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The map label for this gene is fabG2 [H]

Identifier: 87201084

GI number: 87201084

Start: 3291337

End: 3292119

Strand: Reverse

Name: fabG2 [H]

Synonym: Saro_3072

Alternate gene names: 87201084

Gene position: 3292119-3291337 (Counterclockwise)

Preceding gene: 87201085

Following gene: 87201083

Centisome position: 92.43

GC content: 67.18

Gene sequence:

>783_bases
ATGAAGATCGACAGCACGACCAGCGCGGTCGTCACCGGCGGTGCATCCGGCCTCGGCCGCGCAACGGCAGAGGCGCTCGC
GGCCGCCGGGGTGAAGGTCGCCATATTCGACGTGAACGAGGAACTCGGCGAGCAGGTCGCCGCCGCGATCGGCGGGCTGT
TCTGCAAGGTCGACATCACCAGCGAGGAGTCGGTCGTCGAAGGCTTTGCCAAGGCGCGCGCCGCGCACGGCCAGGAACGC
ATCTGCGTCCACTGCGCGATGACCCAGCGCAAGGGCCGGACGATCAGCCGCAACAAGGAGACCGGCGAGTTCGTTCGCTT
CCCGACGGAGGACTATGCCTTTGCCGCGCAGGGCATTCTGGTCGCCAGCTACCGTGTCGCCTCGCTTTCCGCGCTTGGCA
TGGCGGGGCTTGATCCGCTGGAAGACGGCGAACGCGGAACGATCATTCTCACCGCCTCGGTCGCGGCGCAGGACGCCCAG
ATCGGGCAGGTGGCCTACGGTTCGCTCAAGGCCGGGGTGAACGGCCTGGTCCTGCCGATGGCACGCGACCTGATGGACCT
CGGCATCCGCGTCAACTCGATCATGCCGGGCATCTTCGGCACGCCGCTGCTCGGCCGCCTGCCGGAAAAGGTGCTCGACA
GTCTCAGCGCTTCGGTGCCGTTCCCCAAGCGGCTCGGCAAGCCCGAGGAATATGCCAGCCTTGCGATGGAACTGGTGCGC
AATTCCTATTTCAACGGCCAGTGCATCCGCCTCGACGGCGCGATCCGCATGGCCCCGCGCTGA

Upstream 100 bases:

>100_bases
AGGGCCTGATCCACGACATTCCCACCTGCCAGCAGCTGATCGAGCGTATCGTGGCCGACGCCGAGGACATCATCCGGGGC
AGGCTCGGAGGGTTCCTGGC

Downstream 100 bases:

>100_bases
GGATCGAACCGATGAGCCAATCTCCCTTCCGCGACGACGTCCTCGCCGGCAAGACCGCGTTCATCGCGGGCGGAACCAGC
GGCATCAATCTGGGCATCGC

Product: short-chain dehydrogenase/reductase SDR

Products: 3-oxoacyl-CoA; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 260; Mature: 260

Protein sequence:

>260_residues
MKIDSTTSAVVTGGASGLGRATAEALAAAGVKVAIFDVNEELGEQVAAAIGGLFCKVDITSEESVVEGFAKARAAHGQER
ICVHCAMTQRKGRTISRNKETGEFVRFPTEDYAFAAQGILVASYRVASLSALGMAGLDPLEDGERGTIILTASVAAQDAQ
IGQVAYGSLKAGVNGLVLPMARDLMDLGIRVNSIMPGIFGTPLLGRLPEKVLDSLSASVPFPKRLGKPEEYASLAMELVR
NSYFNGQCIRLDGAIRMAPR

Sequences:

>Translated_260_residues
MKIDSTTSAVVTGGASGLGRATAEALAAAGVKVAIFDVNEELGEQVAAAIGGLFCKVDITSEESVVEGFAKARAAHGQER
ICVHCAMTQRKGRTISRNKETGEFVRFPTEDYAFAAQGILVASYRVASLSALGMAGLDPLEDGERGTIILTASVAAQDAQ
IGQVAYGSLKAGVNGLVLPMARDLMDLGIRVNSIMPGIFGTPLLGRLPEKVLDSLSASVPFPKRLGKPEEYASLAMELVR
NSYFNGQCIRLDGAIRMAPR
>Mature_260_residues
MKIDSTTSAVVTGGASGLGRATAEALAAAGVKVAIFDVNEELGEQVAAAIGGLFCKVDITSEESVVEGFAKARAAHGQER
ICVHCAMTQRKGRTISRNKETGEFVRFPTEDYAFAAQGILVASYRVASLSALGMAGLDPLEDGERGTIILTASVAAQDAQ
IGQVAYGSLKAGVNGLVLPMARDLMDLGIRVNSIMPGIFGTPLLGRLPEKVLDSLSASVPFPKRLGKPEEYASLAMELVR
NSYFNGQCIRLDGAIRMAPR

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI4758504, Length=253, Percent_Identity=44.2687747035573, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI83715985, Length=253, Percent_Identity=41.897233201581, Blast_Score=178, Evalue=5e-45,
Organism=Homo sapiens, GI15277342, Length=261, Percent_Identity=29.1187739463602, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI40254992, Length=249, Percent_Identity=25.7028112449799, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI31542939, Length=241, Percent_Identity=27.8008298755187, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1787335, Length=256, Percent_Identity=29.6875, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI87082100, Length=262, Percent_Identity=26.3358778625954, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1787905, Length=257, Percent_Identity=29.1828793774319, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17538182, Length=252, Percent_Identity=42.4603174603175, Blast_Score=186, Evalue=9e-48,
Organism=Caenorhabditis elegans, GI17555706, Length=258, Percent_Identity=26.7441860465116, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI25147288, Length=257, Percent_Identity=26.0700389105058, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17737361, Length=253, Percent_Identity=45.4545454545455, Blast_Score=206, Evalue=1e-53,
Organism=Drosophila melanogaster, GI24639444, Length=259, Percent_Identity=31.6602316602317, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.35

Molecular weight: Translated: 27319; Mature: 27319

Theoretical pI: Translated: 6.53; Mature: 6.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIDSTTSAVVTGGASGLGRATAEALAAAGVKVAIFDVNEELGEQVAAAIGGLFCKVDIT
CCCCCCCCEEEECCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCEEEEEEEC
SEESVVEGFAKARAAHGQERICVHCAMTQRKGRTISRNKETGEFVRFPTEDYAFAAQGIL
CCHHHHHHHHHHHHHCCCCEEEEEEEEHHHCCCCCCCCCCCCCEEECCCHHHHHHHCCEE
VASYRVASLSALGMAGLDPLEDGERGTIILTASVAAQDAQIGQVAYGSLKAGVNGLVLPM
EEHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEHHH
ARDLMDLGIRVNSIMPGIFGTPLLGRLPEKVLDSLSASVPFPKRLGKPEEYASLAMELVR
HHHHHHHCCCHHHHCCCCCCCCHHHHCHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHH
NSYFNGQCIRLDGAIRMAPR
CCCCCCEEEEECCEEEECCC
>Mature Secondary Structure
MKIDSTTSAVVTGGASGLGRATAEALAAAGVKVAIFDVNEELGEQVAAAIGGLFCKVDIT
CCCCCCCCEEEECCCCCCHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHCCEEEEEEEC
SEESVVEGFAKARAAHGQERICVHCAMTQRKGRTISRNKETGEFVRFPTEDYAFAAQGIL
CCHHHHHHHHHHHHHCCCCEEEEEEEEHHHCCCCCCCCCCCCCEEECCCHHHHHHHCCEE
VASYRVASLSALGMAGLDPLEDGERGTIILTASVAAQDAQIGQVAYGSLKAGVNGLVLPM
EEHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHCCCCEEEHHH
ARDLMDLGIRVNSIMPGIFGTPLLGRLPEKVLDSLSASVPFPKRLGKPEEYASLAMELVR
HHHHHHHCCCHHHHCCCCCCCCHHHHCHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHH
NSYFNGQCIRLDGAIRMAPR
CCCCCCEEEEECCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-3-hydroxyacyl-CoA; NAD+

Specific reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]