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The map label for this gene is hemH

Identifier: 88608466

GI number: 88608466

Start: 701760

End: 702737

Strand: Reverse

Name: hemH

Synonym: NSE_0790

Alternate gene names: 88608466

Gene position: 702737-701760 (Counterclockwise)

Preceding gene: 88608335

Following gene: 88608641

Centisome position: 81.81

GC content: 42.43

Gene sequence:

>978_bases
ATGAGTAAAGTAGCTGTGGTCTTGCTTAATCTTGGGGGTCCCGACTCCCTTGATGCTGTGCGGCCCTTTTTGTTTAATCT
CTTTTGTGATCGTAGGATCATTAATTTGCCCAACCCGTTCAGGTTTTGTCTTGCTTGGTGGATTTCCCGTAAGAGATTTC
GCGAAGCTTGCAAGATATATAGCAAGATGGGTGGTAAGTCGTCGATATTGCCTGAGACAAATATGCAGGCGAAGCTTCTT
GGGGACTTACTTGGTCCCCAATATGAGGTTTTTGTTGCTATGCGGCATTGGCACCCGTTTATTCAGCAAAGCGCAACCAG
AATCAATGGAGGAGAATTTGCAAAGGCTATTCTGTTACCACTTTATCCTCAATTTTCCACCACTACTTCTTTGTCATCAA
TAGAACAGTGTTTAAAGGTCTTGCGTATTCCAACGCAAGTTGTGTGTTGTTACTATGATAACCAGCTCTTTATAGAGGCA
CATGTGGAAACTATTCTACCGATTTACGCCGAGGCATGTGCTTTTGGGAAACCCATTATTTTATTTTCAGCGCATGGCCT
GCCGTTGAGTGTTATTAAGGCTGGTGATCCGTATAAATTCCAAGTAGAAGAATTTGTAAGGAGGGTAGTTGCAGCCTTGA
AAATAGAAAACTTGGACTGGGAATTGTGCTATCAGAGTAGAGTTGGTAAAGCAAAGTGGCTTTGTCCTGACACGGCGAGT
ACTATACAATCTCACTCAGAACGACCTATAGTGGTTGTACCAATAGCATTCGTTTCCGAGCATTCAGAGACACGCGTAGA
ACTAGATATCGAATATGCGTTACTAGCTAGGGCAGGATACTTCAGAGTTCCTACTCTTTCCTCTCATCCAAAATTTATAC
GTTGCCTGGCTGAATTATGTCTTAATTTCTGTGAAAAGGTTGAATCAGAGTGCTCTATGAAACATAAGATGTGTTTTTGC
AGGTTTGAAACTGGGTAG

Upstream 100 bases:

>100_bases
TATTCCTCCTTGCGGCCACTTATTGTTGGGCGTGTGATCGGTGGTGTCGGGTCCAGCCGTTAGTGTTGTACTGTGCTAGA
TTTGAATTTAAGGGTACTGT

Downstream 100 bases:

>100_bases
TTCTTACATTTATCGCTCTAAGAGGGTCTGCAGTGTCCCACTCCACTTTCTTGAGGGAAGGCACTTGTTACCTCTAGGGG
TTCTTCGTATTCCATGACCG

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 325; Mature: 324

Protein sequence:

>325_residues
MSKVAVVLLNLGGPDSLDAVRPFLFNLFCDRRIINLPNPFRFCLAWWISRKRFREACKIYSKMGGKSSILPETNMQAKLL
GDLLGPQYEVFVAMRHWHPFIQQSATRINGGEFAKAILLPLYPQFSTTTSLSSIEQCLKVLRIPTQVVCCYYDNQLFIEA
HVETILPIYAEACAFGKPIILFSAHGLPLSVIKAGDPYKFQVEEFVRRVVAALKIENLDWELCYQSRVGKAKWLCPDTAS
TIQSHSERPIVVVPIAFVSEHSETRVELDIEYALLARAGYFRVPTLSSHPKFIRCLAELCLNFCEKVESECSMKHKMCFC
RFETG

Sequences:

>Translated_325_residues
MSKVAVVLLNLGGPDSLDAVRPFLFNLFCDRRIINLPNPFRFCLAWWISRKRFREACKIYSKMGGKSSILPETNMQAKLL
GDLLGPQYEVFVAMRHWHPFIQQSATRINGGEFAKAILLPLYPQFSTTTSLSSIEQCLKVLRIPTQVVCCYYDNQLFIEA
HVETILPIYAEACAFGKPIILFSAHGLPLSVIKAGDPYKFQVEEFVRRVVAALKIENLDWELCYQSRVGKAKWLCPDTAS
TIQSHSERPIVVVPIAFVSEHSETRVELDIEYALLARAGYFRVPTLSSHPKFIRCLAELCLNFCEKVESECSMKHKMCFC
RFETG
>Mature_324_residues
SKVAVVLLNLGGPDSLDAVRPFLFNLFCDRRIINLPNPFRFCLAWWISRKRFREACKIYSKMGGKSSILPETNMQAKLLG
DLLGPQYEVFVAMRHWHPFIQQSATRINGGEFAKAILLPLYPQFSTTTSLSSIEQCLKVLRIPTQVVCCYYDNQLFIEAH
VETILPIYAEACAFGKPIILFSAHGLPLSVIKAGDPYKFQVEEFVRRVVAALKIENLDWELCYQSRVGKAKWLCPDTAST
IQSHSERPIVVVPIAFVSEHSETRVELDIEYALLARAGYFRVPTLSSHPKFIRCLAELCLNFCEKVESECSMKHKMCFCR
FETG

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499025, Length=333, Percent_Identity=33.6336336336336, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI60499021, Length=333, Percent_Identity=33.6336336336336, Blast_Score=133, Evalue=3e-31,
Organism=Escherichia coli, GI1786681, Length=325, Percent_Identity=25.5384615384615, Blast_Score=91, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6324750, Length=320, Percent_Identity=28.4375, Blast_Score=124, Evalue=3e-29,
Organism=Drosophila melanogaster, GI17864156, Length=342, Percent_Identity=31.5789473684211, Blast_Score=145, Evalue=5e-35,
Organism=Drosophila melanogaster, GI24651774, Length=256, Percent_Identity=30.46875, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI45552018, Length=151, Percent_Identity=36.4238410596026, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 36987; Mature: 36856

Theoretical pI: Translated: 8.28; Mature: 8.28

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
6.5 %Cys+Met (Translated Protein)
4.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKVAVVLLNLGGPDSLDAVRPFLFNLFCDRRIINLPNPFRFCLAWWISRKRFREACKIY
CCCEEEEEEECCCCCCHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHH
SKMGGKSSILPETNMQAKLLGDLLGPQYEVFVAMRHWHPFIQQSATRINGGEFAKAILLP
HHCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEEHHHHHHHHHHHCCCCCCHHHHHHHHHH
LYPQFSTTTSLSSIEQCLKVLRIPTQVVCCYYDNQLFIEAHVETILPIYAEACAFGKPII
CCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEEEHHHHHHHHHHHHHHCCCCEE
LFSAHGLPLSVIKAGDPYKFQVEEFVRRVVAALKIENLDWELCYQSRVGKAKWLCPDTAS
EEECCCCCEEEEECCCCCEEEHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEECCCHHH
TIQSHSERPIVVVPIAFVSEHSETRVELDIEYALLARAGYFRVPTLSSHPKFIRCLAELC
HHHCCCCCCEEEEEEHHHCCCCCCEEEEEEHHHHHHCCCCEECCCCCCCHHHHHHHHHHH
LNFCEKVESECSMKHKMCFCRFETG
HHHHHHHHHHHHHHHCEEEEEECCC
>Mature Secondary Structure 
SKVAVVLLNLGGPDSLDAVRPFLFNLFCDRRIINLPNPFRFCLAWWISRKRFREACKIY
CCEEEEEEECCCCCCHHHHHHHHHHHHHCCEEECCCCHHHHHHHHHHHHHHHHHHHHHH
SKMGGKSSILPETNMQAKLLGDLLGPQYEVFVAMRHWHPFIQQSATRINGGEFAKAILLP
HHCCCCCCCCCCCCCHHHHHHHHHCCCEEEEEEHHHHHHHHHHHCCCCCCHHHHHHHHHH
LYPQFSTTTSLSSIEQCLKVLRIPTQVVCCYYDNQLFIEAHVETILPIYAEACAFGKPII
CCCCCCCHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEEEHHHHHHHHHHHHHHCCCCEE
LFSAHGLPLSVIKAGDPYKFQVEEFVRRVVAALKIENLDWELCYQSRVGKAKWLCPDTAS
EEECCCCCEEEEECCCCCEEEHHHHHHHHHHHHHHCCCCHHHHHHHCCCCEEEECCCHHH
TIQSHSERPIVVVPIAFVSEHSETRVELDIEYALLARAGYFRVPTLSSHPKFIRCLAELC
HHHCCCCCCEEEEEEHHHCCCCCCEEEEEEHHHHHHCCCCEECCCCCCCHHHHHHHHHHH
LNFCEKVESECSMKHKMCFCRFETG
HHHHHHHHHHHHHHHCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA