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The map label for this gene is tdcB [H]

Identifier: 89054151

GI number: 89054151

Start: 1643489

End: 1644463

Strand: Direct

Name: tdcB [H]

Synonym: Jann_1660

Alternate gene names: 89054151

Gene position: 1643489-1644463 (Clockwise)

Preceding gene: 89054150

Following gene: 89054155

Centisome position: 38.06

GC content: 67.28

Gene sequence:

>975_bases
ATGATCACGATTGACGATATCGAAGCCTCCGCCAGCCGGGCCGAGGGTGTTGTCCGGCGTACGCCGTTGCTGTCGTCGCC
CTTCATTGACGAGATCGCTGGGCGTCGCGTGCTCCTGAAGGCCGAGGTTTTGCAGCATACCGGGTCGTTCAAGTTTCGCG
GCGGGTGGTCTGCGTTAACGGCGTTAACCAAGGACGCGCGCGGGGTGATCGCCTATTCCTCGGGCAACCACGCGCAGGGG
GTGGCGCGGGCGGCCGAGATTTTGGGCGTGCCCGCGACGATCCTGATGCCCGCCGATGCGCCCGCGTTGAAAATCGCCAA
CACTCGCGCCATGGGAGCCGATGTGGTGCTCTATGATCGCGCGGGCGGAGAGGACCGGGCCGAGATTGGCGCGCGGTTGA
GCGAGGAACGGGGACTGACGCTGGTGAAACCCTACGACGATCCGAAGGTGATGGCCGGGCAGGGTACTTGCGGGCTGGAG
ATTGCGGAGCAGGCTTTGGCAGCGGGGGTGGCGGAGGCGACGGTTTTGACGTGCTGTGGTGGGGGTGGTTTGACCTCTGG
CATTTCCACGGCGCTGGAGGCGAAGGCCCCGAGCCTGCGGGTGCGCCCGGTGGAGCCCGAGGGGTTCGACGACGCCACGC
GGTCGCTGGCGGCGGGCGAAATCCTGTCCAATGCGGGCGCGGAGGTGGGCTTGTGCGATGCGGTGCTGACGCCCGCACCC
GGGCGGCTGACCTTCCCGGTGATGCAGCGGCTTTGTGGGCCGGGGATTGTTGTCACGGAGCGCCAGGTGAAATCGGCCAT
GGCGGTGGCGGCGAGCCGGTTGAAACTGGTGGTGGAACCCGGTGGAGCCGTGGCCTTGGCCGCGGCGCTCTACCATGGCG
ATGCGTTGGCCGACGGACCGGTTATTGCGACGCTGTCGGGGGGGAATGTGGACCTGGGAGTATTCGCGCAGATCGTGGCG
GAGGCCGAGGGCTAG

Upstream 100 bases:

>100_bases
CGGATATGGCGTTCGTGGAACTGGCGGACCGGGGCCATGTGCCGTTTCTGGATGAGCCGGGCGCGCGGGCCGTCATTGAG
ACCGTTTTGGAGCGCGTGGC

Downstream 100 bases:

>100_bases
GCGGCCTCTCGCGGGGTCGGGCGAGCGCGTCCGTGGCGGATGGCGAAGATGGCGAAGGCACCGGCCATGAGGACGGCGGC
CACAAGAAACGGCGCGCCGG

Product: pyridoxal-5'-phosphate-dependent enzyme subunit beta

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MITIDDIEASASRAEGVVRRTPLLSSPFIDEIAGRRVLLKAEVLQHTGSFKFRGGWSALTALTKDARGVIAYSSGNHAQG
VARAAEILGVPATILMPADAPALKIANTRAMGADVVLYDRAGGEDRAEIGARLSEERGLTLVKPYDDPKVMAGQGTCGLE
IAEQALAAGVAEATVLTCCGGGGLTSGISTALEAKAPSLRVRPVEPEGFDDATRSLAAGEILSNAGAEVGLCDAVLTPAP
GRLTFPVMQRLCGPGIVVTERQVKSAMAVAASRLKLVVEPGGAVALAAALYHGDALADGPVIATLSGGNVDLGVFAQIVA
EAEG

Sequences:

>Translated_324_residues
MITIDDIEASASRAEGVVRRTPLLSSPFIDEIAGRRVLLKAEVLQHTGSFKFRGGWSALTALTKDARGVIAYSSGNHAQG
VARAAEILGVPATILMPADAPALKIANTRAMGADVVLYDRAGGEDRAEIGARLSEERGLTLVKPYDDPKVMAGQGTCGLE
IAEQALAAGVAEATVLTCCGGGGLTSGISTALEAKAPSLRVRPVEPEGFDDATRSLAAGEILSNAGAEVGLCDAVLTPAP
GRLTFPVMQRLCGPGIVVTERQVKSAMAVAASRLKLVVEPGGAVALAAALYHGDALADGPVIATLSGGNVDLGVFAQIVA
EAEG
>Mature_324_residues
MITIDDIEASASRAEGVVRRTPLLSSPFIDEIAGRRVLLKAEVLQHTGSFKFRGGWSALTALTKDARGVIAYSSGNHAQG
VARAAEILGVPATILMPADAPALKIANTRAMGADVVLYDRAGGEDRAEIGARLSEERGLTLVKPYDDPKVMAGQGTCGLE
IAEQALAAGVAEATVLTCCGGGGLTSGISTALEAKAPSLRVRPVEPEGFDDATRSLAAGEILSNAGAEVGLCDAVLTPAP
GRLTFPVMQRLCGPGIVVTERQVKSAMAVAASRLKLVVEPGGAVALAAALYHGDALADGPVIATLSGGNVDLGVFAQIVA
EAEG

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=330, Percent_Identity=34.2424242424242, Blast_Score=181, Evalue=9e-46,
Organism=Escherichia coli, GI1789505, Length=321, Percent_Identity=35.202492211838, Blast_Score=154, Evalue=6e-39,
Organism=Escherichia coli, GI1790207, Length=302, Percent_Identity=34.1059602649007, Blast_Score=103, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17508781, Length=314, Percent_Identity=33.4394904458599, Blast_Score=154, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI71991565, Length=321, Percent_Identity=34.2679127725857, Blast_Score=127, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17537387, Length=317, Percent_Identity=31.5457413249211, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6322631, Length=323, Percent_Identity=37.7708978328173, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6320930, Length=254, Percent_Identity=38.9763779527559, Blast_Score=126, Evalue=6e-30,
Organism=Saccharomyces cerevisiae, GI6319788, Length=287, Percent_Identity=25.0871080139373, Blast_Score=67, Evalue=3e-12,
Organism=Drosophila melanogaster, GI21355833, Length=320, Percent_Identity=35.9375, Blast_Score=133, Evalue=1e-31,
Organism=Drosophila melanogaster, GI24645328, Length=224, Percent_Identity=34.375, Blast_Score=75, Evalue=8e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 32989; Mature: 32989

Theoretical pI: Translated: 4.83; Mature: 4.83

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITIDDIEASASRAEGVVRRTPLLSSPFIDEIAGRRVLLKAEVLQHTGSFKFRGGWSALT
CEEECCCCCHHHHHCCHHHCCCCCCCCCHHHHCCCEEEEEHHHHHHCCCEEECCCHHHHH
ALTKDARGVIAYSSGNHAQGVARAAEILGVPATILMPADAPALKIANTRAMGADVVLYDR
HHHHCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCCEEEECCCCCCCEEEEEEC
AGGEDRAEIGARLSEERGLTLVKPYDDPKVMAGQGTCGLEIAEQALAAGVAEATVLTCCG
CCCCCHHHHHHHHHHHCCEEEECCCCCCCEEECCCCCCHHHHHHHHHHHHHHEEEEEEEC
GGGLTSGISTALEAKAPSLRVRPVEPEGFDDATRSLAAGEILSNAGAEVGLCDAVLTPAP
CCCHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEHHHEECCCC
GRLTFPVMQRLCGPGIVVTERQVKSAMAVAASRLKLVVEPGGAVALAAALYHGDALADGP
CCEEHHHHHHHCCCCEEEEHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHCCCCCCCCC
VIATLSGGNVDLGVFAQIVAEAEG
EEEEECCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MITIDDIEASASRAEGVVRRTPLLSSPFIDEIAGRRVLLKAEVLQHTGSFKFRGGWSALT
CEEECCCCCHHHHHCCHHHCCCCCCCCCHHHHCCCEEEEEHHHHHHCCCEEECCCHHHHH
ALTKDARGVIAYSSGNHAQGVARAAEILGVPATILMPADAPALKIANTRAMGADVVLYDR
HHHHCCCEEEEECCCCCHHHHHHHHHHHCCCEEEEECCCCCCEEEECCCCCCCEEEEEEC
AGGEDRAEIGARLSEERGLTLVKPYDDPKVMAGQGTCGLEIAEQALAAGVAEATVLTCCG
CCCCCHHHHHHHHHHHCCEEEECCCCCCCEEECCCCCCHHHHHHHHHHHHHHEEEEEEEC
GGGLTSGISTALEAKAPSLRVRPVEPEGFDDATRSLAAGEILSNAGAEVGLCDAVLTPAP
CCCHHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEHHHEECCCC
GRLTFPVMQRLCGPGIVVTERQVKSAMAVAASRLKLVVEPGGAVALAAALYHGDALADGP
CCEEHHHHHHHCCCCEEEEHHHHHHHHHHHHHHEEEEECCCCHHHHHHHHHCCCCCCCCC
VIATLSGGNVDLGVFAQIVAEAEG
EEEEECCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA