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The map label for this gene is ctaD

Identifier: 88608253

GI number: 88608253

Start: 543552

End: 545111

Strand: Direct

Name: ctaD

Synonym: NSE_0622

Alternate gene names: 88608253

Gene position: 543552-545111 (Clockwise)

Preceding gene: 88608267

Following gene: 88608368

Centisome position: 63.28

GC content: 42.69

Gene sequence:

>1560_bases
ATGAATAAACATTCAGAGGTCCCTAGCGGCATAAGGCGTTGGCTTTTTTCAACAAATCATAAAGACATAGGCACTTTGTA
CATTATTCTTTCTGTAGCTGGGGGAATTGTAGGTGGCCTTTTCTCGTTGATGCTACGTGCACAACTTGCACACCTAGATG
TCTTTATGGGCAACTATCAACTCTACAATGTATCTATAACTGCTCATGCGGCGGTTATGGTGTTCTTCATGCTTATGCCA
GCACTCATAGCTGGATTTGGAAACTGGTTCGTTCCACTTATGATAGGAGCACCAGACATGTGTTTTCCGAGGCTCAATAA
CATCAGCTTTTGGATACTTTTCTTCTCTCTGGTGATTATCGTCATGTCCGCGCTTATTGGCGAAGGACCTGGTACAGGTT
GGACGTTCTATCCGCCACTCGCGGGAATTCATTTTCATCCTGATGTATCCATTGATTTAGCAATTTTCGGTTTACATTTG
GCTGGTATTTCATCAATTCTCGGGGCCATTAACTTTGTCGCAACTATATTGAACATGCGCGCACCTGGTATGACATTGTT
CAAGATGCCACTTTTTGTATGGTCTATTTTTGTGACATCTATACTGGTCCTTATAGTAATGCCGGTTCTGGCTGGCGCTC
TTATGATGCTGCTCACCGACCGTAATTTGGGTACAGCTTTTTTTGAAGTCGCAGGTGGTGGTGATCCACTTCTTTTTCAA
CACTTGTTCTGGTTCTTTGGTCACCCTGAAGTTTATATTATCATCCTTCCTGCCTTTGGTATTGTTAGTGAAGTTGTGTC
TACCTTCTCGCAAAAGCCGGTTTTTGGGTACAAAGGTATGGTTGCTGCAATGGCAATAATCGGCATAATCGGTTGTTTCG
TGTGGGCTCACCACATGTTTATTACTGGTATTAACTTCAATGCTCTTGCCTATTTCACCGTTGCAACAATGCTAGTTGGC
GTTCCAACAGGCATAAAAGTCTTTAGTTGGATAGCAACAATGTGGGGTGGTTCTATAGATCTTAAAGCACCTATGCTTTT
TGCTATAGGCTTCATGTTCTTGTTTGTGGTCGGTGGCGTTACGGGTATTGCACTTTCGAATTCTGCGCTAGATAAGGCTC
TACACGACACATACTATGTTGTTGGACACTTTCACTATGTGATGTCGATCGCAGCGCTGTTTGTTGTATACAGCGCTTTC
TATTACTGGATTGGTAAAATTTCAGGGAAACAGTACAACGAGTGCTTTGCTAAAATCCATTTTTGGATTACGCTCGTTAG
CGTAAATATAACATTCCTACCACAGCACTTTTTAGGTTTAGCAGGTATGCCAAGAAGAATACCCGACTATCCGGATGCCT
TCATTCCATGGAACTATGTCTCTTCCTTTGGCGCAGCACTTTCGTTTGGATCGGCGTTATTTTTTGTGTTTATAGTCTTT
CATACACTCTGTAAGGGGAAAAAATGTGAAGCTAATCCTTGGGGTGGAAAGACTCTAGAATGGACTTTGTCATCCCCTCC
TCCGTTCCATTCGTTTGAAAAGCAACCTGTGGTAGAATAG

Upstream 100 bases:

>100_bases
CCTATAGCTGTGACTGCCGTAAGTAAAGAAGCATTTAAAGAATGGGTTACTCAAGCGAAAGACAGTTTTTAGTTTTGGAG
ATTAGTTAAGGTTAATTATT

Downstream 100 bases:

>100_bases
CATTGCAAGGTGTTTCAGGTTGTATCCAAGACTGATTGGCTGACCGTGAGGGCGTACTTTGCCCTCCTCAAGCCTCGTGT
TGTCAGTTTGGTCACTTTTA

Product: cytochrome c oxidase subunit I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I [H]

Number of amino acids: Translated: 519; Mature: 519

Protein sequence:

>519_residues
MNKHSEVPSGIRRWLFSTNHKDIGTLYIILSVAGGIVGGLFSLMLRAQLAHLDVFMGNYQLYNVSITAHAAVMVFFMLMP
ALIAGFGNWFVPLMIGAPDMCFPRLNNISFWILFFSLVIIVMSALIGEGPGTGWTFYPPLAGIHFHPDVSIDLAIFGLHL
AGISSILGAINFVATILNMRAPGMTLFKMPLFVWSIFVTSILVLIVMPVLAGALMMLLTDRNLGTAFFEVAGGGDPLLFQ
HLFWFFGHPEVYIIILPAFGIVSEVVSTFSQKPVFGYKGMVAAMAIIGIIGCFVWAHHMFITGINFNALAYFTVATMLVG
VPTGIKVFSWIATMWGGSIDLKAPMLFAIGFMFLFVVGGVTGIALSNSALDKALHDTYYVVGHFHYVMSIAALFVVYSAF
YYWIGKISGKQYNECFAKIHFWITLVSVNITFLPQHFLGLAGMPRRIPDYPDAFIPWNYVSSFGAALSFGSALFFVFIVF
HTLCKGKKCEANPWGGKTLEWTLSSPPPFHSFEKQPVVE

Sequences:

>Translated_519_residues
MNKHSEVPSGIRRWLFSTNHKDIGTLYIILSVAGGIVGGLFSLMLRAQLAHLDVFMGNYQLYNVSITAHAAVMVFFMLMP
ALIAGFGNWFVPLMIGAPDMCFPRLNNISFWILFFSLVIIVMSALIGEGPGTGWTFYPPLAGIHFHPDVSIDLAIFGLHL
AGISSILGAINFVATILNMRAPGMTLFKMPLFVWSIFVTSILVLIVMPVLAGALMMLLTDRNLGTAFFEVAGGGDPLLFQ
HLFWFFGHPEVYIIILPAFGIVSEVVSTFSQKPVFGYKGMVAAMAIIGIIGCFVWAHHMFITGINFNALAYFTVATMLVG
VPTGIKVFSWIATMWGGSIDLKAPMLFAIGFMFLFVVGGVTGIALSNSALDKALHDTYYVVGHFHYVMSIAALFVVYSAF
YYWIGKISGKQYNECFAKIHFWITLVSVNITFLPQHFLGLAGMPRRIPDYPDAFIPWNYVSSFGAALSFGSALFFVFIVF
HTLCKGKKCEANPWGGKTLEWTLSSPPPFHSFEKQPVVE
>Mature_519_residues
MNKHSEVPSGIRRWLFSTNHKDIGTLYIILSVAGGIVGGLFSLMLRAQLAHLDVFMGNYQLYNVSITAHAAVMVFFMLMP
ALIAGFGNWFVPLMIGAPDMCFPRLNNISFWILFFSLVIIVMSALIGEGPGTGWTFYPPLAGIHFHPDVSIDLAIFGLHL
AGISSILGAINFVATILNMRAPGMTLFKMPLFVWSIFVTSILVLIVMPVLAGALMMLLTDRNLGTAFFEVAGGGDPLLFQ
HLFWFFGHPEVYIIILPAFGIVSEVVSTFSQKPVFGYKGMVAAMAIIGIIGCFVWAHHMFITGINFNALAYFTVATMLVG
VPTGIKVFSWIATMWGGSIDLKAPMLFAIGFMFLFVVGGVTGIALSNSALDKALHDTYYVVGHFHYVMSIAALFVVYSAF
YYWIGKISGKQYNECFAKIHFWITLVSVNITFLPQHFLGLAGMPRRIPDYPDAFIPWNYVSSFGAALSFGSALFFVFIVF
HTLCKGKKCEANPWGGKTLEWTLSSPPPFHSFEKQPVVE

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=504, Percent_Identity=55.7539682539683, Blast_Score=566, Evalue=1e-161,
Organism=Escherichia coli, GI1786634, Length=515, Percent_Identity=39.0291262135922, Blast_Score=375, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6226519, Length=533, Percent_Identity=53.4709193245779, Blast_Score=577, Evalue=1e-165,
Organism=Saccharomyces cerevisiae, GI6226524, Length=323, Percent_Identity=58.5139318885449, Blast_Score=389, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6226523, Length=248, Percent_Identity=54.4354838709677, Blast_Score=261, Evalue=1e-70,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 57264; Mature: 57264

Theoretical pI: Translated: 8.24; Mature: 8.24

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKHSEVPSGIRRWLFSTNHKDIGTLYIILSVAGGIVGGLFSLMLRAQLAHLDVFMGNYQ
CCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEE
LYNVSITAHAAVMVFFMLMPALIAGFGNWFVPLMIGAPDMCFPRLNNISFWILFFSLVII
EEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHCCCCCCCHHHHHHHHHHHH
VMSALIGEGPGTGWTFYPPLAGIHFHPDVSIDLAIFGLHLAGISSILGAINFVATILNMR
HHHHHHCCCCCCCCEECCCCCCEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCC
APGMTLFKMPLFVWSIFVTSILVLIVMPVLAGALMMLLTDRNLGTAFFEVAGGGDPLLFQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHH
HLFWFFGHPEVYIIILPAFGIVSEVVSTFSQKPVFGYKGMVAAMAIIGIIGCFVWAHHMF
HHHHHHCCCCEEEEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ITGINFNALAYFTVATMLVGVPTGIKVFSWIATMWGGSIDLKAPMLFAIGFMFLFVVGGV
HCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCH
TGIALSNSALDKALHDTYYVVGHFHYVMSIAALFVVYSAFYYWIGKISGKQYNECFAKIH
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
FWITLVSVNITFLPQHFLGLAGMPRRIPDYPDAFIPWNYVSSFGAALSFGSALFFVFIVF
HHHHEEEHEEEEHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
HTLCKGKKCEANPWGGKTLEWTLSSPPPFHSFEKQPVVE
HHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCC
>Mature Secondary Structure
MNKHSEVPSGIRRWLFSTNHKDIGTLYIILSVAGGIVGGLFSLMLRAQLAHLDVFMGNYQ
CCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCEE
LYNVSITAHAAVMVFFMLMPALIAGFGNWFVPLMIGAPDMCFPRLNNISFWILFFSLVII
EEEEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHCCCCCCCHHHHHHHHHHHH
VMSALIGEGPGTGWTFYPPLAGIHFHPDVSIDLAIFGLHLAGISSILGAINFVATILNMR
HHHHHHCCCCCCCCEECCCCCCEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHCC
APGMTLFKMPLFVWSIFVTSILVLIVMPVLAGALMMLLTDRNLGTAFFEVAGGGDPLLFQ
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCHHHHH
HLFWFFGHPEVYIIILPAFGIVSEVVSTFSQKPVFGYKGMVAAMAIIGIIGCFVWAHHMF
HHHHHHCCCCEEEEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
ITGINFNALAYFTVATMLVGVPTGIKVFSWIATMWGGSIDLKAPMLFAIGFMFLFVVGGV
HCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCH
TGIALSNSALDKALHDTYYVVGHFHYVMSIAALFVVYSAFYYWIGKISGKQYNECFAKIH
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHH
FWITLVSVNITFLPQHFLGLAGMPRRIPDYPDAFIPWNYVSSFGAALSFGSALFFVFIVF
HHHHEEEHEEEEHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
HTLCKGKKCEANPWGGKTLEWTLSSPPPFHSFEKQPVVE
HHHHCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]