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The map label for this gene is moaA

Identifier: 89055778

GI number: 89055778

Start: 3339813

End: 3340850

Strand: Direct

Name: moaA

Synonym: Jann_3287

Alternate gene names: 89055778

Gene position: 3339813-3340850 (Clockwise)

Preceding gene: 89055775

Following gene: 89055779

Centisome position: 77.35

GC content: 62.24

Gene sequence:

>1038_bases
ATGACCCATGCATTTTCCCAGGCCGCCCCCCTGATTGATCCCTTCGCGCGCGCGATCACCTACCTGCGCGTCAGCGTCAC
CGACCGCTGCGATTTCCGCTGCGTCTATTGCATGTCCGAGAACATGCAGTTCCTGCCCAAGAAGGAACTTCTGACGCTGG
AGGAGCTGGACCGCATGTGTTCCACCTTCATCCGTCTGGGCGTGCGTAAGCTGCGGATCACCGGGGGCGAACCGTTGGTG
CGCCGCGATATCATGACGTTTTTTCAGGGCATGAAGCGGCATCTGGACACGGGCGATCTGGAAGAATTGACGCTGACCAC
CAACGGCAGCCAGTTGGCCCGGTTTGCCGAGCCGCTGGTGGCCGCAGGCGTCAAGCGGATCAACATCTCCCTCGATACGA
TTGATGAGAAAAAATTCGCCGAAATCACCCGCTGGGGTCGCCTGAAACAGGTGATGGACGGCATCGACGCCGCCTTGGCC
GCGGGCCTGAAGGTGAAAATCAACGCCGTGGCGCTCAAGGGGTTCAATGAGGATGAGTTGTTCACCCTGCAAGACTGGTG
TCTGGAACGCGGCATGGACCTGACCTTCATCGAGGTCATGCCGATGGGCGATCTGGGCAATGAAGACCGGCTCGATCAAT
ACTGGTCTCTCAACGACCTGCGCGCGCGTCTGGCCGAGCGGTTTACGCTGATTGATCTGGCCGAGCGCACCGGAGGACCC
GCGCGCTATGTGCAATTGCAGGAGACCGGCCAGAAGATCGGCTTCATCACGCCGCTCAGCCACAATTTCTGCGAAAGCTG
CAACCGCGTGCGCCTGACCTGCACGGGCCAGCTTTACATGTGCCTGGGCCAGGAAGACATGGCCGACCTGCGCGCGCCGC
TGCGCGCCAGCGCCCCGGATCGCGACGGCGAGGACAGCTTGCTGGAGGAGCGCATCCGCGCCGCCATCGGGCGCAAGCCC
AAAGGCCACGACTTCGACTATTCCCGCCAGTCCGTCGACGGCCAGATGTCCCGCCACATGAGCCACACCGGCGGGTGA

Upstream 100 bases:

>100_bases
TCGCACCTCTCAACACGTTTCGCGGATCAGGTTAGGCGGGCACCAACCCGTGATCAACCGCCACCTTGTGCGGGCGGCCC
CGCGCTCATACTGTCCGCCC

Downstream 100 bases:

>100_bases
GATGCGGTCCAGGTGAACCCTGCCAAACACTCCACTGGAGCGCTTGAGCCCCGGGACGGGCGGTTTGGACCAATGAAAGG
TGTGTTCGACTTTTCACACC

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 344

Protein sequence:

>345_residues
MTHAFSQAAPLIDPFARAITYLRVSVTDRCDFRCVYCMSENMQFLPKKELLTLEELDRMCSTFIRLGVRKLRITGGEPLV
RRDIMTFFQGMKRHLDTGDLEELTLTTNGSQLARFAEPLVAAGVKRINISLDTIDEKKFAEITRWGRLKQVMDGIDAALA
AGLKVKINAVALKGFNEDELFTLQDWCLERGMDLTFIEVMPMGDLGNEDRLDQYWSLNDLRARLAERFTLIDLAERTGGP
ARYVQLQETGQKIGFITPLSHNFCESCNRVRLTCTGQLYMCLGQEDMADLRAPLRASAPDRDGEDSLLEERIRAAIGRKP
KGHDFDYSRQSVDGQMSRHMSHTGG

Sequences:

>Translated_345_residues
MTHAFSQAAPLIDPFARAITYLRVSVTDRCDFRCVYCMSENMQFLPKKELLTLEELDRMCSTFIRLGVRKLRITGGEPLV
RRDIMTFFQGMKRHLDTGDLEELTLTTNGSQLARFAEPLVAAGVKRINISLDTIDEKKFAEITRWGRLKQVMDGIDAALA
AGLKVKINAVALKGFNEDELFTLQDWCLERGMDLTFIEVMPMGDLGNEDRLDQYWSLNDLRARLAERFTLIDLAERTGGP
ARYVQLQETGQKIGFITPLSHNFCESCNRVRLTCTGQLYMCLGQEDMADLRAPLRASAPDRDGEDSLLEERIRAAIGRKP
KGHDFDYSRQSVDGQMSRHMSHTGG
>Mature_344_residues
THAFSQAAPLIDPFARAITYLRVSVTDRCDFRCVYCMSENMQFLPKKELLTLEELDRMCSTFIRLGVRKLRITGGEPLVR
RDIMTFFQGMKRHLDTGDLEELTLTTNGSQLARFAEPLVAAGVKRINISLDTIDEKKFAEITRWGRLKQVMDGIDAALAA
GLKVKINAVALKGFNEDELFTLQDWCLERGMDLTFIEVMPMGDLGNEDRLDQYWSLNDLRARLAERFTLIDLAERTGGPA
RYVQLQETGQKIGFITPLSHNFCESCNRVRLTCTGQLYMCLGQEDMADLRAPLRASAPDRDGEDSLLEERIRAAIGRKPK
GHDFDYSRQSVDGQMSRHMSHTGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=347, Percent_Identity=36.5994236311239, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI22027536, Length=347, Percent_Identity=36.5994236311239, Blast_Score=193, Evalue=2e-49,
Organism=Escherichia coli, GI1786999, Length=341, Percent_Identity=36.0703812316716, Blast_Score=205, Evalue=3e-54,
Organism=Caenorhabditis elegans, GI32566331, Length=317, Percent_Identity=35.6466876971609, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI32566329, Length=317, Percent_Identity=35.6466876971609, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17561210, Length=317, Percent_Identity=35.6466876971609, Blast_Score=198, Evalue=3e-51,
Organism=Drosophila melanogaster, GI28574490, Length=319, Percent_Identity=38.5579937304075, Blast_Score=200, Evalue=1e-51,
Organism=Drosophila melanogaster, GI28574488, Length=325, Percent_Identity=37.8461538461538, Blast_Score=199, Evalue=3e-51,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 39070; Mature: 38939

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
6.7 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTHAFSQAAPLIDPFARAITYLRVSVTDRCDFRCVYCMSENMQFLPKKELLTLEELDRMC
CCCCCHHCCCHHHHHHHHHHHHEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
STFIRLGVRKLRITGGEPLVRRDIMTFFQGMKRHLDTGDLEELTLTTNGSQLARFAEPLV
HHHHHHCHHEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHH
AAGVKRINISLDTIDEKKFAEITRWGRLKQVMDGIDAALAAGLKVKINAVALKGFNEDEL
HCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCE
FTLQDWCLERGMDLTFIEVMPMGDLGNEDRLDQYWSLNDLRARLAERFTLIDLAERTGGP
EHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCC
ARYVQLQETGQKIGFITPLSHNFCESCNRVRLTCTGQLYMCLGQEDMADLRAPLRASAPD
CEEEEEHHCCCEEEEECCCCHHHHHCCCCEEEEEECEEEEEECCHHHHHHHCCCCCCCCC
RDGEDSLLEERIRAAIGRKPKGHDFDYSRQSVDGQMSRHMSHTGG
CCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
THAFSQAAPLIDPFARAITYLRVSVTDRCDFRCVYCMSENMQFLPKKELLTLEELDRMC
CCCCHHCCCHHHHHHHHHHHHEEEECCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
STFIRLGVRKLRITGGEPLVRRDIMTFFQGMKRHLDTGDLEELTLTTNGSQLARFAEPLV
HHHHHHCHHEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHHH
AAGVKRINISLDTIDEKKFAEITRWGRLKQVMDGIDAALAAGLKVKINAVALKGFNEDEL
HCCCEEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEEEECCCCCCE
FTLQDWCLERGMDLTFIEVMPMGDLGNEDRLDQYWSLNDLRARLAERFTLIDLAERTGGP
EHHHHHHHHCCCCEEEEEEEECCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCC
ARYVQLQETGQKIGFITPLSHNFCESCNRVRLTCTGQLYMCLGQEDMADLRAPLRASAPD
CEEEEEHHCCCEEEEECCCCHHHHHCCCCEEEEEECEEEEEECCHHHHHHHCCCCCCCCC
RDGEDSLLEERIRAAIGRKPKGHDFDYSRQSVDGQMSRHMSHTGG
CCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA