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The map label for this gene is virB11 [H]

Identifier: 88607229

GI number: 88607229

Start: 1462472

End: 1463470

Strand: Reverse

Name: virB11 [H]

Synonym: APH_1403

Alternate gene names: 88607229

Gene position: 1463470-1462472 (Counterclockwise)

Preceding gene: 88607929

Following gene: 88607785

Centisome position: 99.47

GC content: 42.64

Gene sequence:

>999_bases
ATGACTGGGGGTGGTGCAGCTTTAGAAACTTATCTTGAACCGCTTCGGGATATATTTGCTGAAGAAGGAGTAAATGAAAT
ATCAATAAATAACTCATGTGAAGTATGGGTTGAAAATAGGGGAAATATTAGGTGCGAGCATATTGCAGCATTGACGACTT
CTCATCTCAGGGGGTTAGGGCGTCTTATTGCTCAGGCTACGGAGCAAAAGTTAAGTGAGGAAACGCCACTGCTTTCTGCG
TCTTTACCCAACGGGTTTCGTGTACAGGTAGTTTTTCCTCCGGCATGTGAGGGTGATAAGATAGTGATGTCGATTCGTAA
GCCTTCTGCGATGCAGTTGTCGCTTGATGATTATGAAAAAATGGGGGCATTTTCTCATGTTGCTCAGCAGAATGACAAGC
TCAGAGATGAAAATAGCGAATTAGGTGAGTTGCTATCTAAGGGTAAAATAAAGGAATTTTTAGAAACGGCGGTACAAAAA
AAGAAGAATATAATTGTGAGTGGTGGTACCTCTACAGGGAAGACTACATTTACTAACGCTGCCTTGAGAGCTATACCTTT
AGAAGAGAGGATTATTACTGTTGAAGACTCGAGGGAAATTGTCCTATCTCATCCAAATCGCGTACATTTACTTGCTTCTA
AAGGTGGGCAAGGTAGAGCACGTGTTGGTACGCAAGATTTGATCGAAGCATGTCTTCGTCTTCGTCCGGATAGGATTATA
GTGGGGGAGTTGAGGGGTGCTGAAGCCTTTAGTTTTTTGAGGGCTATTAATACTGGGCATCCTGGATCTATTTCTACGTT
GCACGCTGATACTCCAAGGATGGCTATAGAGCAGTTAAAGCTTATGGTAATACAGGCAGGAACGGGATTACCAGCAGATC
AGATTGTGAATTACATAATGAATATTGTGGATGTGATAGTGCAGCTGAAGAGGAGCTCTGGTGGAGTGCGCCATGTTTCA
GACATTTTGTTCACTAAGTGTTCAGAGGGTAATAAGTAA

Upstream 100 bases:

>100_bases
ATGAAGGTATTTGTGAATCAGGACGTAGTATTTCCTCGTGATGCGGTGAGGTAGGTATGGAGGTGAAACGTTGTTTTGGT
AGGGAGGATTTAGGTAGGAT

Downstream 100 bases:

>100_bases
TCTGCGGTTATAATTACTTGTGAGCACTTTTGTTTTGTAGTAGCGCTAGATATGCATAGTTCCAATCATATACGAAATAT
TTTGGTATTCTTTTGTGGGC

Product: type IV secretion system ATPase VirB11

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 332; Mature: 331

Protein sequence:

>332_residues
MTGGGAALETYLEPLRDIFAEEGVNEISINNSCEVWVENRGNIRCEHIAALTTSHLRGLGRLIAQATEQKLSEETPLLSA
SLPNGFRVQVVFPPACEGDKIVMSIRKPSAMQLSLDDYEKMGAFSHVAQQNDKLRDENSELGELLSKGKIKEFLETAVQK
KKNIIVSGGTSTGKTTFTNAALRAIPLEERIITVEDSREIVLSHPNRVHLLASKGGQGRARVGTQDLIEACLRLRPDRII
VGELRGAEAFSFLRAINTGHPGSISTLHADTPRMAIEQLKLMVIQAGTGLPADQIVNYIMNIVDVIVQLKRSSGGVRHVS
DILFTKCSEGNK

Sequences:

>Translated_332_residues
MTGGGAALETYLEPLRDIFAEEGVNEISINNSCEVWVENRGNIRCEHIAALTTSHLRGLGRLIAQATEQKLSEETPLLSA
SLPNGFRVQVVFPPACEGDKIVMSIRKPSAMQLSLDDYEKMGAFSHVAQQNDKLRDENSELGELLSKGKIKEFLETAVQK
KKNIIVSGGTSTGKTTFTNAALRAIPLEERIITVEDSREIVLSHPNRVHLLASKGGQGRARVGTQDLIEACLRLRPDRII
VGELRGAEAFSFLRAINTGHPGSISTLHADTPRMAIEQLKLMVIQAGTGLPADQIVNYIMNIVDVIVQLKRSSGGVRHVS
DILFTKCSEGNK
>Mature_331_residues
TGGGAALETYLEPLRDIFAEEGVNEISINNSCEVWVENRGNIRCEHIAALTTSHLRGLGRLIAQATEQKLSEETPLLSAS
LPNGFRVQVVFPPACEGDKIVMSIRKPSAMQLSLDDYEKMGAFSHVAQQNDKLRDENSELGELLSKGKIKEFLETAVQKK
KNIIVSGGTSTGKTTFTNAALRAIPLEERIITVEDSREIVLSHPNRVHLLASKGGQGRARVGTQDLIEACLRLRPDRIIV
GELRGAEAFSFLRAINTGHPGSISTLHADTPRMAIEQLKLMVIQAGTGLPADQIVNYIMNIVDVIVQLKRSSGGVRHVSD
ILFTKCSEGNK

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG0630

COG function: function code NU; Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis

Gene ontology:

Cell location: Cell inner membrane (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP E family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR014155
- InterPro:   IPR001482 [H]

Pfam domain/function: PF00437 GSPII_E [H]

EC number: NA

Molecular weight: Translated: 36230; Mature: 36099

Theoretical pI: Translated: 7.22; Mature: 7.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGGGAALETYLEPLRDIFAEEGVNEISINNSCEVWVENRGNIRCEHIAALTTSHLRGLG
CCCCHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEECCCCCEEEHHHHHHHHHHHHHHH
RLIAQATEQKLSEETPLLSASLPNGFRVQVVFPPACEGDKIVMSIRKPSAMQLSLDDYEK
HHHHHHHHHHHHHCCCEEEECCCCCEEEEEEECCCCCCCEEEEEECCCCCEEEEHHHHHH
MGAFSHVAQQNDKLRDENSELGELLSKGKIKEFLETAVQKKKNIIVSGGTSTGKTTFTNA
HHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCEEEECCCCCCCEEHHCH
ALRAIPLEERIITVEDSREIVLSHPNRVHLLASKGGQGRARVGTQDLIEACLRLRPDRII
HHEEECCCCEEEEEECCCEEEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEE
VGELRGAEAFSFLRAINTGHPGSISTLHADTPRMAIEQLKLMVIQAGTGLPADQIVNYIM
EECCCCHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHEEEEECCCCCCHHHHHHHHH
NIVDVIVQLKRSSGGVRHVSDILFTKCSEGNK
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TGGGAALETYLEPLRDIFAEEGVNEISINNSCEVWVENRGNIRCEHIAALTTSHLRGLG
CCCHHHHHHHHHHHHHHHHHCCCCEEECCCCEEEEECCCCCEEEHHHHHHHHHHHHHHH
RLIAQATEQKLSEETPLLSASLPNGFRVQVVFPPACEGDKIVMSIRKPSAMQLSLDDYEK
HHHHHHHHHHHHHCCCEEEECCCCCEEEEEEECCCCCCCEEEEEECCCCCEEEEHHHHHH
MGAFSHVAQQNDKLRDENSELGELLSKGKIKEFLETAVQKKKNIIVSGGTSTGKTTFTNA
HHHHHHHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHHHCCEEEECCCCCCCEEHHCH
ALRAIPLEERIITVEDSREIVLSHPNRVHLLASKGGQGRARVGTQDLIEACLRLRPDRII
HHEEECCCCEEEEEECCCEEEEECCCEEEEEECCCCCCCCCCCHHHHHHHHHHCCCCEEE
VGELRGAEAFSFLRAINTGHPGSISTLHADTPRMAIEQLKLMVIQAGTGLPADQIVNYIM
EECCCCHHHHHHHHHHCCCCCCCCEEEECCCHHHHHHHHHEEEEECCCCCCHHHHHHHHH
NIVDVIVQLKRSSGGVRHVSDILFTKCSEGNK
HHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10882236 [H]