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The map label for this gene is virB10 [H]

Identifier: 88607929

GI number: 88607929

Start: 1463517

End: 1464821

Strand: Reverse

Name: virB10 [H]

Synonym: APH_1404

Alternate gene names: 88607929

Gene position: 1464821-1463517 (Counterclockwise)

Preceding gene: 88607325

Following gene: 88607229

Centisome position: 99.56

GC content: 44.29

Gene sequence:

>1305_bases
ATGGCTGACGAAATAAGGGGTTCTAGCAGCGGGGAGAACATTGAGGATAATGTTAATGTAGTAGGTGTAGCAAAGAGTAA
GAAGCTCTTTGTTATCATAGTGGTGCTGATTGCTACTGGACTTATGTACTATTTTTTCTTCTTCAATAAGGAGTCTTCGG
ATAATGAGGAAGATACTCAGATTCCTCGTGTTATCGAAGAGAAGGAAGTAGAAAAATTGAGGAAGGATGCGGGAAGGCCG
GCTCAGGAGACTGCTCCTAGAATCTTGACGCCACCACCGAGGTTGCCTGAGTTGCCGCCGCTTGTAATGCCTACTGTACC
TGATATTCCTGTGGTAACAAAATTGCTTAAGCCGCCTGTAGAGGAGGAGTTTGTTGAAGAGTATAACGTTCAAGAGGTTC
CTTCACCAATGGGTAATATTGCTCCTCCTGAACGCGAGGAGATATCTTTACCTTTGCCGTATAAGACGATAACAACTGAG
CAGCCGTCGTTTCTGGGGTATGATAAAGAAAAAAGAGGAGCCCCTATGATCGCATTTGGTGGCGGTGGTGGCGAAGCTGC
TGGTAGTGAATCCGGTGATGGTTCTGTTGGCGGGAAGGAAGATGCTCGGTTTACTGCGTGGCAAGGGTTAGAGGGTACTC
AATCTCCTAGTGTTAGAGCGACAAGAGTGGGGGATACGAGATATATAATACTGCAAGGTCACATGATTGATGCTGTTTTA
GAGACAGCAATAAACTCGGATATTTCAGGGGTGCTCAGGGCTGTGGTATCCAGAGATGTATATGCTTCTTCTGGAGATGC
GGTTGTAATACCGAAGGGGTCTAGGCTTATTGGTAGTTATTTCTTTGATTCTGCTGGTAACAATGTAAGGGTTGATGTTA
ATTGGTCCAGGGTCATTTTACCTCATGGCGTTGATATACAGATAGCGTCTAGTGGAACTGATGAACTAGGAAGAAATGGT
ATTTCTGGTGTTGTAGATAATAAAGTGGGCTCCATATTGACCTCTACTATCTTTTTGGCGGGTATATCTTTGGGGACAGC
TTATGTGACCGAGCAGATACCGTCGTTGCGGACTGAGACTGTTAAGGTTGAGACTCCTGCGGATGGTAAAGACGGGAAGA
AAACTACTTCATCATCTCTTTCAACAAAGATAGTTTCTGATGCTATTAAGGATTTCTCTGACTCTATGAAAGAGATTGTG
AATAAGTATTCTAATAGGACTCCGACTGTCTATGTAGATCAGGGTACTGTGATGAAGGTATTTGTGAATCAGGACGTAGT
ATTTCCTCGTGATGCGGTGAGGTAG

Upstream 100 bases:

>100_bases
AGGGGGTGCATGAGCTGTTTTACCTTGATTTTGGTGATGGCAGGAGTGTAGAAGTTGTGAATCAGGCTCTTAGTTAGAAT
TTGTCGATAGTAGGTGCAGG

Downstream 100 bases:

>100_bases
GTATGGAGGTGAAACGTTGTTTTGGTAGGGAGGATTTAGGTAGGATATGACTGGGGGTGGTGCAGCTTTAGAAACTTATC
TTGAACCGCTTCGGGATATA

Product: type IV secretion system protein VirB10

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 434; Mature: 433

Protein sequence:

>434_residues
MADEIRGSSSGENIEDNVNVVGVAKSKKLFVIIVVLIATGLMYYFFFFNKESSDNEEDTQIPRVIEEKEVEKLRKDAGRP
AQETAPRILTPPPRLPELPPLVMPTVPDIPVVTKLLKPPVEEEFVEEYNVQEVPSPMGNIAPPEREEISLPLPYKTITTE
QPSFLGYDKEKRGAPMIAFGGGGGEAAGSESGDGSVGGKEDARFTAWQGLEGTQSPSVRATRVGDTRYIILQGHMIDAVL
ETAINSDISGVLRAVVSRDVYASSGDAVVIPKGSRLIGSYFFDSAGNNVRVDVNWSRVILPHGVDIQIASSGTDELGRNG
ISGVVDNKVGSILTSTIFLAGISLGTAYVTEQIPSLRTETVKVETPADGKDGKKTTSSSLSTKIVSDAIKDFSDSMKEIV
NKYSNRTPTVYVDQGTVMKVFVNQDVVFPRDAVR

Sequences:

>Translated_434_residues
MADEIRGSSSGENIEDNVNVVGVAKSKKLFVIIVVLIATGLMYYFFFFNKESSDNEEDTQIPRVIEEKEVEKLRKDAGRP
AQETAPRILTPPPRLPELPPLVMPTVPDIPVVTKLLKPPVEEEFVEEYNVQEVPSPMGNIAPPEREEISLPLPYKTITTE
QPSFLGYDKEKRGAPMIAFGGGGGEAAGSESGDGSVGGKEDARFTAWQGLEGTQSPSVRATRVGDTRYIILQGHMIDAVL
ETAINSDISGVLRAVVSRDVYASSGDAVVIPKGSRLIGSYFFDSAGNNVRVDVNWSRVILPHGVDIQIASSGTDELGRNG
ISGVVDNKVGSILTSTIFLAGISLGTAYVTEQIPSLRTETVKVETPADGKDGKKTTSSSLSTKIVSDAIKDFSDSMKEIV
NKYSNRTPTVYVDQGTVMKVFVNQDVVFPRDAVR
>Mature_433_residues
ADEIRGSSSGENIEDNVNVVGVAKSKKLFVIIVVLIATGLMYYFFFFNKESSDNEEDTQIPRVIEEKEVEKLRKDAGRPA
QETAPRILTPPPRLPELPPLVMPTVPDIPVVTKLLKPPVEEEFVEEYNVQEVPSPMGNIAPPEREEISLPLPYKTITTEQ
PSFLGYDKEKRGAPMIAFGGGGGEAAGSESGDGSVGGKEDARFTAWQGLEGTQSPSVRATRVGDTRYIILQGHMIDAVLE
TAINSDISGVLRAVVSRDVYASSGDAVVIPKGSRLIGSYFFDSAGNNVRVDVNWSRVILPHGVDIQIASSGTDELGRNGI
SGVVDNKVGSILTSTIFLAGISLGTAYVTEQIPSLRTETVKVETPADGKDGKKTTSSSLSTKIVSDAIKDFSDSMKEIVN
KYSNRTPTVYVDQGTVMKVFVNQDVVFPRDAVR

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG2948

COG function: function code U; Type IV secretory pathway, VirB10 components

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trbI/virB10 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005498 [H]

Pfam domain/function: PF03743 TrbI [H]

EC number: NA

Molecular weight: Translated: 46901; Mature: 46769

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADEIRGSSSGENIEDNVNVVGVAKSKKLFVIIVVLIATGLMYYFFFFNKESSDNEEDTQ
CCCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHH
IPRVIEEKEVEKLRKDAGRPAQETAPRILTPPPRLPELPPLVMPTVPDIPVVTKLLKPPV
HHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCH
EEEFVEEYNVQEVPSPMGNIAPPEREEISLPLPYKTITTEQPSFLGYDKEKRGAPMIAFG
HHHHHHHCCHHHCCCCCCCCCCCCHHCEECCCCCCEECCCCCCCCCCCHHHCCCCEEEEC
GGGGEAAGSESGDGSVGGKEDARFTAWQGLEGTQSPSVRATRVGDTRYIILQGHMIDAVL
CCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEECCEEEEEEECHHHHHHH
ETAINSDISGVLRAVVSRDVYASSGDAVVIPKGSRLIGSYFFDSAGNNVRVDVNWSRVIL
HHHHCCCHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHCCCCCEEEEEEEEEEEEE
PHGVDIQIASSGTDELGRNGISGVVDNKVGSILTSTIFLAGISLGTAYVTEQIPSLRTET
CCCCEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
VKVETPADGKDGKKTTSSSLSTKIVSDAIKDFSDSMKEIVNKYSNRTPTVYVDQGTVMKV
EEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEE
FVNQDVVFPRDAVR
EECCCEECCHHHCC
>Mature Secondary Structure 
ADEIRGSSSGENIEDNVNVVGVAKSKKLFVIIVVLIATGLMYYFFFFNKESSDNEEDTQ
CCCCCCCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHEECCCCCCCCHHHH
IPRVIEEKEVEKLRKDAGRPAQETAPRILTPPPRLPELPPLVMPTVPDIPVVTKLLKPPV
HHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCH
EEEFVEEYNVQEVPSPMGNIAPPEREEISLPLPYKTITTEQPSFLGYDKEKRGAPMIAFG
HHHHHHHCCHHHCCCCCCCCCCCCHHCEECCCCCCEECCCCCCCCCCCHHHCCCCEEEEC
GGGGEAAGSESGDGSVGGKEDARFTAWQGLEGTQSPSVRATRVGDTRYIILQGHMIDAVL
CCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCEEEEEECCEEEEEEECHHHHHHH
ETAINSDISGVLRAVVSRDVYASSGDAVVIPKGSRLIGSYFFDSAGNNVRVDVNWSRVIL
HHHHCCCHHHHHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHCCCCCEEEEEEEEEEEEE
PHGVDIQIASSGTDELGRNGISGVVDNKVGSILTSTIFLAGISLGTAYVTEQIPSLRTET
CCCCEEEEECCCCHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCE
VKVETPADGKDGKKTTSSSLSTKIVSDAIKDFSDSMKEIVNKYSNRTPTVYVDQGTVMKV
EEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEEE
FVNQDVVFPRDAVR
EECCCEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10882236 [H]