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The map label for this gene is cyoE

Identifier: 88608368

GI number: 88608368

Start: 545121

End: 546029

Strand: Direct

Name: cyoE

Synonym: NSE_0623

Alternate gene names: 88608368

Gene position: 545121-546029 (Clockwise)

Preceding gene: 88608253

Following gene: 88608022

Centisome position: 63.46

GC content: 43.34

Gene sequence:

>909_bases
GTGTTTCAGGTTGTATCCAAGACTGATTGGCTGACCGTGAGGGCGTACTTTGCCCTCCTCAAGCCTCGTGTTGTCAGTTT
GGTCACTTTTACGGCAGTGACCGGTGCTGTGCTTGCATATTTTTCTGGGTATCATGCACCTTTTTTTTCAGTATTCACTG
CTATTTTTTGCATTGCTGTGGGTTCTGGTGCGGCCGGTGCACTAAATATGTATTATGATCGTGACATAGACGCGATCATG
AGCCGTACCAGCAAAAGGCCTATCCCACAAGGAAAGATCTCACCAGAAGCGGCATTGGTCTTCGGGTTGGTACTTTTTGC
GTTGTCCGTACTACTAATGGAATTGGCAGTGAATCACTTGTCCGCGGTTCTTTTATCCGTAGCGGTATTCTACTATTCTG
TGATTTATACGGTCTATTTGAAGAGACGTACACCTCAAAATATCGTCGTAGGAGGTGGTGCTGGAGCATTTCCACCCATG
ATCGGATGGGCAGCCGTGGCTAATCATATAGGCGTGGAAAGCTTAGTTCTTTTTCTGATAATATTCCTCTGGACTCCCCC
GCATTTCTGGGCATTAGCATTAAAAAATTCAGGAGAATATGAGGCTGCTGGGATCCCTATGTTACCAGTTACTTCCGGAG
TCAAGGCAACAAAAATGCAGATATTGTGTTATTCTGTCCTCCTATTTATAACTTCAATCCTACCATACCTCTTAAGGTTC
TCCGGTGGAACCTATATGATCGTGGCCTTCATACTCGGGCTTGTCTTTTTGTATTATGCAATTAATGTTTATCTAGACGA
GAAGAAATGTATGAAGTTATTCTATTATTCCGTGTTATACTTATTCCTGCTTTTTGGAGTATTCATTCTTGATGCAGCTT
TGTCCACGGCTTTGGGTATGCTTATTTAA

Upstream 100 bases:

>100_bases
AGCTAATCCTTGGGGTGGAAAGACTCTAGAATGGACTTTGTCATCCCCTCCTCCGTTCCATTCGTTTGAAAAGCAACCTG
TGGTAGAATAGCATTGCAAG

Downstream 100 bases:

>100_bases
TTTTCTGTAGACAGATGGTAGATAAAAAAAGAAGAGATTTCATAGTTACAACTACGGTTGCCTTCGGTGCTGGTGGTGCT
GTTGCTGCTACCTGGCCCTT

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase

Number of amino acids: Translated: 302; Mature: 302

Protein sequence:

>302_residues
MFQVVSKTDWLTVRAYFALLKPRVVSLVTFTAVTGAVLAYFSGYHAPFFSVFTAIFCIAVGSGAAGALNMYYDRDIDAIM
SRTSKRPIPQGKISPEAALVFGLVLFALSVLLMELAVNHLSAVLLSVAVFYYSVIYTVYLKRRTPQNIVVGGGAGAFPPM
IGWAAVANHIGVESLVLFLIIFLWTPPHFWALALKNSGEYEAAGIPMLPVTSGVKATKMQILCYSVLLFITSILPYLLRF
SGGTYMIVAFILGLVFLYYAINVYLDEKKCMKLFYYSVLYLFLLFGVFILDAALSTALGMLI

Sequences:

>Translated_302_residues
MFQVVSKTDWLTVRAYFALLKPRVVSLVTFTAVTGAVLAYFSGYHAPFFSVFTAIFCIAVGSGAAGALNMYYDRDIDAIM
SRTSKRPIPQGKISPEAALVFGLVLFALSVLLMELAVNHLSAVLLSVAVFYYSVIYTVYLKRRTPQNIVVGGGAGAFPPM
IGWAAVANHIGVESLVLFLIIFLWTPPHFWALALKNSGEYEAAGIPMLPVTSGVKATKMQILCYSVLLFITSILPYLLRF
SGGTYMIVAFILGLVFLYYAINVYLDEKKCMKLFYYSVLYLFLLFGVFILDAALSTALGMLI
>Mature_302_residues
MFQVVSKTDWLTVRAYFALLKPRVVSLVTFTAVTGAVLAYFSGYHAPFFSVFTAIFCIAVGSGAAGALNMYYDRDIDAIM
SRTSKRPIPQGKISPEAALVFGLVLFALSVLLMELAVNHLSAVLLSVAVFYYSVIYTVYLKRRTPQNIVVGGGAGAFPPM
IGWAAVANHIGVESLVLFLIIFLWTPPHFWALALKNSGEYEAAGIPMLPVTSGVKATKMQILCYSVLLFITSILPYLLRF
SGGTYMIVAFILGLVFLYYAINVYLDEKKCMKLFYYSVLYLFLLFGVFILDAALSTALGMLI

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily

Homologues:

Organism=Homo sapiens, GI17921982, Length=265, Percent_Identity=29.0566037735849, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI1786631, Length=269, Percent_Identity=29.7397769516729, Blast_Score=117, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI71998235, Length=269, Percent_Identity=30.4832713754647, Blast_Score=83, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6325085, Length=220, Percent_Identity=31.3636363636364, Blast_Score=94, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19921064, Length=284, Percent_Identity=30.2816901408451, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COXX_NEOSM (Q2GDE4)

Other databases:

- EMBL:   CP000237
- RefSeq:   YP_506502.1
- STRING:   Q2GDE4
- GeneID:   3931532
- GenomeReviews:   CP000237_GR
- KEGG:   nse:NSE_0623
- TIGR:   NSE_0623
- eggNOG:   COG0109
- HOGENOM:   HBG656003
- OMA:   SYYQLTK
- PhylomeDB:   Q2GDE4
- ProtClustDB:   PRK04375
- BioCyc:   NSEN222891:NSE_0623-MONOMER
- HAMAP:   MF_00154
- InterPro:   IPR006369
- InterPro:   IPR000537
- PANTHER:   PTHR11048:SF3
- TIGRFAMs:   TIGR01473

Pfam domain/function: PF01040 UbiA

EC number: 2.5.1.-

Molecular weight: Translated: 33219; Mature: 33219

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xf980c40)-; HASH(0x108631cc)-; HASH(0x1144c7c4)-; HASH(0x10ac3cd8)-; HASH(0x10e9af94)-; HASH(0xfbd9a1c)-; HASH(0x10b6c02c)-; HASH(0xf91cfb0)-; HASH(0x10f2a6c0)-;

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQVVSKTDWLTVRAYFALLKPRVVSLVTFTAVTGAVLAYFSGYHAPFFSVFTAIFCIAV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
GSGAAGALNMYYDRDIDAIMSRTSKRPIPQGKISPEAALVFGLVLFALSVLLMELAVNHL
CCCCCCHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SAVLLSVAVFYYSVIYTVYLKRRTPQNIVVGGGAGAFPPMIGWAAVANHIGVESLVLFLI
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHH
IFLWTPPHFWALALKNSGEYEAAGIPMLPVTSGVKATKMQILCYSVLLFITSILPYLLRF
HHHHCCCHHEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SGGTYMIVAFILGLVFLYYAINVYLDEKKCMKLFYYSVLYLFLLFGVFILDAALSTALGM
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LI
CH
>Mature Secondary Structure
MFQVVSKTDWLTVRAYFALLKPRVVSLVTFTAVTGAVLAYFSGYHAPFFSVFTAIFCIAV
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
GSGAAGALNMYYDRDIDAIMSRTSKRPIPQGKISPEAALVFGLVLFALSVLLMELAVNHL
CCCCCCHHHHHHCCCHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SAVLLSVAVFYYSVIYTVYLKRRTPQNIVVGGGAGAFPPMIGWAAVANHIGVESLVLFLI
HHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHHHCCHHHHHHHHH
IFLWTPPHFWALALKNSGEYEAAGIPMLPVTSGVKATKMQILCYSVLLFITSILPYLLRF
HHHHCCCHHEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
SGGTYMIVAFILGLVFLYYAINVYLDEKKCMKLFYYSVLYLFLLFGVFILDAALSTALGM
CCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LI
CH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA