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The map label for this gene is fghA [H]

Identifier: 89052543

GI number: 89052543

Start: 47376

End: 48209

Strand: Direct

Name: fghA [H]

Synonym: Jann_0052

Alternate gene names: 89052543

Gene position: 47376-48209 (Clockwise)

Preceding gene: 89052542

Following gene: 89052544

Centisome position: 1.1

GC content: 62.83

Gene sequence:

>834_bases
ATGGAAACCATCTCTGAGAACAAAGCCTTCGGCGGCACGCAGGGCGTCTACACCCACGCCTCGGATGCGACGGATTGCGA
CATGACCTTCGGCCTGTTCCTGCCCGGTGAGGCCGCAGACGGCCCCGTGCCGGTCCTATGGTATCTGTCAGGTCTGACCT
GCACCCATGAGAACGCGATGAGCAAAGCCGGCGCGCAGGGATGGGCCGCCGAGCAAGGCATCGCGCTGATTTTCCCCGAT
ACCTCCCCACGCGGGGAAGGCGTGGCCGATGACCCGTCTTACGATCTGGGCCAGGGGGCGGGCTTTTATGTGAACGCCAC
GCAAAACCCCTGGGCCCCGCATTTCAGGATGTGGGACTACATCGTGGACGATCTGCCTGCGCTGGTGTTTGAGCATTTCA
CGCTGGACCGTGACAGGCAGGCCATCACGGGTCATTCCATGGGCGGGCACGGTGCGCTGACCATCGCGATGCACCACCCG
GATCGGTTCACCTCCGTCTCGGCCTTCGCGCCGATCTGCAACCCCTGCGACAGCGACTGGGGGCGCAAGCAGATGACATC
CTACCTTGGGATGGATGAAGATACCTGGGCCGCCCACGACGCGACCCTTTTGATGCATGCGGCGGGGTTTGACGGGCCCA
TGCTGATCGACACCGGCACCGATGATCAGTTCGGGGATCTTCTGAAGACCGAGGCCTTTGCCCACGCCGCCGCCCTGCGC
CGCCAACAGCTGACACTTCGGATGCAGCCGGGATACGACCATTCCTATTTCTTCGTGTCGAGCTTCATGGAAGACCATGT
CGCGTTCCACGCCGACGCGCTCTACGCAGTCTGA

Upstream 100 bases:

>100_bases
CAAAGGATGAGCAAACATCCCCGGCGACGAGATGTAGACGTTGCACCGCCCACCGCGCCCGCGTTACGTGGGGGGAGGCG
ATTTGGGGGAGCATCACGCT

Downstream 100 bases:

>100_bases
TGGCGGTCTCAGCGGTCATCTTCGACATCGGCAACGTGCTGATCGAGTGGCAACCCGAACGTCACTACGACCGCGTGATC
GGTGAGGCACAGCGGCGAGA

Product: carboxylesterase

Products: NA

Alternate protein names: FGH [H]

Number of amino acids: Translated: 277; Mature: 277

Protein sequence:

>277_residues
METISENKAFGGTQGVYTHASDATDCDMTFGLFLPGEAADGPVPVLWYLSGLTCTHENAMSKAGAQGWAAEQGIALIFPD
TSPRGEGVADDPSYDLGQGAGFYVNATQNPWAPHFRMWDYIVDDLPALVFEHFTLDRDRQAITGHSMGGHGALTIAMHHP
DRFTSVSAFAPICNPCDSDWGRKQMTSYLGMDEDTWAAHDATLLMHAAGFDGPMLIDTGTDDQFGDLLKTEAFAHAAALR
RQQLTLRMQPGYDHSYFFVSSFMEDHVAFHADALYAV

Sequences:

>Translated_277_residues
METISENKAFGGTQGVYTHASDATDCDMTFGLFLPGEAADGPVPVLWYLSGLTCTHENAMSKAGAQGWAAEQGIALIFPD
TSPRGEGVADDPSYDLGQGAGFYVNATQNPWAPHFRMWDYIVDDLPALVFEHFTLDRDRQAITGHSMGGHGALTIAMHHP
DRFTSVSAFAPICNPCDSDWGRKQMTSYLGMDEDTWAAHDATLLMHAAGFDGPMLIDTGTDDQFGDLLKTEAFAHAAALR
RQQLTLRMQPGYDHSYFFVSSFMEDHVAFHADALYAV
>Mature_277_residues
METISENKAFGGTQGVYTHASDATDCDMTFGLFLPGEAADGPVPVLWYLSGLTCTHENAMSKAGAQGWAAEQGIALIFPD
TSPRGEGVADDPSYDLGQGAGFYVNATQNPWAPHFRMWDYIVDDLPALVFEHFTLDRDRQAITGHSMGGHGALTIAMHHP
DRFTSVSAFAPICNPCDSDWGRKQMTSYLGMDEDTWAAHDATLLMHAAGFDGPMLIDTGTDDQFGDLLKTEAFAHAAALR
RQQLTLRMQPGYDHSYFFVSSFMEDHVAFHADALYAV

Specific function: Serine hydrolase involved in the detoxification of formaldehyde. Hydrolyzes S-formylglutathione to glutathione and formate (Probable) [H]

COG id: COG0627

COG function: function code R; Predicted esterase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the esterase D family [H]

Homologues:

Organism=Homo sapiens, GI33413400, Length=281, Percent_Identity=46.9750889679715, Blast_Score=271, Evalue=4e-73,
Organism=Escherichia coli, GI1788477, Length=277, Percent_Identity=55.2346570397112, Blast_Score=296, Evalue=7e-82,
Organism=Escherichia coli, GI1786551, Length=275, Percent_Identity=44.7272727272727, Blast_Score=264, Evalue=5e-72,
Organism=Caenorhabditis elegans, GI17510185, Length=280, Percent_Identity=46.4285714285714, Blast_Score=256, Evalue=6e-69,
Organism=Saccharomyces cerevisiae, GI6322393, Length=296, Percent_Identity=41.8918918918919, Blast_Score=210, Evalue=2e-55,
Organism=Drosophila melanogaster, GI45551932, Length=282, Percent_Identity=45.3900709219858, Blast_Score=248, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24648347, Length=282, Percent_Identity=45.3900709219858, Blast_Score=248, Evalue=4e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000801
- InterPro:   IPR014186 [H]

Pfam domain/function: PF00756 Esterase [H]

EC number: =3.1.2.12 [H]

Molecular weight: Translated: 30254; Mature: 30254

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
METISENKAFGGTQGVYTHASDATDCDMTFGLFLPGEAADGPVPVLWYLSGLTCTHENAM
CCCCCCCCCCCCCCCEEECCCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCEEECHHHH
SKAGAQGWAAEQGIALIFPDTSPRGEGVADDPSYDLGQGAGFYVNATQNPWAPHFRMWDY
HHCCCCCCHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHH
IVDDLPALVFEHFTLDRDRQAITGHSMGGHGALTIAMHHPDRFTSVSAFAPICNPCDSDW
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHCCCCCCCCCCC
GRKQMTSYLGMDEDTWAAHDATLLMHAAGFDGPMLIDTGTDDQFGDLLKTEAFAHAAALR
HHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHH
RQQLTLRMQPGYDHSYFFVSSFMEDHVAFHADALYAV
HHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHEECC
>Mature Secondary Structure
METISENKAFGGTQGVYTHASDATDCDMTFGLFLPGEAADGPVPVLWYLSGLTCTHENAM
CCCCCCCCCCCCCCCEEECCCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCEEECHHHH
SKAGAQGWAAEQGIALIFPDTSPRGEGVADDPSYDLGQGAGFYVNATQNPWAPHFRMWDY
HHCCCCCCHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCCCCHHHHHH
IVDDLPALVFEHFTLDRDRQAITGHSMGGHGALTIAMHHPDRFTSVSAFAPICNPCDSDW
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCHHHHCCCCCCCCCCC
GRKQMTSYLGMDEDTWAAHDATLLMHAAGFDGPMLIDTGTDDQFGDLLKTEAFAHAAALR
HHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHH
RQQLTLRMQPGYDHSYFFVSSFMEDHVAFHADALYAV
HHHEEEEECCCCCCCHHHHHHHHHHHHHHHHHHEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8892832 [H]