Click here to switch to the map view.

The map label for this gene is dxs

Identifier: 87198187

GI number: 87198187

Start: 158147

End: 160069

Strand: Direct

Name: dxs

Synonym: Saro_0161

Alternate gene names: 87198187

Gene position: 158147-160069 (Clockwise)

Preceding gene: 87198186

Following gene: 87198190

Centisome position: 4.44

GC content: 65.16

Gene sequence:

>1923_bases
ATGAGCCAAGAACCGGCAACGCCGTTGCTAGACACGGTCAAGACCCCAGACGACCTTCGCAAGCTTGCGCCAACGCAGCT
CCGCCAACTGGCGGACGAACTGCGTGTCGAGATGATATCCGCCGTCGGCCAGACGGGCGGGCACCTCGGTTCCGGCCTGG
GCGTGGTCGAGCTGACCGTGGCAATCCACTATGTGTTCAACACGCCCGAGGACAGGCTTGTGTGGGACGTGGGCCACCAG
GCCTATCCTCACAAGATCCTGACCGGGCGGCGCGACCGGATCCGCACCCTGCGTCAGGCAGGCGGCCTTTCCGGCTTCAC
CAAGCGCAGCGAGAGCGAGTACGACCCTTTCGGGACGGCGCACTCGTCCACCTCGATTTCAGCGGCGCTCGGCTTTGCCA
TCGCTAACAAGCTTTCGGGCAGACTGGGCAAGGGCATCGCGGTGATCGGCGATGGCGCCATGAGCGCGGGCATGGCCTAC
GAAGCGATGAACAACGCCGAGGCCGCAGGCAATCGGCTGATCGTCATTCTCAACGACAACGACATGTCCATCGCGCCGCC
CGTCGGCGGGCTTTCGGCCTATCTGGCGCGGCTGGTTTCGTCCGGTCCGTTTTTGGGGCTCCGCGACATTGCCCGCAGGC
TTTCGCGCAAGCTGCCCCGCCCGCTGCACGAAGCCGCGCGCAAGACCGACGAGTTCGCTCGCGGCATGGCGATGGGCGGT
ACCCTGTTCGAGGAGCTTGGCTTCTATTACGTCGGCCCGATTGACGGCCACAACATCGACCAGCTCATCCCGGTTCTCGA
AAACGTGCGCGATGCGGCCGAAGGGCCGTGTCTGATCCATGTGGTGACGCAGAAGGGCAAGGGGTATGCCCCTGCCGAAG
CCGCGGCCGACAAGTATCACGGCGTGCAGAAGTTCGACGTCATCACTGGTGAGCAGGTGAAGGCCAAGGCTGCCGCGCCC
GCCTATCAGAACGTGTTCGGCGAGACGCTGGCCAAGCTGGCGGACGCCGACCCGACGATCTGCGCGATCACCGCCGCAAT
GCCCAGCGGCACCGGCGTCGACAAGTTTGCCAAGGCTCATCCCGACCGCACCTTCGATGTCGGCATTGCCGAACAGCATG
CGGTGACCTTTGCTGCGGGCCTCGCCGCAGAAGGGATGCGGCCGTTCTGCGCGATCTATTCGACCTTCCTGCAGCGCGCT
TTCGACCAGGTCGTCCACGACGTGGCGATCCAGAACCTGCCGGTGCGCTTCGCCATCGACCGCGCAGGCCTGGTGGGCGC
GGATGGTGCAACCCACGCCGGTTCGTTCGACGTGACCTATCTGGCAACGTTGCCGAACCTGGTCGTCATGGCTGCTGCCG
ACGAGGCGGAACTGGTCCACATGACCTATACCGCGGCACTGCATGACAGCGGCCCGATCGCTTTCCGCTATCCGCGCGGA
AACGGTGTGGGCGTGCCACTGCCCGAGGTTCCCGAGCGGCTCGAGATTGGCAAGGGCCGGATCATCAGGCAGGGTAGCAA
GGTCGCGCTGCTGTCGTTGGGTACGCGGCTGGCAGAGGCGCTCAAGGCTGCCGATCAGCTCGACGCCAGGGGATTGTCGA
CGACTGTCGCCGACCTGCGCTTTGCCAAGCCGCTGGACGTGGCGCTGATCCGTCAGCTGATGACCACGCATGACGTGATC
GTGACGGTGGAGGAAGGCTCGATCGGCGGCCTGGGCGCGCACGTCCTGACCATGGCGAGCGACGAGGGACTGGTGGACGG
GGGCCTCAAGATCAGGACCATGCGCTTGCCCGATCTGTTCCAGGACCACGACGCGCCTGAAAAGCAGTATGACGAGGCGG
GGCTCAACGCGCCGCATATCGTCGATACCGTACTGAAGGCGCTGCGGCACAACAGCGCCGGGGTAAGTGAAGCGCGGGCC
TGA

Upstream 100 bases:

>100_bases
TGCGCTGCTTCTGCCCGAGCGGAGACCCCGGCACATCGGGAAGGTTCGTTTCACCTGATCCCGTTCGACACCGCGCGCGC
ATGCGTGTAAGGGCGGTCGG

Downstream 100 bases:

>100_bases
CGCAGGAGCCGCGCCACCCGTTCAGGCGATCAGCCGATCCACATCCACAAGCCGGCAGGAATGCCGAACAACTCCCAGTG
GATCAGGGTGATGATTACCC

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 640; Mature: 639

Protein sequence:

>640_residues
MSQEPATPLLDTVKTPDDLRKLAPTQLRQLADELRVEMISAVGQTGGHLGSGLGVVELTVAIHYVFNTPEDRLVWDVGHQ
AYPHKILTGRRDRIRTLRQAGGLSGFTKRSESEYDPFGTAHSSTSISAALGFAIANKLSGRLGKGIAVIGDGAMSAGMAY
EAMNNAEAAGNRLIVILNDNDMSIAPPVGGLSAYLARLVSSGPFLGLRDIARRLSRKLPRPLHEAARKTDEFARGMAMGG
TLFEELGFYYVGPIDGHNIDQLIPVLENVRDAAEGPCLIHVVTQKGKGYAPAEAAADKYHGVQKFDVITGEQVKAKAAAP
AYQNVFGETLAKLADADPTICAITAAMPSGTGVDKFAKAHPDRTFDVGIAEQHAVTFAAGLAAEGMRPFCAIYSTFLQRA
FDQVVHDVAIQNLPVRFAIDRAGLVGADGATHAGSFDVTYLATLPNLVVMAAADEAELVHMTYTAALHDSGPIAFRYPRG
NGVGVPLPEVPERLEIGKGRIIRQGSKVALLSLGTRLAEALKAADQLDARGLSTTVADLRFAKPLDVALIRQLMTTHDVI
VTVEEGSIGGLGAHVLTMASDEGLVDGGLKIRTMRLPDLFQDHDAPEKQYDEAGLNAPHIVDTVLKALRHNSAGVSEARA

Sequences:

>Translated_640_residues
MSQEPATPLLDTVKTPDDLRKLAPTQLRQLADELRVEMISAVGQTGGHLGSGLGVVELTVAIHYVFNTPEDRLVWDVGHQ
AYPHKILTGRRDRIRTLRQAGGLSGFTKRSESEYDPFGTAHSSTSISAALGFAIANKLSGRLGKGIAVIGDGAMSAGMAY
EAMNNAEAAGNRLIVILNDNDMSIAPPVGGLSAYLARLVSSGPFLGLRDIARRLSRKLPRPLHEAARKTDEFARGMAMGG
TLFEELGFYYVGPIDGHNIDQLIPVLENVRDAAEGPCLIHVVTQKGKGYAPAEAAADKYHGVQKFDVITGEQVKAKAAAP
AYQNVFGETLAKLADADPTICAITAAMPSGTGVDKFAKAHPDRTFDVGIAEQHAVTFAAGLAAEGMRPFCAIYSTFLQRA
FDQVVHDVAIQNLPVRFAIDRAGLVGADGATHAGSFDVTYLATLPNLVVMAAADEAELVHMTYTAALHDSGPIAFRYPRG
NGVGVPLPEVPERLEIGKGRIIRQGSKVALLSLGTRLAEALKAADQLDARGLSTTVADLRFAKPLDVALIRQLMTTHDVI
VTVEEGSIGGLGAHVLTMASDEGLVDGGLKIRTMRLPDLFQDHDAPEKQYDEAGLNAPHIVDTVLKALRHNSAGVSEARA
>Mature_639_residues
SQEPATPLLDTVKTPDDLRKLAPTQLRQLADELRVEMISAVGQTGGHLGSGLGVVELTVAIHYVFNTPEDRLVWDVGHQA
YPHKILTGRRDRIRTLRQAGGLSGFTKRSESEYDPFGTAHSSTSISAALGFAIANKLSGRLGKGIAVIGDGAMSAGMAYE
AMNNAEAAGNRLIVILNDNDMSIAPPVGGLSAYLARLVSSGPFLGLRDIARRLSRKLPRPLHEAARKTDEFARGMAMGGT
LFEELGFYYVGPIDGHNIDQLIPVLENVRDAAEGPCLIHVVTQKGKGYAPAEAAADKYHGVQKFDVITGEQVKAKAAAPA
YQNVFGETLAKLADADPTICAITAAMPSGTGVDKFAKAHPDRTFDVGIAEQHAVTFAAGLAAEGMRPFCAIYSTFLQRAF
DQVVHDVAIQNLPVRFAIDRAGLVGADGATHAGSFDVTYLATLPNLVVMAAADEAELVHMTYTAALHDSGPIAFRYPRGN
GVGVPLPEVPERLEIGKGRIIRQGSKVALLSLGTRLAEALKAADQLDARGLSTTVADLRFAKPLDVALIRQLMTTHDVIV
TVEEGSIGGLGAHVLTMASDEGLVDGGLKIRTMRLPDLFQDHDAPEKQYDEAGLNAPHIVDTVLKALRHNSAGVSEARA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI133778974, Length=608, Percent_Identity=24.3421052631579, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI225637461, Length=543, Percent_Identity=24.4935543278085, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI225637463, Length=543, Percent_Identity=24.4935543278085, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI225637459, Length=543, Percent_Identity=24.4935543278085, Blast_Score=99, Evalue=2e-20,
Organism=Homo sapiens, GI205277463, Length=627, Percent_Identity=23.6044657097289, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI4507521, Length=627, Percent_Identity=23.6044657097289, Blast_Score=95, Evalue=2e-19,
Organism=Homo sapiens, GI156564403, Length=237, Percent_Identity=27.0042194092827, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1786622, Length=613, Percent_Identity=49.9184339314845, Blast_Score=588, Evalue=1e-169,
Organism=Caenorhabditis elegans, GI17539652, Length=430, Percent_Identity=27.2093023255814, Blast_Score=118, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17538422, Length=293, Percent_Identity=29.3515358361775, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24645119, Length=537, Percent_Identity=25.6983240223464, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI45551847, Length=537, Percent_Identity=25.6983240223464, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI45550715, Length=537, Percent_Identity=25.6983240223464, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI24666278, Length=264, Percent_Identity=29.5454545454545, Blast_Score=88, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_NOVAD (Q2GC13)

Other databases:

- EMBL:   CP000248
- RefSeq:   YP_495444.1
- ProteinModelPortal:   Q2GC13
- SMR:   Q2GC13
- STRING:   Q2GC13
- GeneID:   3918296
- GenomeReviews:   CP000248_GR
- KEGG:   nar:Saro_0161
- NMPDR:   fig|48935.1.peg.3635
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- PhylomeDB:   Q2GC13
- ProtClustDB:   PRK05444
- BioCyc:   NARO279238:SARO_0161-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR001017
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF00676 E1_dh; PF02779 Transket_pyr; PF02780 Transketolase_C; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 68041; Mature: 67910

Theoretical pI: Translated: 6.43; Mature: 6.43

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQEPATPLLDTVKTPDDLRKLAPTQLRQLADELRVEMISAVGQTGGHLGSGLGVVELTV
CCCCCCCCHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEE
AIHYVFNTPEDRLVWDVGHQAYPHKILTGRRDRIRTLRQAGGLSGFTKRSESEYDPFGTA
EEEEEECCCCCCEEEECCCCCCCHHHHCCCHHHHHHHHHHCCCCCHHCCCCCCCCCCCCC
HSSTSISAALGFAIANKLSGRLGKGIAVIGDGAMSAGMAYEAMNNAEAAGNRLIVILNDN
CCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHCCHHHHHHCCHHHCCCEEEEEECCC
DMSIAPPVGGLSAYLARLVSSGPFLGLRDIARRLSRKLPRPLHEAARKTDEFARGMAMGG
CCEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
TLFEELGFYYVGPIDGHNIDQLIPVLENVRDAAEGPCLIHVVTQKGKGYAPAEAAADKYH
HHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHC
GVQKFDVITGEQVKAKAAAPAYQNVFGETLAKLADADPTICAITAAMPSGTGVDKFAKAH
CCEEEEEECCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHC
PDRTFDVGIAEQHAVTFAAGLAAEGMRPFCAIYSTFLQRAFDQVVHDVAIQNLPVRFAID
CCCCEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
RAGLVGADGATHAGSFDVTYLATLPNLVVMAAADEAELVHMTYTAALHDSGPIAFRYPRG
CCCEECCCCCCCCCCCCEEHHHHCCCEEEEEECCCCEEEEEEEEEEEECCCCEEEECCCC
NGVGVPLPEVPERLEIGKGRIIRQGSKVALLSLGTRLAEALKAADQLDARGLSTTVADLR
CCCCCCCCCCCHHHHCCCCCEEECCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
FAKPLDVALIRQLMTTHDVIVTVEEGSIGGLGAHVLTMASDEGLVDGGLKIRTMRLPDLF
CCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCCEEEEEEECCHHH
QDHDAPEKQYDEAGLNAPHIVDTVLKALRHNSAGVSEARA
HCCCCCHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHCCC
>Mature Secondary Structure 
SQEPATPLLDTVKTPDDLRKLAPTQLRQLADELRVEMISAVGQTGGHLGSGLGVVELTV
CCCCCCCHHHHCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEE
AIHYVFNTPEDRLVWDVGHQAYPHKILTGRRDRIRTLRQAGGLSGFTKRSESEYDPFGTA
EEEEEECCCCCCEEEECCCCCCCHHHHCCCHHHHHHHHHHCCCCCHHCCCCCCCCCCCCC
HSSTSISAALGFAIANKLSGRLGKGIAVIGDGAMSAGMAYEAMNNAEAAGNRLIVILNDN
CCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHCCHHHHHHCCHHHCCCEEEEEECCC
DMSIAPPVGGLSAYLARLVSSGPFLGLRDIARRLSRKLPRPLHEAARKTDEFARGMAMGG
CCEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
TLFEELGFYYVGPIDGHNIDQLIPVLENVRDAAEGPCLIHVVTQKGKGYAPAEAAADKYH
HHHHHCCCEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCCHHHHHHHHC
GVQKFDVITGEQVKAKAAAPAYQNVFGETLAKLADADPTICAITAAMPSGTGVDKFAKAH
CCEEEEEECCCCHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHC
PDRTFDVGIAEQHAVTFAAGLAAEGMRPFCAIYSTFLQRAFDQVVHDVAIQNLPVRFAID
CCCCEECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEC
RAGLVGADGATHAGSFDVTYLATLPNLVVMAAADEAELVHMTYTAALHDSGPIAFRYPRG
CCCEECCCCCCCCCCCCEEHHHHCCCEEEEEECCCCEEEEEEEEEEEECCCCEEEECCCC
NGVGVPLPEVPERLEIGKGRIIRQGSKVALLSLGTRLAEALKAADQLDARGLSTTVADLR
CCCCCCCCCCCHHHHCCCCCEEECCCCEEHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
FAKPLDVALIRQLMTTHDVIVTVEEGSIGGLGAHVLTMASDEGLVDGGLKIRTMRLPDLF
CCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEECCCCCCCCCEEEEEEECCHHH
QDHDAPEKQYDEAGLNAPHIVDTVLKALRHNSAGVSEARA
HCCCCCHHHHHHCCCCCCHHHHHHHHHHHCCCCCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA