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The map label for this gene is fadH [H]

Identifier: 87201083

GI number: 87201083

Start: 3290531

End: 3291325

Strand: Reverse

Name: fadH [H]

Synonym: Saro_3071

Alternate gene names: 87201083

Gene position: 3291325-3290531 (Counterclockwise)

Preceding gene: 87201084

Following gene: 87201080

Centisome position: 92.41

GC content: 66.16

Gene sequence:

>795_bases
ATGAGCCAATCTCCCTTCCGCGACGACGTCCTCGCCGGCAAGACCGCGTTCATCGCGGGCGGAACCAGCGGCATCAATCT
GGGCATCGCAAAGCGCTTTGCCGAACTGGGCGCGCGGGTCGCCGTCCTCGGTCGCAATCCCGAAAAGGCAGCGTCCGCTG
CTGACGAAATCGGCCACGATGCCATCTGGCGGGCCGCCGACGTGCGCGATTATGGCGCGATCTGCGAGGCGATGAAGTCG
GTCCGCGACGAGATCGGCGCGCTCGACATCGTCGTGTCGGGGGCTGCGGGCAATTTCCTGGCGCCGGTACTCGGCATGTC
CGCCAATGCCTTCAAGACGGTCGTCGACATCGATCTCCTCGGCACGTTCAACGTGTTCCGGGGGTGTCACGAACTGCTCA
ACCCCGGCGCGTCGCTCATCGCGATCACCGCCGGACAGGCGGAGCAGGCCATGGCGATGCAGGCCCATGCCTGCGCCGCG
AAGGCCGGGATCAACCAGCTCGTGCGCACGCTGGCGATCGAATGGGGCCCCGATGTGCGAGTCAACGGCATTTCGCCGGG
TCCGATCGCGGATACCGAGGGCATGGCAAGACTGGCACCCGATGAATCGACGCGCCAGCAGCACTATGCGCGCATCCCGA
TGAAGCGCTGGGGCACCTGTTACGAGATCGCCGAGGCGGCGGTGTACCTGTCGACCCCGGCCGCAAGCTACGTGACCGGC
GCGATCCTCGATGTGGATGGTGGCAGTTCGGTCGGCGATGCCTCTCGCACCAGTCCGAACAAGGGGCTTGCCTGA

Upstream 100 bases:

>100_bases
CCAGCCTTGCGATGGAACTGGTGCGCAATTCCTATTTCAACGGCCAGTGCATCCGCCTCGACGGCGCGATCCGCATGGCC
CCGCGCTGAGGATCGAACCG

Downstream 100 bases:

>100_bases
CGGATCGGGCTGATCGGCGGCGCGAGCAACCGGCGGCTCAACCGGCGTGGTTGCCGGGAAGGATCGGGTCGCCGATGGTC
ATCTTCTTGCCGTCGGTGAT

Product: short chain dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 264; Mature: 263

Protein sequence:

>264_residues
MSQSPFRDDVLAGKTAFIAGGTSGINLGIAKRFAELGARVAVLGRNPEKAASAADEIGHDAIWRAADVRDYGAICEAMKS
VRDEIGALDIVVSGAAGNFLAPVLGMSANAFKTVVDIDLLGTFNVFRGCHELLNPGASLIAITAGQAEQAMAMQAHACAA
KAGINQLVRTLAIEWGPDVRVNGISPGPIADTEGMARLAPDESTRQQHYARIPMKRWGTCYEIAEAAVYLSTPAASYVTG
AILDVDGGSSVGDASRTSPNKGLA

Sequences:

>Translated_264_residues
MSQSPFRDDVLAGKTAFIAGGTSGINLGIAKRFAELGARVAVLGRNPEKAASAADEIGHDAIWRAADVRDYGAICEAMKS
VRDEIGALDIVVSGAAGNFLAPVLGMSANAFKTVVDIDLLGTFNVFRGCHELLNPGASLIAITAGQAEQAMAMQAHACAA
KAGINQLVRTLAIEWGPDVRVNGISPGPIADTEGMARLAPDESTRQQHYARIPMKRWGTCYEIAEAAVYLSTPAASYVTG
AILDVDGGSSVGDASRTSPNKGLA
>Mature_263_residues
SQSPFRDDVLAGKTAFIAGGTSGINLGIAKRFAELGARVAVLGRNPEKAASAADEIGHDAIWRAADVRDYGAICEAMKSV
RDEIGALDIVVSGAAGNFLAPVLGMSANAFKTVVDIDLLGTFNVFRGCHELLNPGASLIAITAGQAEQAMAMQAHACAAK
AGINQLVRTLAIEWGPDVRVNGISPGPIADTEGMARLAPDESTRQQHYARIPMKRWGTCYEIAEAAVYLSTPAASYVTGA
ILDVDGGSSVGDASRTSPNKGLA

Specific function: Auxiliary enzyme of beta-oxidation. It participates in the metabolism of unsaturated fatty enoyl-CoA esters having double bonds in both even- and odd-numbered positions. Catalyzes the NADP-dependent reduction of 2,4-dienoyl-CoA to yield trans-3- enoyl-CoA

COG id: COG1028

COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI10190704, Length=267, Percent_Identity=40.8239700374532, Blast_Score=181, Evalue=6e-46,
Organism=Homo sapiens, GI19923817, Length=263, Percent_Identity=29.277566539924, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI4503301, Length=249, Percent_Identity=33.7349397590361, Blast_Score=119, Evalue=2e-27,
Organism=Homo sapiens, GI7705925, Length=244, Percent_Identity=26.2295081967213, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI40254992, Length=239, Percent_Identity=26.3598326359833, Blast_Score=76, Evalue=3e-14,
Organism=Homo sapiens, GI32483357, Length=250, Percent_Identity=26, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI59889578, Length=239, Percent_Identity=28.8702928870293, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI5031737, Length=253, Percent_Identity=26.4822134387352, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI87082100, Length=255, Percent_Identity=33.7254901960784, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI1787905, Length=244, Percent_Identity=31.1475409836066, Blast_Score=89, Evalue=2e-19,
Organism=Escherichia coli, GI1790717, Length=247, Percent_Identity=27.9352226720648, Blast_Score=88, Evalue=5e-19,
Organism=Escherichia coli, GI87082160, Length=253, Percent_Identity=27.6679841897233, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787335, Length=239, Percent_Identity=28.4518828451883, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI2367365, Length=246, Percent_Identity=30.0813008130081, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789208, Length=245, Percent_Identity=26.530612244898, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1789378, Length=249, Percent_Identity=28.9156626506024, Blast_Score=75, Evalue=6e-15,
Organism=Escherichia coli, GI1788459, Length=246, Percent_Identity=27.2357723577236, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1787545, Length=256, Percent_Identity=26.171875, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17536025, Length=262, Percent_Identity=34.7328244274809, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17536651, Length=260, Percent_Identity=33.8461538461538, Blast_Score=123, Evalue=8e-29,
Organism=Caenorhabditis elegans, GI17561272, Length=250, Percent_Identity=34.8, Blast_Score=110, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17562910, Length=261, Percent_Identity=28.3524904214559, Blast_Score=84, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71994600, Length=257, Percent_Identity=25.6809338521401, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI25147288, Length=253, Percent_Identity=29.6442687747036, Blast_Score=77, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17555706, Length=251, Percent_Identity=27.8884462151394, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17563726, Length=266, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17560676, Length=245, Percent_Identity=26.1224489795918, Blast_Score=74, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17559104, Length=264, Percent_Identity=28.030303030303, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI71994604, Length=252, Percent_Identity=23.015873015873, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI72000259, Length=261, Percent_Identity=24.5210727969349, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562906, Length=263, Percent_Identity=25.8555133079848, Blast_Score=66, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=263, Percent_Identity=26.615969581749, Blast_Score=64, Evalue=7e-11,
Organism=Saccharomyces cerevisiae, GI6324126, Length=257, Percent_Identity=40.4669260700389, Blast_Score=184, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24643142, Length=244, Percent_Identity=26.6393442622951, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24639444, Length=252, Percent_Identity=31.7460317460317, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI21355319, Length=251, Percent_Identity=28.2868525896414, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI21357041, Length=253, Percent_Identity=26.0869565217391, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI23397609, Length=245, Percent_Identity=26.9387755102041, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI28571526, Length=255, Percent_Identity=25.8823529411765, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24644339, Length=250, Percent_Identity=26.8, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI24644337, Length=256, Percent_Identity=28.125, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.34 [H]

Molecular weight: Translated: 27385; Mature: 27254

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQSPFRDDVLAGKTAFIAGGTSGINLGIAKRFAELGARVAVLGRNPEKAASAADEIGHD
CCCCCCCHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHCHH
AIWRAADVRDYGAICEAMKSVRDEIGALDIVVSGAAGNFLAPVLGMSANAFKTVVDIDLL
HHHHHHCHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCHHHHHHCCCCHHHHHHHHHHHH
GTFNVFRGCHELLNPGASLIAITAGQAEQAMAMQAHACAAKAGINQLVRTLAIEWGPDVR
HHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
VNGISPGPIADTEGMARLAPDESTRQQHYARIPMKRWGTCYEIAEAAVYLSTPAASYVTG
ECCCCCCCCCCCCCCEECCCCHHHHHHHHHHCCHHHCCHHHHHHHHHHEEECCCHHHHEE
AILDVDGGSSVGDASRTSPNKGLA
EEEECCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SQSPFRDDVLAGKTAFIAGGTSGINLGIAKRFAELGARVAVLGRNPEKAASAADEIGHD
CCCCCCHHHHCCCEEEEECCCCCCHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHCHH
AIWRAADVRDYGAICEAMKSVRDEIGALDIVVSGAAGNFLAPVLGMSANAFKTVVDIDLL
HHHHHHCHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCHHHHHHCCCCHHHHHHHHHHHH
GTFNVFRGCHELLNPGASLIAITAGQAEQAMAMQAHACAAKAGINQLVRTLAIEWGPDVR
HHHHHHHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEE
VNGISPGPIADTEGMARLAPDESTRQQHYARIPMKRWGTCYEIAEAAVYLSTPAASYVTG
ECCCCCCCCCCCCCCEECCCCHHHHHHHHHHCCHHHCCHHHHHHHHHHEEECCCHHHHEE
AILDVDGGSSVGDASRTSPNKGLA
EEEECCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]