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The map label for this gene is fabG [C]

Identifier: 87200780

GI number: 87200780

Start: 2986394

End: 2987377

Strand: Reverse

Name: fabG [C]

Synonym: Saro_2767

Alternate gene names: 87200780

Gene position: 2987377-2986394 (Counterclockwise)

Preceding gene: 87200781

Following gene: 87200779

Centisome position: 83.88

GC content: 61.99

Gene sequence:

>984_bases
ATGACCAAGACTTTCGGACGCCAGTCCACGACCGACGATGTGCTTGCAGGTCTCGATCTGACAGGAAAGACAATCCTTGT
GACCGGCGTGTCAGCGGGACTTGGCGTTGAAACCACTCGCGCCCTCGTAAGCCGTGGCGCAAAGGTGGTCGGCACGGCGA
GAGACCTTGCCAAGGCCCGCAAGGCTCTGGTCCATGCAGGGGTGGACAGGGCTTCGATAGAATTGGTCGAGCTCGATCTG
GCTGACCTCGCCTCTGTGCGTCGCGCTTCCGACAAGCTCCGCCTTGAAGGTCAGCCGTTCGATCTCGTGATCGCAAATGC
CGGAGTCATGGCCCCGCCGTTCGGTCTCACTGCCGACGGTTTCGAGACTCAGTTCGGGACCAACCATCTCGGGCACTTTG
CATTCGTGAACCGGATCGCAGGGCTCATGCGCCCCGGCTCTCGGCTGGTGCTGCTCGCGTCTTCCGGGCACCGCTTTGCA
AATGTCGATCTGGCGGATCCGAATTTCGAATCCAGTGCCTACGATCCCTTCGTCGCTTACGGCCGCTCCAAGACTGCCAA
CATCCTTTTCGCGGTCGAATTCGACAGGCGCTATCGATCGCTCGGTTTGCGCGCCACCGCCGTCCACCCCGGCGGCATCC
GGACCGAGCTCGACCGCCACATGGGCGACGGCCAGCTCCAGTCGCTGGTCGACCAGATCAATGCCGACATGGCGAAGGAA
GGCAAGCCGCCCTTGGAGTGGAAATCTCCCCCGCAAGGCGCCGCAACGACTCTTTGGGCAGGCCTTGTGGCAGACGCTGA
CGACGTTGGCGGACGCTATTGCGAGGATTGCCAGGTCTCACCGGTTGTCCGCGACGAAAGCATCGGCTTCGCCAGCCCCG
GTGTGCGGCCCTATGCGCTCGATGCGGAAATGGCGAAGGCCTTGTGGGCGAAAAGCGAAGAATGGGTCTCGGAGACTTTC
GATCTCAGGTCTGCTGCCGATTGA

Upstream 100 bases:

>100_bases
CAGCGAGGAAAGATCGCGATCACGGTCGAACCGCAATTCAACCTTCACGAGCAGCGCTGACGTCCGCGCACGTTCTCAGC
AAAGAACATCAGGAGCAGTT

Downstream 100 bases:

>100_bases
GCCGGCTCGCTCGCGCTGCCTCAGCCGGGCTTGCCCAAGTTCAAGGTAGCGCGGGTCAACAATCCCCTCGAAGAATTTCC
TGAAGGATGACGTCATGACG

Product: short-chain dehydrogenase/reductase SDR

Products: (3R)-hydroxyacyl-[acyl-carrier-protein]; NADP; NADPH; Proton; beta-ketoacyl-ACP [C]

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 326

Protein sequence:

>327_residues
MTKTFGRQSTTDDVLAGLDLTGKTILVTGVSAGLGVETTRALVSRGAKVVGTARDLAKARKALVHAGVDRASIELVELDL
ADLASVRRASDKLRLEGQPFDLVIANAGVMAPPFGLTADGFETQFGTNHLGHFAFVNRIAGLMRPGSRLVLLASSGHRFA
NVDLADPNFESSAYDPFVAYGRSKTANILFAVEFDRRYRSLGLRATAVHPGGIRTELDRHMGDGQLQSLVDQINADMAKE
GKPPLEWKSPPQGAATTLWAGLVADADDVGGRYCEDCQVSPVVRDESIGFASPGVRPYALDAEMAKALWAKSEEWVSETF
DLRSAAD

Sequences:

>Translated_327_residues
MTKTFGRQSTTDDVLAGLDLTGKTILVTGVSAGLGVETTRALVSRGAKVVGTARDLAKARKALVHAGVDRASIELVELDL
ADLASVRRASDKLRLEGQPFDLVIANAGVMAPPFGLTADGFETQFGTNHLGHFAFVNRIAGLMRPGSRLVLLASSGHRFA
NVDLADPNFESSAYDPFVAYGRSKTANILFAVEFDRRYRSLGLRATAVHPGGIRTELDRHMGDGQLQSLVDQINADMAKE
GKPPLEWKSPPQGAATTLWAGLVADADDVGGRYCEDCQVSPVVRDESIGFASPGVRPYALDAEMAKALWAKSEEWVSETF
DLRSAAD
>Mature_326_residues
TKTFGRQSTTDDVLAGLDLTGKTILVTGVSAGLGVETTRALVSRGAKVVGTARDLAKARKALVHAGVDRASIELVELDLA
DLASVRRASDKLRLEGQPFDLVIANAGVMAPPFGLTADGFETQFGTNHLGHFAFVNRIAGLMRPGSRLVLLASSGHRFAN
VDLADPNFESSAYDPFVAYGRSKTANILFAVEFDRRYRSLGLRATAVHPGGIRTELDRHMGDGQLQSLVDQINADMAKEG
KPPLEWKSPPQGAATTLWAGLVADADDVGGRYCEDCQVSPVVRDESIGFASPGVRPYALDAEMAKALWAKSEEWVSETFD
LRSAAD

Specific function: Fatty acid biosynthesis pathway; first reduction step. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7706523, Length=324, Percent_Identity=31.7901234567901, Blast_Score=156, Evalue=2e-38,
Organism=Homo sapiens, GI10190746, Length=318, Percent_Identity=33.9622641509434, Blast_Score=151, Evalue=6e-37,
Organism=Homo sapiens, GI225579078, Length=304, Percent_Identity=32.8947368421053, Blast_Score=151, Evalue=7e-37,
Organism=Homo sapiens, GI186928839, Length=276, Percent_Identity=34.0579710144928, Blast_Score=148, Evalue=9e-36,
Organism=Homo sapiens, GI166795268, Length=278, Percent_Identity=32.0143884892086, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI19923931, Length=241, Percent_Identity=34.4398340248963, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI193804850, Length=299, Percent_Identity=28.0936454849498, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI146231950, Length=280, Percent_Identity=30, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI7705421, Length=232, Percent_Identity=28.448275862069, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17532805, Length=334, Percent_Identity=32.0359281437126, Blast_Score=158, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI193207620, Length=336, Percent_Identity=30.3571428571429, Blast_Score=154, Evalue=7e-38,
Organism=Caenorhabditis elegans, GI17535059, Length=323, Percent_Identity=29.7213622291022, Blast_Score=132, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17532791, Length=329, Percent_Identity=30.3951367781155, Blast_Score=132, Evalue=3e-31,
Organism=Caenorhabditis elegans, GI71992402, Length=325, Percent_Identity=29.2307692307692, Blast_Score=131, Evalue=4e-31,
Organism=Caenorhabditis elegans, GI32565532, Length=226, Percent_Identity=30.5309734513274, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17558006, Length=306, Percent_Identity=27.7777777777778, Blast_Score=101, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17505416, Length=222, Percent_Identity=31.5315315315315, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI72001364, Length=219, Percent_Identity=30.5936073059361, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324820, Length=218, Percent_Identity=31.1926605504587, Blast_Score=82, Evalue=1e-16,
Organism=Drosophila melanogaster, GI22024069, Length=305, Percent_Identity=35.7377049180328, Blast_Score=169, Evalue=3e-42,
Organism=Drosophila melanogaster, GI24586328, Length=307, Percent_Identity=34.8534201954397, Blast_Score=160, Evalue=1e-39,
Organism=Drosophila melanogaster, GI28573296, Length=303, Percent_Identity=35.3135313531353, Blast_Score=159, Evalue=2e-39,
Organism=Drosophila melanogaster, GI19921754, Length=306, Percent_Identity=34.3137254901961, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI161076371, Length=305, Percent_Identity=36.7213114754098, Blast_Score=152, Evalue=3e-37,
Organism=Drosophila melanogaster, GI45554248, Length=301, Percent_Identity=33.2225913621262, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24640117, Length=301, Percent_Identity=33.2225913621262, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI20129347, Length=326, Percent_Identity=29.1411042944785, Blast_Score=141, Evalue=5e-34,
Organism=Drosophila melanogaster, GI24647946, Length=325, Percent_Identity=28, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI45553409, Length=306, Percent_Identity=29.0849673202614, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24647948, Length=306, Percent_Identity=29.0849673202614, Blast_Score=102, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24656154, Length=266, Percent_Identity=28.5714285714286, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI19922628, Length=266, Percent_Identity=28.5714285714286, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24647931, Length=285, Percent_Identity=23.5087719298246, Blast_Score=70, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: 1.1.1.100 [C]

Molecular weight: Translated: 34988; Mature: 34857

Theoretical pI: Translated: 5.69; Mature: 5.69

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKTFGRQSTTDDVLAGLDLTGKTILVTGVSAGLGVETTRALVSRGAKVVGTARDLAKAR
CCCCCCCCCCCHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEHHHHHHHHH
KALVHAGVDRASIELVELDLADLASVRRASDKLRLEGQPFDLVIANAGVMAPPFGLTADG
HHHHHCCCCCCEEEEEEECHHHHHHHHHHCCCEEECCCCEEEEEECCCCCCCCCCCCCCC
FETQFGTNHLGHFAFVNRIAGLMRPGSRLVLLASSGHRFANVDLADPNFESSAYDPFVAY
CCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCHHHC
GRSKTANILFAVEFDRRYRSLGLRATAVHPGGIRTELDRHMGDGQLQSLVDQINADMAKE
CCCCCCEEEEEEEECHHHHHCCCEEEEECCCCCHHHHHHCCCCHHHHHHHHHHCHHHHHC
GKPPLEWKSPPQGAATTLWAGLVADADDVGGRYCEDCQVSPVVRDESIGFASPGVRPYAL
CCCCCCCCCCCCCHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
DAEMAKALWAKSEEWVSETFDLRSAAD
CHHHHHHHHCCCHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TKTFGRQSTTDDVLAGLDLTGKTILVTGVSAGLGVETTRALVSRGAKVVGTARDLAKAR
CCCCCCCCCCHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCEEEEHHHHHHHHH
KALVHAGVDRASIELVELDLADLASVRRASDKLRLEGQPFDLVIANAGVMAPPFGLTADG
HHHHHCCCCCCEEEEEEECHHHHHHHHHHCCCEEECCCCEEEEEECCCCCCCCCCCCCCC
FETQFGTNHLGHFAFVNRIAGLMRPGSRLVLLASSGHRFANVDLADPNFESSAYDPFVAY
CCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEECCCCCCCCCCCCCHHHC
GRSKTANILFAVEFDRRYRSLGLRATAVHPGGIRTELDRHMGDGQLQSLVDQINADMAKE
CCCCCCEEEEEEEECHHHHHCCCEEEEECCCCCHHHHHHCCCCHHHHHHHHHHCHHHHHC
GKPPLEWKSPPQGAATTLWAGLVADADDVGGRYCEDCQVSPVVRDESIGFASPGVRPYAL
CCCCCCCCCCCCCHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEE
DAEMAKALWAKSEEWVSETFDLRSAAD
CHHHHHHHHCCCHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NADPH [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Oxoacyl-[acyl-carrier-protein]; NADPH; D-3-hydroxy-acyl-ACP; NADP [C]

Specific reaction: Oxoacyl-[acyl-carrier-protein] + NADPH = (3R)-hydroxyacyl-[acyl-carrier-protein] + NADP+ D-3-hydroxy-acyl-ACP + NADP = NADPH + Proton + beta-ketoacyl-ACP [C]

General reaction: Redox reaction [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8383668 [H]