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The map label for this gene is 89053938

Identifier: 89053938

GI number: 89053938

Start: 1416951

End: 1417493

Strand: Direct

Name: 89053938

Synonym: Jann_1447

Alternate gene names: NA

Gene position: 1416951-1417493 (Clockwise)

Preceding gene: 89053937

Following gene: 89053939

Centisome position: 32.82

GC content: 62.62

Gene sequence:

>543_bases
ATGGCCCGGCTTTCAGCGTTCAACTTCAAGGCTTGGATTGATGAGCATCGCCACCTTCTCAAGCCGCCCGTCGGCAACAA
GATGGTGTATGAGGACGCCGACCTGATGGTCACCGTCGTGGGCGGCCCGAACAAGCGCACCGATTACCATGACGACCCGG
TGGAGGAGTTTTTCTACCAGCTGGAGGGCGATATGGTCCTGAAGCTCTACGACGGGGAGGAGTTCTATGACGTGCCGATC
CGCGAGGGCGAGATTTTCCTGCTGCCGCCCCATATGCGTCATTCCCCGCAGCGCCCGCAGGAGGGCAGCGTGGGGTTGGT
GATCGAGGCCAAGCGGCCCGAGGGGGCGGCGGATGCGATTGAATGGTACTGCTTCAATTGCGGCAATCTGGTGCACCGCG
CCGAGCTGATGCTGACCTCCATCGTGGACGATCTGCCCCCGGTCTATCAGGCGTTTTATGCGTCCGAGGAGGCGCGGACC
TGCGGCTCCTGCGGAGAGGTACACCCCGGCAAGGAGCCGCCGGAGGGATGGGTCACGCTGTAA

Upstream 100 bases:

>100_bases
TGCGTGCATCGGTAACTTTCCTGTAGGTTTTCCGTAACTACAGCCTTGATCTGCCGCGCGATCCGTCCAAACCTAGGGCG
ACAGCAACAGGAGCACCGAT

Downstream 100 bases:

>100_bases
GGGCGCGGCCGACGTTGCACGGGGTCCGGAAATGGGCCACGTTGGTCGTTAACGAGTTCAATGATGTCCGGGCCGGAAAG
AAGCCTCGGGCCGATAGGGA

Product: 3-hydroxyanthranilate 3,4-dioxygenase

Products: NA

Alternate protein names: 3-hydroxyanthranilate oxygenase; 3-HAO; 3-hydroxyanthranilic acid dioxygenase; HAD

Number of amino acids: Translated: 180; Mature: 179

Protein sequence:

>180_residues
MARLSAFNFKAWIDEHRHLLKPPVGNKMVYEDADLMVTVVGGPNKRTDYHDDPVEEFFYQLEGDMVLKLYDGEEFYDVPI
REGEIFLLPPHMRHSPQRPQEGSVGLVIEAKRPEGAADAIEWYCFNCGNLVHRAELMLTSIVDDLPPVYQAFYASEEART
CGSCGEVHPGKEPPEGWVTL

Sequences:

>Translated_180_residues
MARLSAFNFKAWIDEHRHLLKPPVGNKMVYEDADLMVTVVGGPNKRTDYHDDPVEEFFYQLEGDMVLKLYDGEEFYDVPI
REGEIFLLPPHMRHSPQRPQEGSVGLVIEAKRPEGAADAIEWYCFNCGNLVHRAELMLTSIVDDLPPVYQAFYASEEART
CGSCGEVHPGKEPPEGWVTL
>Mature_179_residues
ARLSAFNFKAWIDEHRHLLKPPVGNKMVYEDADLMVTVVGGPNKRTDYHDDPVEEFFYQLEGDMVLKLYDGEEFYDVPIR
EGEIFLLPPHMRHSPQRPQEGSVGLVIEAKRPEGAADAIEWYCFNCGNLVHRAELMLTSIVDDLPPVYQAFYASEEARTC
GSCGEVHPGKEPPEGWVTL

Specific function: Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-HAO family

Homologues:

Organism=Homo sapiens, GI188497625, Length=154, Percent_Identity=41.5584415584416, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17562218, Length=160, Percent_Identity=38.75, Blast_Score=120, Evalue=4e-28,
Organism=Saccharomyces cerevisiae, GI6322485, Length=172, Percent_Identity=38.3720930232558, Blast_Score=125, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): 3HAO_JANSC (Q28SE8)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_509389.1
- ProteinModelPortal:   Q28SE8
- SMR:   Q28SE8
- STRING:   Q28SE8
- GeneID:   3933894
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_1447
- eggNOG:   NOG77058
- HOGENOM:   HBG341987
- OMA:   LKPPVNN
- PhylomeDB:   Q28SE8
- ProtClustDB:   PRK13264
- BioCyc:   JSP290400:JANN_1447-MONOMER
- HAMAP:   MF_00825
- InterPro:   IPR010329
- InterPro:   IPR011051
- InterPro:   IPR014710
- Gene3D:   G3DSA:2.60.120.10
- TIGRFAMs:   TIGR03037

Pfam domain/function: PF06052 3-HAO; SSF51182 RmlC_like_cupin

EC number: =1.13.11.6

Molecular weight: Translated: 20439; Mature: 20308

Theoretical pI: Translated: 4.49; Mature: 4.49

Prosite motif: NA

Important sites: BINDING 46-46 BINDING 56-56 BINDING 98-98 BINDING 109-109

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARLSAFNFKAWIDEHRHLLKPPVGNKMVYEDADLMVTVVGGPNKRTDYHDDPVEEFFYQ
CCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEECCCCCCCCCCCCHHHHHHHH
LEGDMVLKLYDGEEFYDVPIREGEIFLLPPHMRHSPQRPQEGSVGLVIEAKRPEGAADAI
CCCCEEEEEECCCEEEECCCCCCEEEEECCHHCCCCCCCCCCCEEEEEEECCCCCCCHHH
EWYCFNCGNLVHRAELMLTSIVDDLPPVYQAFYASEEARTCGSCGEVHPGKEPPEGWVTL
EEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ARLSAFNFKAWIDEHRHLLKPPVGNKMVYEDADLMVTVVGGPNKRTDYHDDPVEEFFYQ
CCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCEEEEEECCCCCCCCCCCCHHHHHHHH
LEGDMVLKLYDGEEFYDVPIREGEIFLLPPHMRHSPQRPQEGSVGLVIEAKRPEGAADAI
CCCCEEEEEECCCEEEECCCCCCEEEEECCHHCCCCCCCCCCCEEEEEEECCCCCCCHHH
EWYCFNCGNLVHRAELMLTSIVDDLPPVYQAFYASEEARTCGSCGEVHPGKEPPEGWVTL
EEEEECCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA