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The map label for this gene is qor [C]

Identifier: 87200781

GI number: 87200781

Start: 2987418

End: 2988449

Strand: Reverse

Name: qor [C]

Synonym: Saro_2768

Alternate gene names: 87200781

Gene position: 2988449-2987418 (Counterclockwise)

Preceding gene: 87200784

Following gene: 87200780

Centisome position: 83.91

GC content: 64.44

Gene sequence:

>1032_bases
ATGACCACGCCAACCATGATCGCAGCCGTTGTTGAGGAAGCCAACGGGCCCTTCGTTCTTCGCAAGCTTGCGCGTCCGCA
GCCGGCCCCTGGCCAGGTACTTGTACAGATTGAGGCAAGCGGCACCAATCCGCTTGATGCCAAGATCCGGGCTGGCGAGG
CACCGCATGCCCAGCAGCCTCTACCCGCAATCCTCGGAATGGACCTTGCAGGAACCGTCGTCGCGGTCGGGCCGGAGGTG
GATAGTTTCCGCGTCGGCGACGCTGTCTTCGGACTGACGGGTGGGGTCGGCGGACTGCAAGGCACACACGCGCAGTTCGC
GGCGGTGGATGCGCGCTTGCTGGCATCCAAACCGGCTGCCCTGACCATGCGACAGGCGTCTGTTCTGCCGTTGGTCTTCA
TCACCGCGTGGGAAGGTCTGGTGGATCGCGCGCAGGTGCAGGATGGACAGACGGTTCTGATCCAGGGCGGCGGCGGCGGT
GTCGGCCATGTTGCCATACAGATCGCGCTTGCGCGGGGAGCCCGGGTGTTCGCAACCGCGCGGGGCAGCGATCTCGAGTA
TGTCCGAGACCTTGGCGCCACCCCGATCGACGCCTCGAGAGAGCCCGAGGATTACGCCGCCGAGCACACCGCAGGGCAGG
GTTTCGACCTTGTCTACGATACGCTCGGTGGCCCGGTACTCGACGCCTCGTTCAGTGCCGTGAAGCGGTTTGGGCACGTG
GTAAGCTGTCTCGGCTGGGGCACGCACAAGCTCGCCCCGCTCTCCTTCAAGCAGGCGACGTATTCGGGCGTGTTCACGCT
GCACACCCTGTTGGCAAACGAGGGTCTGGCCCACTTCGGCGAGATGCTGAGAGAGGCTGACGCGCTCGTTCAGACGGGCA
AACTCGCCCCTCGTCTCGATCCACGGACCTTCTCCATCGCGGAAATCGGTTCTGCCTATGACGCGGTCCTCGGTCGCAAC
GACGTGCCACGGCAGCGAGGAAAGATCGCGATCACGGTCGAACCGCAATTCAACCTTCACGAGCAGCGCTGA

Upstream 100 bases:

>100_bases
CTTGTGGTCCATTCAAAAATGAATGGGGATCGTGCACTTTTCATGACTGCCAGTCAAAGCGGAATGCGCTCATCTTCTGG
TCATCAGCAGGAGATGGACC

Downstream 100 bases:

>100_bases
CGTCCGCGCACGTTCTCAGCAAAGAACATCAGGAGCAGTTATGACCAAGACTTTCGGACGCCAGTCCACGACCGACGATG
TGCTTGCAGGTCTCGATCTG

Product: alcohol dehydrogenase

Products: NADP(+); Semiquinone. [C]

Alternate protein names: NA

Number of amino acids: Translated: 343; Mature: 342

Protein sequence:

>343_residues
MTTPTMIAAVVEEANGPFVLRKLARPQPAPGQVLVQIEASGTNPLDAKIRAGEAPHAQQPLPAILGMDLAGTVVAVGPEV
DSFRVGDAVFGLTGGVGGLQGTHAQFAAVDARLLASKPAALTMRQASVLPLVFITAWEGLVDRAQVQDGQTVLIQGGGGG
VGHVAIQIALARGARVFATARGSDLEYVRDLGATPIDASREPEDYAAEHTAGQGFDLVYDTLGGPVLDASFSAVKRFGHV
VSCLGWGTHKLAPLSFKQATYSGVFTLHTLLANEGLAHFGEMLREADALVQTGKLAPRLDPRTFSIAEIGSAYDAVLGRN
DVPRQRGKIAITVEPQFNLHEQR

Sequences:

>Translated_343_residues
MTTPTMIAAVVEEANGPFVLRKLARPQPAPGQVLVQIEASGTNPLDAKIRAGEAPHAQQPLPAILGMDLAGTVVAVGPEV
DSFRVGDAVFGLTGGVGGLQGTHAQFAAVDARLLASKPAALTMRQASVLPLVFITAWEGLVDRAQVQDGQTVLIQGGGGG
VGHVAIQIALARGARVFATARGSDLEYVRDLGATPIDASREPEDYAAEHTAGQGFDLVYDTLGGPVLDASFSAVKRFGHV
VSCLGWGTHKLAPLSFKQATYSGVFTLHTLLANEGLAHFGEMLREADALVQTGKLAPRLDPRTFSIAEIGSAYDAVLGRN
DVPRQRGKIAITVEPQFNLHEQR
>Mature_342_residues
TTPTMIAAVVEEANGPFVLRKLARPQPAPGQVLVQIEASGTNPLDAKIRAGEAPHAQQPLPAILGMDLAGTVVAVGPEVD
SFRVGDAVFGLTGGVGGLQGTHAQFAAVDARLLASKPAALTMRQASVLPLVFITAWEGLVDRAQVQDGQTVLIQGGGGGV
GHVAIQIALARGARVFATARGSDLEYVRDLGATPIDASREPEDYAAEHTAGQGFDLVYDTLGGPVLDASFSAVKRFGHVV
SCLGWGTHKLAPLSFKQATYSGVFTLHTLLANEGLAHFGEMLREADALVQTGKLAPRLDPRTFSIAEIGSAYDAVLGRND
VPRQRGKIAITVEPQFNLHEQR

Specific function: Unknown

COG id: COG0604

COG function: function code CR; NADPH:quinone reductase and related Zn-dependent oxidoreductases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily [H]

Homologues:

Organism=Homo sapiens, GI194239674, Length=255, Percent_Identity=30.9803921568627, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI13236495, Length=255, Percent_Identity=30.9803921568627, Blast_Score=108, Evalue=9e-24,
Organism=Homo sapiens, GI194239676, Length=179, Percent_Identity=35.195530726257, Blast_Score=99, Evalue=4e-21,
Organism=Homo sapiens, GI47519420, Length=355, Percent_Identity=28.169014084507, Blast_Score=98, Evalue=1e-20,
Organism=Homo sapiens, GI22538446, Length=246, Percent_Identity=30.8943089430894, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI22538444, Length=246, Percent_Identity=30.8943089430894, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI24308257, Length=338, Percent_Identity=23.0769230769231, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI41872631, Length=293, Percent_Identity=29.6928327645051, Blast_Score=86, Evalue=6e-17,
Organism=Homo sapiens, GI18379349, Length=290, Percent_Identity=30, Blast_Score=85, Evalue=8e-17,
Organism=Homo sapiens, GI28557745, Length=302, Percent_Identity=25.1655629139073, Blast_Score=69, Evalue=4e-12,
Organism=Escherichia coli, GI1790485, Length=232, Percent_Identity=29.7413793103448, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71987554, Length=254, Percent_Identity=30.7086614173228, Blast_Score=91, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17507255, Length=200, Percent_Identity=31.5, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6319520, Length=244, Percent_Identity=27.8688524590164, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24581345, Length=167, Percent_Identity=31.7365269461078, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221330659, Length=213, Percent_Identity=28.6384976525822, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI19920632, Length=213, Percent_Identity=28.6384976525822, Blast_Score=75, Evalue=5e-14,
Organism=Drosophila melanogaster, GI45550423, Length=281, Percent_Identity=26.6903914590747, Blast_Score=65, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR014182
- InterPro:   IPR011032
- InterPro:   IPR016040
- InterPro:   IPR002364 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.6.5.5 [C]

Molecular weight: Translated: 35990; Mature: 35859

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTPTMIAAVVEEANGPFVLRKLARPQPAPGQVLVQIEASGTNPLDAKIRAGEAPHAQQP
CCCHHHHHHHHHCCCCCHHHHHHCCCCCCCCEEEEEEECCCCCCCCCEEECCCCCCCCCC
LPAILGMDLAGTVVAVGPEVDSFRVGDAVFGLTGGVGGLQGTHAQFAAVDARLLASKPAA
CHHHHCCCCCCEEEEECCCCCCEECCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCC
LTMRQASVLPLVFITAWEGLVDRAQVQDGQTVLIQGGGGGVGHVAIQIALARGARVFATA
EEEHHHCCCHHHEEHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEEEEECCCCEEEEEE
RGSDLEYVRDLGATPIDASREPEDYAAEHTAGQGFDLVYDTLGGPVLDASFSAVKRFGHV
CCCCHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHCCCCEEHHHHHHHHHHHHH
VSCLGWGTHKLAPLSFKQATYSGVFTLHTLLANEGLAHFGEMLREADALVQTGKLAPRLD
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCC
PRTFSIAEIGSAYDAVLGRNDVPRQRGKIAITVEPQFNLHEQR
CCEEEHHHHCCHHHHHHCCCCCCHHCCCEEEEECCCCCCCCCC
>Mature Secondary Structure 
TTPTMIAAVVEEANGPFVLRKLARPQPAPGQVLVQIEASGTNPLDAKIRAGEAPHAQQP
CCHHHHHHHHHCCCCCHHHHHHCCCCCCCCEEEEEEECCCCCCCCCEEECCCCCCCCCC
LPAILGMDLAGTVVAVGPEVDSFRVGDAVFGLTGGVGGLQGTHAQFAAVDARLLASKPAA
CHHHHCCCCCCEEEEECCCCCCEECCCEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCC
LTMRQASVLPLVFITAWEGLVDRAQVQDGQTVLIQGGGGGVGHVAIQIALARGARVFATA
EEEHHHCCCHHHEEHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEEEEECCCCEEEEEE
RGSDLEYVRDLGATPIDASREPEDYAAEHTAGQGFDLVYDTLGGPVLDASFSAVKRFGHV
CCCCHHHHHHCCCCCCCCCCCCHHHHHHCCCCCCCHHHHHHCCCCEEHHHHHHHHHHHHH
VSCLGWGTHKLAPLSFKQATYSGVFTLHTLLANEGLAHFGEMLREADALVQTGKLAPRLD
HHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCC
PRTFSIAEIGSAYDAVLGRNDVPRQRGKIAITVEPQFNLHEQR
CCEEEHHHHCCHHHHHHCCCCCCHHCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 0.017 {9,10-phenanthrenequinone}} 0.0153 {2,6-dichlorophenolindophenol}} 0.013 {2,6-dichlorophenolindophenol}} 0.26 {1,4-naphthoquinone}} 0.065 {1,4-benzoquinone}} 0.007 {NADPH}} 0.0069 {NADPH}} 0.0024 {1,2-naphthoquinone}} [C]

Substrates: NADPH; Quinone [C]

Specific reaction: NADPH + Quinone = NADP(+) + Semiquinone. [C]

General reaction: Oxidation; Reduction [C]

Inhibitor: 2, 3-Dimercaptopropanol; 2, 5-Dichloro-3, 6-dihydroxy -1, 4-benzoquinone; 4-Hydroxy coumarin; 5, 5'-Dithiobis (2-nitrobenzoate); ADP; Cibacronblue3GA; Coumarin; Cu2+; Dicoumarol warfarin, coumarin; Dithiothreitol preincubation with 9, 10-phenanthrenequino

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]