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The map label for this gene is uvrC

Identifier: 86748302

GI number: 86748302

Start: 1349728

End: 1351815

Strand: Reverse

Name: uvrC

Synonym: RPB_1177

Alternate gene names: 86748302

Gene position: 1351815-1349728 (Counterclockwise)

Preceding gene: 86748304

Following gene: 86748301

Centisome position: 25.35

GC content: 67.91

Gene sequence:

>2088_bases
ATGAATCACGACCCCGCCGAGACCCGCGACACGGCGGCCGCGCCGCTTGCGGACACCGAATCCCCATCGCCGGTCTCGCC
CGAACTAACGCCGCACCCCGCGCCCGCCGCGCAGGACATCGACACCGCGACCGCCGAACTGACGGTGGACGAGGACGACG
AGGCACGCCTGCCGGAGATCGAGGACGACAGCGCCGAGGTCGCCGACGGCCCGTTGGCGGTCGGCCGCGCCGCGATCGAG
CAGGCGGTCCGGCTGGCGCCGACCTCACCCGGCGTCTACCGCATGCTGAACGCCGCGCACGACGTGCTCTATGTCGGCAA
GGCCAAGAACGTGAAGAAGCGGTTGTCGTCCTATGCGCGGCCGACCGGCCACGTGATGCGGATCGCGCGGATGATCGCCG
CCACCGTCACCGTCGAGATCATTTCGACGTCGACCGAGACCGAGGCGCTGCTGCTCGAAGCCAATCTGATCAAGCAGCTC
CGGCCGCGCTTCAACGTGCTGCTGCGCGACGACAAGTCGTTTCCCTATATCCTGATCACCGGCGACCATTGGGCGCCGCA
GATTCTCAAGCATCGCGGCGCGCAGAGCCGCCCAGGGCGCTATTTCGGCCCGTTCGCCTCGGTCGGCGCGGTCAACCGAA
CCATCACGGCGCTGCAGCGCGCGTTTCTGGTGCGCTCCTGCACCGATTCGTTCTTCGAGAGCCGCACCCGCCCCTGCCTG
CTGTATCAAATCCGGCGCTGCTCCGGCCCTTGCACCGGCGAGGTCGATTTTCCCGGCTACACCGAACTGGTGCGCGAGGC
GAAAGACTTCCTGTCCGGCCGCAGCCGGGCGGTGAAGCAGGAGCTCGCGGTCGAGATGGAGAAGGCCTCGAACGAGCTCG
AATTCGAGACCGCGGCGCTGTATCGCGACCGCCTGGCGGCGCTGTCGGCGATCCAGTCCCAGCAGGGCATCAACCCGCGC
ACCGTCGAGGAAGCCGACGTGTTCGCGATCTATCAGGAGGGCGGCTATTCCTGCGTCGAAGTGTTCTTCTTCCGCACCGG
GCAGAACTGGGGCAACCGCGCCTACTTCCCCCGCGCCGAGAAGTCGTTCACCCCGGAGGAAGTGCTGGCGTCGTTCCTGG
CTCAATTCTACGACGACAAGCCGCCACCGAAGCTGATCCTGCTGTCGCACGACATCGAGGACTGCGCGCTGCTGGCCGAT
GCGCTTTGCATCAAGGCGGACCGCAAGGTCGAGATCTCGACGCCGAAGCGCGGCGAGAAGAAGGAGCTGGTCGCGCACGC
GCTGACCAATGCGCGCGAGGCGCTCGGCCGCAAGCTCGCCGACACCGCGACCCAGACGAGACTGCTGCAGGGCCTCGCCA
CCACGCTGGGACTGCCGAAGCCGCCGCAGCGGATCGAGGTCTACGACAACAGCCACATCCAGGGCACCAACGCGGTCGGC
GCGATGATCGTCGCCGGCCCGGACGGCTTCATCAAGAACCAGTACCGCAAGTTCAACATCCGCTCCGAAGGCCTCACCCC
GGGCGACGACTACGCGATGATGCGCGAGGTGCTGGAGCGGCGGTTCAAGCGGCTGGCCGCCGCGAAGGCCGAAGGCGAGG
CGGCGAAGCCGAACGACGACGAGACTCCGCAATGGCCCGATCTCGTGATCATCGACGGCGGCCGCGGCCAGCTCAACGCC
GCGCGCGGCGTGCTGACCGAGCTCGGGCTCGACGCCGAGGTGACGCTGCTCGGCGTCGCCAAGGGGCCGGATCGCGACGC
CGGCCGCGAAACGCTGTTCATGCCGGAGCGCGAGGCGATCAAGCTCGAGCCCCGCGACCCGGTGCTGTATTTCATCCAGC
GGCTGCGCGACGAGGCGCATCGCTTCGTGATCGGCTCGCACCGCAAGCTGCGCAAGAAGGACATCCGCGAGGCCGGGCTG
CAGGAGATTCCCGGCATCGGTCCGTCGCGCAAGCGCGCGCTGTTGCACCATTTCGGCACCCTGAAGGAGATCGAGCGCGC
CTCGCTCGGCGACCTCGGCAAGGTTCCTGGGATCAGCGCCGAAAGCGCCCGCCGGATCTTCGATTTCTTTCATCCGGGGC
CGGGCTGA

Upstream 100 bases:

>100_bases
GGGGGTGGCGAAAGATCGTCGCCCCGTGGGATGGCAACGCGATGTGGGTTCCGGCCGCGTGCCGCTGGCACCGACCACGC
CGAACGCCTAATTTAGGACC

Downstream 100 bases:

>100_bases
AGCCCGACCAAAGTCGTCTGCGGACCGGGCCGATCTGAACCATGCGGATTTCACCTTTTCCTGATACGGATCGGAGGGCG
CCTTCGTGGGAGTTGACCTT

Product: excinuclease ABC subunit C

Products: NA

Alternate protein names: Protein uvrC; Excinuclease ABC subunit C

Number of amino acids: Translated: 695; Mature: 695

Protein sequence:

>695_residues
MNHDPAETRDTAAAPLADTESPSPVSPELTPHPAPAAQDIDTATAELTVDEDDEARLPEIEDDSAEVADGPLAVGRAAIE
QAVRLAPTSPGVYRMLNAAHDVLYVGKAKNVKKRLSSYARPTGHVMRIARMIAATVTVEIISTSTETEALLLEANLIKQL
RPRFNVLLRDDKSFPYILITGDHWAPQILKHRGAQSRPGRYFGPFASVGAVNRTITALQRAFLVRSCTDSFFESRTRPCL
LYQIRRCSGPCTGEVDFPGYTELVREAKDFLSGRSRAVKQELAVEMEKASNELEFETAALYRDRLAALSAIQSQQGINPR
TVEEADVFAIYQEGGYSCVEVFFFRTGQNWGNRAYFPRAEKSFTPEEVLASFLAQFYDDKPPPKLILLSHDIEDCALLAD
ALCIKADRKVEISTPKRGEKKELVAHALTNAREALGRKLADTATQTRLLQGLATTLGLPKPPQRIEVYDNSHIQGTNAVG
AMIVAGPDGFIKNQYRKFNIRSEGLTPGDDYAMMREVLERRFKRLAAAKAEGEAAKPNDDETPQWPDLVIIDGGRGQLNA
ARGVLTELGLDAEVTLLGVAKGPDRDAGRETLFMPEREAIKLEPRDPVLYFIQRLRDEAHRFVIGSHRKLRKKDIREAGL
QEIPGIGPSRKRALLHHFGTLKEIERASLGDLGKVPGISAESARRIFDFFHPGPG

Sequences:

>Translated_695_residues
MNHDPAETRDTAAAPLADTESPSPVSPELTPHPAPAAQDIDTATAELTVDEDDEARLPEIEDDSAEVADGPLAVGRAAIE
QAVRLAPTSPGVYRMLNAAHDVLYVGKAKNVKKRLSSYARPTGHVMRIARMIAATVTVEIISTSTETEALLLEANLIKQL
RPRFNVLLRDDKSFPYILITGDHWAPQILKHRGAQSRPGRYFGPFASVGAVNRTITALQRAFLVRSCTDSFFESRTRPCL
LYQIRRCSGPCTGEVDFPGYTELVREAKDFLSGRSRAVKQELAVEMEKASNELEFETAALYRDRLAALSAIQSQQGINPR
TVEEADVFAIYQEGGYSCVEVFFFRTGQNWGNRAYFPRAEKSFTPEEVLASFLAQFYDDKPPPKLILLSHDIEDCALLAD
ALCIKADRKVEISTPKRGEKKELVAHALTNAREALGRKLADTATQTRLLQGLATTLGLPKPPQRIEVYDNSHIQGTNAVG
AMIVAGPDGFIKNQYRKFNIRSEGLTPGDDYAMMREVLERRFKRLAAAKAEGEAAKPNDDETPQWPDLVIIDGGRGQLNA
ARGVLTELGLDAEVTLLGVAKGPDRDAGRETLFMPEREAIKLEPRDPVLYFIQRLRDEAHRFVIGSHRKLRKKDIREAGL
QEIPGIGPSRKRALLHHFGTLKEIERASLGDLGKVPGISAESARRIFDFFHPGPG
>Mature_695_residues
MNHDPAETRDTAAAPLADTESPSPVSPELTPHPAPAAQDIDTATAELTVDEDDEARLPEIEDDSAEVADGPLAVGRAAIE
QAVRLAPTSPGVYRMLNAAHDVLYVGKAKNVKKRLSSYARPTGHVMRIARMIAATVTVEIISTSTETEALLLEANLIKQL
RPRFNVLLRDDKSFPYILITGDHWAPQILKHRGAQSRPGRYFGPFASVGAVNRTITALQRAFLVRSCTDSFFESRTRPCL
LYQIRRCSGPCTGEVDFPGYTELVREAKDFLSGRSRAVKQELAVEMEKASNELEFETAALYRDRLAALSAIQSQQGINPR
TVEEADVFAIYQEGGYSCVEVFFFRTGQNWGNRAYFPRAEKSFTPEEVLASFLAQFYDDKPPPKLILLSHDIEDCALLAD
ALCIKADRKVEISTPKRGEKKELVAHALTNAREALGRKLADTATQTRLLQGLATTLGLPKPPQRIEVYDNSHIQGTNAVG
AMIVAGPDGFIKNQYRKFNIRSEGLTPGDDYAMMREVLERRFKRLAAAKAEGEAAKPNDDETPQWPDLVIIDGGRGQLNA
ARGVLTELGLDAEVTLLGVAKGPDRDAGRETLFMPEREAIKLEPRDPVLYFIQRLRDEAHRFVIGSHRKLRKKDIREAGL
QEIPGIGPSRKRALLHHFGTLKEIERASLGDLGKVPGISAESARRIFDFFHPGPG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision

COG id: COG0322

COG function: function code L; Nuclease subunit of the excinuclease complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI87081999, Length=614, Percent_Identity=42.0195439739414, Blast_Score=456, Evalue=1e-129,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRC_RHOP2 (Q2J0X3)

Other databases:

- EMBL:   CP000250
- RefSeq:   YP_484798.1
- ProteinModelPortal:   Q2J0X3
- STRING:   Q2J0X3
- GeneID:   3910112
- GenomeReviews:   CP000250_GR
- KEGG:   rpb:RPB_1177
- eggNOG:   COG0322
- HOGENOM:   HBG566029
- OMA:   DVLYVGK
- ProtClustDB:   PRK00558
- BioCyc:   RPAL316058:RPB_1177-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00203
- InterPro:   IPR003583
- InterPro:   IPR010994
- InterPro:   IPR001943
- InterPro:   IPR009055
- InterPro:   IPR004791
- InterPro:   IPR001162
- InterPro:   IPR000305
- SMART:   SM00465
- SMART:   SM00278
- TIGRFAMs:   TIGR00194

Pfam domain/function: PF01541 GIY-YIG; PF02151 UVR; PF08459 UvrC_HhH_N; SSF47781 RuvA_2_like; SSF46600 UvrB_C; SSF82771 UvrC_N

