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The map label for this gene is hrcA

Identifier: 87200076

GI number: 87200076

Start: 2200325

End: 2201389

Strand: Reverse

Name: hrcA

Synonym: Saro_2060

Alternate gene names: 87200076

Gene position: 2201389-2200325 (Counterclockwise)

Preceding gene: 87200081

Following gene: 87200075

Centisome position: 61.81

GC content: 67.7

Gene sequence:

>1065_bases
ATGACCGCACCCACGCTAACCGATCTGACAGACCGCGCCCGCGAGATTTTCCGTCTCGTGGTAGAAGGTTACATCGCGAG
CGGGCATCCGGTCGGTTCAAAGGCGCTGGCCGGGCATGGCAGCGTGAATCTTTCGCCCGCATCGATCCGCTCTGTCCTGC
AGGAACTCCAGGACGCGGGCCTGCTGGCCGCGCCGCACACCAGCGCCGGGCGCATGCCCACGGAATTCGGCCTGCGCCTG
TTCGTCGATGGCATCATGCAGGTGGCCGAGCCTTCGGCCGCTGAGCGCGCGCAGATCGAGCGCGGGCTGGTCGCGGGCGG
CACTATCGAGAGCGCGCTGGCCGCTGCCAGCACGGCCCTGTCCGAGCTTTCGGCAGGCGCGGCGGTGGTCATGGTGCCCA
AGCGTGAGCCGCGGCTGGTGCAGATCTCGTTCGTCCCGCTCTCGCCGCTGCGCGCGCTGGCGGTGCTGGTGAGCGAGGAC
GGGGGAATCGAGAACCGCGTGATCGACCTTCCCGAACCGGTTGGCCCGTCTGCGCTCGAGCAGGCGGGGAACTATCTGAC
CAGCCGGCTTCATGGGCGCACGCTTGGCGAGGCGGCGGGCGTGGTCCGGGCGGAAATCGCCGGCGGGCGTTCGGCGCTGG
ACGAGGCGAGTGCCGACCTGGTGCAGCGGGGACTCGTGGTTTGGACCCAGGACGCCACCGCGCGGCCCGTAATGGTCGTG
CGCGGGCAGGCGAACCTGCTTGACGAGACCGCGCTTCAGGACATCGAACGGGTTCGGCAATTGCTGGAGGAGCTGGAAGG
CGCCGAGGCCATTGCCCGCGTGCTGGACGCGGCCCGCGAGGCGCAGGCAACACGGATATTCATCGGCAGCGAGAATCGCC
TGTTCTCGCTTTCGGGGTCATCCGTGATCGCTTCCCCGTGGCGCGATGGCGACGGACGCGTGGTTGGCGTGGTGGGCGTT
ATCGGCCCAACCCGGTTGAATTATGCGCGCGTCGTCCCCATGGTGGACTTCACCGCCCAGACCCTGGGCAAATTCATCGG
ACAAGACGGATTTTCGAGAAAATGA

Upstream 100 bases:

>100_bases
CGCGCGGCCGGAAGGTCGCATGAAAGATTTCCCTCGCAAGTTTGCGCGGCCTCTGGCGCATTGCTCTTGAGCCTGCAAGA
GCGGTGAATAGATTGTTGCC

Downstream 100 bases:

>100_bases
GCGATAACGACACGCGCCCCACCGACGCAGAAGTCGAAGCCGAGCTGAAGGGCGTGCCCGAGGACATGATTGACCGGACG
TCCGATAACGATGAACTGGC

Product: heat-inducible transcription repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 354; Mature: 353

Protein sequence:

>354_residues
MTAPTLTDLTDRAREIFRLVVEGYIASGHPVGSKALAGHGSVNLSPASIRSVLQELQDAGLLAAPHTSAGRMPTEFGLRL
FVDGIMQVAEPSAAERAQIERGLVAGGTIESALAAASTALSELSAGAAVVMVPKREPRLVQISFVPLSPLRALAVLVSED
GGIENRVIDLPEPVGPSALEQAGNYLTSRLHGRTLGEAAGVVRAEIAGGRSALDEASADLVQRGLVVWTQDATARPVMVV
RGQANLLDETALQDIERVRQLLEELEGAEAIARVLDAAREAQATRIFIGSENRLFSLSGSSVIASPWRDGDGRVVGVVGV
IGPTRLNYARVVPMVDFTAQTLGKFIGQDGFSRK

Sequences:

>Translated_354_residues
MTAPTLTDLTDRAREIFRLVVEGYIASGHPVGSKALAGHGSVNLSPASIRSVLQELQDAGLLAAPHTSAGRMPTEFGLRL
FVDGIMQVAEPSAAERAQIERGLVAGGTIESALAAASTALSELSAGAAVVMVPKREPRLVQISFVPLSPLRALAVLVSED
GGIENRVIDLPEPVGPSALEQAGNYLTSRLHGRTLGEAAGVVRAEIAGGRSALDEASADLVQRGLVVWTQDATARPVMVV
RGQANLLDETALQDIERVRQLLEELEGAEAIARVLDAAREAQATRIFIGSENRLFSLSGSSVIASPWRDGDGRVVGVVGV
IGPTRLNYARVVPMVDFTAQTLGKFIGQDGFSRK
>Mature_353_residues
TAPTLTDLTDRAREIFRLVVEGYIASGHPVGSKALAGHGSVNLSPASIRSVLQELQDAGLLAAPHTSAGRMPTEFGLRLF
VDGIMQVAEPSAAERAQIERGLVAGGTIESALAAASTALSELSAGAAVVMVPKREPRLVQISFVPLSPLRALAVLVSEDG
GIENRVIDLPEPVGPSALEQAGNYLTSRLHGRTLGEAAGVVRAEIAGGRSALDEASADLVQRGLVVWTQDATARPVMVVR
GQANLLDETALQDIERVRQLLEELEGAEAIARVLDAAREAQATRIFIGSENRLFSLSGSSVIASPWRDGDGRVVGVVGVI
GPTRLNYARVVPMVDFTAQTLGKFIGQDGFSRK

Specific function: Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons

COG id: COG1420

COG function: function code K; Transcriptional regulator of heat shock gene

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hrcA family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HRCA_NOVAD (Q2G6M4)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_497333.1
- ProteinModelPortal:   Q2G6M4
- SMR:   Q2G6M4
- STRING:   Q2G6M4
- GeneID:   3917707
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_2060
- NMPDR:   fig|48935.1.peg.2088
- eggNOG:   COG1420
- HOGENOM:   HBG729878
- OMA:   LEQPHTS
- ProtClustDB:   PRK00082
- BioCyc:   NARO279238:SARO_2060-MONOMER
- GO:   GO:0006350
- HAMAP:   MF_00081
- InterPro:   IPR002571
- InterPro:   IPR021153
- InterPro:   IPR011991
- Gene3D:   G3DSA:1.10.10.10
- PIRSF:   PIRSF005485
- TIGRFAMs:   TIGR00331

Pfam domain/function: PF01628 HrcA

EC number: NA

Molecular weight: Translated: 37235; Mature: 37104

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPTLTDLTDRAREIFRLVVEGYIASGHPVGSKALAGHGSVNLSPASIRSVLQELQDAG
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
LLAAPHTSAGRMPTEFGLRLFVDGIMQVAEPSAAERAQIERGLVAGGTIESALAAASTAL
CEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHH
SELSAGAAVVMVPKREPRLVQISFVPLSPLRALAVLVSEDGGIENRVIDLPEPVGPSALE
HHHCCCCEEEEECCCCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHH
QAGNYLTSRLHGRTLGEAAGVVRAEIAGGRSALDEASADLVQRGLVVWTQDATARPVMVV
HHHHHHHHHHCCCHHHHHHCHHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCCCCEEEE
RGQANLLDETALQDIERVRQLLEELEGAEAIARVLDAAREAQATRIFIGSENRLFSLSGS
ECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEEEEECCCCEEEECCC
SVIASPWRDGDGRVVGVVGVIGPTRLNYARVVPMVDFTAQTLGKFIGQDGFSRK
CEEECCCCCCCCEEEEEEEECCCCCCCHHHCCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
TAPTLTDLTDRAREIFRLVVEGYIASGHPVGSKALAGHGSVNLSPASIRSVLQELQDAG
CCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
LLAAPHTSAGRMPTEFGLRLFVDGIMQVAEPSAAERAQIERGLVAGGTIESALAAASTAL
CEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHH
SELSAGAAVVMVPKREPRLVQISFVPLSPLRALAVLVSEDGGIENRVIDLPEPVGPSALE
HHHCCCCEEEEECCCCCCEEEEEEECCCHHHHHHHHHCCCCCCCCCEEECCCCCCCHHHH
QAGNYLTSRLHGRTLGEAAGVVRAEIAGGRSALDEASADLVQRGLVVWTQDATARPVMVV
HHHHHHHHHHCCCHHHHHHCHHHHHHCCCHHHHHHHHHHHHHCCCEEEECCCCCCCEEEE
RGQANLLDETALQDIERVRQLLEELEGAEAIARVLDAAREAQATRIFIGSENRLFSLSGS
ECCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEEEEECCCCEEEECCC
SVIASPWRDGDGRVVGVVGVIGPTRLNYARVVPMVDFTAQTLGKFIGQDGFSRK
CEEECCCCCCCCEEEEEEEECCCCCCCHHHCCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA