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The map label for this gene is pdxH

Identifier: 89054966

GI number: 89054966

Start: 2472641

End: 2473261

Strand: Reverse

Name: pdxH

Synonym: Jann_2475

Alternate gene names: 89054966

Gene position: 2473261-2472641 (Counterclockwise)

Preceding gene: 89054969

Following gene: 89054965

Centisome position: 57.28

GC content: 63.12

Gene sequence:

>621_bases
ATGAGCGAGCGATCTGGTATTTTCGCGGGCGACGACCCGTTTGTTCTGGCGCGTGCCTGGCTGGCGGAGGCCGAGGCGTC
CGAGCCCAATGATCCCAACGCGATTGCCCTGTCGACGGTCGATGCCGATGGCCTGCCAAATGCGCGCATGGTGCTGTTGA
AAGAGATCGAATCCCACGGTGCGGGGCAGGGCGGTTTCGTGTTCTACACCAATTACGGATCTGCCAAAGGGCAGGAGATC
GCACAGGCCGGAAAGGCCGCCTTCGTGTGCCATTGGAAAAGCCTGCATCGTCAAATTCGCGTGAGGGGGCTGACCGAGAC
AGAGGACGGACCTCAGGCTGATGCCTATTACGCCTCAAGATCCCTCAAGAGCCGTCTCGGGGCCTGGGCCTCGGATCAAT
CAAAACCCCTCAGCAGTCGTGGGGCCTTGATGGCCGATGTGGCCCGGGTCACGGCGGAGCAGGGCACCAATCCCAAGCGC
CCTCCGTTCTGGGGCGGGGTCCGGATCACGCCGCTGGAAATCGAGTTCTGGGCCGATGGCGCGTTCCGCCTGCACGACCG
GTTTCAATGGCGCCGCGGCAGCGTGGATGACCCCTGGGAAGTGCAGCGTCTGAACCCCTAA

Upstream 100 bases:

>100_bases
TCTCGTAGGCCATCCCCCGCAGGGCTTCAAGATTAAGCCAGCCCTTGCCGTGCCCGGTGTGGCCCGCTAGCTCAGGGACG
AGGTGCGAGGGAGACACGAC

Downstream 100 bases:

>100_bases
GTTTCCGTGAACGTCACCTGACTTTAGTGTTGCCGATATGCAATTTCGTTCAACGTGAAATTGCAAGCACCTGATAAGCC
GCGATTCTTTCATCTTGTAT

Product: pyridoxamine 5'-phosphate oxidase

Products: NA

Alternate protein names: PNP/PMP oxidase; PNPOx; Pyridoxal 5'-phosphate synthase

Number of amino acids: Translated: 206; Mature: 205

Protein sequence:

>206_residues
MSERSGIFAGDDPFVLARAWLAEAEASEPNDPNAIALSTVDADGLPNARMVLLKEIESHGAGQGGFVFYTNYGSAKGQEI
AQAGKAAFVCHWKSLHRQIRVRGLTETEDGPQADAYYASRSLKSRLGAWASDQSKPLSSRGALMADVARVTAEQGTNPKR
PPFWGGVRITPLEIEFWADGAFRLHDRFQWRRGSVDDPWEVQRLNP

Sequences:

>Translated_206_residues
MSERSGIFAGDDPFVLARAWLAEAEASEPNDPNAIALSTVDADGLPNARMVLLKEIESHGAGQGGFVFYTNYGSAKGQEI
AQAGKAAFVCHWKSLHRQIRVRGLTETEDGPQADAYYASRSLKSRLGAWASDQSKPLSSRGALMADVARVTAEQGTNPKR
PPFWGGVRITPLEIEFWADGAFRLHDRFQWRRGSVDDPWEVQRLNP
>Mature_205_residues
SERSGIFAGDDPFVLARAWLAEAEASEPNDPNAIALSTVDADGLPNARMVLLKEIESHGAGQGGFVFYTNYGSAKGQEIA
QAGKAAFVCHWKSLHRQIRVRGLTETEDGPQADAYYASRSLKSRLGAWASDQSKPLSSRGALMADVARVTAEQGTNPKRP
PFWGGVRITPLEIEFWADGAFRLHDRFQWRRGSVDDPWEVQRLNP

Specific function: Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP)

COG id: COG0259

COG function: function code H; Pyridoxamine-phosphate oxidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxamine 5'-phosphate oxidase family

Homologues:

Organism=Homo sapiens, GI8922498, Length=184, Percent_Identity=36.9565217391304, Blast_Score=111, Evalue=4e-25,
Organism=Escherichia coli, GI1787926, Length=197, Percent_Identity=38.5786802030457, Blast_Score=137, Evalue=6e-34,
Organism=Caenorhabditis elegans, GI17553712, Length=202, Percent_Identity=37.6237623762376, Blast_Score=117, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6319509, Length=202, Percent_Identity=39.1089108910891, Blast_Score=134, Evalue=8e-33,
Organism=Drosophila melanogaster, GI45551845, Length=225, Percent_Identity=37.3333333333333, Blast_Score=117, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24644901, Length=225, Percent_Identity=37.3333333333333, Blast_Score=117, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PDXH_JANSC (Q28PH0)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_510417.1
- ProteinModelPortal:   Q28PH0
- SMR:   Q28PH0
- STRING:   Q28PH0
- GeneID:   3934933
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_2475
- eggNOG:   COG0259
- HOGENOM:   HBG327559
- OMA:   HWSGFRI
- PhylomeDB:   Q28PH0
- ProtClustDB:   CLSK933776
- BioCyc:   JSP290400:JANN_2475-MONOMER
- HAMAP:   MF_01629
- InterPro:   IPR000659
- InterPro:   IPR019740
- InterPro:   IPR019576
- InterPro:   IPR011576
- InterPro:   IPR012349
- InterPro:   IPR009002
- Gene3D:   G3DSA:2.30.110.10
- PANTHER:   PTHR10851
- PIRSF:   PIRSF000190
- TIGRFAMs:   TIGR00558

Pfam domain/function: PF10590 PNPOx_C; PF01243 Pyridox_oxidase; SSF50475 FMN_binding

EC number: =1.4.3.5

Molecular weight: Translated: 22671; Mature: 22540

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: PS01064 PYRIDOX_OXIDASE

Important sites: BINDING 49-49 BINDING 52-52 BINDING 54-54 BINDING 76-76 BINDING 116-116 BINDING 120-120 BINDING 124-124

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERSGIFAGDDPFVLARAWLAEAEASEPNDPNAIALSTVDADGLPNARMVLLKEIESHG
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCC
AGQGGFVFYTNYGSAKGQEIAQAGKAAFVCHWKSLHRQIRVRGLTETEDGPQADAYYASR
CCCCCEEEEECCCCCCHHHHHHCCCEEEEEEHHHHHHHEEECCCCCCCCCCCCHHHHHHH
SLKSRLGAWASDQSKPLSSRGALMADVARVTAEQGTNPKRPPFWGGVRITPLEIEFWADG
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEECCC
AFRLHDRFQWRRGSVDDPWEVQRLNP
EEEECCHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SERSGIFAGDDPFVLARAWLAEAEASEPNDPNAIALSTVDADGLPNARMVLLKEIESHG
CCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCC
AGQGGFVFYTNYGSAKGQEIAQAGKAAFVCHWKSLHRQIRVRGLTETEDGPQADAYYASR
CCCCCEEEEECCCCCCHHHHHHCCCEEEEEEHHHHHHHEEECCCCCCCCCCCCHHHHHHH
SLKSRLGAWASDQSKPLSSRGALMADVARVTAEQGTNPKRPPFWGGVRITPLEIEFWADG
HHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEEEEEECCC
AFRLHDRFQWRRGSVDDPWEVQRLNP
EEEECCHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA