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The map label for this gene is tme [H]

Identifier: 89052701

GI number: 89052701

Start: 202704

End: 204968

Strand: Direct

Name: tme [H]

Synonym: Jann_0210

Alternate gene names: 89052701

Gene position: 202704-204968 (Clockwise)

Preceding gene: 89052699

Following gene: 89052704

Centisome position: 4.69

GC content: 59.43

Gene sequence:

>2265_bases
ATGGCCGACAAACAAAAGATCACCCGCGAAGAGGCATTGGCCTACCATCTGGACCCGCGCCCGGGGAAGATCGATATCAA
CGCTTCCACCGCGATGGCGACACAGCGCGATCTGTCACTGGCCTATTCGCCGGGCGTAGCCGTGCCGTGTGAGGTGATCG
CCGATAATCCCGAAACGGCCTACGATTACACGACGAAGGGCAACATGGTTGCCGTAATTTCCAATGGTACAGCGGTTCTG
GGCCTTGGAAACCTTGGCGCGTTGGCGTCTAAGCCAGTGATGGAGGGGAAGGCGGTGTTGTTCAAACGCTTCGCCGATGT
GAACTCCATCGATATCGAGTTGGACACGGAAGACGTCGACGAATTCGTTAACGCCGTGAAGCTGATGGGGCCGTCCTTCG
GCGGCATTAACCTTGAAGACATCAAAGCGCCCGAGTGCTTCATGATTGAACAGCAGCTCAAGGAGCTGATGGATATCCCG
GTTTTCCACGACGATCAGCACGGCACAGCCGTGATCTGCGCTGCCGGTTTGATCAATGCGCTGCATATCAGCGGCAAGAA
GATTGAGGATTGCCGGATTGTGCTGAACGGGGCGGGCGCGGCTGGGATTGCTTGTATCGAATTGCTGAAATCCATGGGCG
CACGCCATGAAAATTGCATTGTTTGCGATACAAAGGGCGTGATTTACCAAGGTCGAACCGAAGGCATGAACCAGTGGAAA
TCGGCCCATGCGGTCTCTACCAAGTTGCGGAGCCTGGAAGAGGCGATGGACGGCGCGGACGTTTTCCTGGGCGTTTCCGT
CAAAGGGGCTGTCACGCCCGAGATGGTGAAATCCATGAACGATAACCCGGTGATTTTCGCCATGGCTAACCCCGATCCCG
AGATCACGCCGGAGGAGGCCCACGCCGTGCGTGCCGATGCGATCGTGGCGACAGGCCGGTCGGATTATCCCAATCAAGTC
AATAACGTACTCGGCTTTCCGTATCTGTTCCGTGGTGCCCTCGATGTCCATGCGCGCGCGATCAATGATGAGATGAAAAT
CGCCTGCGCGAAGGCTTTGGCGGAACTGGCGCGTGAAGATGTGCCCGATGAAGTCGCGATGGCGTACGGGCGGAAACTCA
GTTTTGGGCGCGACTACATTATCCCCACGCCGTTCGACCCGCGGCTCATATACATGATCCCGCCGGCTGTTGCGCAAGCG
GGCATGGATACGGGCGCGGCTCGGCGTCCGATTATTGATCTTGATGGATACGCGAAGGATTTGCAGGCGCGGATGGATCC
GACGTCGTCGATCTTGCAGGGCGTCTATGCGCGGGCGCGCAACGCCCAGGCGCGGATGATCTTTGCGGAAGGGGATGACC
CTCGCGTGCTGCGTGCCGCCGTCGCGTATCAACGCCAGGGCCTTGGGCGCGCGTTGGTGATCGGGCGCGATGCGGATGTC
CGGGAAAAGCTCGACGCCGTTGGCCTTGGTGATGCGGCGCGAGAGCTGGATATCGTGAACGCCGCCAACACGCGGCATTT
GGAAACGTACAAGGAATTTCTCTATACCCGCCTGCAACGCAAAGGCTTTGACCGGACTGATATTCACCGGCTTGCAGCGC
GTGACAGGCATGTCTTCGCGTCGCTCATGTTGGCCCATGGGCACGGCGACGGGATGCTGACGGGGGCGACACGGAAGTCA
GCGCAAGTGCTTGAGATGGTGGGGAAAGTCTTTGATGCGCGGGCAGAAGACGGCGCCGTTGGTGTCACCGCGCTGCTGCA
TAAGGGACGGATCGTTTTGATCGGGGATACGCTGGTGCACGAATGGCCGTCGGACACGGATATGGCGCTGATTGCCGAGC
GTGGGGCGCAGGTGGCGCGGGGGCTGGGGATTGAGCCTCGGGTTGCCTTTGTCAGCTTCTCAACCTTCGGCTATCCGGTG
TCTGAGCGGGCCGAAAAGATGCACCGTGCCCCTGCCGTTCTTGACGCGAAGGGTGTGGATTTTGAGTACGATGGGGAAAT
GACCGTCGACGTCGCGTTGAACCCTGCGGTGATGGCGAACTACCCCTTCACCCGTCTGTCCGGACCCGCGAATGTGCTGG
TTGTGCCCGCGCGCCACTCCGCGTCGATCAGCGTGAAACTGATGCAGGAGATGGCGGGCGCGACGGTGATTGGGCCGATC
TTGACGGGTCTTGATCGCCCGGTTCAAATCGCCTCCACGGTCAGCACATCGAACGACATTCTGAACATGGCAGTGATGGC
GGCTTGTGAGATTGGACGGACGTGA

Upstream 100 bases:

>100_bases
CCACGGGCGAATCTATACGAAGCGAAGCCCAAGTTTGAAGCGCAATCGGTTGCTCCTTCTCCTCCGGCACGGTTAAGTCG
TTCCGTTCAGGGAGGACCCA

Downstream 100 bases:

>100_bases
GCAGGCCAAAACCTGGTGTAAAGAACCTGTCGTTATCCTGTCGTTTTTCCGTAACTACACTTTGCCTTATGGGCCGAATT
CTGTTCGCCACAAAAAAACC

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 754; Mature: 753

Protein sequence:

>754_residues
MADKQKITREEALAYHLDPRPGKIDINASTAMATQRDLSLAYSPGVAVPCEVIADNPETAYDYTTKGNMVAVISNGTAVL
GLGNLGALASKPVMEGKAVLFKRFADVNSIDIELDTEDVDEFVNAVKLMGPSFGGINLEDIKAPECFMIEQQLKELMDIP
VFHDDQHGTAVICAAGLINALHISGKKIEDCRIVLNGAGAAGIACIELLKSMGARHENCIVCDTKGVIYQGRTEGMNQWK
SAHAVSTKLRSLEEAMDGADVFLGVSVKGAVTPEMVKSMNDNPVIFAMANPDPEITPEEAHAVRADAIVATGRSDYPNQV
NNVLGFPYLFRGALDVHARAINDEMKIACAKALAELAREDVPDEVAMAYGRKLSFGRDYIIPTPFDPRLIYMIPPAVAQA
GMDTGAARRPIIDLDGYAKDLQARMDPTSSILQGVYARARNAQARMIFAEGDDPRVLRAAVAYQRQGLGRALVIGRDADV
REKLDAVGLGDAARELDIVNAANTRHLETYKEFLYTRLQRKGFDRTDIHRLAARDRHVFASLMLAHGHGDGMLTGATRKS
AQVLEMVGKVFDARAEDGAVGVTALLHKGRIVLIGDTLVHEWPSDTDMALIAERGAQVARGLGIEPRVAFVSFSTFGYPV
SERAEKMHRAPAVLDAKGVDFEYDGEMTVDVALNPAVMANYPFTRLSGPANVLVVPARHSASISVKLMQEMAGATVIGPI
LTGLDRPVQIASTVSTSNDILNMAVMAACEIGRT

Sequences:

>Translated_754_residues
MADKQKITREEALAYHLDPRPGKIDINASTAMATQRDLSLAYSPGVAVPCEVIADNPETAYDYTTKGNMVAVISNGTAVL
GLGNLGALASKPVMEGKAVLFKRFADVNSIDIELDTEDVDEFVNAVKLMGPSFGGINLEDIKAPECFMIEQQLKELMDIP
VFHDDQHGTAVICAAGLINALHISGKKIEDCRIVLNGAGAAGIACIELLKSMGARHENCIVCDTKGVIYQGRTEGMNQWK
SAHAVSTKLRSLEEAMDGADVFLGVSVKGAVTPEMVKSMNDNPVIFAMANPDPEITPEEAHAVRADAIVATGRSDYPNQV
NNVLGFPYLFRGALDVHARAINDEMKIACAKALAELAREDVPDEVAMAYGRKLSFGRDYIIPTPFDPRLIYMIPPAVAQA
GMDTGAARRPIIDLDGYAKDLQARMDPTSSILQGVYARARNAQARMIFAEGDDPRVLRAAVAYQRQGLGRALVIGRDADV
REKLDAVGLGDAARELDIVNAANTRHLETYKEFLYTRLQRKGFDRTDIHRLAARDRHVFASLMLAHGHGDGMLTGATRKS
AQVLEMVGKVFDARAEDGAVGVTALLHKGRIVLIGDTLVHEWPSDTDMALIAERGAQVARGLGIEPRVAFVSFSTFGYPV
SERAEKMHRAPAVLDAKGVDFEYDGEMTVDVALNPAVMANYPFTRLSGPANVLVVPARHSASISVKLMQEMAGATVIGPI
LTGLDRPVQIASTVSTSNDILNMAVMAACEIGRT
>Mature_753_residues
ADKQKITREEALAYHLDPRPGKIDINASTAMATQRDLSLAYSPGVAVPCEVIADNPETAYDYTTKGNMVAVISNGTAVLG
LGNLGALASKPVMEGKAVLFKRFADVNSIDIELDTEDVDEFVNAVKLMGPSFGGINLEDIKAPECFMIEQQLKELMDIPV
FHDDQHGTAVICAAGLINALHISGKKIEDCRIVLNGAGAAGIACIELLKSMGARHENCIVCDTKGVIYQGRTEGMNQWKS
AHAVSTKLRSLEEAMDGADVFLGVSVKGAVTPEMVKSMNDNPVIFAMANPDPEITPEEAHAVRADAIVATGRSDYPNQVN
NVLGFPYLFRGALDVHARAINDEMKIACAKALAELAREDVPDEVAMAYGRKLSFGRDYIIPTPFDPRLIYMIPPAVAQAG
MDTGAARRPIIDLDGYAKDLQARMDPTSSILQGVYARARNAQARMIFAEGDDPRVLRAAVAYQRQGLGRALVIGRDADVR
EKLDAVGLGDAARELDIVNAANTRHLETYKEFLYTRLQRKGFDRTDIHRLAARDRHVFASLMLAHGHGDGMLTGATRKSA
QVLEMVGKVFDARAEDGAVGVTALLHKGRIVLIGDTLVHEWPSDTDMALIAERGAQVARGLGIEPRVAFVSFSTFGYPVS
ERAEKMHRAPAVLDAKGVDFEYDGEMTVDVALNPAVMANYPFTRLSGPANVLVVPARHSASISVKLMQEMAGATVIGPIL
TGLDRPVQIASTVSTSNDILNMAVMAACEIGRT

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=343, Percent_Identity=25.6559766763848, Blast_Score=87, Evalue=5e-17,
Organism=Homo sapiens, GI62420882, Length=354, Percent_Identity=26.8361581920904, Blast_Score=80, Evalue=1e-14,
Organism=Homo sapiens, GI62420880, Length=354, Percent_Identity=26.8361581920904, Blast_Score=80, Evalue=1e-14,
Organism=Homo sapiens, GI239049447, Length=354, Percent_Identity=26.8361581920904, Blast_Score=80, Evalue=1e-14,
Organism=Escherichia coli, GI1788806, Length=750, Percent_Identity=45.7333333333333, Blast_Score=637, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=314, Percent_Identity=27.0700636942675, Blast_Score=104, Evalue=2e-23,
Organism=Escherichia coli, GI1788800, Length=316, Percent_Identity=27.8481012658228, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI87081919, Length=405, Percent_Identity=22.962962962963, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17537199, Length=417, Percent_Identity=25.4196642685851, Blast_Score=76, Evalue=7e-14,
Organism=Saccharomyces cerevisiae, GI6322823, Length=269, Percent_Identity=27.1375464684015, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24646388, Length=401, Percent_Identity=26.4339152119701, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24646386, Length=401, Percent_Identity=26.4339152119701, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI281362674, Length=396, Percent_Identity=26.2626262626263, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI281362672, Length=396, Percent_Identity=26.2626262626263, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI21356279, Length=396, Percent_Identity=26.2626262626263, Blast_Score=85, Evalue=2e-16,
Organism=Drosophila melanogaster, GI78707242, Length=484, Percent_Identity=25, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI78707238, Length=484, Percent_Identity=25, Blast_Score=78, Evalue=2e-14,
Organism=Drosophila melanogaster, GI78707240, Length=422, Percent_Identity=26.0663507109005, Blast_Score=78, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 81265; Mature: 81134

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: PS00331 MALIC_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADKQKITREEALAYHLDPRPGKIDINASTAMATQRDLSLAYSPGVAVPCEVIADNPETA
CCCHHHHHHHHHHEEEECCCCCEEEECCHHHHHHHHCCEEEECCCCCCCEEEEECCCCCC
YDYTTKGNMVAVISNGTAVLGLGNLGALASKPVMEGKAVLFKRFADVNSIDIELDTEDVD
EEEECCCCEEEEEECCEEEEEECCCCCHHCCCCCCHHHHHHHHHCCCCEEEEEECHHHHH
EFVNAVKLMGPSFGGINLEDIKAPECFMIEQQLKELMDIPVFHDDQHGTAVICAAGLINA
HHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHCCCCEECCCCCCEEEEHHHHHHH
LHISGKKIEDCRIVLNGAGAAGIACIELLKSMGARHENCIVCDTKGVIYQGRTEGMNQWK
HHCCCCEECCEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEECCCCCEEECCHHHHHHHH
SAHAVSTKLRSLEEAMDGADVFLGVSVKGAVTPEMVKSMNDNPVIFAMANPDPEITPEEA
HHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHCCCCCCEEEEEECCCCCCCCCHH
HAVRADAIVATGRSDYPNQVNNVLGFPYLFRGALDVHARAINDEMKIACAKALAELARED
HHHHHCEEEECCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHC
VPDEVAMAYGRKLSFGRDYIIPTPFDPRLIYMIPPAVAQAGMDTGAARRPIIDLDGYAKD
CCHHHHHHHCCCCCCCCCEECCCCCCCEEEEEECHHHHHCCCCCCCCCCCEEECCCCHHH
LQARMDPTSSILQGVYARARNAQARMIFAEGDDPRVLRAAVAYQRQGLGRALVIGRDADV
HHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCH
REKLDAVGLGDAARELDIVNAANTRHLETYKEFLYTRLQRKGFDRTDIHRLAARDRHVFA
HHHHHHCCCCCHHHHEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
SLMLAHGHGDGMLTGATRKSAQVLEMVGKVFDARAEDGAVGVTALLHKGRIVLIGDTLVH
HHHHEECCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEEEECHHHH
EWPSDTDMALIAERGAQVARGLGIEPRVAFVSFSTFGYPVSERAEKMHRAPAVLDAKGVD
CCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCEEECCCCC
FEYDGEMTVDVALNPAVMANYPFTRLSGPANVLVVPARHSASISVKLMQEMAGATVIGPI
EEECCCEEEEEEECCCEEECCCHHHCCCCCCEEEEECCCCCCCHHHHHHHHCCCEEHHHH
LTGLDRPVQIASTVSTSNDILNMAVMAACEIGRT
HHCCCCCEEHHHHHCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
ADKQKITREEALAYHLDPRPGKIDINASTAMATQRDLSLAYSPGVAVPCEVIADNPETA
CCHHHHHHHHHHEEEECCCCCEEEECCHHHHHHHHCCEEEECCCCCCCEEEEECCCCCC
YDYTTKGNMVAVISNGTAVLGLGNLGALASKPVMEGKAVLFKRFADVNSIDIELDTEDVD
EEEECCCCEEEEEECCEEEEEECCCCCHHCCCCCCHHHHHHHHHCCCCEEEEEECHHHHH
EFVNAVKLMGPSFGGINLEDIKAPECFMIEQQLKELMDIPVFHDDQHGTAVICAAGLINA
HHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHCCCCEECCCCCCEEEEHHHHHHH
LHISGKKIEDCRIVLNGAGAAGIACIELLKSMGARHENCIVCDTKGVIYQGRTEGMNQWK
HHCCCCEECCEEEEEECCCCHHHHHHHHHHHHCCCCCCEEEECCCCCEEECCHHHHHHHH
SAHAVSTKLRSLEEAMDGADVFLGVSVKGAVTPEMVKSMNDNPVIFAMANPDPEITPEEA
HHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHCCCCCCEEEEEECCCCCCCCCHH
HAVRADAIVATGRSDYPNQVNNVLGFPYLFRGALDVHARAINDEMKIACAKALAELARED
HHHHHCEEEECCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHC
VPDEVAMAYGRKLSFGRDYIIPTPFDPRLIYMIPPAVAQAGMDTGAARRPIIDLDGYAKD
CCHHHHHHHCCCCCCCCCEECCCCCCCEEEEEECHHHHHCCCCCCCCCCCEEECCCCHHH
LQARMDPTSSILQGVYARARNAQARMIFAEGDDPRVLRAAVAYQRQGLGRALVIGRDADV
HHHHCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEECCCCH
REKLDAVGLGDAARELDIVNAANTRHLETYKEFLYTRLQRKGFDRTDIHRLAARDRHVFA
HHHHHHCCCCCHHHHEEEECCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHH
SLMLAHGHGDGMLTGATRKSAQVLEMVGKVFDARAEDGAVGVTALLHKGRIVLIGDTLVH
HHHHEECCCCCEEECCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCEEEEECHHHH
EWPSDTDMALIAERGAQVARGLGIEPRVAFVSFSTFGYPVSERAEKMHRAPAVLDAKGVD
CCCCCCCHHHHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHHHHHHCCCCEEECCCCC
FEYDGEMTVDVALNPAVMANYPFTRLSGPANVLVVPARHSASISVKLMQEMAGATVIGPI
EEECCCEEEEEEECCCEEECCCHHHCCCCCCEEEEECCCCCCCHHHHHHHHCCCEEHHHH
LTGLDRPVQIASTVSTSNDILNMAVMAACEIGRT
HHCCCCCEEHHHHHCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9535928; 11481430; 10407149 [H]