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The map label for this gene is tetA [H]

Identifier: 87201319

GI number: 87201319

Start: 3525997

End: 3527214

Strand: Direct

Name: tetA [H]

Synonym: Saro_3307

Alternate gene names: 87201319

Gene position: 3525997-3527214 (Clockwise)

Preceding gene: 87201318

Following gene: 87201322

Centisome position: 99.0

GC content: 67.57

Gene sequence:

>1218_bases
ATGCAGCACCGCGCCTCGTTCGGTATCGTCTTCGCGATCGTGATGATCGACATGCTGGGCTTCGGGATCGTCACCCCGGT
GCTGCCCGGCCTGATCATCGAGCTGACCCGCGTCGACATCGGCACAGCGGCGGAATACGCGGGCTGGCTGGGCGCCGGAT
ATGCGACGATGCAGTTCGTGTTCGCGCCGGTCATCGGCAACCTGTCCGACCGGTTCGGGCGCAGGCCGGTGCTTCTTGCC
GCGATCCTGATGCTCGGGCTGGACTACCTGCTTCAGGCCATGGCCCCGCATTTCTGGTGGCTGATCATCGGCCGGCTGCT
GGCGGGCGTCACCGGCGCGAGCTTTTCGGCCGCCTACGCCTATATCGCCGACGTGACCCCGCCCGAAAAGCGCGCGGCAA
ACTTCGGAATGATGGGCCTTGCCTTCGGGTTCGGCTTCGTGGTCGGTCCCGCGATGGGGGGACTTCTTGGCGCGATAAGC
CCGCGCCTGCCGTTCTATGCGGCATCCGCCCTCGCATTGACGAACTTCGTGTTCGGCATGTTCTTCCTGCGCGAATCGCT
CGCACCGGAAAACCGCCGCCCATTCGACTGGCGGCGGGCAAACGCACTGTCGTCGCTGCGCGCGCTGCGGGGACGGAGCC
GGACCGTGCTGTGGTTCGTTGCTGCGCTGGGCGCGTGGCAGCTCGCCCACGTGGTCTACCCGGCGGTCTGGCCCTATTTC
GCCATCGCCGCCTACGGTTTTTCGACCCGCGACGTCGGACTGGCACTGGCGATGGTAGGGTTTTCGAGCGCGCTGGTTCA
GGGCTTCGGCCTGCGCTTTGCCCTGCCGCGGCTGGGCGAGCGCCGCGCCGTGGTGCTGGGGGTGGCCGGACTGTGCGCAT
CGGCCGTGCTCTACAACCTCGCCCAGCACACCTGGCAGGTCTATCTGGCGATTGCCGTGGGCGCCTTGCAGGGCTTCGTC
CAGCCGCCGATCGCCGCGTTCAACAGCCGCGCGGTCGATGCGCGCAGCCAGGGCGAATTGCAGGGCGCGGTGCAATCGAT
CGGCTCGATCGCGGCCATCGTCGGTCCGCCGCTCTATACCCAGACGCTAGCGCGGTTCAGCGGGCCGCACGCCATCGTCA
ACCTGCCGGGGATGCCGATGCTGCTTTCGGCGGCGATCTCGCTGATGACGCTGGCCCTGTTCTGGAAGGGCGCCTCGCTG
CTGCGCGAGAGCGAATGA

Upstream 100 bases:

>100_bases
CATCGCGCAGCTCATGGCGGAAAGCGAAACGGCCCTGACGCGCCGCTGACGCCGCCCGGCCCGGCGGCTCCGCCGGACCA
CCGGCACCGGAGATTTCCCA

Downstream 100 bases:

>100_bases
GCCCGCTTAGTGCCTGATCCGAAACTATCGTTTCGGATGGTTCGGCACCGGCCCGCTCCCCCTCCCGGCCGCCCATGAGA
ATACAATGTCTTGGGTGGCC

Product: major facilitator transporter

Products: NA

Alternate protein names: TetA(C) [H]

Number of amino acids: Translated: 405; Mature: 405

Protein sequence:

>405_residues
MQHRASFGIVFAIVMIDMLGFGIVTPVLPGLIIELTRVDIGTAAEYAGWLGAGYATMQFVFAPVIGNLSDRFGRRPVLLA
AILMLGLDYLLQAMAPHFWWLIIGRLLAGVTGASFSAAYAYIADVTPPEKRAANFGMMGLAFGFGFVVGPAMGGLLGAIS
PRLPFYAASALALTNFVFGMFFLRESLAPENRRPFDWRRANALSSLRALRGRSRTVLWFVAALGAWQLAHVVYPAVWPYF
AIAAYGFSTRDVGLALAMVGFSSALVQGFGLRFALPRLGERRAVVLGVAGLCASAVLYNLAQHTWQVYLAIAVGALQGFV
QPPIAAFNSRAVDARSQGELQGAVQSIGSIAAIVGPPLYTQTLARFSGPHAIVNLPGMPMLLSAAISLMTLALFWKGASL
LRESE

Sequences:

>Translated_405_residues
MQHRASFGIVFAIVMIDMLGFGIVTPVLPGLIIELTRVDIGTAAEYAGWLGAGYATMQFVFAPVIGNLSDRFGRRPVLLA
AILMLGLDYLLQAMAPHFWWLIIGRLLAGVTGASFSAAYAYIADVTPPEKRAANFGMMGLAFGFGFVVGPAMGGLLGAIS
PRLPFYAASALALTNFVFGMFFLRESLAPENRRPFDWRRANALSSLRALRGRSRTVLWFVAALGAWQLAHVVYPAVWPYF
AIAAYGFSTRDVGLALAMVGFSSALVQGFGLRFALPRLGERRAVVLGVAGLCASAVLYNLAQHTWQVYLAIAVGALQGFV
QPPIAAFNSRAVDARSQGELQGAVQSIGSIAAIVGPPLYTQTLARFSGPHAIVNLPGMPMLLSAAISLMTLALFWKGASL
LRESE
>Mature_405_residues
MQHRASFGIVFAIVMIDMLGFGIVTPVLPGLIIELTRVDIGTAAEYAGWLGAGYATMQFVFAPVIGNLSDRFGRRPVLLA
AILMLGLDYLLQAMAPHFWWLIIGRLLAGVTGASFSAAYAYIADVTPPEKRAANFGMMGLAFGFGFVVGPAMGGLLGAIS
PRLPFYAASALALTNFVFGMFFLRESLAPENRRPFDWRRANALSSLRALRGRSRTVLWFVAALGAWQLAHVVYPAVWPYF
AIAAYGFSTRDVGLALAMVGFSSALVQGFGLRFALPRLGERRAVVLGVAGLCASAVLYNLAQHTWQVYLAIAVGALQGFV
QPPIAAFNSRAVDARSQGELQGAVQSIGSIAAIVGPPLYTQTLARFSGPHAIVNLPGMPMLLSAAISLMTLALFWKGASL
LRESE

Specific function: Resistance to tetracycline by an active tetracycline efflux. This is an energy-dependent process that decreases the accumulation of the antibiotic in whole cells. This protein functions as a metal-tetracycline/H(+) antiporter [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. TCR/tet family [H]

Homologues:

Organism=Homo sapiens, GI39753965, Length=310, Percent_Identity=28.0645161290323, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI94721311, Length=361, Percent_Identity=28.808864265928, Blast_Score=114, Evalue=2e-25,
Organism=Homo sapiens, GI225703104, Length=153, Percent_Identity=31.3725490196078, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI225703102, Length=153, Percent_Identity=31.3725490196078, Blast_Score=79, Evalue=5e-15,
Organism=Homo sapiens, GI217416366, Length=244, Percent_Identity=25.4098360655738, Blast_Score=73, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71996331, Length=325, Percent_Identity=26.1538461538462, Blast_Score=105, Evalue=4e-23,
Organism=Caenorhabditis elegans, GI17551570, Length=335, Percent_Identity=22.6865671641791, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI221513297, Length=313, Percent_Identity=27.7955271565495, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI21357569, Length=310, Percent_Identity=28.7096774193548, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI161080926, Length=310, Percent_Identity=28.7096774193548, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI161080924, Length=310, Percent_Identity=28.7096774193548, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24656463, Length=310, Percent_Identity=28.7096774193548, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24656468, Length=310, Percent_Identity=28.7096774193548, Blast_Score=107, Evalue=1e-23,
Organism=Drosophila melanogaster, GI17738085, Length=336, Percent_Identity=25, Blast_Score=101, Evalue=7e-22,
Organism=Drosophila melanogaster, GI24652013, Length=324, Percent_Identity=24.6913580246914, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24652011, Length=351, Percent_Identity=23.9316239316239, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24667557, Length=152, Percent_Identity=28.2894736842105, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196
- InterPro:   IPR005829
- InterPro:   IPR001958 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 43323; Mature: 43323

Theoretical pI: Translated: 10.43; Mature: 10.43

Prosite motif: PS50850 MFS ; PS00216 SUGAR_TRANSPORT_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQHRASFGIVFAIVMIDMLGFGIVTPVLPGLIIELTRVDIGTAAEYAGWLGAGYATMQFV
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHHHHHHHH
FAPVIGNLSDRFGRRPVLLAAILMLGLDYLLQAMAPHFWWLIIGRLLAGVTGASFSAAYA
HHHHHHCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
YIADVTPPEKRAANFGMMGLAFGFGFVVGPAMGGLLGAISPRLPFYAASALALTNFVFGM
HHCCCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
FFLRESLAPENRRPFDWRRANALSSLRALRGRSRTVLWFVAALGAWQLAHVVYPAVWPYF
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
AIAAYGFSTRDVGLALAMVGFSSALVQGFGLRFALPRLGERRAVVLGVAGLCASAVLYNL
HHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHHHHHHHHH
AQHTWQVYLAIAVGALQGFVQPPIAAFNSRAVDARSQGELQGAVQSIGSIAAIVGPPLYT
HHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHH
QTLARFSGPHAIVNLPGMPMLLSAAISLMTLALFWKGASLLRESE
HHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCHHHHHCCC
>Mature Secondary Structure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HHHHHHCCCCEEEECCCHHHHHHHHHHHHHHHHHHHCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 383387; 6337373; 6307828; 1517220 [H]