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The map label for this gene is phoQ [H]

Identifier: 87200081

GI number: 87200081

Start: 2204941

End: 2206344

Strand: Reverse

Name: phoQ [H]

Synonym: Saro_2065

Alternate gene names: 87200081

Gene position: 2206344-2204941 (Counterclockwise)

Preceding gene: 87200082

Following gene: 87200076

Centisome position: 61.95

GC content: 67.31

Gene sequence:

>1404_bases
GTGGCCGAACGAGGGCCCGCCCGAGAAGCACCGCCGCAGCCAGCGCCGCATACCGGCTCGCTGGCGCGGCGCATGCTGCT
CATCGCGGCGGGGTGGATTTCGGTCCTGCTCCTCGGTGGCGGTCTCGCGCTCGACCAGACGCTGACCGGCCTCGTCACGC
GCAATTTCGACGAACAGCTTGGCTACATGCTGACCGCGATGGTCGCCTCGGCCGAGATCGGTCCCGACGGCGAGGTGTTC
TTCAACCGCCCGCTCGGCGACCAGCGCTTTCTCGAACCGAACAGCGGCCTCTACTGGCAGATTTCGGGGCAGGGGCACGA
GGATTTTCCCTCGCGCTCGCTGTGGGATCGCTCTCTGCGCACCGATCTCGACAACAACTACATCGATCCCAGGATCGACG
ACAGCGACCAGTTCGAAGGTGAGCGCCTGCGCATCATCAAGCGGTCGGTGATCCTGCCGGGCAGCAATACCCTGTGGGAG
TTCCAGGTTGCCGCCAGCCGGGGCGAGATCGATTCCCAGATCAGGCGCATCCGCTCGATCCTGATATGGTCGTTCCTCGT
TCTCGGCTTCGGCCTGTTCGTCATGGCGGGCTTGCAGACCTACTACGGCCTCGGGCCGCTGCGCCGCGTGCGGCTGGCCA
TCGCCCGAATGCGCGAGGGCGGAGCGAGCCGCGTTACCGATCCCCTGCCGCTGGAAGTCCAGCCGCTGGTGCTCGAACTC
AACGCCCTGCTCGAACACTCCGAACGCCAGGCAGAGGAAGCGCGCACGCACGCCGGCAACCTTGCCCACGCGCTGAAAAC
GCCGCTGACCGTGGTGATGAACGCCGCGACGGCCCAGGCGCCCGACCTGGCCGACACGGTGATCCGCGAGGCCGCGGTGA
TGCGCCGACAGGTCGACCATCACCTTGCCCGAGCCCGTGCGGTCGGCCGCCGCGCTGTCGGCCTGTCGCGCGCGCAGGTC
TGGGAAAGCGCCGAGGCGGTGGAGCGCGCGGTGGTGCGGCTCTACCCGCAGGTGCGGCTCGACATGGACGGCAACCGCAC
CGCCGAAGTCTCGATAGAGCGGCAGGACCTCGACGAGATTCTCGGCAACCTGATCGAGAATGCCGCGAAGTACGGTGGCG
GCTCCGTTTTCATCACCATCGACGCGGCCCCGGCCGATCCCAAGTTCTGCGAGATATGGGTCGAGGATGACGGTGTCGGC
ATTCCCGAGGAAGCGCGCGAACGCATCTTCGATCGCGGCGCGCGGCTCGACACCGGCAAGCCGGGCACGGGCCTCGGCCT
CGCCATCGTGCGCGACGTGGCGGAAATCTATGGTGGCAGCGTCGAACTCAAGGAAAGCGAGGACCTTGGTGGCCTTCTCT
CGGTGCTGAGGCTGCCCCGGCCGGCAACCACTGCCATCAAATAG

Upstream 100 bases:

>100_bases
CACGCGCATTCGCAAGAAGCTGGGGCCGGACGTGATCACCACGATCCGTGGCCTTGGCTACAGCCTCGACGATCCGGCCG
AACCCGGCCGCGGCTAATTC

Downstream 100 bases:

>100_bases
GCGTTGTCGCTCAGGCGCGCGGATGCGCGTTGCGGTAGACGTCGAGCAGGGTTGCCGCATCGACCCGCGTGTAGATCTGG
GTCGACGACAGGCTGGCGTG

Product: periplasmic sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 466

Protein sequence:

>467_residues
MAERGPAREAPPQPAPHTGSLARRMLLIAAGWISVLLLGGGLALDQTLTGLVTRNFDEQLGYMLTAMVASAEIGPDGEVF
FNRPLGDQRFLEPNSGLYWQISGQGHEDFPSRSLWDRSLRTDLDNNYIDPRIDDSDQFEGERLRIIKRSVILPGSNTLWE
FQVAASRGEIDSQIRRIRSILIWSFLVLGFGLFVMAGLQTYYGLGPLRRVRLAIARMREGGASRVTDPLPLEVQPLVLEL
NALLEHSERQAEEARTHAGNLAHALKTPLTVVMNAATAQAPDLADTVIREAAVMRRQVDHHLARARAVGRRAVGLSRAQV
WESAEAVERAVVRLYPQVRLDMDGNRTAEVSIERQDLDEILGNLIENAAKYGGGSVFITIDAAPADPKFCEIWVEDDGVG
IPEEARERIFDRGARLDTGKPGTGLGLAIVRDVAEIYGGSVELKESEDLGGLLSVLRLPRPATTAIK

Sequences:

>Translated_467_residues
MAERGPAREAPPQPAPHTGSLARRMLLIAAGWISVLLLGGGLALDQTLTGLVTRNFDEQLGYMLTAMVASAEIGPDGEVF
FNRPLGDQRFLEPNSGLYWQISGQGHEDFPSRSLWDRSLRTDLDNNYIDPRIDDSDQFEGERLRIIKRSVILPGSNTLWE
FQVAASRGEIDSQIRRIRSILIWSFLVLGFGLFVMAGLQTYYGLGPLRRVRLAIARMREGGASRVTDPLPLEVQPLVLEL
NALLEHSERQAEEARTHAGNLAHALKTPLTVVMNAATAQAPDLADTVIREAAVMRRQVDHHLARARAVGRRAVGLSRAQV
WESAEAVERAVVRLYPQVRLDMDGNRTAEVSIERQDLDEILGNLIENAAKYGGGSVFITIDAAPADPKFCEIWVEDDGVG
IPEEARERIFDRGARLDTGKPGTGLGLAIVRDVAEIYGGSVELKESEDLGGLLSVLRLPRPATTAIK
>Mature_466_residues
AERGPAREAPPQPAPHTGSLARRMLLIAAGWISVLLLGGGLALDQTLTGLVTRNFDEQLGYMLTAMVASAEIGPDGEVFF
NRPLGDQRFLEPNSGLYWQISGQGHEDFPSRSLWDRSLRTDLDNNYIDPRIDDSDQFEGERLRIIKRSVILPGSNTLWEF
QVAASRGEIDSQIRRIRSILIWSFLVLGFGLFVMAGLQTYYGLGPLRRVRLAIARMREGGASRVTDPLPLEVQPLVLELN
ALLEHSERQAEEARTHAGNLAHALKTPLTVVMNAATAQAPDLADTVIREAAVMRRQVDHHLARARAVGRRAVGLSRAQVW
ESAEAVERAVVRLYPQVRLDMDGNRTAEVSIERQDLDEILGNLIENAAKYGGGSVFITIDAAPADPKFCEIWVEDDGVGI
PEEARERIFDRGARLDTGKPGTGLGLAIVRDVAEIYGGSVELKESEDLGGLLSVLRLPRPATTAIK

Specific function: Member of the two-component regulatory system phoQ/phoP involved in virulence, adaptation to low Mg(2+) environments and the control of acid resistance genes. In presence of low periplasmic Mg(2+) concentrations, phoQ functions as a membrane- associated p

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1787374, Length=286, Percent_Identity=29.7202797202797, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI1790861, Length=334, Percent_Identity=29.3413173652695, Blast_Score=86, Evalue=7e-18,
Organism=Escherichia coli, GI1789808, Length=260, Percent_Identity=28.8461538461538, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI1786912, Length=197, Percent_Identity=30.9644670050761, Blast_Score=70, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR015014
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF08918 PhoQ_Sensor [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 51285; Mature: 51154

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS50109 HIS_KIN ; PS00211 ABC_TRANSPORTER_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAERGPAREAPPQPAPHTGSLARRMLLIAAGWISVLLLGGGLALDQTLTGLVTRNFDEQL
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHH
GYMLTAMVASAEIGPDGEVFFNRPLGDQRFLEPNSGLYWQISGQGHEDFPSRSLWDRSLR
HHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHH
TDLDNNYIDPRIDDSDQFEGERLRIIKRSVILPGSNTLWEFQVAASRGEIDSQIRRIRSI
HCCCCCCCCCCCCCCCCCCCHHHHHHHHHEECCCCCCEEEEEEECCCCCHHHHHHHHHHH
LIWSFLVLGFGLFVMAGLQTYYGLGPLRRVRLAIARMREGGASRVTDPLPLEVQPLVLEL
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
NALLEHSERQAEEARTHAGNLAHALKTPLTVVMNAATAQAPDLADTVIREAAVMRRQVDH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEECHHCCCCCHHHHHHHHHHHHHHHHHH
HLARARAVGRRAVGLSRAQVWESAEAVERAVVRLYPQVRLDMDGNRTAEVSIERQDLDEI
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEECHHHHHHH
LGNLIENAAKYGGGSVFITIDAAPADPKFCEIWVEDDGVGIPEEARERIFDRGARLDTGK
HHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCC
PGTGLGLAIVRDVAEIYGGSVELKESEDLGGLLSVLRLPRPATTAIK
CCCCHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
AERGPAREAPPQPAPHTGSLARRMLLIAAGWISVLLLGGGLALDQTLTGLVTRNFDEQL
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHH
GYMLTAMVASAEIGPDGEVFFNRPLGDQRFLEPNSGLYWQISGQGHEDFPSRSLWDRSLR
HHHHHHHHHHCCCCCCCCEEEECCCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHH
TDLDNNYIDPRIDDSDQFEGERLRIIKRSVILPGSNTLWEFQVAASRGEIDSQIRRIRSI
HCCCCCCCCCCCCCCCCCCCHHHHHHHHHEECCCCCCEEEEEEECCCCCHHHHHHHHHHH
LIWSFLVLGFGLFVMAGLQTYYGLGPLRRVRLAIARMREGGASRVTDPLPLEVQPLVLEL
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHH
NALLEHSERQAEEARTHAGNLAHALKTPLTVVMNAATAQAPDLADTVIREAAVMRRQVDH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEECHHCCCCCHHHHHHHHHHHHHHHHHH
HLARARAVGRRAVGLSRAQVWESAEAVERAVVRLYPQVRLDMDGNRTAEVSIERQDLDEI
HHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCEEEEEECHHHHHHH
LGNLIENAAKYGGGSVFITIDAAPADPKFCEIWVEDDGVGIPEEARERIFDRGARLDTGK
HHHHHHHHHHHCCCEEEEEEECCCCCCCEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCC
PGTGLGLAIVRDVAEIYGGSVELKESEDLGGLLSVLRLPRPATTAIK
CCCCHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]