTGTGGTGGACACGGTCATGATCTCGCCGCTCGGGACCGTCCCGCTTGCGGCGGCAGGCG
TGACGACGGCGGTGCTGATCATCCTGATCTCGGCCCTTTGGGGGCTGCTCACGGTGATCTCGGTCCAGATCAGTCAGGCC
GATGGCGCGGCTGACCCGGCGCGCGTGGCGCTTGCGGTCCGCTCCGGTCTGCTGCTGTGCCTGATCGGAGGAGTCCTGGG
CGCCGGTCTCATGCTGGCGGTCTACCCGCTCCTTCGTCCCCTGGGCCAACCGGAAGAGGTGCTCGCCATTCTCCTGCCCT
ACTGGGCGGCGATGGCGCTCTGGATCGTGCCCTTCACGCTGTTTTTCGGCCTCAAAGCCCTGTTCGACGCCGTCGACTGG
CCGTGGACAGCCGTCGGCCTCAGCTACATCGGGGTGCTGGTGAACATCCCCGCGAACTACACCTTCATCCATGTGCTGGA
TATGGGGCTACTGGGGGCGGGCTTGGCCTCCATTCTGTCGCAAAGCCTCTCGCTGCTGGCCGCCTGGCTGGTCTTCACCC
GGGCGCCGGGTCTGGCCGCGTATCGCCAAAAGGTGGCCGTTGCCTGGGCCGACGTGCGCGCGCAGCTGAAGGACAGCGCG
CCTCTGTGCTTGGGGTACGCAGGCGAAGGCGGGGCCTACGCGATGATCGGTCTGATGATCGGCTGGATCGGGGCGGAGGC
GCTGGCCGCCCATCAGATCGTCAACGCGCTCGGCGGGGTGGCCTATGTCATCCCGCTCGGCATGGCAGGGGCCGTGTCGA
TCCGTGTCGGCAACGCCGTCGGTGCGGGCCAGATCGCGCGTCTGCGTTCGATCCTGAAGGCCTCATTCCTGATGGTGGTG
CTTTGGCAGGCCCTGGCCGCGTTGGTGTTCATATTCGGCGGACGGATCATGGCCGAGGCGATGTCATCCGACCCCGCTGT
CATCCAATTGGCCGCAACGTTATTTATCGTGATGGCGATGATGCAGATCGCCGACGGTATTCAGGGCACGTCGCTCGGGG
CGCTGCGTGGCATGTCCGACATGATCCGCCCGACGACAATCACGTTGATCGCCTATTGGCCGCTCGCCTTGCCTGCAAGC
TACCTGCTTGGCATCACGCTGGACTTCGGCGCGATTGGGATCTGGCTGGGATACACGCTCGGTCTGGCGGTCGCGGCTGT
CGCCTTGCCGGTGCGGTTCTGGCGTCTCACTGCTTGA

Upstream 100 bases:

>100_bases
AAGGCGTCTGCCCGCTGCGGCGGGCGTCAGCTTGTCACCCCAAGGCCATCTCTGTCAGGAGGCCGATTGACTCGGCCCTC
CACAGGCGTAGACGGGCGAT

Downstream 100 bases:

>100_bases
GATCGGCCCTGCGCCGCGCCCCTACCCGCGCTTTTCGCGGCGCTCAAAGATTACGAACCACGCCAGCAGAATAAACATCG
GATGCGTCAGCCCGCCCGAG

Product: MATE efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 438; Mature: 437

Protein sequence:

>438_residues
MTTAILPSAKAELAPLIRLSVPLMVGLTAALLIGVVDTVMISPLGTVPLAAAGVTTAVLIILISALWGLLTVISVQISQA
DGAADPARVALAVRSGLLLCLIGGVLGAGLMLAVYPLLRPLGQPEEVLAILLPYWAAMALWIVPFTLFFGLKALFDAVDW
PWTAVGLSYIGVLVNIPANYTFIHVLDMGLLGAGLASILSQSLSLLAAWLVFTRAPGLAAYRQKVAVAWADVRAQLKDSA
PLCLGYAGEGGAYAMIGLMIGWIGAEALAAHQIVNALGGVAYVIPLGMAGAVSIRVGNAVGAGQIARLRSILKASFLMVV
LWQALAALVFIFGGRIMAEAMSSDPAVIQLAATLFIVMAMMQIADGIQGTSLGALRGMSDMIRPTTITLIAYWPLALPAS
YLLGITLDFGAIGIWLGYTLGLAVAAVALPVRFWRLTA

Sequences:

