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The map label for this gene is fadB [H]

Identifier: 87198891

GI number: 87198891

Start: 923513

End: 924769

Strand: Reverse

Name: fadB [H]

Synonym: Saro_0869

Alternate gene names: 87198891

Gene position: 924769-923513 (Counterclockwise)

Preceding gene: 87198892

Following gene: 87198890

Centisome position: 25.97

GC content: 65.63

Gene sequence:

>1257_bases
ATGTCCGACCCCATTCCCGGCGCCAAGGAGCACATCGACGCGGCGCGCAAGCTTGCCGCGACCATCGATGACATCCCGGC
CGACACCGCGCTGCTCCCGATCAATCGCGTCGGCGTGATCGGCGCCGGCACGATGGGCGGCGGCATCACCATGAACTTCC
TGACCGCAGGGATTCCGGTGACGATCGTGGAAATGACGCAGGAAGCGCTCGACCGCGGCGTCGCCACGATGGCCCGGAAC
TACGAGAACACCGTCAAGCGCGGGAAGATGGACGCCGCCGACGCACAGGCCGCGATGGCGCGCCTGACGCCGACGCTCGA
CTTCGGTGCCCTGGCCGAAGCGGACCTCGTGATCGAGGCGGTCTATGAAAGCATGGACGTGAAGAAGGACGTGTTCGGAC
GCCTCGACAAGGTGGCCAAGCCGGGTGCGATCCTCGCGTCGAACACCAGCTATCTCGACATCGACGAGATCGCGAGCGTG
ACGAGCCGGCCCGAAGCGGTGATGGGCATGCACTTCTTCTCGCCCGCCAACGTGATGAAGCTGCTGGAAGTGGTGCGCGG
CAAGGCAACCGGGAAGGCGCAACTGGCCACGGTGATGGCGCTGTCGGTGAAGATCGGCAAGGTGCCGGTCGTGTCGGGCG
TCTGCCACGGCTTCATCGGCAACCGCATGCTTTCGCCCCGTCAGGCGCAGGCGCAGGCGCTGATCATGGAAGGCGCGAAT
TACTGGGACGTGGACGAGGCGCTGCTGGAATTCGGTTTCCCGATGGGACCGTGGCAGATGGCCGACCTCGCCGGCGTGGA
CATCGGCTGGCACCGCGATCCCAGCCGCATCGAAACCCTGCGCGATGCACTGTGCGCGGTCGGTCGCTGGGGGCAGAAGA
CCAAGAAGGGCTTCTACGACTATGACGACAACCGCCAGCGCACGCCTTCGGACGAGGTGAAGGCGATCATCGCCGACTTC
GCGAAGAAGGCCGGCAAGCCGCAGCGCGAGATCGGCAAGGACGAGATCCGCGAGCGCCTGCTCTATCCGATGATCAGCGA
AGGCGCGCTGATCCTGGAGGAAGGCATTTCGCAGCGGGCAAGCGACATCGATACGGTCTGGCTCAACGGCTATGGCTGGC
CGGCGTGGACCGGCGGGCCGATGTTCTGGGCCGATCATATCGGACTGGATACCGTGGTTGCGGGCCTGAAGAAGCACGGG
CTGCCGGTGGCACCTCTGCTGGAGCGCAAGGCGGCCGCGGGCGAAACGTTCAACTGA

Upstream 100 bases:

>100_bases
TATCCCTCGTTCATCTATCCCATCCGGCGTCAGTTGAAGACGCTGATCTACAGCGCGCTGACGGAAAGCCGCGCCTGACA
ACTGCCTAGGAGAAACGACG

Downstream 100 bases:

>100_bases
ACCGGAGAACGGTGATGCGGATCGAGGATATCGTCGAAAGCGAATTCACGCCGCTGAGCGACATAATCCGCGCCCATGCC
GCAAGGCGGGGCGCGGCAGT

Product: 3-hydroxyacyl-CoA dehydrogenase

Products: NA

Alternate protein names: Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimerase; 3-hydroxyacyl-CoA dehydrogenase [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MSDPIPGAKEHIDAARKLAATIDDIPADTALLPINRVGVIGAGTMGGGITMNFLTAGIPVTIVEMTQEALDRGVATMARN
YENTVKRGKMDAADAQAAMARLTPTLDFGALAEADLVIEAVYESMDVKKDVFGRLDKVAKPGAILASNTSYLDIDEIASV
TSRPEAVMGMHFFSPANVMKLLEVVRGKATGKAQLATVMALSVKIGKVPVVSGVCHGFIGNRMLSPRQAQAQALIMEGAN
YWDVDEALLEFGFPMGPWQMADLAGVDIGWHRDPSRIETLRDALCAVGRWGQKTKKGFYDYDDNRQRTPSDEVKAIIADF
AKKAGKPQREIGKDEIRERLLYPMISEGALILEEGISQRASDIDTVWLNGYGWPAWTGGPMFWADHIGLDTVVAGLKKHG
LPVAPLLERKAAAGETFN

Sequences:

>Translated_418_residues
MSDPIPGAKEHIDAARKLAATIDDIPADTALLPINRVGVIGAGTMGGGITMNFLTAGIPVTIVEMTQEALDRGVATMARN
YENTVKRGKMDAADAQAAMARLTPTLDFGALAEADLVIEAVYESMDVKKDVFGRLDKVAKPGAILASNTSYLDIDEIASV
TSRPEAVMGMHFFSPANVMKLLEVVRGKATGKAQLATVMALSVKIGKVPVVSGVCHGFIGNRMLSPRQAQAQALIMEGAN
YWDVDEALLEFGFPMGPWQMADLAGVDIGWHRDPSRIETLRDALCAVGRWGQKTKKGFYDYDDNRQRTPSDEVKAIIADF
AKKAGKPQREIGKDEIRERLLYPMISEGALILEEGISQRASDIDTVWLNGYGWPAWTGGPMFWADHIGLDTVVAGLKKHG
LPVAPLLERKAAAGETFN
>Mature_417_residues
SDPIPGAKEHIDAARKLAATIDDIPADTALLPINRVGVIGAGTMGGGITMNFLTAGIPVTIVEMTQEALDRGVATMARNY
ENTVKRGKMDAADAQAAMARLTPTLDFGALAEADLVIEAVYESMDVKKDVFGRLDKVAKPGAILASNTSYLDIDEIASVT
SRPEAVMGMHFFSPANVMKLLEVVRGKATGKAQLATVMALSVKIGKVPVVSGVCHGFIGNRMLSPRQAQAQALIMEGANY
WDVDEALLEFGFPMGPWQMADLAGVDIGWHRDPSRIETLRDALCAVGRWGQKTKKGFYDYDDNRQRTPSDEVKAIIADFA
KKAGKPQREIGKDEIRERLLYPMISEGALILEEGISQRASDIDTVWLNGYGWPAWTGGPMFWADHIGLDTVVAGLKKHGL
PVAPLLERKAAAGETFN

Specific function: Catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities [H]

COG id: COG1250

COG function: function code I; 3-hydroxyacyl-CoA dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the 3- hydroxyacyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI261878539, Length=389, Percent_Identity=43.4447300771208, Blast_Score=307, Evalue=1e-83,
Organism=Homo sapiens, GI68989263, Length=389, Percent_Identity=43.4447300771208, Blast_Score=307, Evalue=1e-83,
Organism=Homo sapiens, GI20127408, Length=379, Percent_Identity=32.1899736147757, Blast_Score=200, Evalue=2e-51,
Organism=Homo sapiens, GI296179429, Length=287, Percent_Identity=33.4494773519164, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI296179427, Length=304, Percent_Identity=31.5789473684211, Blast_Score=141, Evalue=1e-33,
Organism=Escherichia coli, GI1790281, Length=344, Percent_Identity=33.7209302325581, Blast_Score=219, Evalue=2e-58,
Organism=Escherichia coli, GI1788682, Length=378, Percent_Identity=30.6878306878307, Blast_Score=182, Evalue=5e-47,
Organism=Escherichia coli, GI1787661, Length=289, Percent_Identity=36.3321799307958, Blast_Score=170, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI71985923, Length=411, Percent_Identity=34.5498783454988, Blast_Score=250, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI71985930, Length=374, Percent_Identity=35.5614973262032, Blast_Score=235, Evalue=3e-62,
Organism=Caenorhabditis elegans, GI17508951, Length=407, Percent_Identity=33.4152334152334, Blast_Score=224, Evalue=4e-59,
Organism=Caenorhabditis elegans, GI17508953, Length=407, Percent_Identity=33.4152334152334, Blast_Score=224, Evalue=6e-59,
Organism=Caenorhabditis elegans, GI17558304, Length=380, Percent_Identity=35, Blast_Score=218, Evalue=4e-57,
Organism=Caenorhabditis elegans, GI25144276, Length=302, Percent_Identity=35.0993377483444, Blast_Score=191, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI17549919, Length=290, Percent_Identity=34.4827586206897, Blast_Score=154, Evalue=6e-38,
Organism=Caenorhabditis elegans, GI17553560, Length=295, Percent_Identity=32.8813559322034, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI17563036, Length=288, Percent_Identity=32.6388888888889, Blast_Score=138, Evalue=7e-33,
Organism=Drosophila melanogaster, GI19921000, Length=395, Percent_Identity=33.6708860759494, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI24583077, Length=395, Percent_Identity=33.6708860759494, Blast_Score=215, Evalue=4e-56,
Organism=Drosophila melanogaster, GI24583079, Length=395, Percent_Identity=33.6708860759494, Blast_Score=215, Evalue=4e-56,
Organism=Drosophila melanogaster, GI45549573, Length=240, Percent_Identity=26.25, Blast_Score=66, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006180
- InterPro:   IPR006176
- InterPro:   IPR006108
- InterPro:   IPR008927
- InterPro:   IPR001753
- InterPro:   IPR013328
- InterPro:   IPR012799
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00725 3HCDH; PF02737 3HCDH_N; PF00378 ECH [H]

EC number: =4.2.1.17; =5.1.2.3; =5.3.3.8; =1.1.1.35 [H]

Molecular weight: Translated: 45138; Mature: 45007

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDPIPGAKEHIDAARKLAATIDDIPADTALLPINRVGVIGAGTMGGGITMNFLTAGIPV
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEECCCCCCCEEEHHHHCCCCE
TIVEMTQEALDRGVATMARNYENTVKRGKMDAADAQAAMARLTPTLDFGALAEADLVIEA
EHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
VYESMDVKKDVFGRLDKVAKPGAILASNTSYLDIDEIASVTSRPEAVMGMHFFSPANVMK
HHHHHCHHHHHHHHHHHHCCCCEEEECCCCEECHHHHHHHHCCCHHHHHHHHCCHHHHHH
LLEVVRGKATGKAQLATVMALSVKIGKVPVVSGVCHGFIGNRMLSPRQAQAQALIMEGAN
HHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCC
YWDVDEALLEFGFPMGPWQMADLAGVDIGWHRDPSRIETLRDALCAVGRWGQKTKKGFYD
CCCHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCC
YDDNRQRTPSDEVKAIIADFAKKAGKPQREIGKDEIRERLLYPMISEGALILEEGISQRA
CCCCCCCCCHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
SDIDTVWLNGYGWPAWTGGPMFWADHIGLDTVVAGLKKHGLPVAPLLERKAAAGETFN
CCCCEEEECCCCCCCCCCCCCHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SDPIPGAKEHIDAARKLAATIDDIPADTALLPINRVGVIGAGTMGGGITMNFLTAGIPV
CCCCCCHHHHHHHHHHHHHHHHCCCCCCEEECCCCCCEEECCCCCCCEEEHHHHCCCCE
TIVEMTQEALDRGVATMARNYENTVKRGKMDAADAQAAMARLTPTLDFGALAEADLVIEA
EHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHH
VYESMDVKKDVFGRLDKVAKPGAILASNTSYLDIDEIASVTSRPEAVMGMHFFSPANVMK
HHHHHCHHHHHHHHHHHHCCCCEEEECCCCEECHHHHHHHHCCCHHHHHHHHCCHHHHHH
LLEVVRGKATGKAQLATVMALSVKIGKVPVVSGVCHGFIGNRMLSPRQAQAQALIMEGAN
HHHHHHCCCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCC
YWDVDEALLEFGFPMGPWQMADLAGVDIGWHRDPSRIETLRDALCAVGRWGQKTKKGFYD
CCCHHHHHHHCCCCCCCCHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCHHHHCCCCC
YDDNRQRTPSDEVKAIIADFAKKAGKPQREIGKDEIRERLLYPMISEGALILEEGISQRA
CCCCCCCCCHHHHHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHHHCCCHHHHHHHHHHHH
SDIDTVWLNGYGWPAWTGGPMFWADHIGLDTVVAGLKKHGLPVAPLLERKAAAGETFN
CCCCEEEECCCCCCCCCCCCCHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA