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The map label for this gene is clpP

Identifier: 88608072

GI number: 88608072

Start: 669394

End: 670029

Strand: Direct

Name: clpP

Synonym: NSE_0752

Alternate gene names: 88608072

Gene position: 669394-670029 (Clockwise)

Preceding gene: 88608214

Following gene: 88608107

Centisome position: 77.93

GC content: 43.55

Gene sequence:

>636_bases
ATGGAAATGGATACTCTTGTCAGAGAAAAAATGAATCTTGTTCCGATGGTAGTTGATCAAACACCTCGGGGCGAGAGAGC
GTACGACATATTTTCAAGACTCTTGAAAGAACGTGTTGTTTTCCTCACAGGACCGATAGAGGATGGAATGGCTAGTCTCA
TAGTCGCACAGCTCCTTTTTCTCGAAGCAGAGAACCCTGATAAGGATATTTTTATGTATATTAACTCTCCAGGTGGTGTC
GTGACTGCTGGCCTTTCGATATATGATACAATGCAGTACATAAAGCCATCTGTCTCAACCGTTTGCGTCGGTCAAGCCGC
TTCTGCTGCCTCTTTGATACTCGCTTCTGGCGCAGAGGGAAAACGTTTTGCTCTTCCGCATTCGCGTGTAATGGTACATC
AGCCCTCTGGTGGGGTACGAGGCCAGGCAACCGATATGGAGATTCACGTAAAAGAGATATTACAGCTCAAGAGAATGATT
AATGAGATCTACCAAAAACATACAGGTGAAACAATAAAGAAAATAGAAACGTTGCTCGAGAGAGATACCTTTTTGAGCCC
GGAAGAAGCGAAAAAGGTTGGCATAATTGATGACATAATCACACAGAGGAAAGAGAATAGTGGTAAACAAGAGTGA

Upstream 100 bases:

>100_bases
TGCATTACTGGAAACCGTGCAGAAGGAAGCTGAAGCTTCGAGTGTTGATGAAATACTCGGTTGTACAGAAGAAAAAGTTG
GGACACAGGTATAGACACAA

Downstream 100 bases:

>100_bases
TCTGGTTCCGAAGTGCTCTTTTTGTGGTGAGACGGAAGACAAAGTACGGAAACTTGTTGCGGGTATGTCCGCATTTATCT
GTGACAGATGCATAGCGTTA

Product: ATP-dependent Clp protease, proteolytic subunit ClpP

Products: NA

Alternate protein names: Endopeptidase Clp [H]

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MEMDTLVREKMNLVPMVVDQTPRGERAYDIFSRLLKERVVFLTGPIEDGMASLIVAQLLFLEAENPDKDIFMYINSPGGV
VTAGLSIYDTMQYIKPSVSTVCVGQAASAASLILASGAEGKRFALPHSRVMVHQPSGGVRGQATDMEIHVKEILQLKRMI
NEIYQKHTGETIKKIETLLERDTFLSPEEAKKVGIIDDIITQRKENSGKQE

Sequences:

>Translated_211_residues
MEMDTLVREKMNLVPMVVDQTPRGERAYDIFSRLLKERVVFLTGPIEDGMASLIVAQLLFLEAENPDKDIFMYINSPGGV
VTAGLSIYDTMQYIKPSVSTVCVGQAASAASLILASGAEGKRFALPHSRVMVHQPSGGVRGQATDMEIHVKEILQLKRMI
NEIYQKHTGETIKKIETLLERDTFLSPEEAKKVGIIDDIITQRKENSGKQE
>Mature_211_residues
MEMDTLVREKMNLVPMVVDQTPRGERAYDIFSRLLKERVVFLTGPIEDGMASLIVAQLLFLEAENPDKDIFMYINSPGGV
VTAGLSIYDTMQYIKPSVSTVCVGQAASAASLILASGAEGKRFALPHSRVMVHQPSGGVRGQATDMEIHVKEILQLKRMI
NEIYQKHTGETIKKIETLLERDTFLSPEEAKKVGIIDDIITQRKENSGKQE

Specific function: Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins [H]

COG id: COG0740

COG function: function code OU; Protease subunit of ATP-dependent Clp proteases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S14 family [H]

Homologues:

Organism=Homo sapiens, GI5174419, Length=196, Percent_Identity=57.6530612244898, Blast_Score=250, Evalue=6e-67,
Organism=Escherichia coli, GI1786641, Length=194, Percent_Identity=64.9484536082474, Blast_Score=279, Evalue=8e-77,
Organism=Caenorhabditis elegans, GI17538017, Length=189, Percent_Identity=54.4973544973545, Blast_Score=217, Evalue=3e-57,
Organism=Drosophila melanogaster, GI20129427, Length=196, Percent_Identity=59.6938775510204, Blast_Score=259, Evalue=1e-69,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001907
- InterPro:   IPR018215 [H]

Pfam domain/function: PF00574 CLP_protease [H]

EC number: =3.4.21.92 [H]

Molecular weight: Translated: 23465; Mature: 23465

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00381 CLP_PROTEASE_SER ; PS00382 CLP_PROTEASE_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEMDTLVREKMNLVPMVVDQTPRGERAYDIFSRLLKERVVFLTGPIEDGMASLIVAQLLF
CCHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHH
LEAENPDKDIFMYINSPGGVVTAGLSIYDTMQYIKPSVSTVCVGQAASAASLILASGAEG
HHCCCCCCEEEEEECCCCCEEEECHHHHHHHHHHCCCHHHEECCCCHHHHHHHEECCCCC
KRFALPHSRVMVHQPSGGVRGQATDMEIHVKEILQLKRMINEIYQKHTGETIKKIETLLE
CEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
RDTFLSPEEAKKVGIIDDIITQRKENSGKQE
HHCCCCHHHHHHCCHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MEMDTLVREKMNLVPMVVDQTPRGERAYDIFSRLLKERVVFLTGPIEDGMASLIVAQLLF
CCHHHHHHHHHCCCEEEECCCCCCCHHHHHHHHHHHHCEEEEECCCHHHHHHHHHHHHHH
LEAENPDKDIFMYINSPGGVVTAGLSIYDTMQYIKPSVSTVCVGQAASAASLILASGAEG
HHCCCCCCEEEEEECCCCCEEEECHHHHHHHHHHCCCHHHEECCCCHHHHHHHEECCCCC
KRFALPHSRVMVHQPSGGVRGQATDMEIHVKEILQLKRMINEIYQKHTGETIKKIETLLE
CEEECCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHH
RDTFLSPEEAKKVGIIDDIITQRKENSGKQE
HHCCCCHHHHHHCCHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA