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The map label for this gene is envZ [H]

Identifier: 89054324

GI number: 89054324

Start: 1818999

End: 1820306

Strand: Direct

Name: envZ [H]

Synonym: Jann_1833

Alternate gene names: 89054324

Gene position: 1818999-1820306 (Clockwise)

Preceding gene: 89054321

Following gene: 89054325

Centisome position: 42.13

GC content: 64.91

Gene sequence:

>1308_bases
ATGACACCGTCGACCTGGATCAAGCAATTTCTGCCGCGTGGCCTTTACGGGCGTGCGGCCCTGATCCTGATCGTGCCCGT
GGTCACGATCCAGCTTGTAGTCAGTTCCGTCTTTCTGCAACGCCATTTCGAGGACGTGACGCGGGAGATGACGAGCGCGC
TGAGCCTCGATCTGAACCTGGTGCTGGACACTCTTGCACGCTCTGGACCCGAGGTCGCCACGGCGCTTGCGGATGCGTTG
GAGATCGAAATCGTGACGCCCGGACAGGCGAACGGAGATGCACGCTATTTCTACGACCTTTCGGGCGTTGTTGTCATCGA
AGTTCTGCGCGCGCGCATGTCCGGTGTGCAGGCCGTCGATCTGCGCATGGATGAGCGGCGGGTCTATGTTGAGCTGGCCC
GCGAGGGTGGGGCGCCCATGGCGTTTGATATCTCTCGGCGTCGCGCCTCGGCGCCTGCGCCGCACCAGCTTCTGGTGATC
ATGGTGGCGACGGGCATATTGATGACGCTTGTCGCGTATTTGTTTCTGCGCAACCAATTACGGCCGATCCGCCGCCTTGC
GGTTGCGGCGGAGGCGTTCGGTAAGGGCAGGCGGACGGAATACCACCTTTCGGGTGCCACGGAAGTTCGCTCGGCCGGGC
GCGCGTTTCTGGATATGCGGGGCCGGATCGAAGGATATCTGGAACAGCGCACGCTGATGCTGTCGGGCGTGAGCCACGAC
CTGCGCACACCGCTGACGCGGATGCGGTTGGCATTGGGGATGATGGAGGACGGCCCGGACCGCGATGCATTGGTTCAGGA
TGTGGAAGAGATGGAGGTGCTGGTCGCCACCTTCCTCGATTTCGTGCGGGGCGACGCGCTTGATGATCCCGAATCCGTGG
ACCCGCTGGCGCTGGTGGCGGACGTCGTGGAGAAGGCCCGGCGGGGCGGTGGCGAAATTGCGCTGGATCTGCCCGACGCG
ATGGCACCCGCCATGGTGCGCCCCATGGCCGTGCAGCGCGCGGTGACGAACCTTGTGGCCAACGCCCTGCGCTACGGGGG
GCGTGCGGCGGTTTCCGTCACGGTGCAGGAGCGCACATTCCGCATCACGGTGGAGGATGCGGGCCCGGGTATTCCCGAGG
ATCAACGCGCCGACGCTTTGCGCCCTTTCATCCGCCTCGACACCTCGCGCAACCAGAACCAGGGCTCGGGCGTCGGGCTG
GGGCTGGCGATCACCGAGGACATCACCCGCCGCCACGGCGGATCCCTAGCCCTGAGTGAGAGCGCCAAGATGGGTGGTCT
GCGGGTGGATCTGACGCTCCCAAGGTGA

Upstream 100 bases:

>100_bases
TGGGGGCCGTGATGCGGCGCAGGTCCGGGGCCAGGTGCGTCGACGACGGATGTCTCGTTTCGCTTTGCATGCAGTGTGCG
CCCTCGCGTAGGTTATGGCC

Downstream 100 bases:

>100_bases
CGCGCTTGGTGCCCTCAAGCATGTTGTTGGGACAATCAGAGCCAATAAATCATGGAGTTTGGGGTGTTTTTGGTAGGCCC
GGCAGGACTTGAACCCGCAA

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 435; Mature: 434

Protein sequence:

>435_residues
MTPSTWIKQFLPRGLYGRAALILIVPVVTIQLVVSSVFLQRHFEDVTREMTSALSLDLNLVLDTLARSGPEVATALADAL
EIEIVTPGQANGDARYFYDLSGVVVIEVLRARMSGVQAVDLRMDERRVYVELAREGGAPMAFDISRRRASAPAPHQLLVI
MVATGILMTLVAYLFLRNQLRPIRRLAVAAEAFGKGRRTEYHLSGATEVRSAGRAFLDMRGRIEGYLEQRTLMLSGVSHD
LRTPLTRMRLALGMMEDGPDRDALVQDVEEMEVLVATFLDFVRGDALDDPESVDPLALVADVVEKARRGGGEIALDLPDA
MAPAMVRPMAVQRAVTNLVANALRYGGRAAVSVTVQERTFRITVEDAGPGIPEDQRADALRPFIRLDTSRNQNQGSGVGL
GLAITEDITRRHGGSLALSESAKMGGLRVDLTLPR

Sequences:

>Translated_435_residues
MTPSTWIKQFLPRGLYGRAALILIVPVVTIQLVVSSVFLQRHFEDVTREMTSALSLDLNLVLDTLARSGPEVATALADAL
EIEIVTPGQANGDARYFYDLSGVVVIEVLRARMSGVQAVDLRMDERRVYVELAREGGAPMAFDISRRRASAPAPHQLLVI
MVATGILMTLVAYLFLRNQLRPIRRLAVAAEAFGKGRRTEYHLSGATEVRSAGRAFLDMRGRIEGYLEQRTLMLSGVSHD
LRTPLTRMRLALGMMEDGPDRDALVQDVEEMEVLVATFLDFVRGDALDDPESVDPLALVADVVEKARRGGGEIALDLPDA
MAPAMVRPMAVQRAVTNLVANALRYGGRAAVSVTVQERTFRITVEDAGPGIPEDQRADALRPFIRLDTSRNQNQGSGVGL
GLAITEDITRRHGGSLALSESAKMGGLRVDLTLPR
>Mature_434_residues
TPSTWIKQFLPRGLYGRAALILIVPVVTIQLVVSSVFLQRHFEDVTREMTSALSLDLNLVLDTLARSGPEVATALADALE
IEIVTPGQANGDARYFYDLSGVVVIEVLRARMSGVQAVDLRMDERRVYVELAREGGAPMAFDISRRRASAPAPHQLLVIM
VATGILMTLVAYLFLRNQLRPIRRLAVAAEAFGKGRRTEYHLSGATEVRSAGRAFLDMRGRIEGYLEQRTLMLSGVSHDL
RTPLTRMRLALGMMEDGPDRDALVQDVEEMEVLVATFLDFVRGDALDDPESVDPLALVADVVEKARRGGGEIALDLPDAM
APAMVRPMAVQRAVTNLVANALRYGGRAAVSVTVQERTFRITVEDAGPGIPEDQRADALRPFIRLDTSRNQNQGSGVGLG
LAITEDITRRHGGSLALSESAKMGGLRVDLTLPR

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=270, Percent_Identity=39.6296296296296, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI1787894, Length=308, Percent_Identity=29.2207792207792, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1790346, Length=271, Percent_Identity=31.3653136531365, Blast_Score=114, Evalue=2e-26,
Organism=Escherichia coli, GI87082128, Length=297, Percent_Identity=27.6094276094276, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1788393, Length=276, Percent_Identity=28.2608695652174, Blast_Score=82, Evalue=9e-17,
Organism=Escherichia coli, GI1790551, Length=290, Percent_Identity=27.5862068965517, Blast_Score=80, Evalue=3e-16,
Organism=Escherichia coli, GI1786783, Length=237, Percent_Identity=27.4261603375527, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786912, Length=222, Percent_Identity=29.2792792792793, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI87081816, Length=232, Percent_Identity=25.8620689655172, Blast_Score=65, Evalue=1e-11,
Organism=Escherichia coli, GI1790861, Length=271, Percent_Identity=26.1992619926199, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1789149, Length=222, Percent_Identity=24.7747747747748, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI145693157, Length=216, Percent_Identity=24.537037037037, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47492; Mature: 47360

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPSTWIKQFLPRGLYGRAALILIVPVVTIQLVVSSVFLQRHFEDVTREMTSALSLDLNL
CCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLDTLARSGPEVATALADALEIEIVTPGQANGDARYFYDLSGVVVIEVLRARMSGVQAVD
HHHHHHCCCHHHHHHHHHHHEEEEECCCCCCCCCEEEEECCHHHHHHHHHHHHCCCEEEE
LRMDERRVYVELAREGGAPMAFDISRRRASAPAPHQLLVIMVATGILMTLVAYLFLRNQL
EEECCHHHHHHHHHCCCCCEEEECHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RPIRRLAVAAEAFGKGRRTEYHLSGATEVRSAGRAFLDMRGRIEGYLEQRTLMLSGVSHD
HHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LRTPLTRMRLALGMMEDGPDRDALVQDVEEMEVLVATFLDFVRGDALDDPESVDPLALVA
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
DVVEKARRGGGEIALDLPDAMAPAMVRPMAVQRAVTNLVANALRYGGRAAVSVTVQERTF
HHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEE
RITVEDAGPGIPEDQRADALRPFIRLDTSRNQNQGSGVGLGLAITEDITRRHGGSLALSE
EEEEECCCCCCCCCCHHHHHHHHHEECCCCCCCCCCCEEEEEEEHHHHHHHCCCCEEECC
SAKMGGLRVDLTLPR
CCCCCCEEEEEECCC
>Mature Secondary Structure 
TPSTWIKQFLPRGLYGRAALILIVPVVTIQLVVSSVFLQRHFEDVTREMTSALSLDLNL
CCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLDTLARSGPEVATALADALEIEIVTPGQANGDARYFYDLSGVVVIEVLRARMSGVQAVD
HHHHHHCCCHHHHHHHHHHHEEEEECCCCCCCCCEEEEECCHHHHHHHHHHHHCCCEEEE
LRMDERRVYVELAREGGAPMAFDISRRRASAPAPHQLLVIMVATGILMTLVAYLFLRNQL
EEECCHHHHHHHHHCCCCCEEEECHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
RPIRRLAVAAEAFGKGRRTEYHLSGATEVRSAGRAFLDMRGRIEGYLEQRTLMLSGVSHD
HHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHH
LRTPLTRMRLALGMMEDGPDRDALVQDVEEMEVLVATFLDFVRGDALDDPESVDPLALVA
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHH
DVVEKARRGGGEIALDLPDAMAPAMVRPMAVQRAVTNLVANALRYGGRAAVSVTVQERTF
HHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEEEEE
RITVEDAGPGIPEDQRADALRPFIRLDTSRNQNQGSGVGLGLAITEDITRRHGGSLALSE
EEEEECCCCCCCCCCHHHHHHHHHEECCCCCCCCCCCEEEEEEEHHHHHHHCCCCEEECC
SAKMGGLRVDLTLPR
CCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]