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The map label for this gene is pcoA [H]

Identifier: 87200152

GI number: 87200152

Start: 2275546

End: 2277300

Strand: Reverse

Name: pcoA [H]

Synonym: Saro_2136

Alternate gene names: 87200152

Gene position: 2277300-2275546 (Counterclockwise)

Preceding gene: 87200153

Following gene: 87200151

Centisome position: 63.94

GC content: 62.17

Gene sequence:

>1755_bases
ATGTATTCTTTTGCGCTTAATCGCCGTACCCTCATTCGTTCGGCTGCCCTGGGGGGCGGGGGCCTCGCGCTTTCGGCAGT
GCTCCCAGCCTGGGCGCGCAGCGGAACCTCTGGTCTTGGAGTCCCGATGGCCGAGGTGTCCGGGGAGCAAATCGCACTAT
CCATCGGTCATGCCTCGCTCCGTGTCGGCGGGCGTGACGGGCATGCCATCGGCATCAACGGTGCGACACCTGGCCCGGTT
ATCCGGTTAAAAGAGGGTCAGAAGGTTCGCCTCGCAGTGAACAACACGCTGAAGGAAGAAACCTCGATCCATTGGCACGG
GCTGCTCGTGCCCTTCCAGATGGACGGCGTGCCGGGGGTGAGCTTTCCCGGGATCAAGGCCGGCCAGACTTTCGTCTATG
AATTCCCCGTCCGGCAGTCCGGGACCTACTGGTATCACAGCCACTCGGGCATGCAGGAGGCGATGGGCATGTATGGCGCG
ATTGTGATCGATCCCGCAGCACCCGATCCAATTGCCTATGACCGCGAACACGTGATCATGCTCGCCGACTGGAGCTTCAT
GCACCCACACACGCAGCTGCGGAAGCTGAAGGCGCAGCCCGGCTACTTCAACCTGCAAAAGCAGACCCTCTCGGGACTAC
TTGCGGGAAAGGACCAGTCGGCCTCCGAACGGCGCATGTGGGCCGGGATGCGGATGGACCCGACCGACATTTCCGATGTC
ACCGGCGCCACTTATCATTTCATGGTCAACGGGCATGACAGCGCCGCGAACTGGACTGGACTGTTCGCACCCGGAGAGCG
TGTGCGCCTGCGCATCATCAATGCTGCCGCCATGACCAACTTCAATGTCCGGATTCCGGGCCTTGCGATGACCGTGGTTG
CCGCCGACGGGCAGAACGTGCAGCCAGTCGAGACCGACGAGTTCCAGATCGGCATCGCCGAGACCTATGACGTGATTGTC
GTGCCCAGAGCCGACGAGGCCTATGGCTTCATCGCCGAAGCCATCGACCGCTCCGGTCAGGTGCGCGCCACGCTCGCCCC
GCGCCTCGGCATGGTCGCGCCGATCCCGGCGATCCGCGAACGCCCGCTGCTGTCCATGCAAGACATGGGCATGGGCGATA
TGGCGGCACCCGGTGCCGATGCGAGTGCAACTGATCACGCAGCCATGGGCCACGCCATGCCCGGGATGGATCACGGCTCG
ATGAAGATGCGCGATCCCGCGGTCGCGCCGCAGGTCAAAATGGGACCAGGCGTTGCGACGCTTTCGCCAATGCCCATGGA
CCGCACGGGCGAACGTCCGACCGGCCTTGAGAAGGTCGATCACCGGGTGCTGACTTATCGTGACCTCAAAGCGCTGCCCC
CCAATGCAGACAAGCGCACGCCGTCGCGAGAGATCGATATCCATCTGACCGCCAACATGGAGCGCTACATGTGGTCCTTC
GATGGCGTAAAGTTCAGCGAGAACACCGAGCCGATCGCGTTCCGCCACATGGAGCGGGTGCGCGTCAATCTCATCAATGA
CACCATGATGCCCCATCCGATTCACCTGCACGGTCATTTCTTCGAACTGGTCACAGGTAATCCGGGTCATCATCCGCTGA
AGCACACGGTCAATGTCTTGCCCGGTGGCAAGGTTTCGTTCGACCTGACGGCCGATGAACTCGGCGACTGGGCATTTCAC
TGTCACATGCTGCTGCACATGATGTCGGGGATGTTCCGGGTCGTGACCGTGCGCCATGAGGAGGACGCGGCATGA

Upstream 100 bases:

>100_bases
AGGGGAAAATTAAAAGCGATGCTTGGCGACCAGATCTGAGGGGTAAGGAAAGCGGCTGCGTAGAGAACTATGAAGCCGTC
AATCGTACCGGACACCATTC

Downstream 100 bases:

>100_bases
AGGCGACCCTTCTCATCAGCGCTGCTGTCTTGCTGGCAACGCCCGGCTTTGCGGGGGCTCAATCCACCATGCCAGGCATG
GAAATGAAGGATGCGCCCGG

Product: copper-resistance protein CopA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 584; Mature: 584

Protein sequence:

>584_residues
MYSFALNRRTLIRSAALGGGGLALSAVLPAWARSGTSGLGVPMAEVSGEQIALSIGHASLRVGGRDGHAIGINGATPGPV
IRLKEGQKVRLAVNNTLKEETSIHWHGLLVPFQMDGVPGVSFPGIKAGQTFVYEFPVRQSGTYWYHSHSGMQEAMGMYGA
IVIDPAAPDPIAYDREHVIMLADWSFMHPHTQLRKLKAQPGYFNLQKQTLSGLLAGKDQSASERRMWAGMRMDPTDISDV
TGATYHFMVNGHDSAANWTGLFAPGERVRLRIINAAAMTNFNVRIPGLAMTVVAADGQNVQPVETDEFQIGIAETYDVIV
VPRADEAYGFIAEAIDRSGQVRATLAPRLGMVAPIPAIRERPLLSMQDMGMGDMAAPGADASATDHAAMGHAMPGMDHGS
MKMRDPAVAPQVKMGPGVATLSPMPMDRTGERPTGLEKVDHRVLTYRDLKALPPNADKRTPSREIDIHLTANMERYMWSF
DGVKFSENTEPIAFRHMERVRVNLINDTMMPHPIHLHGHFFELVTGNPGHHPLKHTVNVLPGGKVSFDLTADELGDWAFH
CHMLLHMMSGMFRVVTVRHEEDAA

Sequences:

>Translated_584_residues
MYSFALNRRTLIRSAALGGGGLALSAVLPAWARSGTSGLGVPMAEVSGEQIALSIGHASLRVGGRDGHAIGINGATPGPV
IRLKEGQKVRLAVNNTLKEETSIHWHGLLVPFQMDGVPGVSFPGIKAGQTFVYEFPVRQSGTYWYHSHSGMQEAMGMYGA
IVIDPAAPDPIAYDREHVIMLADWSFMHPHTQLRKLKAQPGYFNLQKQTLSGLLAGKDQSASERRMWAGMRMDPTDISDV
TGATYHFMVNGHDSAANWTGLFAPGERVRLRIINAAAMTNFNVRIPGLAMTVVAADGQNVQPVETDEFQIGIAETYDVIV
VPRADEAYGFIAEAIDRSGQVRATLAPRLGMVAPIPAIRERPLLSMQDMGMGDMAAPGADASATDHAAMGHAMPGMDHGS
MKMRDPAVAPQVKMGPGVATLSPMPMDRTGERPTGLEKVDHRVLTYRDLKALPPNADKRTPSREIDIHLTANMERYMWSF
DGVKFSENTEPIAFRHMERVRVNLINDTMMPHPIHLHGHFFELVTGNPGHHPLKHTVNVLPGGKVSFDLTADELGDWAFH
CHMLLHMMSGMFRVVTVRHEEDAA
>Mature_584_residues
MYSFALNRRTLIRSAALGGGGLALSAVLPAWARSGTSGLGVPMAEVSGEQIALSIGHASLRVGGRDGHAIGINGATPGPV
IRLKEGQKVRLAVNNTLKEETSIHWHGLLVPFQMDGVPGVSFPGIKAGQTFVYEFPVRQSGTYWYHSHSGMQEAMGMYGA
IVIDPAAPDPIAYDREHVIMLADWSFMHPHTQLRKLKAQPGYFNLQKQTLSGLLAGKDQSASERRMWAGMRMDPTDISDV
TGATYHFMVNGHDSAANWTGLFAPGERVRLRIINAAAMTNFNVRIPGLAMTVVAADGQNVQPVETDEFQIGIAETYDVIV
VPRADEAYGFIAEAIDRSGQVRATLAPRLGMVAPIPAIRERPLLSMQDMGMGDMAAPGADASATDHAAMGHAMPGMDHGS
MKMRDPAVAPQVKMGPGVATLSPMPMDRTGERPTGLEKVDHRVLTYRDLKALPPNADKRTPSREIDIHLTANMERYMWSF
DGVKFSENTEPIAFRHMERVRVNLINDTMMPHPIHLHGHFFELVTGNPGHHPLKHTVNVLPGGKVSFDLTADELGDWAFH
CHMLLHMMSGMFRVVTVRHEEDAA

Specific function: Required for the copper-inducible expression of copper resistance. May have oxidase activity [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family. CopA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=600, Percent_Identity=24, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6321067, Length=562, Percent_Identity=25.4448398576512, Blast_Score=124, Evalue=5e-29,
Organism=Saccharomyces cerevisiae, GI6320714, Length=293, Percent_Identity=25.5972696245734, Blast_Score=89, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6323703, Length=278, Percent_Identity=28.0575539568345, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24585842, Length=590, Percent_Identity=25.9322033898305, Blast_Score=119, Evalue=7e-27,
Organism=Drosophila melanogaster, GI281360167, Length=590, Percent_Identity=25.9322033898305, Blast_Score=118, Evalue=1e-26,
Organism=Drosophila melanogaster, GI18859919, Length=570, Percent_Identity=25.9649122807018, Blast_Score=115, Evalue=8e-26,
Organism=Drosophila melanogaster, GI221330000, Length=591, Percent_Identity=26.3959390862944, Blast_Score=112, Evalue=1e-24,
Organism=Drosophila melanogaster, GI28574104, Length=618, Percent_Identity=24.9190938511327, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI221329998, Length=279, Percent_Identity=31.8996415770609, Blast_Score=101, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24650186, Length=575, Percent_Identity=21.5652173913043, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001117
- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR006376
- InterPro:   IPR002355
- InterPro:   IPR008972
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00394 Cu-oxidase; PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 63726; Mature: 63726

Theoretical pI: Translated: 6.98; Mature: 6.98

Prosite motif: PS00079 MULTICOPPER_OXIDASE1 ; PS00080 MULTICOPPER_OXIDASE2 ; PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
6.2 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
6.2 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYSFALNRRTLIRSAALGGGGLALSAVLPAWARSGTSGLGVPMAEVSGEQIALSIGHASL
CCEEECCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEEEEECCEEE
RVGGRDGHAIGINGATPGPVIRLKEGQKVRLAVNNTLKEETSIHWHGLLVPFQMDGVPGV
EECCCCCCEEEECCCCCCCEEEECCCCEEEEEECCCCCCCCCEEEEEEEEEEEECCCCCC
SFPGIKAGQTFVYEFPVRQSGTYWYHSHSGMQEAMGMYGAIVIDPAAPDPIAYDREHVIM
CCCCCCCCCEEEEEECCCCCCCEEEECCCCHHHHHCCCEEEEECCCCCCCCCCCCCEEEE
LADWSFMHPHTQLRKLKAQPGYFNLQKQTLSGLLAGKDQSASERRMWAGMRMDPTDISDV
EECCCCCCCHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCC
TGATYHFMVNGHDSAANWTGLFAPGERVRLRIINAAAMTNFNVRIPGLAMTVVAADGQNV
CCCEEEEEEECCCCCCCEEEEECCCCEEEEEEEEEEHEEECEEECCCEEEEEEEECCCCC
QPVETDEFQIGIAETYDVIVVPRADEAYGFIAEAIDRSGQVRATLAPRLGMVAPIPAIRE
CCCCCCCEEEEEECCEEEEEEECCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHC
RPLLSMQDMGMGDMAAPGADASATDHAAMGHAMPGMDHGSMKMRDPAVAPQVKMGPGVAT
CCCCCHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCEECCCCCCCCEECCCCEEE
LSPMPMDRTGERPTGLEKVDHRVLTYRDLKALPPNADKRTPSREIDIHLTANMERYMWSF
CCCCCCCCCCCCCCCHHHHCCEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCHHEEEEE
DGVKFSENTEPIAFRHMERVRVNLINDTMMPHPIHLHGHFFELVTGNPGHHPLKHTVNVL
CCEEECCCCCCHHHHHHHHHEEEEECCCCCCCEEEECCEEEEEEECCCCCCCHHHEEEEC
PGGKVSFDLTADELGDWAFHCHMLLHMMSGMFRVVTVRHEEDAA
CCCEEEEEEEHHHHCCHHHHHHHHHHHHCCCEEEEEEECCCCCC
>Mature Secondary Structure
MYSFALNRRTLIRSAALGGGGLALSAVLPAWARSGTSGLGVPMAEVSGEQIALSIGHASL
CCEEECCCHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHCCCCEEEEEECCEEE
RVGGRDGHAIGINGATPGPVIRLKEGQKVRLAVNNTLKEETSIHWHGLLVPFQMDGVPGV
EECCCCCCEEEECCCCCCCEEEECCCCEEEEEECCCCCCCCCEEEEEEEEEEEECCCCCC
SFPGIKAGQTFVYEFPVRQSGTYWYHSHSGMQEAMGMYGAIVIDPAAPDPIAYDREHVIM
CCCCCCCCCEEEEEECCCCCCCEEEECCCCHHHHHCCCEEEEECCCCCCCCCCCCCEEEE
LADWSFMHPHTQLRKLKAQPGYFNLQKQTLSGLLAGKDQSASERRMWAGMRMDPTDISDV
EECCCCCCCHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCCHHHHHHCCCCCCCCCCCCC
TGATYHFMVNGHDSAANWTGLFAPGERVRLRIINAAAMTNFNVRIPGLAMTVVAADGQNV
CCCEEEEEEECCCCCCCEEEEECCCCEEEEEEEEEEHEEECEEECCCEEEEEEEECCCCC
QPVETDEFQIGIAETYDVIVVPRADEAYGFIAEAIDRSGQVRATLAPRLGMVAPIPAIRE
CCCCCCCEEEEEECCEEEEEEECCCCHHHHHHHHHCCCCCEEEEECCCCCCCCCCCHHHC
RPLLSMQDMGMGDMAAPGADASATDHAAMGHAMPGMDHGSMKMRDPAVAPQVKMGPGVAT
CCCCCHHHCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCEECCCCCCCCEECCCCEEE
LSPMPMDRTGERPTGLEKVDHRVLTYRDLKALPPNADKRTPSREIDIHLTANMERYMWSF
CCCCCCCCCCCCCCCHHHHCCEEEEEECCCCCCCCCCCCCCCCEEEEEEECCCHHEEEEE
DGVKFSENTEPIAFRHMERVRVNLINDTMMPHPIHLHGHFFELVTGNPGHHPLKHTVNVL
CCEEECCCCCCHHHHHHHHHEEEEECCCCCCCEEEECCEEEEEEECCCCCCCHHHEEEEC
PGGKVSFDLTADELGDWAFHCHMLLHMMSGMFRVVTVRHEEDAA
CCCEEEEEEEHHHHCCHHHHHHHHHHHHCCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8594334 [H]