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The map label for this gene is fdh [H]

Identifier: 86750298

GI number: 86750298

Start: 3643842

End: 3645011

Strand: Reverse

Name: fdh [H]

Synonym: RPB_3187

Alternate gene names: 86750298

Gene position: 3645011-3643842 (Counterclockwise)

Preceding gene: 86750300

Following gene: 86750292

Centisome position: 68.37

GC content: 64.27

Gene sequence:

>1170_bases
ATGAAGGCGCTGACCTGGCACGGCAAGAGCGATATCCGCTGCGAAAGCGTGCCCGATCCAAAAATCGAGCATGGCCGTGA
TGCGATCATCCGGGTCACCGCCTGTGCGATCTGCGGTTCGGACCTGCATCTGTTCGACGGCGTGATGCCGTCGATGAAGA
GCGGCGACGTGCTGGGACACGAGACGATGGGCGAGGTCGTCGAGGTCGGCGCCGACAACAAGGCGCTGAAGGTCGGCGAC
CGCGTGGTGGTGCCGTTCACGATCTCCTGCGGCGAGTGTTTCTTCTGCAAGCGCGGCTTCTACAGCGGCTGCGAGCGCTC
CAATCCGAACGCCGAGCAGGCCGCGAAACTCTGGGGCCATTCGCCCGCCGGTCTGTTCGGCTATTCGCATCTGCTCGGCG
GCTTTGCCGGCGGGCAGGCGGAATATCTGCGCGTACCTTACGCCGATGTCGGTCCGATCAAGGTGCCGGACGGGATGACC
GACGAGCAGGCGCTGTTCCTGTCCGATATCTTTCCGACGGGATTCATGGCGGCGGATTTCTGTAACCTGAAGGGTGGCGA
GACGGTCGCGATCTGGGGCTGCGGTCCGGTGGGGCAATTCGCGATCAAGAGCGCGTTTCTGCTCGGCGCCGAGCGCGTGA
TCGCGATCGATACGGTGCCGGAGCGGTTGGAGATGGCCCGCGCCTCGGGGGCGATCACCATCGATTTCAGGAACGAGGAC
GTCTACGACCGCATCCAGGATCTGACCCATGGTCGCGGCGCCGATGCCTGCATCGACGCGGTCGGCACCGAGCCGGACAC
GGCGTCCGGATTCGACGCGATCGTCGACCGGATCAAGGTGGCGACCTTCATGGGCACCGACCGGCCGCATGTGCTGCGCC
AGGCGATCCATTGCTGCCGCAACTTCGGAACGGTGTCGATCGTCGGCGTCTATGGCGGCCTGCTCGACAACATCCCGATG
GGCTCGGCGATCAATCGGGGGCTGACGTTCCGAATGGCGCAGACCCCGGTCCAGCATTATCTGCCGCAACTGCTGGCGCG
GATCGAGAAAGGCGAGATCGATCCCACCTTCGTCATCACCCATCGCGCCACGCTGGAGGATGGCCCGGAGCTGTACAAGA
CGTTCCGCGACAAGCAGGACGGCTGCATCAAGGTGGTGATGAAGCCCTGA

Upstream 100 bases:

>100_bases
CCGATGAGATCATAGCAGGTCTCGAGACCGGACCCTCAATTTAGGAACAACGGTGCCTCGGTGTGTTTGTCTGGGAGATG
AACACAATCGGAGGTACGAG

Downstream 100 bases:

>100_bases
GTCTCAGGACGTCGCGAACGCCTGTCCGTAGAGGATGATGCAGGCGCCCGGCGGTGGATCGGTGGCGAGCCGGCTCGCGA
GCTCGGTGACGGAGCCGCGA

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: Glutathione-dependent formaldehyde dehydrogenase; FALDH; FDH [H]

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MKALTWHGKSDIRCESVPDPKIEHGRDAIIRVTACAICGSDLHLFDGVMPSMKSGDVLGHETMGEVVEVGADNKALKVGD
RVVVPFTISCGECFFCKRGFYSGCERSNPNAEQAAKLWGHSPAGLFGYSHLLGGFAGGQAEYLRVPYADVGPIKVPDGMT
DEQALFLSDIFPTGFMAADFCNLKGGETVAIWGCGPVGQFAIKSAFLLGAERVIAIDTVPERLEMARASGAITIDFRNED
VYDRIQDLTHGRGADACIDAVGTEPDTASGFDAIVDRIKVATFMGTDRPHVLRQAIHCCRNFGTVSIVGVYGGLLDNIPM
GSAINRGLTFRMAQTPVQHYLPQLLARIEKGEIDPTFVITHRATLEDGPELYKTFRDKQDGCIKVVMKP

Sequences:

>Translated_389_residues
MKALTWHGKSDIRCESVPDPKIEHGRDAIIRVTACAICGSDLHLFDGVMPSMKSGDVLGHETMGEVVEVGADNKALKVGD
RVVVPFTISCGECFFCKRGFYSGCERSNPNAEQAAKLWGHSPAGLFGYSHLLGGFAGGQAEYLRVPYADVGPIKVPDGMT
DEQALFLSDIFPTGFMAADFCNLKGGETVAIWGCGPVGQFAIKSAFLLGAERVIAIDTVPERLEMARASGAITIDFRNED
VYDRIQDLTHGRGADACIDAVGTEPDTASGFDAIVDRIKVATFMGTDRPHVLRQAIHCCRNFGTVSIVGVYGGLLDNIPM
GSAINRGLTFRMAQTPVQHYLPQLLARIEKGEIDPTFVITHRATLEDGPELYKTFRDKQDGCIKVVMKP
>Mature_389_residues
MKALTWHGKSDIRCESVPDPKIEHGRDAIIRVTACAICGSDLHLFDGVMPSMKSGDVLGHETMGEVVEVGADNKALKVGD
RVVVPFTISCGECFFCKRGFYSGCERSNPNAEQAAKLWGHSPAGLFGYSHLLGGFAGGQAEYLRVPYADVGPIKVPDGMT
DEQALFLSDIFPTGFMAADFCNLKGGETVAIWGCGPVGQFAIKSAFLLGAERVIAIDTVPERLEMARASGAITIDFRNED
VYDRIQDLTHGRGADACIDAVGTEPDTASGFDAIVDRIKVATFMGTDRPHVLRQAIHCCRNFGTVSIVGVYGGLLDNIPM
GSAINRGLTFRMAQTPVQHYLPQLLARIEKGEIDPTFVITHRATLEDGPELYKTFRDKQDGCIKVVMKP

Specific function: Unknown

COG id: COG1063

COG function: function code ER; Threonine dehydrogenase and related Zn-dependent dehydrogenases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily [H]

Homologues:

Organism=Homo sapiens, GI156523966, Length=398, Percent_Identity=25.8793969849246, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI4501939, Length=385, Percent_Identity=26.2337662337662, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI4501929, Length=269, Percent_Identity=28.2527881040892, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI71565154, Length=268, Percent_Identity=26.865671641791, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI34577061, Length=268, Percent_Identity=27.2388059701493, Blast_Score=67, Evalue=3e-11,
Organism=Homo sapiens, GI4501933, Length=268, Percent_Identity=26.4925373134328, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1786825, Length=395, Percent_Identity=46.8354430379747, Blast_Score=339, Evalue=1e-94,
Organism=Escherichia coli, GI87082125, Length=280, Percent_Identity=30.7142857142857, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790045, Length=398, Percent_Identity=27.6381909547739, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI1788073, Length=390, Percent_Identity=26.1538461538462, Blast_Score=101, Evalue=9e-23,
Organism=Escherichia coli, GI226510992, Length=377, Percent_Identity=25.9946949602122, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI87081918, Length=232, Percent_Identity=34.051724137931, Blast_Score=86, Evalue=5e-18,
Organism=Escherichia coli, GI1787863, Length=372, Percent_Identity=23.6559139784946, Blast_Score=85, Evalue=7e-18,
Organism=Escherichia coli, GI1788075, Length=403, Percent_Identity=27.2952853598015, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1786552, Length=359, Percent_Identity=28.133704735376, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1788407, Length=253, Percent_Identity=28.0632411067194, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1790718, Length=307, Percent_Identity=22.8013029315961, Blast_Score=69, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17562876, Length=390, Percent_Identity=25.1282051282051, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17562878, Length=268, Percent_Identity=27.9850746268657, Blast_Score=89, Evalue=5e-18,
Organism=Caenorhabditis elegans, GI25146526, Length=379, Percent_Identity=25.5936675461741, Blast_Score=85, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI71997431, Length=378, Percent_Identity=25.1322751322751, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17565904, Length=295, Percent_Identity=26.7796610169492, Blast_Score=77, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319257, Length=423, Percent_Identity=27.6595744680851, Blast_Score=101, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6320033, Length=410, Percent_Identity=26.8292682926829, Blast_Score=92, Evalue=1e-19,
Organism=Saccharomyces cerevisiae, GI6323099, Length=391, Percent_Identity=26.3427109974425, Blast_Score=88, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6319258, Length=249, Percent_Identity=30.9236947791165, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6324486, Length=365, Percent_Identity=27.9452054794521, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6323961, Length=364, Percent_Identity=27.1978021978022, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6323729, Length=256, Percent_Identity=30.078125, Blast_Score=70, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6319621, Length=396, Percent_Identity=26.010101010101, Blast_Score=69, Evalue=2e-12,
Organism=Drosophila melanogaster, GI17737895, Length=283, Percent_Identity=30.3886925795053, Blast_Score=88, Evalue=1e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.284 [H]

Molecular weight: Translated: 42106; Mature: 42106

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKALTWHGKSDIRCESVPDPKIEHGRDAIIRVTACAICGSDLHLFDGVMPSMKSGDVLGH
CCCEEECCCCCCEECCCCCCCCCCCCCCEEEEEEHHHCCCCHHHHHCCCCCCCCCCCCCH
ETMGEVVEVGADNKALKVGDRVVVPFTISCGECFFCKRGFYSGCERSNPNAEQAAKLWGH
HHHHHHHHCCCCCCEEEECCEEEEEEEECCCCEEEECCCHHCCCCCCCCCHHHHHHHHCC
SPAGLFGYSHLLGGFAGGQAEYLRVPYADVGPIKVPDGMTDEQALFLSDIFPTGFMAADF
CCCHHHHHHHHHCCCCCCCCEEEECCCCCCCCEECCCCCCCCHHHHHHHHCCCCHHHHHH
CNLKGGETVAIWGCGPVGQFAIKSAFLLGAERVIAIDTVPERLEMARASGAITIDFRNED
HCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCEEEEEECCCH
VYDRIQDLTHGRGADACIDAVGTEPDTASGFDAIVDRIKVATFMGTDRPHVLRQAIHCCR
HHHHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
NFGTVSIVGVYGGLLDNIPMGSAINRGLTFRMAQTPVQHYLPQLLARIEKGEIDPTFVIT
CCCCEEEEEHHHHHHHCCCCCHHHCCCEEEEEHHCCHHHHHHHHHHHHHCCCCCCEEEEE
HRATLEDGPELYKTFRDKQDGCIKVVMKP
EECCCCCCHHHHHHHHCCCCCEEEEEECC
>Mature Secondary Structure
MKALTWHGKSDIRCESVPDPKIEHGRDAIIRVTACAICGSDLHLFDGVMPSMKSGDVLGH
CCCEEECCCCCCEECCCCCCCCCCCCCCEEEEEEHHHCCCCHHHHHCCCCCCCCCCCCCH
ETMGEVVEVGADNKALKVGDRVVVPFTISCGECFFCKRGFYSGCERSNPNAEQAAKLWGH
HHHHHHHHCCCCCCEEEECCEEEEEEEECCCCEEEECCCHHCCCCCCCCCHHHHHHHHCC
SPAGLFGYSHLLGGFAGGQAEYLRVPYADVGPIKVPDGMTDEQALFLSDIFPTGFMAADF
CCCHHHHHHHHHCCCCCCCCEEEECCCCCCCCEECCCCCCCCHHHHHHHHCCCCHHHHHH
CNLKGGETVAIWGCGPVGQFAIKSAFLLGAERVIAIDTVPERLEMARASGAITIDFRNED
HCCCCCCEEEEEECCCHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHCCCEEEEEECCCH
VYDRIQDLTHGRGADACIDAVGTEPDTASGFDAIVDRIKVATFMGTDRPHVLRQAIHCCR
HHHHHHHHHCCCCCHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHH
NFGTVSIVGVYGGLLDNIPMGSAINRGLTFRMAQTPVQHYLPQLLARIEKGEIDPTFVIT
CCCCEEEEEHHHHHHHCCCCCHHHCCCEEEEEHHCCHHHHHHHHHHHHHCCCCCCEEEEE
HRATLEDGPELYKTFRDKQDGCIKVVMKP
EECCCCCCHHHHHHHHCCCCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7926692 [H]