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The map label for this gene is hisZ [H]

Identifier: 87200694

GI number: 87200694

Start: 2920156

End: 2921307

Strand: Direct

Name: hisZ [H]

Synonym: Saro_2681

Alternate gene names: 87200694

Gene position: 2920156-2921307 (Clockwise)

Preceding gene: 87200693

Following gene: 87200696

Centisome position: 81.99

GC content: 69.62

Gene sequence:

>1152_bases
ATGGACACCAGCGACCCCGATCTGCTGCCGGAAGGCCTCGAAGACCGTCTGCCCCGCGATGCGGCCACCGCCACGCGCGT
CATGCGCGCGATCCACGGCGTGATGCACGGCCACGGCTACGACCGGGTCATGCCCCCGTCCATCGAGTACGAGCGCAGCT
TCGCCGCGCGCATGGCCGGCATCCAGTCGCGCCGCATGTTCCGCTTCGTCGATCCGTCGAGCCTGCGCATGATGGCCCTG
CGAAGCGACTTCACCCCGCAGATCGGCCGCCTTGCCGAAACGCGCCTGGCCGAAGCGCCGCGTCCGTTGCGCCTGTGCTA
TGCGGGCCAGGTCGTCACGATCAAGGCTGACGGCCTCAACCCCTCGCGCGAAAAGCTCCAGTGCGGCGCCGAACTCGTCG
GTGCCGACAATGTCGCCGCCGCCGCCGAAGTCGTCGCCATCGCCATCGAGGCACTTCAGGCCGCGGGCGCCACGGGCGTC
AGCGTCGATTTCACGCTGCCCGACCTGGTCGATACGCTGGCCGAAAAGGCCCTCCCCCTGGCCCCCGGCCAGATCGAGGC
CGTCCGCCGCGAACTCGACACCAAGGACGCAGGCGGCCTGCGCGATGTCGGCGGCGAAGCCTACGTGCCGTTGCTCTACG
CCACCGGCGAATTCGACACGGCGATCGACAAGCTTGCCGCGATCGATGCCGGCGGCGCGCTTGCCAGCCGCATCGACGCG
CTCCGGCAGATCGCCGCTCGCCTCGGCGGCGCAGCGCGCCTGACGCTGGACCCGAGCGAGCGCCATGGCTTCGAATACCA
GACCTGGTTCGGCTTCACCCTCTATGCCGAAGGGGTGCGCGGCATCGTCGGGCGCGGCGGCACCTATCGCATCGCGGGTT
CCGATGCCGATGCACGTCAGGCCAATGCACGACAGCAAGGCGAAGCCGCCACCGGCTTCTCGCTCTATCCCAACGCCCTG
ATCGATCTCCTGGCCGCGAACGAGCCCGCCGAAGATACCGTCTTCCTCCCGCTCGGCCATGACCGCGACGAAGCCGCCCG
CCTGCGCGCCATCGGCTGGCGAACGGTCGCGGCGCTCAGCGAAGCGGACAGCGCGGACGCTCTCCGCTGCACGCACATGC
TCGGCGCGAACGGACCGGAAAAGCTGGCATAA

Upstream 100 bases:

>100_bases
GATTTCCCCTGCGGCGGCAAATTGCTTTTTGGGGGTCGCAGTGCTTTTTGCGAAAAACCGGTTCCCACTTTTTCGCGCTA
TGCTTTAGGGGCACCGAATC

Downstream 100 bases:

>100_bases
GCTCTTCCCAGGGTCGGGCCCGACCGGCGCCTGCCCCTGGTCAGCTTCCGAACGTCGCTTTCAGCCACCGATCCATCACG
GGCGTCGCTGCATAGTCGGG

Product: tRNA synthetase, class II (G, H, P and S)

Products: ATP; 5-phospho-alpha-D-ribose 1-diphosphate

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MDTSDPDLLPEGLEDRLPRDAATATRVMRAIHGVMHGHGYDRVMPPSIEYERSFAARMAGIQSRRMFRFVDPSSLRMMAL
RSDFTPQIGRLAETRLAEAPRPLRLCYAGQVVTIKADGLNPSREKLQCGAELVGADNVAAAAEVVAIAIEALQAAGATGV
SVDFTLPDLVDTLAEKALPLAPGQIEAVRRELDTKDAGGLRDVGGEAYVPLLYATGEFDTAIDKLAAIDAGGALASRIDA
LRQIAARLGGAARLTLDPSERHGFEYQTWFGFTLYAEGVRGIVGRGGTYRIAGSDADARQANARQQGEAATGFSLYPNAL
IDLLAANEPAEDTVFLPLGHDRDEAARLRAIGWRTVAALSEADSADALRCTHMLGANGPEKLA

Sequences:

>Translated_383_residues
MDTSDPDLLPEGLEDRLPRDAATATRVMRAIHGVMHGHGYDRVMPPSIEYERSFAARMAGIQSRRMFRFVDPSSLRMMAL
RSDFTPQIGRLAETRLAEAPRPLRLCYAGQVVTIKADGLNPSREKLQCGAELVGADNVAAAAEVVAIAIEALQAAGATGV
SVDFTLPDLVDTLAEKALPLAPGQIEAVRRELDTKDAGGLRDVGGEAYVPLLYATGEFDTAIDKLAAIDAGGALASRIDA
LRQIAARLGGAARLTLDPSERHGFEYQTWFGFTLYAEGVRGIVGRGGTYRIAGSDADARQANARQQGEAATGFSLYPNAL
IDLLAANEPAEDTVFLPLGHDRDEAARLRAIGWRTVAALSEADSADALRCTHMLGANGPEKLA
>Mature_383_residues
MDTSDPDLLPEGLEDRLPRDAATATRVMRAIHGVMHGHGYDRVMPPSIEYERSFAARMAGIQSRRMFRFVDPSSLRMMAL
RSDFTPQIGRLAETRLAEAPRPLRLCYAGQVVTIKADGLNPSREKLQCGAELVGADNVAAAAEVVAIAIEALQAAGATGV
SVDFTLPDLVDTLAEKALPLAPGQIEAVRRELDTKDAGGLRDVGGEAYVPLLYATGEFDTAIDKLAAIDAGGALASRIDA
LRQIAARLGGAARLTLDPSERHGFEYQTWFGFTLYAEGVRGIVGRGGTYRIAGSDADARQANARQQGEAATGFSLYPNAL
IDLLAANEPAEDTVFLPLGHDRDEAARLRAIGWRTVAALSEADSADALRCTHMLGANGPEKLA

Specific function: Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine [H]

COG id: COG3705

COG function: function code E; ATP phosphoribosyltransferase involved in histidine biosynthesis

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. HisZ subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR004516 [H]

Pfam domain/function: PF00587 tRNA-synt_2b [H]

EC number: 2.4.2.17

Molecular weight: Translated: 40838; Mature: 40838

Theoretical pI: Translated: 4.89; Mature: 4.89

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDTSDPDLLPEGLEDRLPRDAATATRVMRAIHGVMHGHGYDRVMPPSIEYERSFAARMAG
CCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
IQSRRMFRFVDPSSLRMMALRSDFTPQIGRLAETRLAEAPRPLRLCYAGQVVTIKADGLN
HHHCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCEEEEEEECCCC
PSREKLQCGAELVGADNVAAAAEVVAIAIEALQAAGATGVSVDFTLPDLVDTLAEKALPL
CHHHHHHHCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHCCCC
APGQIEAVRRELDTKDAGGLRDVGGEAYVPLLYATGEFDTAIDKLAAIDAGGALASRIDA
CCCHHHHHHHHHCCCCCCCCHHCCCCEEEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHH
LRQIAARLGGAARLTLDPSERHGFEYQTWFGFTLYAEGVRGIVGRGGTYRIAGSDADARQ
HHHHHHHCCCCEEEEECCHHHCCCEEEEEECCCEEHHHHHHHHCCCCEEEEECCCCHHHH
ANARQQGEAATGFSLYPNALIDLLAANEPAEDTVFLPLGHDRDEAARLRAIGWRTVAALS
HHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHH
EADSADALRCTHMLGANGPEKLA
CCCCCHHHHHHHHHCCCCHHCCC
>Mature Secondary Structure
MDTSDPDLLPEGLEDRLPRDAATATRVMRAIHGVMHGHGYDRVMPPSIEYERSFAARMAG
CCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHH
IQSRRMFRFVDPSSLRMMALRSDFTPQIGRLAETRLAEAPRPLRLCYAGQVVTIKADGLN
HHHCCEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHCCCCCEEEEECCEEEEEEECCCC
PSREKLQCGAELVGADNVAAAAEVVAIAIEALQAAGATGVSVDFTLPDLVDTLAEKALPL
CHHHHHHHCHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHCCCC
APGQIEAVRRELDTKDAGGLRDVGGEAYVPLLYATGEFDTAIDKLAAIDAGGALASRIDA
CCCHHHHHHHHHCCCCCCCCHHCCCCEEEEEEEECCCHHHHHHHHHHHCCCHHHHHHHHH
LRQIAARLGGAARLTLDPSERHGFEYQTWFGFTLYAEGVRGIVGRGGTYRIAGSDADARQ
HHHHHHHCCCCEEEEECCHHHCCCEEEEEECCCEEHHHHHHHHCCCCEEEEECCCCHHHH
ANARQQGEAATGFSLYPNALIDLLAANEPAEDTVFLPLGHDRDEAARLRAIGWRTVAALS
HHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHH
EADSADALRCTHMLGANGPEKLA
CCCCCHHHHHHHHHCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 1-(5-phospho-D-ribosyl)-ATP; diphosphate

Specific reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA