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The map label for this gene is envZ [H]

Identifier: 87200631

GI number: 87200631

Start: 2832091

End: 2833401

Strand: Reverse

Name: envZ [H]

Synonym: Saro_2618

Alternate gene names: 87200631

Gene position: 2833401-2832091 (Counterclockwise)

Preceding gene: 87200632

Following gene: 87200630

Centisome position: 79.55

GC content: 66.97

Gene sequence:

>1311_bases
TTGACCTTCCTGCGCAGGTCCGGACTGCCCGAGCGGCTGCTGGCGATCCTGCTGCTGGTCGCTGGCGTGGATTTCGCCGC
GAATACCCTGCTGTTTGACCGCGCCAGCCGTTTTGCCCTGCGCGAGGACGATGCCGCGCGCGTCGCCGAGCATCTCGTCA
TCGCCAGCCGCGCGATCGAGCGCACTCCAGCGGCCGAGCGCGAGAAGATCACTCGCGAACTCAGCACGCCGCGTTTCTCG
CTGCGCTGGAGCGAGCGCGGGCCGCGACCCGCGGGCTCGGTGGCGCTCGGCACCATGCGTGAGCAGATTCTCGACATTAC
CGGCGAGTTCGACCACGCCGACCTGCAACTTCATCTCAAGCCGCTTGGCAGTCCGGGGAACGTTGTCGGCTCCGTACTGC
TCTCGGATCGCAGCGTCCTGACCTTCCAGACTTATGCCAGCGATGCCTGGACGCTGAACGCGGGCCGCATCGCCACGCTG
CTTCTGCCAACGCTCGTCCTGGTGGTGCTGGCCTGGGTGCTGTTCCGGGCAACCCTGGCGCCTCTGGGCGTGCTTGTCCG
GGCCACGCGCAAGGTCGGCTCCGACACGCCGGAAGCCGTGGCAGAGCAGGGGACCGACGAGGTGCGCGAGCTTATCCGCG
CCTTCAACCAGATGCAGCAGCGCATCCATCGCTCGATGACCGACCGGATGCAGTCCATGCTGGCGATCGGGCACGACCTG
CGCACGCCGCTCGCCCGCATGCAGCTTCGGCTGGAAAATGCCGGGCTCGATGCCCAGACCCGCGACGAGATGGCGGTCGA
CCTTGGCGAGATGCGCCACATGCTGGAATCGCTCCAGGCCTTCGTGGAAAGCGGCGGCTCGCGCCTTCCGGCCGAACGCG
TCGACGTCGCAGTCATGGCCCAGACGCTTGTAGATACGGCAGCCGATGAAGGCCGCGATGCATATTTCCACGGTCTCGAA
AGCCTCGAGATCATGGCTCGCCCGGTCTCGCTTCGCCGCGCGCTGTCGAACCTTCTCGAAAACGCGCTTCACTACGCGGG
CAATGTCCACGTCACTGTGCGCCGCGATGGCGACATGGCGGAGATCGTGTTCGAGGACGATGGCCCGGGCATTCCGGAGG
ACCGGCTCGACGATGTCCTCCAGCCCTTCGTGCGGCTCGACGTGGCGCGCAAGCGGGATACGCCGGGGATGGGGCTGGGC
CTGCCCATCGTCAGCAGGGCGGTGAAGCTTGAAGGCGGAAGCCTCGACCTGCGCAACAAGCCGGGCGGGGGGCTGGCGGT
TACGGTCCGTTTGCCTTGTGCGACTAGCTGA

Upstream 100 bases:

>100_bases
TCAGCCGCCTCCGCCGCAAGCTGTCCGCTGCGGGGGGCAATGCACCGATCGTCACGGTGCGCGGCGTTGGCTATATGTTC
AGGGCCGAGGTCGCGCGCAG

Downstream 100 bases:

>100_bases
ATCTCAAAGAAATATTTCGTAACCTTGGCGCCCAAGAGAGGCAAAGGCGAAGAGTTACCTTGGTTCACAATCGCGGCATC
CCTGTCGCGGTCAACCGCTC

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 435

Protein sequence:

>436_residues
MTFLRRSGLPERLLAILLLVAGVDFAANTLLFDRASRFALREDDAARVAEHLVIASRAIERTPAAEREKITRELSTPRFS
LRWSERGPRPAGSVALGTMREQILDITGEFDHADLQLHLKPLGSPGNVVGSVLLSDRSVLTFQTYASDAWTLNAGRIATL
LLPTLVLVVLAWVLFRATLAPLGVLVRATRKVGSDTPEAVAEQGTDEVRELIRAFNQMQQRIHRSMTDRMQSMLAIGHDL
RTPLARMQLRLENAGLDAQTRDEMAVDLGEMRHMLESLQAFVESGGSRLPAERVDVAVMAQTLVDTAADEGRDAYFHGLE
SLEIMARPVSLRRALSNLLENALHYAGNVHVTVRRDGDMAEIVFEDDGPGIPEDRLDDVLQPFVRLDVARKRDTPGMGLG
LPIVSRAVKLEGGSLDLRNKPGGGLAVTVRLPCATS

Sequences:

>Translated_436_residues
MTFLRRSGLPERLLAILLLVAGVDFAANTLLFDRASRFALREDDAARVAEHLVIASRAIERTPAAEREKITRELSTPRFS
LRWSERGPRPAGSVALGTMREQILDITGEFDHADLQLHLKPLGSPGNVVGSVLLSDRSVLTFQTYASDAWTLNAGRIATL
LLPTLVLVVLAWVLFRATLAPLGVLVRATRKVGSDTPEAVAEQGTDEVRELIRAFNQMQQRIHRSMTDRMQSMLAIGHDL
RTPLARMQLRLENAGLDAQTRDEMAVDLGEMRHMLESLQAFVESGGSRLPAERVDVAVMAQTLVDTAADEGRDAYFHGLE
SLEIMARPVSLRRALSNLLENALHYAGNVHVTVRRDGDMAEIVFEDDGPGIPEDRLDDVLQPFVRLDVARKRDTPGMGLG
LPIVSRAVKLEGGSLDLRNKPGGGLAVTVRLPCATS
>Mature_435_residues
TFLRRSGLPERLLAILLLVAGVDFAANTLLFDRASRFALREDDAARVAEHLVIASRAIERTPAAEREKITRELSTPRFSL
RWSERGPRPAGSVALGTMREQILDITGEFDHADLQLHLKPLGSPGNVVGSVLLSDRSVLTFQTYASDAWTLNAGRIATLL
LPTLVLVVLAWVLFRATLAPLGVLVRATRKVGSDTPEAVAEQGTDEVRELIRAFNQMQQRIHRSMTDRMQSMLAIGHDLR
TPLARMQLRLENAGLDAQTRDEMAVDLGEMRHMLESLQAFVESGGSRLPAERVDVAVMAQTLVDTAADEGRDAYFHGLES
LEIMARPVSLRRALSNLLENALHYAGNVHVTVRRDGDMAEIVFEDDGPGIPEDRLDDVLQPFVRLDVARKRDTPGMGLGL
PIVSRAVKLEGGSLDLRNKPGGGLAVTVRLPCATS

Specific function: Member of the two-component regulatory system envZ/ompR involved in the regulation of osmoregulation (genes ompF and ompC). EnvZ functions as a membrane-associated protein kinase that phosphorylates ompR in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1789808, Length=403, Percent_Identity=29.5285359801489, Blast_Score=130, Evalue=2e-31,
Organism=Escherichia coli, GI1790346, Length=242, Percent_Identity=31.8181818181818, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI1788393, Length=272, Percent_Identity=26.8382352941176, Blast_Score=95, Evalue=7e-21,
Organism=Escherichia coli, GI1787894, Length=227, Percent_Identity=33.0396475770925, Blast_Score=95, Evalue=8e-21,
Organism=Escherichia coli, GI1786600, Length=227, Percent_Identity=29.9559471365639, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1790551, Length=286, Percent_Identity=27.2727272727273, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87082128, Length=297, Percent_Identity=25.2525252525253, Blast_Score=75, Evalue=8e-15,
Organism=Escherichia coli, GI1786783, Length=225, Percent_Identity=26.6666666666667, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI87081816, Length=248, Percent_Identity=29.0322580645161, Blast_Score=73, Evalue=4e-14,
Organism=Escherichia coli, GI145693157, Length=107, Percent_Identity=34.5794392523364, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1786912, Length=220, Percent_Identity=29.0909090909091, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1790861, Length=292, Percent_Identity=25.3424657534247, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1788713, Length=262, Percent_Identity=24.4274809160305, Blast_Score=66, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 47835; Mature: 47704

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTFLRRSGLPERLLAILLLVAGVDFAANTLLFDRASRFALREDDAARVAEHLVIASRAIE
CCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
RTPAAEREKITRELSTPRFSLRWSERGPRPAGSVALGTMREQILDITGEFDHADLQLHLK
CCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEE
PLGSPGNVVGSVLLSDRSVLTFQTYASDAWTLNAGRIATLLLPTLVLVVLAWVLFRATLA
ECCCCHHHHHHHHHCCCCEEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
PLGVLVRATRKVGSDTPEAVAEQGTDEVRELIRAFNQMQQRIHRSMTDRMQSMLAIGHDL
HHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTPLARMQLRLENAGLDAQTRDEMAVDLGEMRHMLESLQAFVESGGSRLPAERVDVAVMA
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
QTLVDTAADEGRDAYFHGLESLEIMARPVSLRRALSNLLENALHYAGNVHVTVRRDGDMA
HHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEE
EIVFEDDGPGIPEDRLDDVLQPFVRLDVARKRDTPGMGLGLPIVSRAVKLEGGSLDLRNK
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHEECCCCEECCCC
PGGGLAVTVRLPCATS
CCCCEEEEEECCCCCC
>Mature Secondary Structure 
TFLRRSGLPERLLAILLLVAGVDFAANTLLFDRASRFALREDDAARVAEHLVIASRAIE
CCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
RTPAAEREKITRELSTPRFSLRWSERGPRPAGSVALGTMREQILDITGEFDHADLQLHLK
CCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCCCCEEEEEEE
PLGSPGNVVGSVLLSDRSVLTFQTYASDAWTLNAGRIATLLLPTLVLVVLAWVLFRATLA
ECCCCHHHHHHHHHCCCCEEEEEEECCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
PLGVLVRATRKVGSDTPEAVAEQGTDEVRELIRAFNQMQQRIHRSMTDRMQSMLAIGHDL
HHHHHHHHHHHHCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RTPLARMQLRLENAGLDAQTRDEMAVDLGEMRHMLESLQAFVESGGSRLPAERVDVAVMA
HHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
QTLVDTAADEGRDAYFHGLESLEIMARPVSLRRALSNLLENALHYAGNVHVTVRRDGDMA
HHHHHHHHCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCEE
EIVFEDDGPGIPEDRLDDVLQPFVRLDVARKRDTPGMGLGLPIVSRAVKLEGGSLDLRNK
EEEEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHEECCCCEECCCC
PGGGLAVTVRLPCATS
CCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 6292200; 2997120; 9278503; 8132603; 2277041; 2824492; 1323560; 9817206; 10426948 [H]