EC number: NA

Molecular weight: Translated: 76775; Mature: 76775

Theoretical pI: Translated: 6.76; Mature: 6.76

Prosite motif: PS50151 UVR; PS50164 UVRC_1; PS50165 UVRC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNHDPAETRDTAAAPLADTESPSPVSPELTPHPAPAAQDIDTATAELTVDEDDEARLPEI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCC
EDDSAEVADGPLAVGRAAIEQAVRLAPTSPGVYRMLNAAHDVLYVGKAKNVKKRLSSYAR
CCCCCHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEEECCCHHHHHHHHHHCC
PTGHVMRIARMIAATVTVEIISTSTETEALLLEANLIKQLRPRFNVLLRDDKSFPYILIT
CHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHCHHHEEEEECCCCCCEEEEE
GDHWAPQILKHRGAQSRPGRYFGPFASVGAVNRTITALQRAFLVRSCTDSFFESRTRPCL
CCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
LYQIRRCSGPCTGEVDFPGYTELVREAKDFLSGRSRAVKQELAVEMEKASNELEFETAAL
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHH
YRDRLAALSAIQSQQGINPRTVEEADVFAIYQEGGYSCVEVFFFRTGQNWGNRAYFPRAE
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEHHHHHHCCCCCCCCCCCCCCC
KSFTPEEVLASFLAQFYDDKPPPKLILLSHDIEDCALLADALCIKADRKVEISTPKRGEK
CCCCHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEECCCCCCCH
KELVAHALTNAREALGRKLADTATQTRLLQGLATTLGLPKPPQRIEVYDNSHIQGTNAVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCE
AMIVAGPDGFIKNQYRKFNIRSEGLTPGDDYAMMREVLERRFKRLAAAKAEGEAAKPNDD
EEEEECCCCHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
ETPQWPDLVIIDGGRGQLNAARGVLTELGLDAEVTLLGVAKGPDRDAGRETLFMPEREAI
CCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEECCCCCCE
KLEPRDPVLYFIQRLRDEAHRFVIGSHRKLRKKDIREAGLQEIPGIGPSRKRALLHHFGT
EECCCCHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LKEIERASLGDLGKVPGISAESARRIFDFFHPGPG
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNHDPAETRDTAAAPLADTESPSPVSPELTPHPAPAAQDIDTATAELTVDEDDEARLPEI
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCC
EDDSAEVADGPLAVGRAAIEQAVRLAPTSPGVYRMLNAAHDVLYVGKAKNVKKRLSSYAR
CCCCCHHCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHEEEECCCHHHHHHHHHHCC
PTGHVMRIARMIAATVTVEIISTSTETEALLLEANLIKQLRPRFNVLLRDDKSFPYILIT
CHHHHHHHHHHHHHHHEEEEEECCCCCHHHHHHHHHHHHHCHHHEEEEECCCCCCEEEEE
GDHWAPQILKHRGAQSRPGRYFGPFASVGAVNRTITALQRAFLVRSCTDSFFESRTRPCL
CCCHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHH
LYQIRRCSGPCTGEVDFPGYTELVREAKDFLSGRSRAVKQELAVEMEKASNELEFETAAL
HHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHHHHHH
YRDRLAALSAIQSQQGINPRTVEEADVFAIYQEGGYSCVEVFFFRTGQNWGNRAYFPRAE
HHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCEEEHHHHHHCCCCCCCCCCCCCCC
KSFTPEEVLASFLAQFYDDKPPPKLILLSHDIEDCALLADALCIKADRKVEISTPKRGEK
CCCCHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHCCCCEEEECCCCCCCH
KELVAHALTNAREALGRKLADTATQTRLLQGLATTLGLPKPPQRIEVYDNSHIQGTNAVG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCE
AMIVAGPDGFIKNQYRKFNIRSEGLTPGDDYAMMREVLERRFKRLAAAKAEGEAAKPNDD
EEEEECCCCHHHCCCEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
ETPQWPDLVIIDGGRGQLNAARGVLTELGLDAEVTLLGVAKGPDRDAGRETLFMPEREAI
CCCCCCCEEEEECCCCCCHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCEEECCCCCCE
KLEPRDPVLYFIQRLRDEAHRFVIGSHRKLRKKDIREAGLQEIPGIGPSRKRALLHHFGT
EECCCCHHHHHHHHHHHHHHHEECCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHH
LKEIERASLGDLGKVPGISAESARRIFDFFHPGPG
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA