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The map label for this gene is purL

Identifier: 87200270

GI number: 87200270

Start: 2394320

End: 2396479

Strand: Direct

Name: purL

Synonym: Saro_2256

Alternate gene names: 87200270

Gene position: 2394320-2396479 (Clockwise)

Preceding gene: 87200269

Following gene: 87200272

Centisome position: 67.23

GC content: 66.11

Gene sequence:

>2160_bases
ATGTCTCAGATCACTCCTGATGTCGTCGCCGCCCATGGGCTGTCCGAGGAAGAATACCAGCGCGTGCTGCACGCGCTCGG
GCGCGAGCCGAACCTTGTCGAGCTCGGCATCTTCTCGGTCATGTGGTCGGAGCATTGCTCCTACAAGTCGAGCCGCATCC
ACCTCAAGAAACTGCCGACTTCGGCCCCCTGGGTGATCTGCGGGCCCGGCGAGAACGCTGGCGTGATCGACATCGGCGAT
GGCCAGGCCGCCATCTTCAAGATGGAGAGCCACAACCACCCGTCGTACATCGAACCCTACCAGGGCGCGGCGACGGGCGT
CGGCGGCATCCTGCGCGACGTGTTCACGATGGGCGCCCGCCCGGTGGCGAACATGAACGCCCTGCGCTTCGGCCGCCCGG
ATCACCCGAAGATGAAGCACCTCGTGCAGGGCGTCGTCGCGGGCATCGGCGGCTACGGCAACTGCGTCGGCGTGCCGACG
GTGGGTGGCGAGACCAACTTCCACAAGGCCTATGACGGCAACATCCTCGTCAACGCGATGACCGTTGGCGTGGCGGACAC
CGACAAGATCTTCTATTCGGCCGCCACCGGCCTCGGTAACCCGATCGTCTACGTCGGCTCCAAGACCGGGCGCGACGGCA
TCCACGGCGCGACCATGGCCTCGGCCGACTTCGACGAGAAGTCCGACGAGAAGCGCCCGACCGTGCAGGTAGGCGACCCC
TTCACCGAGAAGCTGCTGATCGAGGCCTGCCTCGAACTGATGGCGACCGACGCGATCGTGGCCATCCAGGACATGGGCGC
TGCGGGCCTCACCTCGTCGTCGGTCGAAATGGCGACCAACGGCAAGGCCGGCATCATCCTCGACATGGACAAGGTGCCGT
GCCGCGAAGAAGGCATGACGCCTTACGAGATGATGCTCTCGGAAAGCCAGGAGCGCATGCTCATGGTCCTGAAGCCCGGC
AAGGAAGCCATGGCCGAAGCCATCTTCCGCAAGTGGGAGCTGGACTTCGCGGTGATCGGCGAAGTGACCGACACCGGCCA
CATGGTCCTGAAGTTCCAGGGCGAAACCGTCTGCGACATTCCGCTCGGCCCCCTTGCCGAAGACGCCCCGCTCTATGACC
GCCCCGCCCTTTCGCTGGCCGACTACAAGGCCTGGGCCAATGTCGCACCGCTCGGCACCGTGCCGGAAAGCACGGATCTT
GGCGCGGATCTGGTGAAGCTGATCGGCTGCCCCGACCTCGCCAACCGCCGCTGGATCTTCGAGCAGTACGACAGCCAGGT
CGGCGCCGACACGCTGCAGAAGTCCGGCGGAGATGCGGCGGTCGTGCGCATCCACGGCACCAGCAAGGCTCTCGCGATCA
GCACCGACTGCACGCCGCGCTATTGCTATGCCGATCCCTATGAAGGCGGCAAGCAGGCCGTCGCGGAAACGTGGCGCAAC
ATCTGCGCGGTGGGCGCGCGTCCGCTGGCGATCACCAATTGCCTCAACTTCGCCAACCCGCAGCGCCCCGAGATCATGGC
CCAGATCGTCCAGGCGCTGAACGGCATGGGCGATGCGTGCCGCGCGCTGGATTACCCGATCGTCTCGGGCAACGTCTCGC
TCTACAACGAATCGAAGGCCACCGGCGGCGGCTCGGCCATCCTGCCCACGCCCGCCATCGGCGGCGTCGGCCTGATGCTC
GACCACGAAGTGATGACCACGGTCGCGTTCAAGGATGAAGGCGATGCGATCTGGCTGGTGGGCGGCGAAGGCACCCACCT
TGGTCAGTCGCTCTACCTGCGCGAAATCCACGGCCGCGAGGATGGCGATGCACCGTCGGTCGATCTGGCGGTCGAGCGCA
GGAACGGCGAGCAGGTCCGCGAATGGATCGCCGCCGGCAGGCTGAGCGCCGTGCACGATATTTCCGACGGTGGCCTTCTG
GTCGCGCTGACCGAAATGGCGCTGGCCGGAAACAAGGGCTGCACCCTCGACATCGCCCTCACCACCGCCGCCGCATTCGG
TGAAGACCAGTCGCGCTACGTCGTCACGACGCGGGCGGGCGAAGTGCTGGAAGGTGCGACCCGCCTCGGCACGGTCGGCG
GCTCGCAGGTTGCAGGCGTCGAACTCGCCGCGCTGCGCGAAGCAAACGAGGCCTTCTTCCGCGACTGGATGGAAGGCTAA

Upstream 100 bases:

>100_bases
GTTCGCCACGATGGTCGCCGCCACCGCCGCCACCTGGTTCACACTCAGGTTCGCCGGTTAGGACTAGCCTCTTGCGCGCC
ACATCGCTAAGGCGCGCGCC

Downstream 100 bases:

>100_bases
GCCAGGCCTTCATACCTGCGCCCCCCGAATGGCGGGGCGCAGGCCGGTCCTCCCGGTCAGGCCGCCAGTTTGGAGGCGTT
CTTCCCCAGCAGGTCATAGG

Product: phosphoribosylformylglycinamidine synthase II

Products: NA

Alternate protein names: Phosphoribosylformylglycinamidine synthase II; FGAM synthase II

Number of amino acids: Translated: 719; Mature: 718

Protein sequence:

>719_residues
MSQITPDVVAAHGLSEEEYQRVLHALGREPNLVELGIFSVMWSEHCSYKSSRIHLKKLPTSAPWVICGPGENAGVIDIGD
GQAAIFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPVANMNALRFGRPDHPKMKHLVQGVVAGIGGYGNCVGVPT
VGGETNFHKAYDGNILVNAMTVGVADTDKIFYSAATGLGNPIVYVGSKTGRDGIHGATMASADFDEKSDEKRPTVQVGDP
FTEKLLIEACLELMATDAIVAIQDMGAAGLTSSSVEMATNGKAGIILDMDKVPCREEGMTPYEMMLSESQERMLMVLKPG
KEAMAEAIFRKWELDFAVIGEVTDTGHMVLKFQGETVCDIPLGPLAEDAPLYDRPALSLADYKAWANVAPLGTVPESTDL
GADLVKLIGCPDLANRRWIFEQYDSQVGADTLQKSGGDAAVVRIHGTSKALAISTDCTPRYCYADPYEGGKQAVAETWRN
ICAVGARPLAITNCLNFANPQRPEIMAQIVQALNGMGDACRALDYPIVSGNVSLYNESKATGGGSAILPTPAIGGVGLML
DHEVMTTVAFKDEGDAIWLVGGEGTHLGQSLYLREIHGREDGDAPSVDLAVERRNGEQVREWIAAGRLSAVHDISDGGLL
VALTEMALAGNKGCTLDIALTTAAAFGEDQSRYVVTTRAGEVLEGATRLGTVGGSQVAGVELAALREANEAFFRDWMEG

Sequences:

>Translated_719_residues
MSQITPDVVAAHGLSEEEYQRVLHALGREPNLVELGIFSVMWSEHCSYKSSRIHLKKLPTSAPWVICGPGENAGVIDIGD
GQAAIFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPVANMNALRFGRPDHPKMKHLVQGVVAGIGGYGNCVGVPT
VGGETNFHKAYDGNILVNAMTVGVADTDKIFYSAATGLGNPIVYVGSKTGRDGIHGATMASADFDEKSDEKRPTVQVGDP
FTEKLLIEACLELMATDAIVAIQDMGAAGLTSSSVEMATNGKAGIILDMDKVPCREEGMTPYEMMLSESQERMLMVLKPG
KEAMAEAIFRKWELDFAVIGEVTDTGHMVLKFQGETVCDIPLGPLAEDAPLYDRPALSLADYKAWANVAPLGTVPESTDL
GADLVKLIGCPDLANRRWIFEQYDSQVGADTLQKSGGDAAVVRIHGTSKALAISTDCTPRYCYADPYEGGKQAVAETWRN
ICAVGARPLAITNCLNFANPQRPEIMAQIVQALNGMGDACRALDYPIVSGNVSLYNESKATGGGSAILPTPAIGGVGLML
DHEVMTTVAFKDEGDAIWLVGGEGTHLGQSLYLREIHGREDGDAPSVDLAVERRNGEQVREWIAAGRLSAVHDISDGGLL
VALTEMALAGNKGCTLDIALTTAAAFGEDQSRYVVTTRAGEVLEGATRLGTVGGSQVAGVELAALREANEAFFRDWMEG
>Mature_718_residues
SQITPDVVAAHGLSEEEYQRVLHALGREPNLVELGIFSVMWSEHCSYKSSRIHLKKLPTSAPWVICGPGENAGVIDIGDG
QAAIFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGARPVANMNALRFGRPDHPKMKHLVQGVVAGIGGYGNCVGVPTV
GGETNFHKAYDGNILVNAMTVGVADTDKIFYSAATGLGNPIVYVGSKTGRDGIHGATMASADFDEKSDEKRPTVQVGDPF
TEKLLIEACLELMATDAIVAIQDMGAAGLTSSSVEMATNGKAGIILDMDKVPCREEGMTPYEMMLSESQERMLMVLKPGK
EAMAEAIFRKWELDFAVIGEVTDTGHMVLKFQGETVCDIPLGPLAEDAPLYDRPALSLADYKAWANVAPLGTVPESTDLG
ADLVKLIGCPDLANRRWIFEQYDSQVGADTLQKSGGDAAVVRIHGTSKALAISTDCTPRYCYADPYEGGKQAVAETWRNI
CAVGARPLAITNCLNFANPQRPEIMAQIVQALNGMGDACRALDYPIVSGNVSLYNESKATGGGSAILPTPAIGGVGLMLD
HEVMTTVAFKDEGDAIWLVGGEGTHLGQSLYLREIHGREDGDAPSVDLAVERRNGEQVREWIAAGRLSAVHDISDGGLLV
ALTEMALAGNKGCTLDIALTTAAAFGEDQSRYVVTTRAGEVLEGATRLGTVGGSQVAGVELAALREANEAFFRDWMEG

Specific function: Unknown

COG id: COG0046

COG function: function code F; Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGAMS family

Homologues:

Organism=Escherichia coli, GI48994899, Length=776, Percent_Identity=25.5154639175258, Blast_Score=134, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6321498, Length=750, Percent_Identity=22.9333333333333, Blast_Score=111, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24582111, Length=656, Percent_Identity=23.780487804878, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24582109, Length=656, Percent_Identity=23.780487804878, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI17137292, Length=656, Percent_Identity=23.780487804878, Blast_Score=99, Evalue=7e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PURL_NOVAD (Q2G630)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_497527.1
- ProteinModelPortal:   Q2G630
- SMR:   Q2G630
- STRING:   Q2G630
- GeneID:   3916572
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_2256
- NMPDR:   fig|48935.1.peg.1737
- eggNOG:   COG0046
- HOGENOM:   HBG311214
- OMA:   YGNSFGV
- PhylomeDB:   Q2G630
- ProtClustDB:   PRK01213
- BioCyc:   NARO279238:SARO_2256-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00420
- InterPro:   IPR000728
- InterPro:   IPR010918
- InterPro:   IPR010074
- InterPro:   IPR016188
- TIGRFAMs:   TIGR01736

Pfam domain/function: PF00586 AIRS; PF02769 AIRS_C; SSF56042 AIR_synth_C; SSF55326 PurM_N-like

EC number: =6.3.5.3

Molecular weight: Translated: 76495; Mature: 76363

Theoretical pI: Translated: 4.60; Mature: 4.60

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQITPDVVAAHGLSEEEYQRVLHALGREPNLVELGIFSVMWSEHCSYKSSRIHLKKLPT
CCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCCCCCEEEEECCC
SAPWVICGPGENAGVIDIGDGQAAIFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGAR
CCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
PVANMNALRFGRPDHPKMKHLVQGVVAGIGGYGNCVGVPTVGGETNFHKAYDGNILVNAM
CCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCEECCCCEEEEEE
TVGVADTDKIFYSAATGLGNPIVYVGSKTGRDGIHGATMASADFDEKSDEKRPTVQVGDP
EECCCCCCHHHEEHHCCCCCCEEEECCCCCCCCCCCCEEECCCCCCCCCCCCCEEEECCC
FTEKLLIEACLELMATDAIVAIQDMGAAGLTSSSVEMATNGKAGIILDMDKVPCREEGMT
HHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEECCCCEEEEEECCCCCCCCCCCC
PYEMMLSESQERMLMVLKPGKEAMAEAIFRKWELDFAVIGEVTDTGHMVLKFQGETVCDI
HHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCEEEEC
PLGPLAEDAPLYDRPALSLADYKAWANVAPLGTVPESTDLGADLVKLIGCPDLANRRWIF
CCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHH
EQYDSQVGADTLQKSGGDAAVVRIHGTSKALAISTDCTPRYCYADPYEGGKQAVAETWRN
HHHHHHCCHHHHHHCCCCEEEEEEECCCCEEEEECCCCCCEEECCCCCCHHHHHHHHHHH
ICAVGARPLAITNCLNFANPQRPEIMAQIVQALNGMGDACRALDYPIVSGNVSLYNESKA
HHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEECCEEEEECCCC
TGGGSAILPTPAIGGVGLMLDHEVMTTVAFKDEGDAIWLVGGEGTHLGQSLYLREIHGRE
CCCCCEECCCCCCCCEEEEECHHEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHCCCC
DGDAPSVDLAVERRNGEQVREWIAAGRLSAVHDISDGGLLVALTEMALAGNKGCTLDIAL
CCCCCCEEEEEECCCCHHHHHHHHHCCCHHEEECCCCCEEEEEEHHHHCCCCCCEEEEEE
TTAAAFGEDQSRYVVTTRAGEVLEGATRLGTVGGSQVAGVELAALREANEAFFRDWMEG
EEHHHCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SQITPDVVAAHGLSEEEYQRVLHALGREPNLVELGIFSVMWSEHCSYKSSRIHLKKLPT
CCCCCHHHHHCCCCHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHCCCCCCCEEEEECCC
SAPWVICGPGENAGVIDIGDGQAAIFKMESHNHPSYIEPYQGAATGVGGILRDVFTMGAR
CCCEEEECCCCCCCEEEECCCCEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCCC
PVANMNALRFGRPDHPKMKHLVQGVVAGIGGYGNCVGVPTVGGETNFHKAYDGNILVNAM
CCCCCCCEECCCCCCHHHHHHHHHHHHHCCCCCCEEECCCCCCCCCCCEECCCCEEEEEE
TVGVADTDKIFYSAATGLGNPIVYVGSKTGRDGIHGATMASADFDEKSDEKRPTVQVGDP
EECCCCCCHHHEEHHCCCCCCEEEECCCCCCCCCCCCEEECCCCCCCCCCCCCEEEECCC
FTEKLLIEACLELMATDAIVAIQDMGAAGLTSSSVEMATNGKAGIILDMDKVPCREEGMT
HHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCEEEECCCCEEEEEECCCCCCCCCCCC
PYEMMLSESQERMLMVLKPGKEAMAEAIFRKWELDFAVIGEVTDTGHMVLKFQGETVCDI
HHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEECCCEEEEC
PLGPLAEDAPLYDRPALSLADYKAWANVAPLGTVPESTDLGADLVKLIGCPDLANRRWIF
CCCCCCCCCCCCCCCCCCHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCCHH
EQYDSQVGADTLQKSGGDAAVVRIHGTSKALAISTDCTPRYCYADPYEGGKQAVAETWRN
HHHHHHCCHHHHHHCCCCEEEEEEECCCCEEEEECCCCCCEEECCCCCCHHHHHHHHHHH
ICAVGARPLAITNCLNFANPQRPEIMAQIVQALNGMGDACRALDYPIVSGNVSLYNESKA
HHHCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCEEECCEEEEECCCC
TGGGSAILPTPAIGGVGLMLDHEVMTTVAFKDEGDAIWLVGGEGTHLGQSLYLREIHGRE
CCCCCEECCCCCCCCEEEEECHHEEEEEEEECCCCEEEEECCCCCCCCHHHHHHHHCCCC
DGDAPSVDLAVERRNGEQVREWIAAGRLSAVHDISDGGLLVALTEMALAGNKGCTLDIAL
CCCCCCEEEEEECCCCHHHHHHHHHCCCHHEEECCCCCEEEEEEHHHHCCCCCCEEEEEE
TTAAAFGEDQSRYVVTTRAGEVLEGATRLGTVGGSQVAGVELAALREANEAFFRDWMEG
EEHHHCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA