Click here to switch to the map view.

The map label for this gene is copR [H]

Identifier: 87199616

GI number: 87199616

Start: 1662598

End: 1663284

Strand: Direct

Name: copR [H]

Synonym: Saro_1599

Alternate gene names: 87199616

Gene position: 1662598-1663284 (Clockwise)

Preceding gene: 87199611

Following gene: 87199617

Centisome position: 46.68

GC content: 65.07

Gene sequence:

>687_bases
ATGAGCCAGAAGATCCTGCTTGTTGAAGACGATGCCGACACCGCCGCGTTCATCGTCGGCGGCCTGGCCGAGGAGGGCTT
CGTGGTCGATCGCGCCCGCGATGGGCGAGAGGGTCTGTTCATGGGTACGGACCACACATATCAGTGCATCGTGCTCGACC
GGATGTTGCCGGGGTTGGACGGCATGGCGGTTCTGGCAGCGCTGCGCGGTGCCGGGGTGCACACGCCGGTCATCATCCTT
TCGGCCCTTGGTGCGACGGAAGATCGGATCACGGGCCTGACCCGGGGGGCGGACGACTATCTGGCCAAGCCCTTTGCCTT
TGCGGAACTGCTGGCGCGTATCCGGCTTCTGGTCCGGAGGGGCAGCGGGGCGCCGACCGAACAGACCAAGCTGTCCTGCG
GCGACCTTGAAATGGACCTGCTTTCGCGCCGCGTTCGACGCGGGGCGCGGGCAATCGACCTCCAGCCGCGCGAATTCCGC
CTGCTCGAGTTCCTGCTGCGCCATGCAGATCAGGTCGTGACCCGAACGATGCTTCTGGAAGGCGTCTGGGACTATCACTT
CGATCCAGGCACCAACGTGATCGACGTCCACATCAGTCGCCTGCGCAAGAAGATCGACGAGGGCGAGGTCGTCGCCTTGC
TTCACACCGTGCGGGGCGCCGGTTACCGCATCGGCACAGGTGCGTGA

Upstream 100 bases:

>100_bases
TGGAGCCAACATGAAAAATCGGCAATGTTGGGGCCAATCCCTCGCGATTGCCGGGCGTGCATGGCATGACAGTACCTTCC
AGAGCGTGCCGAGTTGCCGG

Downstream 100 bases:

>100_bases
TGCTGCGCGGGATGCTGCGCTCGACGACCGTGCGGTTCGCCGCGCTCGTGTTCCTGCTGCAGGTCGTGGCAGCGGCGTTC
ATGCTGGGCGGCCTTGGCGC

Product: two component transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 227

Protein sequence:

>228_residues
MSQKILLVEDDADTAAFIVGGLAEEGFVVDRARDGREGLFMGTDHTYQCIVLDRMLPGLDGMAVLAALRGAGVHTPVIIL
SALGATEDRITGLTRGADDYLAKPFAFAELLARIRLLVRRGSGAPTEQTKLSCGDLEMDLLSRRVRRGARAIDLQPREFR
LLEFLLRHADQVVTRTMLLEGVWDYHFDPGTNVIDVHISRLRKKIDEGEVVALLHTVRGAGYRIGTGA

Sequences:

>Translated_228_residues
MSQKILLVEDDADTAAFIVGGLAEEGFVVDRARDGREGLFMGTDHTYQCIVLDRMLPGLDGMAVLAALRGAGVHTPVIIL
SALGATEDRITGLTRGADDYLAKPFAFAELLARIRLLVRRGSGAPTEQTKLSCGDLEMDLLSRRVRRGARAIDLQPREFR
LLEFLLRHADQVVTRTMLLEGVWDYHFDPGTNVIDVHISRLRKKIDEGEVVALLHTVRGAGYRIGTGA
>Mature_227_residues
SQKILLVEDDADTAAFIVGGLAEEGFVVDRARDGREGLFMGTDHTYQCIVLDRMLPGLDGMAVLAALRGAGVHTPVIILS
ALGATEDRITGLTRGADDYLAKPFAFAELLARIRLLVRRGSGAPTEQTKLSCGDLEMDLLSRRVRRGARAIDLQPREFRL
LEFLLRHADQVVTRTMLLEGVWDYHFDPGTNVIDVHISRLRKKIDEGEVVALLHTVRGAGYRIGTGA

Specific function: Member of the two-component regulatory system CopS/CopR. Involved in the activation of copper resistance gene operon CopABCD. Phosphorylation of CopR by CopS would convert it into an active state to induce expression of the cop operon by binding to a spec

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=219, Percent_Identity=47.4885844748858, Blast_Score=201, Evalue=4e-53,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=42.9223744292237, Blast_Score=179, Evalue=1e-46,
Organism=Escherichia coli, GI1786599, Length=234, Percent_Identity=37.6068376068376, Blast_Score=144, Evalue=3e-36,
Organism=Escherichia coli, GI1789402, Length=222, Percent_Identity=36.9369369369369, Blast_Score=140, Evalue=9e-35,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=37.8378378378378, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI1789809, Length=227, Percent_Identity=35.2422907488987, Blast_Score=123, Evalue=8e-30,
Organism=Escherichia coli, GI1786911, Length=222, Percent_Identity=34.2342342342342, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1787375, Length=219, Percent_Identity=31.0502283105023, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI2367329, Length=227, Percent_Identity=38.3259911894273, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI1790860, Length=223, Percent_Identity=31.390134529148, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1788394, Length=232, Percent_Identity=30.1724137931034, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI145693140, Length=231, Percent_Identity=33.3333333333333, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=29.004329004329, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=28.0701754385965, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI1788550, Length=119, Percent_Identity=31.0924369747899, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 25035; Mature: 24904

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQKILLVEDDADTAAFIVGGLAEEGFVVDRARDGREGLFMGTDHTYQCIVLDRMLPGLD
CCCCEEEEECCCCCCHHHHHCCCCCCEEEECCCCCCCCEEECCCCCEEEEEEEHHCCCCC
GMAVLAALRGAGVHTPVIILSALGATEDRITGLTRGADDYLAKPFAFAELLARIRLLVRR
HHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHHHC
GSGAPTEQTKLSCGDLEMDLLSRRVRRGARAIDLQPREFRLLEFLLRHADQVVTRTMLLE
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
GVWDYHFDPGTNVIDVHISRLRKKIDEGEVVALLHTVRGAGYRIGTGA
HHHHCCCCCCCCEEHHHHHHHHHHCCCCCEEHHHHHHCCCCEECCCCC
>Mature Secondary Structure 
SQKILLVEDDADTAAFIVGGLAEEGFVVDRARDGREGLFMGTDHTYQCIVLDRMLPGLD
CCCEEEEECCCCCCHHHHHCCCCCCEEEECCCCCCCCEEECCCCCEEEEEEEHHCCCCC
GMAVLAALRGAGVHTPVIILSALGATEDRITGLTRGADDYLAKPFAFAELLARIRLLVRR
HHHHHHHHHCCCCCHHHHHHHHCCCCHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHHHC
GSGAPTEQTKLSCGDLEMDLLSRRVRRGARAIDLQPREFRLLEFLLRHADQVVTRTMLLE
CCCCCCCCCCCCCCCCCHHHHHHHHHCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
GVWDYHFDPGTNVIDVHISRLRKKIDEGEVVALLHTVRGAGYRIGTGA
HHHHCCCCCCCCEEHHHHHHHHHHCCCCCEEHHHHHHCCCCEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8449873; 8078459 [H]