Click here to switch to the map view.

The map label for this gene is argH

Identifier: 89052988

GI number: 89052988

Start: 495148

End: 496578

Strand: Direct

Name: argH

Synonym: Jann_0497

Alternate gene names: 89052988

Gene position: 495148-496578 (Clockwise)

Preceding gene: 89052986

Following gene: 89052989

Centisome position: 11.47

GC content: 62.26

Gene sequence:

>1431_bases
ATGACGGATACGGGTTCCTCTGACACCAACACCGATACGACCGGCACCAGCAAGGCCAACACCATGTGGGGCGGCCGGTT
TGCGGCGGGTCCCGATGCGATCATGGAGGCCATCAATGCCTCGATCTCATTTGACCAGCGGATGGCGCGCCAGGATATCG
AAGGCTCCCGTGCCCATGCGGCCATGCTCGCCGCCACAGGCATTGTTGAGAGTAGCGATGTCGACGTGATCCGGGAAGGC
CTGCTCACGGTCTTGTCAGAGATTGAGGGTGGCACGTTCCAATATTCCACCGCGCTGGAGGACATCCACATGAATGTGGA
GGCCCGTTTGACCGAGATTATCGGCACGCCCGCTGGCCGCCTGCACACCGCGCGGTCGCGCAATGATCAGGTCGCGACCG
ATTTCAAGCTGTGGGTTCGGGACCAGATGGATGCCGCGATCAGCGGGATCGAGGCGTTGCAGCGCGCGCTTCTGGGTCAA
GCCGAGGCCGGGGCCGATTGGGTTATGCCCGGGTTCACGCATTTGCAGACTGCGCAGCCGGTCACCTGGGGCCATCACAT
GATGGCCTACGTGGAAATGCTGGGTCGCGATGCGAGCCGGTTCCGGGATGCACGCACACGAATGAACGAGAGCCCACTGG
GTGCTGCGGCGCTCGCGGGTACGTCTTTTCCGATTGACCGGGATATGACGGCTGAGGCGCTCGGGTTTGATCGCCCCTCT
GCCAACTCGCTCGACGCCGTGGCCGACCGGGACTTTGCGCTCGAATTCCTCTCTGCCGCCTCCATCTGCGCCATGCACCT
GTCGCGGTTTGCCGAAGAGCTAGTGATCTGGTCCTCGGCCCAGTTCCGCTTCGTGGCGCTGAGTGACCGCTTCTCCACCG
GATCCTCGATCATGCCGCAGAAGAAGAACCCCGATGCGGCCGAGCTGATCCGCGCCAAGATCGGGCGGATTTTTGGGGCC
AATGTGGCGCTGATGACGGTGATGAAGGGTCTTCCGCTGACCTATTCCAAGGACATGCAGGAAGATAAGGAACAGACGTT
TGATGCCGCCGATAACCTGATGCTGGCGCTGGCCGCCATGGAAGGCATGGTGCGCGACATGCAGGCCAATGTGCCCTCGC
TGGAGGCGGCAGCGTCGAGCGGGTTTTCCACTGCCACGGACCTTGCCGACTGGTTGGTTCGGGAGTTGAACATGCCGTTC
CGGGAGGCCCATCATGTCACGGGCAGTCTGGTAAAACTGGCGGAAGACAAGGGCTGTGACCTGCCGGATCTGGCGCTGTC
TGACATGCACTCCGTCCACGGCGATATCACCGACGGCGTTTTTGACGTGTTGGGCGTGCATAATTCTGTCGCGTCGCGCA
CCTCCTATGGCGGCACATCGCCGGTGCAAGTGCGCGAGCAGGTGGCGCGGTGGCGCGACATCCTGGGATAA

Upstream 100 bases:

>100_bases
CGCGACGAGGGCATTTGCACCAAGGGCGCTCGCGATGTAAGCGGCGATCAATAGTTTATTGCGGATCATCTTTGGTCCTC
TGAAGGTAAGGCTGCGGCAC

Downstream 100 bases:

>100_bases
GCGCCTGCACGCCGATGTGCCGGTTGTTGCTGGACAGCGGGCGCTGCCCGACCGACACTGCGCTGGATGAAGGAGTTTCC
CGATGCGTTATCTTGTTGTC

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase

Number of amino acids: Translated: 476; Mature: 475

Protein sequence:

>476_residues
MTDTGSSDTNTDTTGTSKANTMWGGRFAAGPDAIMEAINASISFDQRMARQDIEGSRAHAAMLAATGIVESSDVDVIREG
LLTVLSEIEGGTFQYSTALEDIHMNVEARLTEIIGTPAGRLHTARSRNDQVATDFKLWVRDQMDAAISGIEALQRALLGQ
AEAGADWVMPGFTHLQTAQPVTWGHHMMAYVEMLGRDASRFRDARTRMNESPLGAAALAGTSFPIDRDMTAEALGFDRPS
ANSLDAVADRDFALEFLSAASICAMHLSRFAEELVIWSSAQFRFVALSDRFSTGSSIMPQKKNPDAAELIRAKIGRIFGA
NVALMTVMKGLPLTYSKDMQEDKEQTFDAADNLMLALAAMEGMVRDMQANVPSLEAAASSGFSTATDLADWLVRELNMPF
REAHHVTGSLVKLAEDKGCDLPDLALSDMHSVHGDITDGVFDVLGVHNSVASRTSYGGTSPVQVREQVARWRDILG

Sequences:

>Translated_476_residues
MTDTGSSDTNTDTTGTSKANTMWGGRFAAGPDAIMEAINASISFDQRMARQDIEGSRAHAAMLAATGIVESSDVDVIREG
LLTVLSEIEGGTFQYSTALEDIHMNVEARLTEIIGTPAGRLHTARSRNDQVATDFKLWVRDQMDAAISGIEALQRALLGQ
AEAGADWVMPGFTHLQTAQPVTWGHHMMAYVEMLGRDASRFRDARTRMNESPLGAAALAGTSFPIDRDMTAEALGFDRPS
ANSLDAVADRDFALEFLSAASICAMHLSRFAEELVIWSSAQFRFVALSDRFSTGSSIMPQKKNPDAAELIRAKIGRIFGA
NVALMTVMKGLPLTYSKDMQEDKEQTFDAADNLMLALAAMEGMVRDMQANVPSLEAAASSGFSTATDLADWLVRELNMPF
REAHHVTGSLVKLAEDKGCDLPDLALSDMHSVHGDITDGVFDVLGVHNSVASRTSYGGTSPVQVREQVARWRDILG
>Mature_475_residues
TDTGSSDTNTDTTGTSKANTMWGGRFAAGPDAIMEAINASISFDQRMARQDIEGSRAHAAMLAATGIVESSDVDVIREGL
LTVLSEIEGGTFQYSTALEDIHMNVEARLTEIIGTPAGRLHTARSRNDQVATDFKLWVRDQMDAAISGIEALQRALLGQA
EAGADWVMPGFTHLQTAQPVTWGHHMMAYVEMLGRDASRFRDARTRMNESPLGAAALAGTSFPIDRDMTAEALGFDRPSA
NSLDAVADRDFALEFLSAASICAMHLSRFAEELVIWSSAQFRFVALSDRFSTGSSIMPQKKNPDAAELIRAKIGRIFGAN
VALMTVMKGLPLTYSKDMQEDKEQTFDAADNLMLALAAMEGMVRDMQANVPSLEAAASSGFSTATDLADWLVRELNMPFR
EAHHVTGSLVKLAEDKGCDLPDLALSDMHSVHGDITDGVFDVLGVHNSVASRTSYGGTSPVQVREQVARWRDILG

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily

Homologues:

Organism=Homo sapiens, GI31541964, Length=460, Percent_Identity=42.8260869565217, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI68303542, Length=460, Percent_Identity=42.8260869565217, Blast_Score=378, Evalue=1e-105,
Organism=Homo sapiens, GI68303549, Length=460, Percent_Identity=40.6521739130435, Blast_Score=343, Evalue=2e-94,
Organism=Homo sapiens, GI68303547, Length=460, Percent_Identity=40.6521739130435, Blast_Score=343, Evalue=2e-94,
Organism=Escherichia coli, GI1790398, Length=450, Percent_Identity=46.6666666666667, Blast_Score=395, Evalue=1e-111,
Organism=Saccharomyces cerevisiae, GI6321806, Length=457, Percent_Identity=40.9190371991247, Blast_Score=353, Evalue=3e-98,
Organism=Drosophila melanogaster, GI221473854, Length=447, Percent_Identity=39.5973154362416, Blast_Score=333, Evalue=2e-91,
Organism=Drosophila melanogaster, GI78706858, Length=447, Percent_Identity=39.5973154362416, Blast_Score=333, Evalue=2e-91,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARLY_JANSC (Q28V48)

Other databases:

- EMBL:   CP000264
- RefSeq:   YP_508439.1
- ProteinModelPortal:   Q28V48
- SMR:   Q28V48
- STRING:   Q28V48
- GeneID:   3932938
- GenomeReviews:   CP000264_GR
- KEGG:   jan:Jann_0497
- eggNOG:   COG0165
- HOGENOM:   HBG539632
- OMA:   EDIHTVI
- PhylomeDB:   Q28V48
- ProtClustDB:   PRK00855
- BioCyc:   JSP290400:JANN_0497-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00006
- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761
- PANTHER:   PTHR11444:SF3
- PRINTS:   PR00145
- PRINTS:   PR00149
- TIGRFAMs:   TIGR00838

Pfam domain/function: PF00206 Lyase_1; SSF48557 L-Aspartase-like

EC number: =4.3.2.1

Molecular weight: Translated: 51473; Mature: 51342

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDTGSSDTNTDTTGTSKANTMWGGRFAAGPDAIMEAINASISFDQRMARQDIEGSRAHA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCHHHH
AMLAATGIVESSDVDVIREGLLTVLSEIEGGTFQYSTALEDIHMNVEARLTEIIGTPAGR
HHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCHHHHHHHHHCCCCHH
LHTARSRNDQVATDFKLWVRDQMDAAISGIEALQRALLGQAEAGADWVMPGFTHLQTAQP
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCC
VTWGHHMMAYVEMLGRDASRFRDARTRMNESPLGAAALAGTSFPIDRDMTAEALGFDRPS
CCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCHHHHCCCCCC
ANSLDAVADRDFALEFLSAASICAMHLSRFAEELVIWSSAQFRFVALSDRFSTGSSIMPQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCC
KKNPDAAELIRAKIGRIFGANVALMTVMKGLPLTYSKDMQEDKEQTFDAADNLMLALAAM
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EGMVRDMQANVPSLEAAASSGFSTATDLADWLVRELNMPFREAHHVTGSLVKLAEDKGCD
HHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
LPDLALSDMHSVHGDITDGVFDVLGVHNSVASRTSYGGTSPVQVREQVARWRDILG
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TDTGSSDTNTDTTGTSKANTMWGGRFAAGPDAIMEAINASISFDQRMARQDIEGSRAHA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHCCCCCHHHH
AMLAATGIVESSDVDVIREGLLTVLSEIEGGTFQYSTALEDIHMNVEARLTEIIGTPAGR
HHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHCCHHHHHHHHHCCCCHH
LHTARSRNDQVATDFKLWVRDQMDAAISGIEALQRALLGQAEAGADWVMPGFTHLQTAQP
HHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHCCCCC
VTWGHHMMAYVEMLGRDASRFRDARTRMNESPLGAAALAGTSFPIDRDMTAEALGFDRPS
CCHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHCCCCCCCCCCCCHHHHCCCCCC
ANSLDAVADRDFALEFLSAASICAMHLSRFAEELVIWSSAQFRFVALSDRFSTGSSIMPQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCC
KKNPDAAELIRAKIGRIFGANVALMTVMKGLPLTYSKDMQEDKEQTFDAADNLMLALAAM
CCCCCHHHHHHHHHHHHHCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
EGMVRDMQANVPSLEAAASSGFSTATDLADWLVRELNMPFREAHHVTGSLVKLAEDKGCD
HHHHHHHHCCCCCHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
LPDLALSDMHSVHGDITDGVFDVLGVHNSVASRTSYGGTSPVQVREQVARWRDILG
CCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA