Click here to switch to the map view.

The map label for this gene is guaA [H]

Identifier: 89052986

GI number: 89052986

Start: 493791

End: 494378

Strand: Direct

Name: guaA [H]

Synonym: Jann_0495

Alternate gene names: 89052986

Gene position: 493791-494378 (Clockwise)

Preceding gene: 89052981

Following gene: 89052988

Centisome position: 11.44

GC content: 62.41

Gene sequence:

>588_bases
GTGGCAAATGATCGAGCGGACGGGCGGTGCGACTGGTGCGGAACGGACCCCTTGTATGTCGACTATCACGACACCGAGTG
GGGCGTCCCCGAATACGACAGTCGCGCACTGTGGGAGAAGCTGGTGCTTGACGGCTTTCAGGCCGGGCTTGCCTGGATCA
CGATCCTGCGCAAAAGAGATGCGTTTCGCGACGCGTTCGAGGGCTTCAACCCGGAGGTCATCGCAGGGTGGGGGGAGGCG
GACGTGCAGCGTTTGCTGGCCAACCCCGGCATCGTGCGCCACAGGGGCAAGATCGAGGCCACGATCACCAACGCGCAGGC
CTGGATCGCGCTGGAGGAGGGCGAGGGGTTCGACACGTTCATCTGGCGCTATGTCGACGGGACACCGTTGAGAAACAGCT
TTGCCACGATGGCAGAGGTGCCGCCGTCAACAGAGATGAGCACACGGATGTCAAAGGACCTCAAGAAGGCCGGGTTCAAG
TTCTGTGGCCCGACCATCGTCTATGCCTGGCTGGAGGCCACGGGTGTGGTGAACGACCACCTGACGGGGTGTTTCCGTTA
CGACGAAGTGACGGCTCTCGCCCGTTAA

Upstream 100 bases:

>100_bases
CTTTTCACTCCAATCGCCCTCGCGTTTAAGCTTGATGCCGTGCGACCCTTTAAAGAAGGATGAAGGTCGGGATTTGTATA
GAATTTGGAGGAGTTTAGGC

Downstream 100 bases:

>100_bases
GCAGGAGAGGGCTCGGCCCCCCGTTTGCGCGCATAAGGACCGCAGTCTGCCCCGGACACGACCTGCCAAGAAGAAGCGGT
AAGGCACCCACCGCCTGCGC

Product: DNA-3-methyladenine glycosylase I

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase [H]

Number of amino acids: Translated: 195; Mature: 194

Protein sequence:

>195_residues
MANDRADGRCDWCGTDPLYVDYHDTEWGVPEYDSRALWEKLVLDGFQAGLAWITILRKRDAFRDAFEGFNPEVIAGWGEA
DVQRLLANPGIVRHRGKIEATITNAQAWIALEEGEGFDTFIWRYVDGTPLRNSFATMAEVPPSTEMSTRMSKDLKKAGFK
FCGPTIVYAWLEATGVVNDHLTGCFRYDEVTALAR

Sequences:

>Translated_195_residues
MANDRADGRCDWCGTDPLYVDYHDTEWGVPEYDSRALWEKLVLDGFQAGLAWITILRKRDAFRDAFEGFNPEVIAGWGEA
DVQRLLANPGIVRHRGKIEATITNAQAWIALEEGEGFDTFIWRYVDGTPLRNSFATMAEVPPSTEMSTRMSKDLKKAGFK
FCGPTIVYAWLEATGVVNDHLTGCFRYDEVTALAR
>Mature_194_residues
ANDRADGRCDWCGTDPLYVDYHDTEWGVPEYDSRALWEKLVLDGFQAGLAWITILRKRDAFRDAFEGFNPEVIAGWGEAD
VQRLLANPGIVRHRGKIEATITNAQAWIALEEGEGFDTFIWRYVDGTPLRNSFATMAEVPPSTEMSTRMSKDLKKAGFKF
CGPTIVYAWLEATGVVNDHLTGCFRYDEVTALAR

Specific function: Catalyzes the synthesis of GMP from XMP [H]

COG id: COG2818

COG function: function code L; 3-methyladenine DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 3 N-acetyltransferase domains [H]

Homologues:

Organism=Escherichia coli, GI1789971, Length=180, Percent_Identity=50.5555555555556, Blast_Score=202, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000182
- InterPro:   IPR016181
- InterPro:   IPR005019
- InterPro:   IPR001962
- InterPro:   IPR001317
- InterPro:   IPR011257
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00583 Acetyltransf_1; PF03352 Adenine_glyco; PF00733 Asn_synthase; PF00117 GATase; PF00958 GMP_synt_C [H]

EC number: =6.3.5.2 [H]

Molecular weight: Translated: 21992; Mature: 21861

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANDRADGRCDWCGTDPLYVDYHDTEWGVPEYDSRALWEKLVLDGFQAGLAWITILRKRD
CCCCCCCCEECCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFRDAFEGFNPEVIAGWGEADVQRLLANPGIVRHRGKIEATITNAQAWIALEEGEGFDTF
HHHHHHCCCCCEEEECCCHHHHHHHHHCCCEEEECCEEEEEEECCEEEEEEECCCCCCEE
IWRYVDGTPLRNSFATMAEVPPSTEMSTRMSKDLKKAGFKFCGPTIVYAWLEATGVVNDH
EEEEECCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHH
LTGCFRYDEVTALAR
HHHEEEHHHHHHHCC
>Mature Secondary Structure 
ANDRADGRCDWCGTDPLYVDYHDTEWGVPEYDSRALWEKLVLDGFQAGLAWITILRKRD
CCCCCCCEECCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AFRDAFEGFNPEVIAGWGEADVQRLLANPGIVRHRGKIEATITNAQAWIALEEGEGFDTF
HHHHHHCCCCCEEEECCCHHHHHHHHHCCCEEEECCEEEEEEECCEEEEEEECCCCCCEE
IWRYVDGTPLRNSFATMAEVPPSTEMSTRMSKDLKKAGFKFCGPTIVYAWLEATGVVNDH
EEEEECCCCCCHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHH
LTGCFRYDEVTALAR
HHHEEEHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12810954 [H]