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The map label for this gene is map [H]

Identifier: 88657622

GI number: 88657622

Start: 1091502

End: 1092302

Strand: Reverse

Name: map [H]

Synonym: ECH_1064

Alternate gene names: 88657622

Gene position: 1092302-1091502 (Counterclockwise)

Preceding gene: 88658260

Following gene: 88658386

Centisome position: 92.86

GC content: 35.83

Gene sequence:

>801_bases
ATGGGAAATTTAGGAAGAAGTATCACTATTCATAGTAAAGAAGACTTTAAGTATATGCATAATGCTGGAAGGCTTGCAGC
AGAGGTGTTAGATTTTATTACTCCATATGTAAAACCAGGAGTTTCTAGCAATGAGCTTAACGATTTATGTCATGATTTTA
TTATTAACGCTGGTGCAATTCCTGCTCCGCTTGGATATAGGGGATACCCTAAGTCTATTTGTACCTCGAAAAATTTTGTT
GTATGTCATGGTATTCCTGATGATTTGCCTTTAAAAGAAGGTGATATTGTGAATATAGATGTCACTGTTATACTAGACGG
TTGGCATGGAGATACTAGTAGAATGTATTGGGTTGGGGAGCCATCGATTAAAGCAAAACGTTTATGTGAAGCTGCATATA
GAGCATTAACTGTAGCGATTGAACAAGTGATACCTGGACAAAAGCTTAATCAGATTGGTTTGGCTATTGAAAAAGAGATG
AAGAAATATGGTTATTCTATTGTTCGTGATTATTGTGGGCATGGGTTAGGTAGGGTATTTCATGCTTCGCCGAATGTAGT
ACATTATTATGATCCGGATGATCCTGTAATTATTAGAGAAGGCATGTTTTTTACAATAGAGCCAATGATAAATGCCGGAA
GATGTGATACTGTACTTAGTAAAAAAGATGGATGGACTGTTACAACTCGAGATTTATCTTTGTCAGCGCAATTTGAACAT
TCTTTGGGTGTTACTGAGAATGGAGTAGAAATATTTACATTATCTCCACAAAATATGCATTATCCTCCTTATGTATGCTA
A

Upstream 100 bases:

>100_bases
AAATTGTTTAAAATGATGGGTATTGGTTCTAGTATAAGGATATTAGGCATTAGAGTATTAATACAATAGTTTAGGTCTAG
GATTAAAGGTTATAGAGAAT

Downstream 100 bases:

>100_bases
TTTATTATGGATACTGTAATTTCTTTATTTAATAGAGCTGTTGATTTTTTATCTACTTATAACATAGACAATCCAAAACG
TGATGTAGAGATAATAATAA

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 266; Mature: 265

Protein sequence:

>266_residues
MGNLGRSITIHSKEDFKYMHNAGRLAAEVLDFITPYVKPGVSSNELNDLCHDFIINAGAIPAPLGYRGYPKSICTSKNFV
VCHGIPDDLPLKEGDIVNIDVTVILDGWHGDTSRMYWVGEPSIKAKRLCEAAYRALTVAIEQVIPGQKLNQIGLAIEKEM
KKYGYSIVRDYCGHGLGRVFHASPNVVHYYDPDDPVIIREGMFFTIEPMINAGRCDTVLSKKDGWTVTTRDLSLSAQFEH
SLGVTENGVEIFTLSPQNMHYPPYVC

Sequences:

>Translated_266_residues
MGNLGRSITIHSKEDFKYMHNAGRLAAEVLDFITPYVKPGVSSNELNDLCHDFIINAGAIPAPLGYRGYPKSICTSKNFV
VCHGIPDDLPLKEGDIVNIDVTVILDGWHGDTSRMYWVGEPSIKAKRLCEAAYRALTVAIEQVIPGQKLNQIGLAIEKEM
KKYGYSIVRDYCGHGLGRVFHASPNVVHYYDPDDPVIIREGMFFTIEPMINAGRCDTVLSKKDGWTVTTRDLSLSAQFEH
SLGVTENGVEIFTLSPQNMHYPPYVC
>Mature_265_residues
GNLGRSITIHSKEDFKYMHNAGRLAAEVLDFITPYVKPGVSSNELNDLCHDFIINAGAIPAPLGYRGYPKSICTSKNFVV
CHGIPDDLPLKEGDIVNIDVTVILDGWHGDTSRMYWVGEPSIKAKRLCEAAYRALTVAIEQVIPGQKLNQIGLAIEKEMK
KYGYSIVRDYCGHGLGRVFHASPNVVHYYDPDDPVIIREGMFFTIEPMINAGRCDTVLSKKDGWTVTTRDLSLSAQFEHS
LGVTENGVEIFTLSPQNMHYPPYVC

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=247, Percent_Identity=44.9392712550607, Blast_Score=219, Evalue=3e-57,
Organism=Homo sapiens, GI40385867, Length=254, Percent_Identity=40.9448818897638, Blast_Score=190, Evalue=9e-49,
Organism=Escherichia coli, GI1786364, Length=254, Percent_Identity=55.9055118110236, Blast_Score=290, Evalue=6e-80,
Organism=Caenorhabditis elegans, GI71996291, Length=251, Percent_Identity=41.8326693227092, Blast_Score=194, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6323273, Length=248, Percent_Identity=46.3709677419355, Blast_Score=228, Evalue=9e-61,
Organism=Drosophila melanogaster, GI21355531, Length=261, Percent_Identity=44.0613026819923, Blast_Score=214, Evalue=3e-56,
Organism=Drosophila melanogaster, GI24583427, Length=252, Percent_Identity=40.0793650793651, Blast_Score=193, Evalue=9e-50,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29595; Mature: 29464

Theoretical pI: Translated: 6.34; Mature: 6.34

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNLGRSITIHSKEDFKYMHNAGRLAAEVLDFITPYVKPGVSSNELNDLCHDFIINAGAI
CCCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
PAPLGYRGYPKSICTSKNFVVCHGIPDDLPLKEGDIVNIDVTVILDGWHGDTSRMYWVGE
CCCCCCCCCCHHHHCCCCEEEEECCCCCCCCCCCCEEEEEEEEEEECCCCCCCEEEEECC
PSIKAKRLCEAAYRALTVAIEQVIPGQKLNQIGLAIEKEMKKYGYSIVRDYCGHGLGRVF
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
HASPNVVHYYDPDDPVIIREGMFFTIEPMINAGRCDTVLSKKDGWTVTTRDLSLSAQFEH
ECCCCEEEEECCCCCEEEECCCEEEEECCCCCCCCCHHEECCCCCEEEEECEEEEEEEHH
SLGVTENGVEIFTLSPQNMHYPPYVC
CCCCCCCCEEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
GNLGRSITIHSKEDFKYMHNAGRLAAEVLDFITPYVKPGVSSNELNDLCHDFIINAGAI
CCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
PAPLGYRGYPKSICTSKNFVVCHGIPDDLPLKEGDIVNIDVTVILDGWHGDTSRMYWVGE
CCCCCCCCCCHHHHCCCCEEEEECCCCCCCCCCCCEEEEEEEEEEECCCCCCCEEEEECC
PSIKAKRLCEAAYRALTVAIEQVIPGQKLNQIGLAIEKEMKKYGYSIVRDYCGHGLGRVF
CCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEE
HASPNVVHYYDPDDPVIIREGMFFTIEPMINAGRCDTVLSKKDGWTVTTRDLSLSAQFEH
ECCCCEEEEECCCCCEEEECCCEEEEECCCCCCCCCHHEECCCCCEEEEECEEEEEEEHH
SLGVTENGVEIFTLSPQNMHYPPYVC
CCCCCCCCEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]