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The map label for this gene is serA [H]

Identifier: 87200693

GI number: 87200693

Start: 2918345

End: 2919967

Strand: Direct

Name: serA [H]

Synonym: Saro_2680

Alternate gene names: 87200693

Gene position: 2918345-2919967 (Clockwise)

Preceding gene: 87200692

Following gene: 87200694

Centisome position: 81.94

GC content: 65.13

Gene sequence:

>1623_bases
ATGACGGTGTCTCATTCTGATGGATTGGATCGAAACATGACCAAGCCTAAAGTCCTGATTTCCGACAAGATGGACCCCAA
CGCCGCCCGCATCTTCACCGAGATGGGCTGCGACGTCGATGTGATCACCGGCGAGACGCCGGAACAGCTCATCGCCCGCA
TCGGCGAGTACGATGGCCTTGCCATCCGTTCCTCGACCAAGGTGACCAAGGCGATCCTCGATGCCGCCACCAACCTCAAG
GTCATCGGCCGCGCCGGCATCGGCGTCGACAACGTCGATATCCCGGCAGCATCGGCGCAGGGCGTGGTGGTCATGAACAC
CCCGTTCGGCAACTCGATCACCACTGCCGAACACGCCATCGCGATGATGTTCGCGCTCGCGCGGCAGATCCCCGAAGCCA
ACGCCCAGACCCAGGCGGGCCTGTGGCCGAAGAACGGCTTCATGGGCGTTGAAGTCACCGGCAAGACGCTCGGCCTGATC
GGCGCGGGCAACATCGGCTCGATCGTCGCCTCGCGTGCGCTGGGCCTGAAGATGAAGGTCGTTGCCTTCGACCCGTTCCT
GACGCCCGAACGCGCCGTGGAAATGGGTGTCGAGAAGGCCGATCTCGAAACGCTGCTGGCCAAGGCGGACTTCATCACGC
TGCACACGCCTCTGACCGACCAGACCCGCAACATCCTCAGCCGCGAGAACATCGCCAAGTGCAAGAAGGGCGTGCGCATC
ATCAACTGCGCGCGTGGCGGTCTCGTCGATGAAGCCGCCCTCAAGGACGCGCTCGATTCCGGCCACGTCGCCGGCGCCGC
GCTCGACGTGTTCGAGACCGAGCCCGCCAAGGAATCGCCGCTGTTCGGCACCCCGAACTTCATCTGCACCCCGCACCTGG
GCGCGAGCACGACCGAAGCGCAGGTCAACGTGGCGCTCCAGGTGGCCGAGCAGATGGCGGACTTCCTCGTCACCGGCGGC
GTCACCAACGCGCTCAACATGCCTTCGCTCTCGGCCGAGGAAGCGCCGAAGCTGCGCCCCTACATGGCGCTGGCCGAAAA
GCTGGGCAGCCTCGTCGGCCAGCTTGCGCACGACAACCTCACCAAGATCGCCATCGAGGTCGAGGGCGCTGCCGCGCAGC
TCAACCAGAAGCCGATCACCGCGGCTGTCCTGGCCGGCCTGATGAAGCAGTATTCGCAGACCGTGAACATGGTCAACGCG
CCGTTCCTCGCCAAGGAACGCGGGCTGGACGTTCGCGAAGTGCGCCATGACCGCGAGGGCGAATACCGCACGCTGGTGCG
CGTCACCGTCAGCACTTCGCAGGGCGAACGTTCGGTGGCCGGCACGCTGTTCGGCAACGGCCAGCCGCGCCTCGTCGAGA
TCTTCGGCATCGGCATCGAGGCCGACCTCGACGGCGACATGCTCTACATCGTCAACTCCGACGCGCCCGGCTTCATCGGC
CGCATCGGCACGCTGCTGGGTCAGAACACGATCAACATCGGCACCTTCCACCTCGGCCGCCGCGAAGCTGGTGGCGAGGC
CGTGCTGCTGCTGTCGCTCGACAACCCGGTCAGCGAGGACGTTCTCAAGGAAGCTCGCGAAATCCAGGGCGTTCGGGTCG
TCAAGGCGCTCAAGTTCGCCTGA

Upstream 100 bases:

>100_bases
TCCCGTTCTTCCAGTCGTCACCCTGAACTTGTTTCAGGGTCCATCTCTCCCCCTCAACCGACATTTCCGGCCGAGGGATG
GATGCTGAAACGAGTTCAGC

Downstream 100 bases:

>100_bases
TCCCGCCAAAGGCTTTCGCCGCCCGTTCCCCTCCAGACCTTCGAGGAGCGGGCGGCGAAGACGCCAGGGTTGCAATTTGC
CGTCGCGGGATTTCCCCTGC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 540; Mature: 539

Protein sequence:

>540_residues
MTVSHSDGLDRNMTKPKVLISDKMDPNAARIFTEMGCDVDVITGETPEQLIARIGEYDGLAIRSSTKVTKAILDAATNLK
VIGRAGIGVDNVDIPAASAQGVVVMNTPFGNSITTAEHAIAMMFALARQIPEANAQTQAGLWPKNGFMGVEVTGKTLGLI
GAGNIGSIVASRALGLKMKVVAFDPFLTPERAVEMGVEKADLETLLAKADFITLHTPLTDQTRNILSRENIAKCKKGVRI
INCARGGLVDEAALKDALDSGHVAGAALDVFETEPAKESPLFGTPNFICTPHLGASTTEAQVNVALQVAEQMADFLVTGG
VTNALNMPSLSAEEAPKLRPYMALAEKLGSLVGQLAHDNLTKIAIEVEGAAAQLNQKPITAAVLAGLMKQYSQTVNMVNA
PFLAKERGLDVREVRHDREGEYRTLVRVTVSTSQGERSVAGTLFGNGQPRLVEIFGIGIEADLDGDMLYIVNSDAPGFIG
RIGTLLGQNTINIGTFHLGRREAGGEAVLLLSLDNPVSEDVLKEAREIQGVRVVKALKFA

Sequences:

>Translated_540_residues
MTVSHSDGLDRNMTKPKVLISDKMDPNAARIFTEMGCDVDVITGETPEQLIARIGEYDGLAIRSSTKVTKAILDAATNLK
VIGRAGIGVDNVDIPAASAQGVVVMNTPFGNSITTAEHAIAMMFALARQIPEANAQTQAGLWPKNGFMGVEVTGKTLGLI
GAGNIGSIVASRALGLKMKVVAFDPFLTPERAVEMGVEKADLETLLAKADFITLHTPLTDQTRNILSRENIAKCKKGVRI
INCARGGLVDEAALKDALDSGHVAGAALDVFETEPAKESPLFGTPNFICTPHLGASTTEAQVNVALQVAEQMADFLVTGG
VTNALNMPSLSAEEAPKLRPYMALAEKLGSLVGQLAHDNLTKIAIEVEGAAAQLNQKPITAAVLAGLMKQYSQTVNMVNA
PFLAKERGLDVREVRHDREGEYRTLVRVTVSTSQGERSVAGTLFGNGQPRLVEIFGIGIEADLDGDMLYIVNSDAPGFIG
RIGTLLGQNTINIGTFHLGRREAGGEAVLLLSLDNPVSEDVLKEAREIQGVRVVKALKFA
>Mature_539_residues
TVSHSDGLDRNMTKPKVLISDKMDPNAARIFTEMGCDVDVITGETPEQLIARIGEYDGLAIRSSTKVTKAILDAATNLKV
IGRAGIGVDNVDIPAASAQGVVVMNTPFGNSITTAEHAIAMMFALARQIPEANAQTQAGLWPKNGFMGVEVTGKTLGLIG
AGNIGSIVASRALGLKMKVVAFDPFLTPERAVEMGVEKADLETLLAKADFITLHTPLTDQTRNILSRENIAKCKKGVRII
NCARGGLVDEAALKDALDSGHVAGAALDVFETEPAKESPLFGTPNFICTPHLGASTTEAQVNVALQVAEQMADFLVTGGV
TNALNMPSLSAEEAPKLRPYMALAEKLGSLVGQLAHDNLTKIAIEVEGAAAQLNQKPITAAVLAGLMKQYSQTVNMVNAP
FLAKERGLDVREVRHDREGEYRTLVRVTVSTSQGERSVAGTLFGNGQPRLVEIFGIGIEADLDGDMLYIVNSDAPGFIGR
IGTLLGQNTINIGTFHLGRREAGGEAVLLLSLDNPVSEDVLKEAREIQGVRVVKALKFA

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=397, Percent_Identity=44.3324937027708, Blast_Score=337, Evalue=1e-92,
Organism=Homo sapiens, GI145580578, Length=303, Percent_Identity=33.003300330033, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI4557499, Length=303, Percent_Identity=33.003300330033, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI61743967, Length=302, Percent_Identity=31.1258278145695, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI4557497, Length=300, Percent_Identity=30.3333333333333, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI145580575, Length=303, Percent_Identity=33.003300330033, Blast_Score=137, Evalue=2e-32,
Organism=Homo sapiens, GI6912396, Length=312, Percent_Identity=30.4487179487179, Blast_Score=123, Evalue=4e-28,
Organism=Escherichia coli, GI1789279, Length=291, Percent_Identity=38.8316151202749, Blast_Score=186, Evalue=5e-48,
Organism=Escherichia coli, GI87082289, Length=290, Percent_Identity=33.448275862069, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI1787645, Length=196, Percent_Identity=37.2448979591837, Blast_Score=131, Evalue=1e-31,
Organism=Escherichia coli, GI1788660, Length=304, Percent_Identity=28.6184210526316, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI87081824, Length=235, Percent_Identity=27.6595744680851, Blast_Score=80, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17532191, Length=306, Percent_Identity=46.078431372549, Blast_Score=283, Evalue=2e-76,
Organism=Caenorhabditis elegans, GI25147481, Length=259, Percent_Identity=32.046332046332, Blast_Score=139, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6320925, Length=342, Percent_Identity=35.9649122807018, Blast_Score=207, Evalue=3e-54,
Organism=Saccharomyces cerevisiae, GI6322116, Length=328, Percent_Identity=35.9756097560976, Blast_Score=205, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6324055, Length=265, Percent_Identity=30.188679245283, Blast_Score=129, Evalue=1e-30,
Organism=Saccharomyces cerevisiae, GI6324964, Length=279, Percent_Identity=27.5985663082437, Blast_Score=97, Evalue=5e-21,
Organism=Saccharomyces cerevisiae, GI6325144, Length=113, Percent_Identity=39.8230088495575, Blast_Score=85, Evalue=2e-17,
Organism=Drosophila melanogaster, GI19921140, Length=300, Percent_Identity=45, Blast_Score=263, Evalue=3e-70,
Organism=Drosophila melanogaster, GI28574286, Length=304, Percent_Identity=28.9473684210526, Blast_Score=126, Evalue=3e-29,
Organism=Drosophila melanogaster, GI24646446, Length=290, Percent_Identity=31.7241379310345, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24646448, Length=290, Percent_Identity=31.7241379310345, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24646452, Length=290, Percent_Identity=31.7241379310345, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24646450, Length=290, Percent_Identity=31.7241379310345, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI62472511, Length=290, Percent_Identity=31.7241379310345, Blast_Score=125, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24585516, Length=304, Percent_Identity=27.6315789473684, Blast_Score=122, Evalue=7e-28,
Organism=Drosophila melanogaster, GI24585514, Length=303, Percent_Identity=26.7326732673267, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI28574282, Length=303, Percent_Identity=26.7326732673267, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI28574284, Length=303, Percent_Identity=26.7326732673267, Blast_Score=112, Evalue=5e-25,
Organism=Drosophila melanogaster, GI45551003, Length=303, Percent_Identity=26.7326732673267, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI45552429, Length=303, Percent_Identity=26.7326732673267, Blast_Score=112, Evalue=6e-25,
Organism=Drosophila melanogaster, GI28571528, Length=275, Percent_Identity=30.9090909090909, Blast_Score=111, Evalue=2e-24,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006236
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR015508
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 57283; Mature: 57151

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: PS00670 D_2_HYDROXYACID_DH_2 ; PS00671 D_2_HYDROXYACID_DH_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVSHSDGLDRNMTKPKVLISDKMDPNAARIFTEMGCDVDVITGETPEQLIARIGEYDGL
CCCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHCCCCEEEECCCCHHHHHHHHCCCCCE
AIRSSTKVTKAILDAATNLKVIGRAGIGVDNVDIPAASAQGVVVMNTPFGNSITTAEHAI
EEECCHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHH
AMMFALARQIPEANAQTQAGLWPKNGFMGVEVTGKTLGLIGAGNIGSIVASRALGLKMKV
HHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEECCCHHHHHHHHHCCCEEEE
VAFDPFLTPERAVEMGVEKADLETLLAKADFITLHTPLTDQTRNILSRENIAKCKKGVRI
EEECCCCCHHHHHHHCCCHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEE
INCARGGLVDEAALKDALDSGHVAGAALDVFETEPAKESPLFGTPNFICTPHLGASTTEA
EEECCCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCEEECCCCCCCCCHH
QVNVALQVAEQMADFLVTGGVTNALNMPSLSAEEAPKLRPYMALAEKLGSLVGQLAHDNL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHCCCE
TKIAIEVEGAAAQLNQKPITAAVLAGLMKQYSQTVNMVNAPFLAKERGLDVREVRHDREG
EEEEEEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHCCCCC
EYRTLVRVTVSTSQGERSVAGTLFGNGQPRLVEIFGIGIEADLDGDMLYIVNSDAPGFIG
CEEEEEEEEEECCCCCCCEEEEEECCCCCEEEEEEEEEEEECCCCCEEEEECCCCCHHHH
RIGTLLGQNTINIGTFHLGRREAGGEAVLLLSLDNPVSEDVLKEAREIQGVRVVKALKFA
HHHHHHCCCCEEEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCHHHHHHHHHCC
>Mature Secondary Structure 
TVSHSDGLDRNMTKPKVLISDKMDPNAARIFTEMGCDVDVITGETPEQLIARIGEYDGL
CCCCCCCCCCCCCCCEEEEECCCCCCHHHHHHHCCCCEEEECCCCHHHHHHHHCCCCCE
AIRSSTKVTKAILDAATNLKVIGRAGIGVDNVDIPAASAQGVVVMNTPFGNSITTAEHAI
EEECCHHHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHH
AMMFALARQIPEANAQTQAGLWPKNGFMGVEVTGKTLGLIGAGNIGSIVASRALGLKMKV
HHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCEEEEEECCCHHHHHHHHHCCCEEEE
VAFDPFLTPERAVEMGVEKADLETLLAKADFITLHTPLTDQTRNILSRENIAKCKKGVRI
EEECCCCCHHHHHHHCCCHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHHHHHHHCCCEE
INCARGGLVDEAALKDALDSGHVAGAALDVFETEPAKESPLFGTPNFICTPHLGASTTEA
EEECCCCCCHHHHHHHHHCCCCCCCEEEEEEECCCCCCCCCCCCCCEEECCCCCCCCCHH
QVNVALQVAEQMADFLVTGGVTNALNMPSLSAEEAPKLRPYMALAEKLGSLVGQLAHDNL
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHCCCCCCHHHHHHHHHHHHHHHHHCCCE
TKIAIEVEGAAAQLNQKPITAAVLAGLMKQYSQTVNMVNAPFLAKERGLDVREVRHDREG
EEEEEEECCHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHHHHCCCCC
EYRTLVRVTVSTSQGERSVAGTLFGNGQPRLVEIFGIGIEADLDGDMLYIVNSDAPGFIG
CEEEEEEEEEECCCCCCCEEEEEECCCCCEEEEEEEEEEEECCCCCEEEEECCCCCHHHH
RIGTLLGQNTINIGTFHLGRREAGGEAVLLLSLDNPVSEDVLKEAREIQGVRVVKALKFA
HHHHHHCCCCEEEEEEECCCCCCCCCEEEEEECCCCCHHHHHHHHHHHCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]