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The map label for this gene is mcl1 [H]

Identifier: 89052962

GI number: 89052962

Start: 468823

End: 469779

Strand: Direct

Name: mcl1 [H]

Synonym: Jann_0471

Alternate gene names: 89052962

Gene position: 468823-469779 (Clockwise)

Preceding gene: 89052961

Following gene: 89052963

Centisome position: 10.86

GC content: 58.73

Gene sequence:

>957_bases
ATGAGCTTCCGTATCCAACCGACCCCCATTGCTCGCCCAAACCGTTGCCAATTATTTGGTCCTGGCTCCAACCCGAAACT
GTTCGAGAAGATGGCAGCCTCGGCAGCCGATGTGATCAATCTTGATCTGGAAGACAGCGTTGCCCCCGATGACAAGGCGA
TGGCGCGGTCCAATATCATCAATGCGATCAAGGATGTGGATTGGGGAAACAAGACGCTGAGCGCGCGGATCAATGGTCTC
GACACGCCCTATTGGTACCGTGATGTGGTGGACCTGTTGGAGGCCGATACAGATCGGCTCGACATCATCATGATCCCCAA
GGTCGGCTGTGCGGCCGATATCTATGCGGTGGATGCGCTTGTGACGGCGATCGAGGCAGCCAAGGGGCGCAGCAAACCGG
TCGGATTTGAAGTGATCATCGAAAGTGCTGCGGGCATTGCCCATGTCGAGGAGATTGCGGCCGCCTCCCCCCGGATGCAG
GCGATGAGCTTGGGGGCTGCGGATTTCGCGGCATCGATGGGGATGCAGACGACCGGGATCGGGGGCACGCAAGAGGCGTA
TTACATGCTGCATGAGGGCGCGAAATATTGGTCTGACCCCTGGCACTGGGCCCAGACGGCGATTGTGGCGGCGTGCAGAA
CCCATGGCGTTCTGCCCGTGGATGGCCCGTTCGGGGATTTCTCGGATGATGAGGGGTACCGGGCCCAGGCGCGTCGGTCT
GCGACGTTGGGCATGGTCGGCAAATGGGCGATCCATCCCCGGCAAATCGCTGTCGCTAACGAAGTTTTCACACCGTCAGA
GGAAGCTGTTGCAGAAGCGGAAGAGATTCTGTCTGCGATGGAGGCGGCAAAAGCCTCAGGCGCGGGGGCGACGGTCTATA
AAGGTCGGCTGGTGGACATCGCGTCAATCAAGCAGGCCGAGGTCATCGTGAAACAAGCTAAAATGATCAATAGTTAG

Upstream 100 bases:

>100_bases
AACCGGTAATCCGAGTGCCGCAGTGCAGCACTTGCACAGGCTTGCGCAATAACCTACCCCTCACGCAAAGCACTGCGCAA
TTTCCTTTCTTGAGGTCCCC

Downstream 100 bases:

>100_bases
TCGCAGGCCATTAAGGGCTTTGCAAGCATACATGTATACTGGTGTGTCCTGTAACGAGTTGAAGGGACGCCGCCATGAAC
ACATCCGTCTTTTTTGATAT

Product: citrate lyase

Products: NA

Alternate protein names: (3S)-malyl-CoA/beta-methylmalyl-CoA lyase; L-malyl-CoA/beta-methylmalyl-CoA lyase [H]

Number of amino acids: Translated: 318; Mature: 317

Protein sequence:

>318_residues
MSFRIQPTPIARPNRCQLFGPGSNPKLFEKMAASAADVINLDLEDSVAPDDKAMARSNIINAIKDVDWGNKTLSARINGL
DTPYWYRDVVDLLEADTDRLDIIMIPKVGCAADIYAVDALVTAIEAAKGRSKPVGFEVIIESAAGIAHVEEIAAASPRMQ
AMSLGAADFAASMGMQTTGIGGTQEAYYMLHEGAKYWSDPWHWAQTAIVAACRTHGVLPVDGPFGDFSDDEGYRAQARRS
ATLGMVGKWAIHPRQIAVANEVFTPSEEAVAEAEEILSAMEAAKASGAGATVYKGRLVDIASIKQAEVIVKQAKMINS

Sequences:

>Translated_318_residues
MSFRIQPTPIARPNRCQLFGPGSNPKLFEKMAASAADVINLDLEDSVAPDDKAMARSNIINAIKDVDWGNKTLSARINGL
DTPYWYRDVVDLLEADTDRLDIIMIPKVGCAADIYAVDALVTAIEAAKGRSKPVGFEVIIESAAGIAHVEEIAAASPRMQ
AMSLGAADFAASMGMQTTGIGGTQEAYYMLHEGAKYWSDPWHWAQTAIVAACRTHGVLPVDGPFGDFSDDEGYRAQARRS
ATLGMVGKWAIHPRQIAVANEVFTPSEEAVAEAEEILSAMEAAKASGAGATVYKGRLVDIASIKQAEVIVKQAKMINS
>Mature_317_residues
SFRIQPTPIARPNRCQLFGPGSNPKLFEKMAASAADVINLDLEDSVAPDDKAMARSNIINAIKDVDWGNKTLSARINGLD
TPYWYRDVVDLLEADTDRLDIIMIPKVGCAADIYAVDALVTAIEAAKGRSKPVGFEVIIESAAGIAHVEEIAAASPRMQA
MSLGAADFAASMGMQTTGIGGTQEAYYMLHEGAKYWSDPWHWAQTAIVAACRTHGVLPVDGPFGDFSDDEGYRAQARRSA
TLGMVGKWAIHPRQIAVANEVFTPSEEAVAEAEEILSAMEAAKASGAGATVYKGRLVDIASIKQAEVIVKQAKMINS

Specific function: Catalyzes the reversible condensation of glyoxylate and acetyl-CoA to L-malyl-CoA and the reversible condensation of glyoxylate and propionyl-CoA to beta-methylmalyl-CoA [H]

COG id: COG2301

COG function: function code G; Citrate lyase beta subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HpcH/HpaI aldolase family [H]

Homologues:

Organism=Homo sapiens, GI45545437, Length=316, Percent_Identity=29.746835443038, Blast_Score=128, Evalue=9e-30,
Organism=Escherichia coli, GI87081764, Length=305, Percent_Identity=28.1967213114754, Blast_Score=116, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17557458, Length=320, Percent_Identity=25.625, Blast_Score=95, Evalue=5e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005000
- InterPro:   IPR011206
- InterPro:   IPR015813 [H]

Pfam domain/function: PF03328 HpcH_HpaI [H]

EC number: =4.1.3.24 [H]

Molecular weight: Translated: 34072; Mature: 33941

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFRIQPTPIARPNRCQLFGPGSNPKLFEKMAASAADVINLDLEDSVAPDDKAMARSNII
CCEECCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHH
NAIKDVDWGNKTLSARINGLDTPYWYRDVVDLLEADTDRLDIIMIPKVGCAADIYAVDAL
HHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHH
VTAIEAAKGRSKPVGFEVIIESAAGIAHVEEIAAASPRMQAMSLGAADFAASMGMQTTGI
HHHHHHHCCCCCCCCHHHEEHHHCCHHHHHHHHHCCCCHHHHHCCHHHHHHHCCCCCCCC
GGTQEAYYMLHEGAKYWSDPWHWAQTAIVAACRTHGVLPVDGPFGDFSDDEGYRAQARRS
CCCHHHHHHHHHCHHHCCCCHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCHHHHHHHH
ATLGMVGKWAIHPRQIAVANEVFTPSEEAVAEAEEILSAMEAAKASGAGATVYKGRLVDI
HHHCCCEEEECCCCEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCEEEEH
ASIKQAEVIVKQAKMINS
HHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SFRIQPTPIARPNRCQLFGPGSNPKLFEKMAASAADVINLDLEDSVAPDDKAMARSNII
CEECCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHEEEECCCCCCCCCHHHHHHHHHH
NAIKDVDWGNKTLSARINGLDTPYWYRDVVDLLEADTDRLDIIMIPKVGCAADIYAVDAL
HHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHH
VTAIEAAKGRSKPVGFEVIIESAAGIAHVEEIAAASPRMQAMSLGAADFAASMGMQTTGI
HHHHHHHCCCCCCCCHHHEEHHHCCHHHHHHHHHCCCCHHHHHCCHHHHHHHCCCCCCCC
GGTQEAYYMLHEGAKYWSDPWHWAQTAIVAACRTHGVLPVDGPFGDFSDDEGYRAQARRS
CCCHHHHHHHHHCHHHCCCCHHHHHHHHHHHHHHCCCEECCCCCCCCCCCCCHHHHHHHH
ATLGMVGKWAIHPRQIAVANEVFTPSEEAVAEAEEILSAMEAAKASGAGATVYKGRLVDI
HHHCCCEEEECCCCEEEEHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCEEECCEEEEH
ASIKQAEVIVKQAKMINS
HHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA