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The map label for this gene is cls1 [H]

Identifier: 87201080

GI number: 87201080

Start: 3287258

End: 3288442

Strand: Reverse

Name: cls1 [H]

Synonym: Saro_3068

Alternate gene names: 87201080

Gene position: 3288442-3287258 (Counterclockwise)

Preceding gene: 87201083

Following gene: 87201077

Centisome position: 92.33

GC content: 65.91

Gene sequence:

>1185_bases
ATGACAACCAGCTATAATCGTTACACATTACTCTTCGGCGCTGAAGAGTTCTGGCAAGCTGCGAGGGCGGACATGGCGGC
GGCGCAGCGTCGGGTCCTTGTCCAGGCGATGACTTTCGAGGCCGACCGGGCCGGGCTGTCCGTGGCATCGGGCATCGAAA
ATTCGCCTGCGCGCGAGCGACGTGTGCTGGTTGACGACTACAGTCGCAACGTCATCAACGACACCATGCTCCCCCTGCCG
TTTCGTCCGGCCGACGTCCTTGCCGAGGCACGGGCGACGCTGGCGATGTTCGACCGGCTCGACGCGCTCGGCATCGGGGT
GCGCGTGACGAATCCTGTGCTCGGCAACCCGCTGCGCTATCCCTTGCGCAACCACAAGAAGCTGCTGGTCATGGACGATG
TCGCGCATGTCGGCGGCATCAACTTTTCGGATCACAACTTCTCATGGCACGACCTCATGCTGCGTATCGATGATGCGGAG
GTGGCGGATTTCCTTGCCAGGGATTTCATGAATGACTGGGCCGGCCGGCCCCGGGGCGTCCGGGGGCAATTCGGCGACCT
CGAACTCGTCTGCCTCGACGGCGACACCAACGCCAGCCTGATGCAGCCGCTGATCGATCTGGTGGCTTCGGCGCGCCGGT
CGGTCGAGATGGTCAGCGCCTATCCGACGATGCCGTTCGTCGGCGCGATGGCCGAGGCCGCGCGCCACGGGGCCGAGGTC
ACGATCTACAGCCCTGCGCCGAACAACAAGCCGGTGGTTCGCGATTACCTTGCCGGCGTTGTCGGGCGTGCGGGGATCGC
GCTGCGGCTGCTCCCGAAGATGACGCACGCGAAGGCGATGCTGATCGATGGCGAAACCCTGGTCGTGGGGTCGAGCAATT
TCAACTTCGCATCGCACCGCACCAGCAACGATATCGTGGCGATCGTGCGCGATCCGTTGCTTGTCGCGCAGTTCGAGGAG
CGTCTGCTTACGCCCGCGCGCGGGGCATCGTTTGCGGTCGGCGAGGCCCGGATCCCTGCGTGGCGGCAGTGGCGGGCACG
CGCGACGCTGGAACTGGCCGACGCCGTGCTTGCGAACCTGCGTCACGGCGAGGTCCGCGCGATGGACTGGCAGGCCCTAC
GCGTGCGCGGGAAGGGCAAGCTTGCGCCAGAGCGCCTCAAGCGGCCCCTGCCCGAAGCGGGCTAG

Upstream 100 bases:

>100_bases
CGTGGAGCGAGGTCAACAGCAGCAGGACCTTGGGCGGGGTCGGTGTGTTGTTCATCGAAGGGCAAATGGCACCGTGCTTA
TGCGCTGACAAGGAGCGCGC

Downstream 100 bases:

>100_bases
CCACCATCGCGGCCAGGCGAGCATGGCAAACCAGCCAAGCAGCACGAGGGCGGGCAGCCAGGCTCTCGGGAGTTCCGGCC
CGAGCCCGAGGCCCCAGCCG

Product: phospholipase D/transphosphatidylase

Products: cardiolipin; glycerol [C]

Alternate protein names: CL synthase 1 [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MTTSYNRYTLLFGAEEFWQAARADMAAAQRRVLVQAMTFEADRAGLSVASGIENSPARERRVLVDDYSRNVINDTMLPLP
FRPADVLAEARATLAMFDRLDALGIGVRVTNPVLGNPLRYPLRNHKKLLVMDDVAHVGGINFSDHNFSWHDLMLRIDDAE
VADFLARDFMNDWAGRPRGVRGQFGDLELVCLDGDTNASLMQPLIDLVASARRSVEMVSAYPTMPFVGAMAEAARHGAEV
TIYSPAPNNKPVVRDYLAGVVGRAGIALRLLPKMTHAKAMLIDGETLVVGSSNFNFASHRTSNDIVAIVRDPLLVAQFEE
RLLTPARGASFAVGEARIPAWRQWRARATLELADAVLANLRHGEVRAMDWQALRVRGKGKLAPERLKRPLPEAG

Sequences:

>Translated_394_residues
MTTSYNRYTLLFGAEEFWQAARADMAAAQRRVLVQAMTFEADRAGLSVASGIENSPARERRVLVDDYSRNVINDTMLPLP
FRPADVLAEARATLAMFDRLDALGIGVRVTNPVLGNPLRYPLRNHKKLLVMDDVAHVGGINFSDHNFSWHDLMLRIDDAE
VADFLARDFMNDWAGRPRGVRGQFGDLELVCLDGDTNASLMQPLIDLVASARRSVEMVSAYPTMPFVGAMAEAARHGAEV
TIYSPAPNNKPVVRDYLAGVVGRAGIALRLLPKMTHAKAMLIDGETLVVGSSNFNFASHRTSNDIVAIVRDPLLVAQFEE
RLLTPARGASFAVGEARIPAWRQWRARATLELADAVLANLRHGEVRAMDWQALRVRGKGKLAPERLKRPLPEAG
>Mature_393_residues
TTSYNRYTLLFGAEEFWQAARADMAAAQRRVLVQAMTFEADRAGLSVASGIENSPARERRVLVDDYSRNVINDTMLPLPF
RPADVLAEARATLAMFDRLDALGIGVRVTNPVLGNPLRYPLRNHKKLLVMDDVAHVGGINFSDHNFSWHDLMLRIDDAEV
ADFLARDFMNDWAGRPRGVRGQFGDLELVCLDGDTNASLMQPLIDLVASARRSVEMVSAYPTMPFVGAMAEAARHGAEVT
IYSPAPNNKPVVRDYLAGVVGRAGIALRLLPKMTHAKAMLIDGETLVVGSSNFNFASHRTSNDIVAIVRDPLLVAQFEER
LLTPARGASFAVGEARIPAWRQWRARATLELADAVLANLRHGEVRAMDWQALRVRGKGKLAPERLKRPLPEAG

Specific function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022924
- InterPro:   IPR015679
- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.- [C]

Molecular weight: Translated: 43475; Mature: 43344

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTSYNRYTLLFGAEEFWQAARADMAAAQRRVLVQAMTFEADRAGLSVASGIENSPARER
CCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHCCCCCCCCHHC
RVLVDDYSRNVINDTMLPLPFRPADVLAEARATLAMFDRLDALGIGVRVTNPVLGNPLRY
EEEEEHHCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCC
PLRNHKKLLVMDDVAHVGGINFSDHNFSWHDLMLRIDDAEVADFLARDFMNDWAGRPRGV
CCCCCCEEEEEECHHHHCCCCCCCCCCCHHHEEEEECCHHHHHHHHHHHHHHHCCCCCCC
RGQFGDLELVCLDGDTNASLMQPLIDLVASARRSVEMVSAYPTMPFVGAMAEAARHGAEV
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEE
TIYSPAPNNKPVVRDYLAGVVGRAGIALRLLPKMTHAKAMLIDGETLVVGSSNFNFASHR
EEECCCCCCCCHHHHHHHHHHHCCCCEEEEHHHHCCCEEEEECCCEEEEECCCCCCCCCC
TSNDIVAIVRDPLLVAQFEERLLTPARGASFAVGEARIPAWRQWRARATLELADAVLANL
CCCCEEEEECCCHHHHHHHHHHCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHC
RHGEVRAMDWQALRVRGKGKLAPERLKRPLPEAG
CCCCEEEECCEEEEECCCCCCCHHHHHCCCCCCC
>Mature Secondary Structure 
TTSYNRYTLLFGAEEFWQAARADMAAAQRRVLVQAMTFEADRAGLSVASGIENSPARER
CCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCHHHCCCCCCCCHHC
RVLVDDYSRNVINDTMLPLPFRPADVLAEARATLAMFDRLDALGIGVRVTNPVLGNPLRY
EEEEEHHCCHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCC
PLRNHKKLLVMDDVAHVGGINFSDHNFSWHDLMLRIDDAEVADFLARDFMNDWAGRPRGV
CCCCCCEEEEEECHHHHCCCCCCCCCCCHHHEEEEECCHHHHHHHHHHHHHHHCCCCCCC
RGQFGDLELVCLDGDTNASLMQPLIDLVASARRSVEMVSAYPTMPFVGAMAEAARHGAEV
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEE
TIYSPAPNNKPVVRDYLAGVVGRAGIALRLLPKMTHAKAMLIDGETLVVGSSNFNFASHR
EEECCCCCCCCHHHHHHHHHHHCCCCEEEEHHHHCCCEEEEECCCEEEEECCCCCCCCCC
TSNDIVAIVRDPLLVAQFEERLLTPARGASFAVGEARIPAWRQWRARATLELADAVLANL
CCCCEEEEECCCHHHHHHHHHHCCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHHHHHHC
RHGEVRAMDWQALRVRGKGKLAPERLKRPLPEAG
CCCCEEEECCEEEEECCCCCCCHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 2 L-1-phosphatidyl-glycerol [C]

Specific reaction: 2 L-1-phosphatidyl-glycerol = cardiolipin + glycerol [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA