Click here to switch to the map view.

The map label for this gene is argD

Identifier: 88608008

GI number: 88608008

Start: 752265

End: 753434

Strand: Direct

Name: argD

Synonym: NSE_0850

Alternate gene names: 88608008

Gene position: 752265-753434 (Clockwise)

Preceding gene: 88608359

Following gene: 88608601

Centisome position: 87.57

GC content: 41.37

Gene sequence:

>1170_bases
ATGTCTGCAGTCCTAGGATTTTCAAGGAAATTTCCGGTAAAGATAGTACGAGCCAAAGGTATATATCTTTTCGACTCCAA
TGGAAAACAGTATTGTGACTTCACAAGTGGTATTGCGACCGTTAACTTTGGGCATTGCAATGAGTACATAAACAAAAAAA
TCAGTGAACAAATTCATACGTTGTGGCACTGTTCGAATCTTTTTTCGAGTGAAATCCAAGAACAAACTGCCACAAAACTA
GTTAATTCAACAAATTTTGGAGACAAAGTTTTCTTTTGCTCGTCTGGTCTAGAAGCAATAGAAGCGGCAGTCAAATTCAT
AAAACGGTACTTTTATGAATGTGGTGACACAGCCAGAACCGAAATACTAACACTGAAAAATGGTTTTCACGGAAGGAGCG
CCGCTGGTATTTCAGCTGGTGGCACGGAGGAAGCACGCCGTGGATTTGCACCTTTAGTAAAGGGATTTACACAGATAGAA
GCAAATAACGTAGATAAACTGAAAGCAAAGGTGAGTCATAACACAGCAGCAGTCGTGCTCGAACTTATACAGTCCGAAGG
TGGAATCTACGAAATAACAAATGATTACCTAGAAAATTTACAAATACTAAGGGAGAAATTCGGATTTCTCTTATGTTTCG
ATGAAATACAAACAGGCTTCGGAAGGATTGGACAGCTTTTTCACTATGAAAATCTCGGCGTAGAACCGGATTTACTCACG
TGCGCGAAGGGAATGGGTAACGGATTTCCAGTAGGTGGGTGTATAGTGAGCAAAGATATTGCCTCTGTACTTCCACTAGG
TGCTCACGGGGGAACCTACTCGGGAAACGCACTTGCCATGGCCGCTGTCGATGCAACTTTGGATCTACTAAACAAAGAAT
TTCTGCATAACGTAACAAAGATGTCAGAATATCTGTCAAGCTCTTTAAAAGAGATTGCAGCACTCCTTCCGGACCAGATT
ACAGATATTAGAGGTAGAGGCTTGCTTATGGGAGTAGAGATAGCTCAAAATGTAGATACATGGGATCTGCTGCTGAAATG
CCTAAAATCTGGGCTGGCGCTAAATCGCACATCAAAAAAACAGGTTCTAAGGATTCTACCCCCATTGATTGTAGAGAAAA
GTAATATAGACTTCGCGGTCGAAGTGCTTTACAAGCACCTGAAAAGTTAG

Upstream 100 bases:

>100_bases
AGGCAAGGCAGGATATGCTTACATTTGAGGAGAGATTAGGCGAACGCGATTGGAAAGCTCTCTCGAAGTTATTTGAAAAA
GGATCTGACCCATTGAGTCT

Downstream 100 bases:

>100_bases
GAGACTGAACCAACAGCTGCAGCTTACTGGCTAACCTCGATCTTCTCTATTTTATTGCATAGCTACGACACCTGCCAACA
ATCCAATATCTTTATAATTC

Product: acetylornithine transaminase protein

Products: NA

Alternate protein names: ACOAT [H]

Number of amino acids: Translated: 389; Mature: 388

Protein sequence:

>389_residues
MSAVLGFSRKFPVKIVRAKGIYLFDSNGKQYCDFTSGIATVNFGHCNEYINKKISEQIHTLWHCSNLFSSEIQEQTATKL
VNSTNFGDKVFFCSSGLEAIEAAVKFIKRYFYECGDTARTEILTLKNGFHGRSAAGISAGGTEEARRGFAPLVKGFTQIE
ANNVDKLKAKVSHNTAAVVLELIQSEGGIYEITNDYLENLQILREKFGFLLCFDEIQTGFGRIGQLFHYENLGVEPDLLT
CAKGMGNGFPVGGCIVSKDIASVLPLGAHGGTYSGNALAMAAVDATLDLLNKEFLHNVTKMSEYLSSSLKEIAALLPDQI
TDIRGRGLLMGVEIAQNVDTWDLLLKCLKSGLALNRTSKKQVLRILPPLIVEKSNIDFAVEVLYKHLKS

Sequences:

>Translated_389_residues
MSAVLGFSRKFPVKIVRAKGIYLFDSNGKQYCDFTSGIATVNFGHCNEYINKKISEQIHTLWHCSNLFSSEIQEQTATKL
VNSTNFGDKVFFCSSGLEAIEAAVKFIKRYFYECGDTARTEILTLKNGFHGRSAAGISAGGTEEARRGFAPLVKGFTQIE
ANNVDKLKAKVSHNTAAVVLELIQSEGGIYEITNDYLENLQILREKFGFLLCFDEIQTGFGRIGQLFHYENLGVEPDLLT
CAKGMGNGFPVGGCIVSKDIASVLPLGAHGGTYSGNALAMAAVDATLDLLNKEFLHNVTKMSEYLSSSLKEIAALLPDQI
TDIRGRGLLMGVEIAQNVDTWDLLLKCLKSGLALNRTSKKQVLRILPPLIVEKSNIDFAVEVLYKHLKS
>Mature_388_residues
SAVLGFSRKFPVKIVRAKGIYLFDSNGKQYCDFTSGIATVNFGHCNEYINKKISEQIHTLWHCSNLFSSEIQEQTATKLV
NSTNFGDKVFFCSSGLEAIEAAVKFIKRYFYECGDTARTEILTLKNGFHGRSAAGISAGGTEEARRGFAPLVKGFTQIEA
NNVDKLKAKVSHNTAAVVLELIQSEGGIYEITNDYLENLQILREKFGFLLCFDEIQTGFGRIGQLFHYENLGVEPDLLTC
AKGMGNGFPVGGCIVSKDIASVLPLGAHGGTYSGNALAMAAVDATLDLLNKEFLHNVTKMSEYLSSSLKEIAALLPDQIT
DIRGRGLLMGVEIAQNVDTWDLLLKCLKSGLALNRTSKKQVLRILPPLIVEKSNIDFAVEVLYKHLKS

Specific function: Involved In Both The Arginine And Lysine Biosynthetic Pathways. [C]

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=389, Percent_Identity=30.8483290488432, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI13994255, Length=421, Percent_Identity=29.4536817102138, Blast_Score=149, Evalue=3e-36,
Organism=Homo sapiens, GI284507298, Length=303, Percent_Identity=29.3729372937294, Blast_Score=133, Evalue=2e-31,
Organism=Homo sapiens, GI37574042, Length=412, Percent_Identity=27.4271844660194, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI226442705, Length=412, Percent_Identity=26.4563106796117, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI24119277, Length=412, Percent_Identity=26.6990291262136, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI226442709, Length=381, Percent_Identity=25.4593175853018, Blast_Score=94, Evalue=3e-19,
Organism=Escherichia coli, GI1789759, Length=366, Percent_Identity=37.1584699453552, Blast_Score=241, Evalue=7e-65,
Organism=Escherichia coli, GI1788044, Length=321, Percent_Identity=38.6292834890966, Blast_Score=236, Evalue=3e-63,
Organism=Escherichia coli, GI145693181, Length=380, Percent_Identity=30, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1789016, Length=408, Percent_Identity=27.9411764705882, Blast_Score=159, Evalue=4e-40,
Organism=Escherichia coli, GI1787560, Length=407, Percent_Identity=27.2727272727273, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1786991, Length=394, Percent_Identity=26.1421319796954, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786349, Length=317, Percent_Identity=26.813880126183, Blast_Score=93, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI25144271, Length=385, Percent_Identity=31.9480519480519, Blast_Score=202, Evalue=3e-52,
Organism=Caenorhabditis elegans, GI32564660, Length=434, Percent_Identity=31.1059907834101, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI25144274, Length=267, Percent_Identity=31.8352059925094, Blast_Score=144, Evalue=7e-35,
Organism=Caenorhabditis elegans, GI71992977, Length=419, Percent_Identity=29.1169451073986, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI71981843, Length=161, Percent_Identity=33.5403726708075, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6324432, Length=400, Percent_Identity=34, Blast_Score=210, Evalue=4e-55,
Organism=Saccharomyces cerevisiae, GI6323470, Length=398, Percent_Identity=31.6582914572864, Blast_Score=184, Evalue=2e-47,
Organism=Saccharomyces cerevisiae, GI6324386, Length=250, Percent_Identity=28.4, Blast_Score=80, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6321456, Length=434, Percent_Identity=24.1935483870968, Blast_Score=66, Evalue=9e-12,
Organism=Drosophila melanogaster, GI21357415, Length=388, Percent_Identity=30.6701030927835, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI28574759, Length=430, Percent_Identity=30, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI161085790, Length=435, Percent_Identity=29.4252873563218, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI21356575, Length=413, Percent_Identity=26.634382566586, Blast_Score=122, Evalue=4e-28,
Organism=Drosophila melanogaster, GI281366494, Length=258, Percent_Identity=24.4186046511628, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24667139, Length=258, Percent_Identity=24.4186046511628, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24667143, Length=258, Percent_Identity=24.4186046511628, Blast_Score=69, Evalue=7e-12,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.11 [H]

Molecular weight: Translated: 42685; Mature: 42553

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVLGFSRKFPVKIVRAKGIYLFDSNGKQYCDFTSGIATVNFGHCNEYINKKISEQIHT
CCCCCCCCCCCCEEEEEECEEEEECCCCCEECCCCCCCCEEECHHHHHHHHHHHHHHHHH
LWHCSNLFSSEIQEQTATKLVNSTNFGDKVFFCSSGLEAIEAAVKFIKRYFYECGDTART
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHH
EILTLKNGFHGRSAAGISAGGTEEARRGFAPLVKGFTQIEANNVDKLKAKVSHNTAAVVL
EEEEECCCCCCCCCCCCCCCCCHHHHHCHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHH
ELIQSEGGIYEITNDYLENLQILREKFGFLLCFDEIQTGFGRIGQLFHYENLGVEPDLLT
HHHHCCCCEEEEHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHH
CAKGMGNGFPVGGCIVSKDIASVLPLGAHGGTYSGNALAMAAVDATLDLLNKEFLHNVTK
HHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHH
MSEYLSSSLKEIAALLPDQITDIRGRGLLMGVEIAQNVDTWDLLLKCLKSGLALNRTSKK
HHHHHHHHHHHHHHHCCHHHHHHCCCCEEEEEHHHCCCCHHHHHHHHHHCCCCCCCCHHH
QVLRILPPLIVEKSNIDFAVEVLYKHLKS
HHHHHCCHHHEECCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SAVLGFSRKFPVKIVRAKGIYLFDSNGKQYCDFTSGIATVNFGHCNEYINKKISEQIHT
CCCCCCCCCCCEEEEEECEEEEECCCCCEECCCCCCCCEEECHHHHHHHHHHHHHHHHH
LWHCSNLFSSEIQEQTATKLVNSTNFGDKVFFCSSGLEAIEAAVKFIKRYFYECGDTART
HHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHHHHHHHHHCCCCHHH
EILTLKNGFHGRSAAGISAGGTEEARRGFAPLVKGFTQIEANNVDKLKAKVSHNTAAVVL
EEEEECCCCCCCCCCCCCCCCCHHHHHCHHHHHHHHHHHCCCCHHHHHHHHCCCHHHHHH
ELIQSEGGIYEITNDYLENLQILREKFGFLLCFDEIQTGFGRIGQLFHYENLGVEPDLLT
HHHHCCCCEEEEHHHHHHHHHHHHHHHCCEEEHHHHHHHHHHHHHHHHHCCCCCCCHHHH
CAKGMGNGFPVGGCIVSKDIASVLPLGAHGGTYSGNALAMAAVDATLDLLNKEFLHNVTK
HHHHCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHH
MSEYLSSSLKEIAALLPDQITDIRGRGLLMGVEIAQNVDTWDLLLKCLKSGLALNRTSKK
HHHHHHHHHHHHHHHCCHHHHHHCCCCEEEEEHHHCCCCHHHHHHHHHHCCCCCCCCHHH
QVLRILPPLIVEKSNIDFAVEVLYKHLKS
HHHHHCCHHHEECCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]