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The map label for this gene is adhC [C]

Identifier: 89054155

GI number: 89054155

Start: 1648055

End: 1649137

Strand: Direct

Name: adhC [C]

Synonym: Jann_1664

Alternate gene names: 89054155

Gene position: 1648055-1649137 (Clockwise)

Preceding gene: 89054151

Following gene: 89054156

Centisome position: 38.17

GC content: 64.82

Gene sequence:

>1083_bases
ATGCCCAGGACCATCCGCGCCGCCGTCTGTCACGCCCATGGCGCGCCGCTCACCGTTGAAGAGATCACCCTGCGCGATGC
GGGCCCCGGGGAGGTGGAAGTGACGCTCGATGCCGTGGCGATCTGCCATTCCGACATCTCCTATATGGAAGGGGCCTGGG
GTGGTGATTTGCCGGCAGTTTATGGCCATGAGGCGGCGGGCACGGTGACGGCAATCGGCGATGGCGTGGCGTTGAAGGAA
GGCGACCGCGTGATCGTGACGCTGGCCAAATCCTGCGGCCAATGCCCGTCCTGCGCCGATGCACAGCCGATGTATTGCGG
CGGCAACACGCCGGAGGCTCAGGTGCTGACCACGTCCGAAGGCGCGCCGGTCGTCAAGGCGATGAATTGCGGTGCCTTCG
CCGAAGCCGTCGTCGTCCACGCCAGCCAGACCGCGCCCATCGGCGATGATATCCCGTCCGATGTCGCCTGCCTTCTGGCC
TGTGGCGTGCCCACGGGAATGGGGGCGGCCATCAACACGGCAAAGGTGAAACCCGGCGATAAAGTCGTTGTCATCGGTGC
AGGCGGCGTCGGCCTGAACGCAATCCAAGGCGCGCGCATTGCGGGCGCAGCGCGGATCGTGGCGATGGATCTGGAAGAAA
AGAAGCTGGCCGACGCGCGGGAATTTGGCGCAACCGATACGCTCCCCGCCCAGACAAAAAAGCCTTGGATCGCGCTGTCA
AAGATCCTCGGCGGCACGCTGGCCGATCACGTCTTCGTCTCTGTCGGTGCGATCCCGGCCTACGAGGTCGCCCTGCGGCT
CCTGGCCCCGCGCGGCACCGCCTATGCGGTCGGCATGCCACATACCGGCGAAACCACACCCTATGAGCCGGTCATTTTCG
CCGCCACGGGCCAGGGAATCCGGGGCTCTTACCTTGGCGAAATCGTCCTTAAGCGGGATATCCCCTGGATGGTGGACCTC
TATTCCCAGGGCCGCCTGAAACTGGATGAACTCGTCTCCGCCCGTTGGTCCCTTGACCAGATCAATGAGGCGATCGCCGA
CACCAACACCGGCCAGGCCCGCCGCAACGTCATCACCTTCTAG

Upstream 100 bases:

>100_bases
TTGCAAGCGTCCCGTCGCTGGCGGGTGCGCGGATGACGCATTTTGCCTCGCAATCCGGCCCGCATATCGCAATGGTAGGG
GGCATATTTCGGAGACCGCC

Downstream 100 bases:

>100_bases
TCCGCCGCTCGGCCCCTCCTTCCCTGTTCCATAAATATCCCGGGGGTGTGGGGGCTGGCCCCCACGAGGTGCACCATTCA
TGAAACTCGACACTTTGGAC

Product: zinc-binding alcohol dehydrogenase

Products: NA

Alternate protein names: NAD/mycothiol-dependent formaldehyde dehydrogenase; MD-FALDH [H]

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MPRTIRAAVCHAHGAPLTVEEITLRDAGPGEVEVTLDAVAICHSDISYMEGAWGGDLPAVYGHEAAGTVTAIGDGVALKE
GDRVIVTLAKSCGQCPSCADAQPMYCGGNTPEAQVLTTSEGAPVVKAMNCGAFAEAVVVHASQTAPIGDDIPSDVACLLA
CGVPTGMGAAINTAKVKPGDKVVVIGAGGVGLNAIQGARIAGAARIVAMDLEEKKLADAREFGATDTLPAQTKKPWIALS
KILGGTLADHVFVSVGAIPAYEVALRLLAPRGTAYAVGMPHTGETTPYEPVIFAATGQGIRGSYLGEIVLKRDIPWMVDL
YSQGRLKLDELVSARWSLDQINEAIADTNTGQARRNVITF

Sequences:

