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The map label for this gene is pgsA [H]

Identifier: 86748301

GI number: 86748301

Start: 1348977

End: 1349642

Strand: Reverse

Name: pgsA [H]

Synonym: RPB_1176

Alternate gene names: 86748301

Gene position: 1349642-1348977 (Counterclockwise)

Preceding gene: 86748302

Following gene: 86748300

Centisome position: 25.31

GC content: 64.41

Gene sequence:

>666_bases
GTGGGAGTTGACCTTCCGGCGCGGGCAGTATTGGTAAGTTTGATGAACGATGTTTCGACCAGAGCGCCGGCGCGGGGAGC
GAAGTCGCTGACGCTTCCGAATATCCTGACCTACGCCCGCATCGCGGCGATTCCGGTCGTGGTCGGCTGCATCTATGCGC
AGTCGATCATGGGCGGCCCGCTCGCGCTGCGCTGGGTCGCTCTGGCGGTGTTCATCGCGGCCGCGATCACCGACTTCCTC
GACGGCTATTACGCCCGGATCTGGGACCAGCACTCGGCGTTCGGCCGGATGCTCGACCCGATCGCCGACAAGCTGCTGGT
AGCATCCTGCCTGCTGATGCTCGCCGCCGACGGTATCATCCATGGCTGGACGCTGTGGGCCGCGATCGTGATCCTGTGCC
GCGAGATCCTGGTCTCCGGCCTGCGGGAATATCTCGCCGCATTGCGGGTCAGCGTGCCGGTCACCAAGCTGGCGAAATGG
AAGACCACGGTGCAATTGGTGGCGATCGGCTTCCTGCTCGCCGGCGACGCCGGCGACGAGGTGCTGCCCTACACCACCCA
GATCGGCCTGGCCCTGCTGTGGATATCCGCGCTGGTGACGATGTACACCGGCTACGACTATTTCCGCGCCGGCATCCATC
ACCTGATCGAAGAGGATTCGCGATGA

Upstream 100 bases:

>100_bases
CCGGGGCCGGGCTGAAGCCCGACCAAAGTCGTCTGCGGACCGGGCCGATCTGAACCATGCGGATTTCACCTTTTCCTGAT
ACGGATCGGAGGGCGCCTTC

Downstream 100 bases:

>100_bases
AGGTGAAATACTTCGCCTGGGTCCGCGAGCGGATCGGCCTCGACGAGGAGACCATCGAGCCGCCGGCCGAGGTCGCGACC
GTGTCCGATCTGATCGGCTG

Product: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase

Products: NA

Alternate protein names: Phosphatidylglycerophosphate synthase; PGP synthase [H]

Number of amino acids: Translated: 221; Mature: 220

Protein sequence:

>221_residues
MGVDLPARAVLVSLMNDVSTRAPARGAKSLTLPNILTYARIAAIPVVVGCIYAQSIMGGPLALRWVALAVFIAAAITDFL
DGYYARIWDQHSAFGRMLDPIADKLLVASCLLMLAADGIIHGWTLWAAIVILCREILVSGLREYLAALRVSVPVTKLAKW
KTTVQLVAIGFLLAGDAGDEVLPYTTQIGLALLWISALVTMYTGYDYFRAGIHHLIEEDSR

Sequences:

>Translated_221_residues
MGVDLPARAVLVSLMNDVSTRAPARGAKSLTLPNILTYARIAAIPVVVGCIYAQSIMGGPLALRWVALAVFIAAAITDFL
DGYYARIWDQHSAFGRMLDPIADKLLVASCLLMLAADGIIHGWTLWAAIVILCREILVSGLREYLAALRVSVPVTKLAKW
KTTVQLVAIGFLLAGDAGDEVLPYTTQIGLALLWISALVTMYTGYDYFRAGIHHLIEEDSR
>Mature_220_residues
GVDLPARAVLVSLMNDVSTRAPARGAKSLTLPNILTYARIAAIPVVVGCIYAQSIMGGPLALRWVALAVFIAAAITDFLD
GYYARIWDQHSAFGRMLDPIADKLLVASCLLMLAADGIIHGWTLWAAIVILCREILVSGLREYLAALRVSVPVTKLAKWK
TTVQLVAIGFLLAGDAGDEVLPYTTQIGLALLWISALVTMYTGYDYFRAGIHHLIEEDSR

Specific function: This protein catalyzes the committed step to the synthesis of the acidic phospholipids [H]

COG id: COG0558

COG function: function code I; Phosphatidylglycerophosphate synthase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CDP-alcohol phosphatidyltransferase class-I family [H]

Homologues:

Organism=Homo sapiens, GI188536108, Length=200, Percent_Identity=29, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI10092647, Length=200, Percent_Identity=29, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1788220, Length=194, Percent_Identity=36.0824742268041, Blast_Score=100, Evalue=8e-23,
Organism=Saccharomyces cerevisiae, GI6320059, Length=173, Percent_Identity=29.4797687861272, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000462
- InterPro:   IPR004570 [H]

Pfam domain/function: PF01066 CDP-OH_P_transf [H]

EC number: =2.7.8.5 [H]

Molecular weight: Translated: 23971; Mature: 23839

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS00379 CDP_ALCOHOL_P_TRANSF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGVDLPARAVLVSLMNDVSTRAPARGAKSLTLPNILTYARIAAIPVVVGCIYAQSIMGGP
CCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
LALRWVALAVFIAAAITDFLDGYYARIWDQHSAFGRMLDPIADKLLVASCLLMLAADGII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
HGWTLWAAIVILCREILVSGLREYLAALRVSVPVTKLAKWKTTVQLVAIGFLLAGDAGDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
VLPYTTQIGLALLWISALVTMYTGYDYFRAGIHHLIEEDSR
CCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
GVDLPARAVLVSLMNDVSTRAPARGAKSLTLPNILTYARIAAIPVVVGCIYAQSIMGGP
CCCCHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCH
LALRWVALAVFIAAAITDFLDGYYARIWDQHSAFGRMLDPIADKLLVASCLLMLAADGII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
HGWTLWAAIVILCREILVSGLREYLAALRVSVPVTKLAKWKTTVQLVAIGFLLAGDAGDE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCC
VLPYTTQIGLALLWISALVTMYTGYDYFRAGIHHLIEEDSR
CCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA