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The map label for this gene is ffh [H]

Identifier: 88658536

GI number: 88658536

Start: 453368

End: 454714

Strand: Direct

Name: ffh [H]

Synonym: ECH_0475

Alternate gene names: 88658536

Gene position: 453368-454714 (Clockwise)

Preceding gene: 88657881

Following gene: 88658308

Centisome position: 38.54

GC content: 31.85

Gene sequence:

>1347_bases
ATGTTTGAGTCTTTAACTAGTAGTTTAACTAATGTAATCCAAAAGATGCAGAGTAAGCATGTTATTTCTTCTGAGGATTT
TGATGCTGCGATGGAAGAAGTAAAAGTTGCTTTGCTTGAAGCAGATGTTTCTTTAGCTGTAGTTAAGGATTTTATTAGTA
ATGTAAAAGAGAAAATAGTTGGTGGCACTACTGTAAAAGGTGTATTGCCAACGCAGATGATAATAAAAAAGATCCAGGAT
TGTTTAATTGAAGTATTAGGATCTGAAAAGTGTGAATTAGATATTTCTAAGCCTTTGTCTGTGATTATGATGGTAGGGCT
TCAAGGTGTTGGTAAAACTACAACTACAGCTAAGTTAGCGTTAAAACTTAAAAATAAAAAAAAGGAAGTAGTAATGGCAT
CGTTGGATGTGTATCGTCCTGCAGCTCAAAAGCAATTGGAAATATTAGGCAAACAAATAGATGTTCAAACTTTACCAATT
ATTGAAAATCAGGCTCCTATTGATATAGTAAAGAGAGCAATGGATAATGCTCAGCAGGCTAATTGTGATGTTTTAATTTT
AGATACAGCAGGAAGGTTGCATGTTGATCAAGTGATGATGGAAGAGTTAAGGGCTATAAAAGATCTTACTTCTCCTAGTG
AGGTAATTTTAGTTGTTGATTCTATGATAGGTCAAGATGCTATAAATGTAGCTAAGTCATTTAATGATAATATAGGGATT
ACAGGTATTATTTTAACCCGTATTGATGGTGATTCTAGAGGTGGTGCTGCACTTTCTATGAAAATGTCAGTTGGTAGTCC
TATTAAATTCATTGCTAATGGAGAAAAATTAAGTGATCTAGATGATTTTTATCCAGAAAGAATTGCCAAAAGAATATTAA
ATATGGGTGATGTTGTATCTCTAGTAGAAAAAGCTACAGAAGCTGTAGGCAAGCATGCTATAGATGAGATGCAAAAAAAA
GCTCAGAAAGGTAAATTTGATTTAAATGATTTAGTACAACAACTGAAGGCGTTAAATAAGCTGGGTGGTATTGCCAATAT
TTTAAAATTTATGCCTAATTTTGGTGCTGATGTTAAACGTCAAGTTTCTGGAATTGCAAATGATAGTAGAGTGAAACAGT
ATATTGCAATTGTTAATTCTATGACAAAAAAAGAAAGAGAAAATCCTAAAATATTGAATGGTGCACGTAAGGCTAGAATT
GCTAAAGGTTCTGGAGTACATGTTAATGTTATTAATATGCTTATAAAACAATTTAATCAAATGAGTAGCTTGATGAATAA
ATTTAGTAAAGTTGACTATAGTAAGATTAAAAATACAGACTTCATGAATATGTTTAACAAAGAATAG

Upstream 100 bases:

>100_bases
AAGATGGTAGGAAAATTTTAGGTATATCAAGTATTGATCCTTTAGGATTTACTATAATATTTGGTATGTTATTTATTATT
ATTATGGTCGTTGTATATTT

Downstream 100 bases:

>100_bases
TTTTTATCAGGTGGTATATATTTATAGAGAAGTATTATCGATATGTGTTTGTAAATTCTAAGTTTTTATATGAAAGCTAA
AGTGCAATAAAGTTCTGTAG

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MFESLTSSLTNVIQKMQSKHVISSEDFDAAMEEVKVALLEADVSLAVVKDFISNVKEKIVGGTTVKGVLPTQMIIKKIQD
CLIEVLGSEKCELDISKPLSVIMMVGLQGVGKTTTTAKLALKLKNKKKEVVMASLDVYRPAAQKQLEILGKQIDVQTLPI
IENQAPIDIVKRAMDNAQQANCDVLILDTAGRLHVDQVMMEELRAIKDLTSPSEVILVVDSMIGQDAINVAKSFNDNIGI
TGIILTRIDGDSRGGAALSMKMSVGSPIKFIANGEKLSDLDDFYPERIAKRILNMGDVVSLVEKATEAVGKHAIDEMQKK
AQKGKFDLNDLVQQLKALNKLGGIANILKFMPNFGADVKRQVSGIANDSRVKQYIAIVNSMTKKERENPKILNGARKARI
AKGSGVHVNVINMLIKQFNQMSSLMNKFSKVDYSKIKNTDFMNMFNKE

Sequences:

>Translated_448_residues
MFESLTSSLTNVIQKMQSKHVISSEDFDAAMEEVKVALLEADVSLAVVKDFISNVKEKIVGGTTVKGVLPTQMIIKKIQD
CLIEVLGSEKCELDISKPLSVIMMVGLQGVGKTTTTAKLALKLKNKKKEVVMASLDVYRPAAQKQLEILGKQIDVQTLPI
IENQAPIDIVKRAMDNAQQANCDVLILDTAGRLHVDQVMMEELRAIKDLTSPSEVILVVDSMIGQDAINVAKSFNDNIGI
TGIILTRIDGDSRGGAALSMKMSVGSPIKFIANGEKLSDLDDFYPERIAKRILNMGDVVSLVEKATEAVGKHAIDEMQKK
AQKGKFDLNDLVQQLKALNKLGGIANILKFMPNFGADVKRQVSGIANDSRVKQYIAIVNSMTKKERENPKILNGARKARI
AKGSGVHVNVINMLIKQFNQMSSLMNKFSKVDYSKIKNTDFMNMFNKE
>Mature_448_residues
MFESLTSSLTNVIQKMQSKHVISSEDFDAAMEEVKVALLEADVSLAVVKDFISNVKEKIVGGTTVKGVLPTQMIIKKIQD
CLIEVLGSEKCELDISKPLSVIMMVGLQGVGKTTTTAKLALKLKNKKKEVVMASLDVYRPAAQKQLEILGKQIDVQTLPI
IENQAPIDIVKRAMDNAQQANCDVLILDTAGRLHVDQVMMEELRAIKDLTSPSEVILVVDSMIGQDAINVAKSFNDNIGI
TGIILTRIDGDSRGGAALSMKMSVGSPIKFIANGEKLSDLDDFYPERIAKRILNMGDVVSLVEKATEAVGKHAIDEMQKK
AQKGKFDLNDLVQQLKALNKLGGIANILKFMPNFGADVKRQVSGIANDSRVKQYIAIVNSMTKKERENPKILNGARKARI
AKGSGVHVNVINMLIKQFNQMSSLMNKFSKVDYSKIKNTDFMNMFNKE

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=436, Percent_Identity=28.4403669724771, Blast_Score=195, Evalue=6e-50,
Organism=Homo sapiens, GI226371618, Length=340, Percent_Identity=29.1176470588235, Blast_Score=172, Evalue=5e-43,
Organism=Homo sapiens, GI89061728, Length=142, Percent_Identity=31.6901408450704, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI23308697, Length=318, Percent_Identity=24.5283018867925, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI295424842, Length=318, Percent_Identity=24.5283018867925, Blast_Score=88, Evalue=2e-17,
Organism=Escherichia coli, GI1788963, Length=424, Percent_Identity=43.8679245283019, Blast_Score=360, Evalue=1e-100,
Organism=Escherichia coli, GI1789874, Length=253, Percent_Identity=35.5731225296443, Blast_Score=149, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI17539958, Length=441, Percent_Identity=28.7981859410431, Blast_Score=199, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI193206261, Length=306, Percent_Identity=26.797385620915, Blast_Score=100, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6325345, Length=431, Percent_Identity=28.7703016241299, Blast_Score=192, Evalue=1e-49,
Organism=Saccharomyces cerevisiae, GI6320498, Length=313, Percent_Identity=24.6006389776358, Blast_Score=90, Evalue=7e-19,
Organism=Drosophila melanogaster, GI17647949, Length=433, Percent_Identity=28.6374133949192, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24641198, Length=297, Percent_Identity=25.2525252525253, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 49224; Mature: 49224

Theoretical pI: Translated: 9.75; Mature: 9.75

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFESLTSSLTNVIQKMQSKHVISSEDFDAAMEEVKVALLEADVSLAVVKDFISNVKEKIV
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHC
GGTTVKGVLPTQMIIKKIQDCLIEVLGSEKCELDISKPLSVIMMVGLQGVGKTTTTAKLA
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHCCCCCCCHHHHHHH
LKLKNKKKEVVMASLDVYRPAAQKQLEILGKQIDVQTLPIIENQAPIDIVKRAMDNAQQA
HHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHCHHHC
NCDVLILDTAGRLHVDQVMMEELRAIKDLTSPSEVILVVDSMIGQDAINVAKSFNDNIGI
CCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHCHHHHHHHHHCCCCCCE
TGIILTRIDGDSRGGAALSMKMSVGSPIKFIANGEKLSDLDDFYPERIAKRILNMGDVVS
EEEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCHHHHHH
LVEKATEAVGKHAIDEMQKKAQKGKFDLNDLVQQLKALNKLGGIANILKFMPNFGADVKR
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCHHHHH
QVSGIANDSRVKQYIAIVNSMTKKERENPKILNGARKARIAKGSGVHVNVINMLIKQFNQ
HHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHH
MSSLMNKFSKVDYSKIKNTDFMNMFNKE
HHHHHHHHHHCHHHHHCCCHHHHHHCCC
>Mature Secondary Structure
MFESLTSSLTNVIQKMQSKHVISSEDFDAAMEEVKVALLEADVSLAVVKDFISNVKEKIV
CCHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHC
GGTTVKGVLPTQMIIKKIQDCLIEVLGSEKCELDISKPLSVIMMVGLQGVGKTTTTAKLA
CCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHCCCCCCCHHHHHHH
LKLKNKKKEVVMASLDVYRPAAQKQLEILGKQIDVQTLPIIENQAPIDIVKRAMDNAQQA
HHHHCCHHHHHHHHHHHHCHHHHHHHHHHHHHCCCEECCCCCCCCCHHHHHHHHHCHHHC
NCDVLILDTAGRLHVDQVMMEELRAIKDLTSPSEVILVVDSMIGQDAINVAKSFNDNIGI
CCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCEEEEHHHHHCHHHHHHHHHCCCCCCE
TGIILTRIDGDSRGGAALSMKMSVGSPIKFIANGEKLSDLDDFYPERIAKRILNMGDVVS
EEEEEEEECCCCCCCCEEEEEECCCCCEEEEECCCHHHHHHHHHHHHHHHHHHCHHHHHH
LVEKATEAVGKHAIDEMQKKAQKGKFDLNDLVQQLKALNKLGGIANILKFMPNFGADVKR
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCHHHHH
QVSGIANDSRVKQYIAIVNSMTKKERENPKILNGARKARIAKGSGVHVNVINMLIKQFNQ
HHHCCCCHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHCCCCCCCCHHHHHHHHHHHHH
MSSLMNKFSKVDYSKIKNTDFMNMFNKE
HHHHHHHHHHCHHHHHCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11557893 [H]