>Translated_360_residues
MPRTIRAAVCHAHGAPLTVEEITLRDAGPGEVEVTLDAVAICHSDISYMEGAWGGDLPAVYGHEAAGTVTAIGDGVALKE
GDRVIVTLAKSCGQCPSCADAQPMYCGGNTPEAQVLTTSEGAPVVKAMNCGAFAEAVVVHASQTAPIGDDIPSDVACLLA
CGVPTGMGAAINTAKVKPGDKVVVIGAGGVGLNAIQGARIAGAARIVAMDLEEKKLADAREFGATDTLPAQTKKPWIALS
KILGGTLADHVFVSVGAIPAYEVALRLLAPRGTAYAVGMPHTGETTPYEPVIFAATGQGIRGSYLGEIVLKRDIPWMVDL
YSQGRLKLDELVSARWSLDQINEAIADTNTGQARRNVITF
>Mature_359_residues
PRTIRAAVCHAHGAPLTVEEITLRDAGPGEVEVTLDAVAICHSDISYMEGAWGGDLPAVYGHEAAGTVTAIGDGVALKEG
DRVIVTLAKSCGQCPSCADAQPMYCGGNTPEAQVLTTSEGAPVVKAMNCGAFAEAVVVHASQTAPIGDDIPSDVACLLAC
GVPTGMGAAINTAKVKPGDKVVVIGAGGVGLNAIQGARIAGAARIVAMDLEEKKLADAREFGATDTLPAQTKKPWIALSK
ILGGTLADHVFVSVGAIPAYEVALRLLAPRGTAYAVGMPHTGETTPYEPVIFAATGQGIRGSYLGEIVLKRDIPWMVDLY
SQGRLKLDELVSARWSLDQINEAIADTNTGQARRNVITF

Specific function: Has High Formaldehyde Dehydrogenase Activity In The Presence Of Glutathione And Catalyzes The Oxidation Of Normal Alcohols In A Reaction That Is Not Gsh-Dependent. In Addition, Hemithiolacetals Other Than Those Formed From Gsh, Including Omega-Thiol Fatty

COG id: COG1062

COG function: function code C; Zn-dependent alcohol dehydrogenases, class III

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI262073058, Length=368, Percent_Identity=33.4239130434783, Blast_Score=199, Evalue=5e-51,
Organism=Homo sapiens, GI71743840, Length=368, Percent_Identity=33.4239130434783, Blast_Score=198, Evalue=6e-51,
Organism=Homo sapiens, GI34577061, Length=366, Percent_Identity=32.5136612021858, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI71565154, Length=370, Percent_Identity=33.5135135135135, Blast_Score=186, Evalue=2e-47,
Organism=Homo sapiens, GI4501933, Length=366, Percent_Identity=31.9672131147541, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI4501929, Length=366, Percent_Identity=32.2404371584699, Blast_Score=184, Evalue=1e-46,
Organism=Homo sapiens, GI156523966, Length=366, Percent_Identity=32.7868852459016, Blast_Score=183, Evalue=2e-46,
Organism=Homo sapiens, GI4501939, Length=360, Percent_Identity=33.0555555555556, Blast_Score=180, Evalue=1e-45,
Organism=Homo sapiens, GI71565152, Length=377, Percent_Identity=33.9522546419098, Blast_Score=173, Evalue=3e-43,
Organism=Escherichia coli, GI1786552, Length=371, Percent_Identity=35.5795148247978, Blast_Score=174, Evalue=9e-45,
Organism=Escherichia coli, GI87082125, Length=364, Percent_Identity=27.4725274725275, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1790045, Length=349, Percent_Identity=26.647564469914, Blast_Score=88, Evalue=7e-19,
Organism=Escherichia coli, GI1788075, Length=342, Percent_Identity=26.3157894736842, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1788073, Length=336, Percent_Identity=25.5952380952381, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786518, Length=360, Percent_Identity=28.8888888888889, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1788407, Length=346, Percent_Identity=24.8554913294798, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI226510992, Length=348, Percent_Identity=27.0114942528736, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI87081918, Length=358, Percent_Identity=27.3743016759777, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI87082401, Length=163, Percent_Identity=32.5153374233129, Blast_Score=72, Evalue=5e-14,
Organism=Escherichia coli, GI1787863, Length=353, Percent_Identity=25.2124645892351, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1786825, Length=228, Percent_Identity=30.2631578947368, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790718, Length=311, Percent_Identity=23.7942122186495, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25146526, Length=377, Percent_Identity=31.5649867374005, Blast_Score=174, Evalue=9e-44,
Organism=Caenorhabditis elegans, GI71997431, Length=379, Percent_Identity=31.3984168865435, Blast_Score=170, Evalue=9e-43,
Organism=Caenorhabditis elegans, GI17565904, Length=343, Percent_Identity=30.9037900874636, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI17562876, Length=343, Percent_Identity=28.5714285714286, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17562878, Length=345, Percent_Identity=28.1159420289855, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI71988145, Length=372, Percent_Identity=27.1505376344086, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17562584, Length=329, Percent_Identity=27.0516717325228, Blast_Score=75, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6320033, Length=376, Percent_Identity=33.7765957446808, Blast_Score=186, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6323099, Length=367, Percent_Identity=26.7029972752044, Blast_Score=84, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6319955, Length=353, Percent_Identity=27.4787535410765, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323729, Length=339, Percent_Identity=27.1386430678466, Blast_Score=79, Evalue=8e-16,
Organism=Saccharomyces cerevisiae, GI6322619, Length=353, Percent_Identity=27.4787535410765, Blast_Score=79, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6319258, Length=284, Percent_Identity=27.8169014084507, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6319621, Length=287, Percent_Identity=29.2682926829268, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319257, Length=325, Percent_Identity=26.1538461538462, Blast_Score=71, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323961, Length=353, Percent_Identity=26.628895184136, Blast_Score=69, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6324486, Length=359, Percent_Identity=26.7409470752089, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323980, Length=136, Percent_Identity=32.3529411764706, Blast_Score=64, Evalue=3e-11,
Organism=Drosophila melanogaster, GI17737895, Length=376, Percent_Identity=31.3829787234043, Blast_Score=164, Evalue=9e-41,
Organism=Drosophila melanogaster, GI17737897, Length=343, Percent_Identity=26.8221574344023, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR017816
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.306 [H]

Molecular weight: Translated: 37224; Mature: 37093

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRTIRAAVCHAHGAPLTVEEITLRDAGPGEVEVTLDAVAICHSDISYMEGAWGGDLPAV
CCCCCEEHEECCCCCCEEEEEEEEECCCCCEEEEEEEEEHHHHCCHHHHCCCCCCCCCCC
YGHEAAGTVTAIGDGVALKEGDRVIVTLAKSCGQCPSCADAQPMYCGGNTPEAQVLTTSE
CCCCCCCEEEEECCCEEEECCCEEEEEEEHHCCCCCCCCCCCCEEECCCCCCCEEEEECC
GAPVVKAMNCGAFAEAVVVHASQTAPIGDDIPSDVACLLACGVPTGMGAAINTAKVKPGD
CCCEEEEECCCHHHEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEEECCCC
KVVVIGAGGVGLNAIQGARIAGAARIVAMDLEEKKLADAREFGATDTLPAQTKKPWIALS
EEEEEECCCCCCHHHCCCEECCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCHHHHH
KILGGTLADHVFVSVGAIPAYEVALRLLAPRGTAYAVGMPHTGETTPYEPVIFAATGQGI
HHHCCHHHHHHHEEECCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCEEEEECCCCC
RGSYLGEIVLKRDIPWMVDLYSQGRLKLDELVSARWSLDQINEAIADTNTGQARRNVITF
CCHHHEEEEEECCCCCEEECCCCCCEEHHHHHHHCCCHHHHHHHHHCCCCCHHHHCCCCC
>Mature Secondary Structure 
PRTIRAAVCHAHGAPLTVEEITLRDAGPGEVEVTLDAVAICHSDISYMEGAWGGDLPAV
CCCCEEHEECCCCCCEEEEEEEEECCCCCEEEEEEEEEHHHHCCHHHHCCCCCCCCCCC
YGHEAAGTVTAIGDGVALKEGDRVIVTLAKSCGQCPSCADAQPMYCGGNTPEAQVLTTSE
CCCCCCCEEEEECCCEEEECCCEEEEEEEHHCCCCCCCCCCCCEEECCCCCCCEEEEECC
GAPVVKAMNCGAFAEAVVVHASQTAPIGDDIPSDVACLLACGVPTGMGAAINTAKVKPGD
CCCEEEEECCCHHHEEEEEECCCCCCCCCCCCHHHHHHHHCCCCCCCCCEEEEEEECCCC
KVVVIGAGGVGLNAIQGARIAGAARIVAMDLEEKKLADAREFGATDTLPAQTKKPWIALS
EEEEEECCCCCCHHHCCCEECCCEEEEEECCCHHHHHHHHHCCCCCCCCCCCCCCHHHHH
KILGGTLADHVFVSVGAIPAYEVALRLLAPRGTAYAVGMPHTGETTPYEPVIFAATGQGI
HHHCCHHHHHHHEEECCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCEEEEECCCCC
RGSYLGEIVLKRDIPWMVDLYSQGRLKLDELVSARWSLDQINEAIADTNTGQARRNVITF
CCHHHEEEEEECCCCCEEECCCCCCEEHHHHHHHCCCHHHHHHHHHCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9346279; 1597190; 9202149 [H]