>Translated_438_residues
MTTAILPSAKAELAPLIRLSVPLMVGLTAALLIGVVDTVMISPLGTVPLAAAGVTTAVLIILISALWGLLTVISVQISQA
DGAADPARVALAVRSGLLLCLIGGVLGAGLMLAVYPLLRPLGQPEEVLAILLPYWAAMALWIVPFTLFFGLKALFDAVDW
PWTAVGLSYIGVLVNIPANYTFIHVLDMGLLGAGLASILSQSLSLLAAWLVFTRAPGLAAYRQKVAVAWADVRAQLKDSA
PLCLGYAGEGGAYAMIGLMIGWIGAEALAAHQIVNALGGVAYVIPLGMAGAVSIRVGNAVGAGQIARLRSILKASFLMVV
LWQALAALVFIFGGRIMAEAMSSDPAVIQLAATLFIVMAMMQIADGIQGTSLGALRGMSDMIRPTTITLIAYWPLALPAS
YLLGITLDFGAIGIWLGYTLGLAVAAVALPVRFWRLTA
>Mature_437_residues
TTAILPSAKAELAPLIRLSVPLMVGLTAALLIGVVDTVMISPLGTVPLAAAGVTTAVLIILISALWGLLTVISVQISQAD
GAADPARVALAVRSGLLLCLIGGVLGAGLMLAVYPLLRPLGQPEEVLAILLPYWAAMALWIVPFTLFFGLKALFDAVDWP
WTAVGLSYIGVLVNIPANYTFIHVLDMGLLGAGLASILSQSLSLLAAWLVFTRAPGLAAYRQKVAVAWADVRAQLKDSAP
LCLGYAGEGGAYAMIGLMIGWIGAEALAAHQIVNALGGVAYVIPLGMAGAVSIRVGNAVGAGQIARLRSILKASFLMVVL
WQALAALVFIFGGRIMAEAMSSDPAVIQLAATLFIVMAMMQIADGIQGTSLGALRGMSDMIRPTTITLIAYWPLALPASY
LLGITLDFGAIGIWLGYTLGLAVAAVALPVRFWRLTA

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=432, Percent_Identity=25.2314814814815, Blast_Score=96, Evalue=1e-19,
Organism=Homo sapiens, GI153792564, Length=449, Percent_Identity=26.2806236080178, Blast_Score=86, Evalue=5e-17,
Organism=Homo sapiens, GI38261960, Length=301, Percent_Identity=27.906976744186, Blast_Score=76, Evalue=5e-14,
Organism=Escherichia coli, GI48994890, Length=437, Percent_Identity=28.1464530892449, Blast_Score=129, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6320545, Length=415, Percent_Identity=21.9277108433735, Blast_Score=74, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 45519; Mature: 45388

Theoretical pI: Translated: 8.61; Mature: 8.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAILPSAKAELAPLIRLSVPLMVGLTAALLIGVVDTVMISPLGTVPLAAAGVTTAVLI
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ILISALWGLLTVISVQISQADGAADPARVALAVRSGLLLCLIGGVLGAGLMLAVYPLLRP
HHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LGQPEEVLAILLPYWAAMALWIVPFTLFFGLKALFDAVDWPWTAVGLSYIGVLVNIPANY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEECCCCC
TFIHVLDMGLLGAGLASILSQSLSLLAAWLVFTRAPGLAAYRQKVAVAWADVRAQLKDSA
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC
PLCLGYAGEGGAYAMIGLMIGWIGAEALAAHQIVNALGGVAYVIPLGMAGAVSIRVGNAV
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCEEEEEECCCC
GAGQIARLRSILKASFLMVVLWQALAALVFIFGGRIMAEAMSSDPAVIQLAATLFIVMAM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHH
MQIADGIQGTSLGALRGMSDMIRPTTITLIAYWPLALPASYLLGITLDFGAIGIWLGYTL
HHHHCCCCCCCHHHHHCHHHHCCCHHHHHEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
GLAVAAVALPVRFWRLTA
HHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TTAILPSAKAELAPLIRLSVPLMVGLTAALLIGVVDTVMISPLGTVPLAAAGVTTAVLI
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ILISALWGLLTVISVQISQADGAADPARVALAVRSGLLLCLIGGVLGAGLMLAVYPLLRP
HHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
LGQPEEVLAILLPYWAAMALWIVPFTLFFGLKALFDAVDWPWTAVGLSYIGVLVNIPANY
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHEECCCCC
TFIHVLDMGLLGAGLASILSQSLSLLAAWLVFTRAPGLAAYRQKVAVAWADVRAQLKDSA
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCC
PLCLGYAGEGGAYAMIGLMIGWIGAEALAAHQIVNALGGVAYVIPLGMAGAVSIRVGNAV
CEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCEEEEEECCCC
GAGQIARLRSILKASFLMVVLWQALAALVFIFGGRIMAEAMSSDPAVIQLAATLFIVMAM
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCHHHHHHHHHHHHHHH
MQIADGIQGTSLGALRGMSDMIRPTTITLIAYWPLALPASYLLGITLDFGAIGIWLGYTL
HHHHCCCCCCCHHHHHCHHHHCCCHHHHHEEHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
GLAVAAVALPVRFWRLTA
HHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA