Click here to switch to the map view.

The map label for this gene is ccmE

Identifier: 88608744

GI number: 88608744

Start: 734990

End: 735397

Strand: Reverse

Name: ccmE

Synonym: NSE_0828

Alternate gene names: 88608744

Gene position: 735397-734990 (Counterclockwise)

Preceding gene: 88608757

Following gene: 88608841

Centisome position: 85.61

GC content: 41.42

Gene sequence:

>408_bases
ATGCTACTTCTCCGGTGGAAGAGGTTTTGGTTTTTATCATTAGGCATTCTACTTTTTTCTGGAGTTGTTTCGTTGATGTT
ATTTAATCTCAGTGAGAGTATCTCCTTTTTCTATCTGCCAAGTGATGTTGCGCGTGTTGTTGCTTCAAACAGGGAAATAA
AAGTAGGAGGAATAATCAAGGCTATAAAGAAATCAAAAGATGGTGTGAGATTCTTGCTCTCTGATGGTGCAGCCGAAATA
GAGGTGCTTTATGAGGGTATCCTACCTTCACTTGTGCAGGATGGGATAAATGTCGTAGTTGTTGCTCGATTTGAGGGCGG
GCTGCTTCTTGCTAAAAGAGTCCTAGTCAAACATGATGAGCGGTACTATCCCCCAGAGGACTTTATTAAATCTGTTCGAG
GAGAGTAA

Upstream 100 bases:

>100_bases
TTTAGGGCAGTCACGAAGACAGTGAGGAAGATTGTGCGTGGTTCACTGGCGAGCAGGATAAAGATTCCATTGATAGAAGT
GCAAATAGAAAGGGTATAGC

Downstream 100 bases:

>100_bases
ATACCCTTGGTGAGATGGTGTTTTTTAGCTCTGATATGTTAGAATCTCCGGTGTTATCTTGAACAGGAGGCATAGTTTGG
GACAAGTTTTTATGGTTCAT

Product: putative cytochrome c-type biogenesis protein CcmE

Products: NA

Alternate protein names: Cytochrome c maturation protein E; Heme chaperone CcmE

Number of amino acids: Translated: 135; Mature: 135

Protein sequence:

>135_residues
MLLLRWKRFWFLSLGILLFSGVVSLMLFNLSESISFFYLPSDVARVVASNREIKVGGIIKAIKKSKDGVRFLLSDGAAEI
EVLYEGILPSLVQDGINVVVVARFEGGLLLAKRVLVKHDERYYPPEDFIKSVRGE

Sequences:

>Translated_135_residues
MLLLRWKRFWFLSLGILLFSGVVSLMLFNLSESISFFYLPSDVARVVASNREIKVGGIIKAIKKSKDGVRFLLSDGAAEI
EVLYEGILPSLVQDGINVVVVARFEGGLLLAKRVLVKHDERYYPPEDFIKSVRGE
>Mature_135_residues
MLLLRWKRFWFLSLGILLFSGVVSLMLFNLSESISFFYLPSDVARVVASNREIKVGGIIKAIKKSKDGVRFLLSDGAAEI
EVLYEGILPSLVQDGINVVVVARFEGGLLLAKRVLVKHDERYYPPEDFIKSVRGE

Specific function: Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH

COG id: COG2332

COG function: function code O; Cytochrome c-type biogenesis protein CcmE

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein; Periplasmic side (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CcmE/CycJ family

Homologues:

Organism=Escherichia coli, GI1788525, Length=138, Percent_Identity=32.6086956521739, Blast_Score=75, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCME_NEOSM (Q2GCU8)

Other databases:

- EMBL:   CP000237
- RefSeq:   YP_506698.1
- ProteinModelPortal:   Q2GCU8
- SMR:   Q2GCU8
- STRING:   Q2GCU8
- GeneID:   3931631
- GenomeReviews:   CP000237_GR
- KEGG:   nse:NSE_0828
- TIGR:   NSE_0828
- eggNOG:   COG2332
- HOGENOM:   HBG296631
- OMA:   ENISFFY
- PhylomeDB:   Q2GCU8
- ProtClustDB:   CLSK2528118
- BioCyc:   NSEN222891:NSE_0828-MONOMER
- HAMAP:   MF_01959
- InterPro:   IPR004329
- InterPro:   IPR012340
- Gene3D:   G3DSA:2.40.50.140

Pfam domain/function: PF03100 CcmE; SSF82093 Pyrv/PenolPyrv_Kinase_cat

EC number: NA

Molecular weight: Translated: 15189; Mature: 15189

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: NA

Important sites: BINDING 118-118

Signals:

None

Transmembrane regions:

HASH(0x11372030)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLLLRWKRFWFLSLGILLFSGVVSLMLFNLSESISFFYLPSDVARVVASNREIKVGGIIK
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHCCCCEEHHHHHH
AIKKSKDGVRFLLSDGAAEIEVLYEGILPSLVQDGINVVVVARFEGGLLLAKRVLVKHDE
HHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCC
RYYPPEDFIKSVRGE
CCCCHHHHHHHHCCH
>Mature Secondary Structure
MLLLRWKRFWFLSLGILLFSGVVSLMLFNLSESISFFYLPSDVARVVASNREIKVGGIIK
CEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHCCCCEEHHHHHH
AIKKSKDGVRFLLSDGAAEIEVLYEGILPSLVQDGINVVVVARFEGGLLLAKRVLVKHDE
HHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHHCCC
RYYPPEDFIKSVRGE
CCCCHHHHHHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA