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The map label for this gene is emrA [H]

Identifier: 86747333

GI number: 86747333

Start: 233069

End: 234184

Strand: Direct

Name: emrA [H]

Synonym: RPB_0207

Alternate gene names: 86747333

Gene position: 233069-234184 (Clockwise)

Preceding gene: 86747332

Following gene: 86747334

Centisome position: 4.37

GC content: 66.58

Gene sequence:

>1116_bases
TTGTCCGATGATCGAGGTCAGGCCGGATCGGCGTCACAATCGGGTGCCTGGCGCCGTCTGGCGATTCCGTTGCTCGCCGT
CAGTGCGGCGGTTGCGTTCACCATCGTGGCGACGCTGCGGTGGGATGCCTGGATCGGCAGCCGTGCGGTGCAGACCACCG
ACGACGCCTATGTCCGCGCCCAGATCACGCAGTTGAGCAGCCGCGTTGCGGGCGCGGTCAAGACGGTCGCGGTCGACGAC
TTCCAGCGCGTCAAGGCAGGTGATCTGCTGATCCAGATCGATCCGGCCGATTACATCGCGCAGGTCGAGCAGGCGGAGGC
GGCGGTGGCCGGCGCCGAGGCCGCGCTCGACAATCTCGCCAACCAGATCGACCTGCAGAACGCCACGATCGAGCAGGCCG
AGGCGCAAAGCGTGTCGGCGCAGGCGCTCGAAGTGGAGGCGCAGCAGGAAGACCAGCGCCAGCAGGCGCTGGTACGGACC
GAAGCCGGCACCGTACAGAAATTCCAGCAGGCGGTCGCCGCCTATGCCAAGGCCAAAGCCGATGTCAGAGCCGCCATCGC
GGTGGTGGCGGCACAACGCCAGCAAATGGCCGTGCTGGCCGGCACACGACAGCAATTGACCGCCACGTTGCACGGCGCGA
AGGCCACCCTCGATGCCGCGAAATTGCGCCTCGGCTACACCAGAATCGTCGCGCCGTTCGACGGCGTCGCCAGCGAGCGG
CAGGTGCAGCCCGGCGACTACGTCAACACCGGCAGCAATCTGATCAACGTGGTGCCGCTACCGCGGGTCTACGTCATCGC
CAACTACAAGGAGACTCAGCTGCGTCGGGTTCGGCCCGGACAACGCGTGACCATCGTGGCGGACACGTTCTCCGGCCAGA
CGCTGAAGGGCGAGGTCGAGCGGATTTCGCCGGCCAGCGGTTCGCAATTCGCTCTGCTGCCGCCCGACAATGCCACCGGC
AATTTCACCAAGGTGGTGCAGCGGATCCCGGTCCGGATCCAGTTCGCGCCCGGCCAGCCGCTGCTGGAGCGGTTGCTGCC
GGGCATGTCGGTCACCACCCGAATCCATGCCGATGACGGTCCGGTCGGAGATCATGTCGACAGCGCACATCGTTGA

Upstream 100 bases:

>100_bases
ATCATCCTGGCCTATATCGGCTACGGCTATTGGCTGTTCCGGGGCAAGACCAGGCCCGCGCCAGATCTTCGCCAGAACTG
ACGATCACGGGGGAAATCAC

Downstream 100 bases:

>100_bases
AAGCGGCCCGGTCTCGACCGGCGGCATCGGTCCGCGGCCGCTGTTCGCGGTCGGCGCGGTGCTGCTGGGCTCGTTCCTGT
CGAATTTCGACAGCCGGCTG

Product: secretion protein HlyD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MSDDRGQAGSASQSGAWRRLAIPLLAVSAAVAFTIVATLRWDAWIGSRAVQTTDDAYVRAQITQLSSRVAGAVKTVAVDD
FQRVKAGDLLIQIDPADYIAQVEQAEAAVAGAEAALDNLANQIDLQNATIEQAEAQSVSAQALEVEAQQEDQRQQALVRT
EAGTVQKFQQAVAAYAKAKADVRAAIAVVAAQRQQMAVLAGTRQQLTATLHGAKATLDAAKLRLGYTRIVAPFDGVASER
QVQPGDYVNTGSNLINVVPLPRVYVIANYKETQLRRVRPGQRVTIVADTFSGQTLKGEVERISPASGSQFALLPPDNATG
NFTKVVQRIPVRIQFAPGQPLLERLLPGMSVTTRIHADDGPVGDHVDSAHR

Sequences:

>Translated_371_residues
MSDDRGQAGSASQSGAWRRLAIPLLAVSAAVAFTIVATLRWDAWIGSRAVQTTDDAYVRAQITQLSSRVAGAVKTVAVDD
FQRVKAGDLLIQIDPADYIAQVEQAEAAVAGAEAALDNLANQIDLQNATIEQAEAQSVSAQALEVEAQQEDQRQQALVRT
EAGTVQKFQQAVAAYAKAKADVRAAIAVVAAQRQQMAVLAGTRQQLTATLHGAKATLDAAKLRLGYTRIVAPFDGVASER
QVQPGDYVNTGSNLINVVPLPRVYVIANYKETQLRRVRPGQRVTIVADTFSGQTLKGEVERISPASGSQFALLPPDNATG
NFTKVVQRIPVRIQFAPGQPLLERLLPGMSVTTRIHADDGPVGDHVDSAHR
>Mature_370_residues
SDDRGQAGSASQSGAWRRLAIPLLAVSAAVAFTIVATLRWDAWIGSRAVQTTDDAYVRAQITQLSSRVAGAVKTVAVDDF
QRVKAGDLLIQIDPADYIAQVEQAEAAVAGAEAALDNLANQIDLQNATIEQAEAQSVSAQALEVEAQQEDQRQQALVRTE
AGTVQKFQQAVAAYAKAKADVRAAIAVVAAQRQQMAVLAGTRQQLTATLHGAKATLDAAKLRLGYTRIVAPFDGVASERQ
VQPGDYVNTGSNLINVVPLPRVYVIANYKETQLRRVRPGQRVTIVADTFSGQTLKGEVERISPASGSQFALLPPDNATGN
FTKVVQRIPVRIQFAPGQPLLERLLPGMSVTTRIHADDGPVGDHVDSAHR

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: COG1566

COG function: function code V; Multidrug resistance efflux pump

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=309, Percent_Identity=36.2459546925566, Blast_Score=139, Evalue=3e-34,
Organism=Escherichia coli, GI1788711, Length=351, Percent_Identity=31.6239316239316, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1790519, Length=299, Percent_Identity=29.0969899665552, Blast_Score=104, Evalue=7e-24,
Organism=Escherichia coli, GI87081951, Length=331, Percent_Identity=25.9818731117825, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1789637, Length=320, Percent_Identity=26.5625, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1787013, Length=253, Percent_Identity=30.0395256916996, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 39643; Mature: 39512

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDDRGQAGSASQSGAWRRLAIPLLAVSAAVAFTIVATLRWDAWIGSRAVQTTDDAYVRA
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHH
QITQLSSRVAGAVKTVAVDDFQRVKAGDLLIQIDPADYIAQVEQAEAAVAGAEAALDNLA
HHHHHHHHHHHHHHEEEHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
NQIDLQNATIEQAEAQSVSAQALEVEAQQEDQRQQALVRTEAGTVQKFQQAVAAYAKAKA
HHHCCCCCHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
DVRAAIAVVAAQRQQMAVLAGTRQQLTATLHGAKATLDAAKLRLGYTRIVAPFDGVASER
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCEEEECCCCCCCCCC
QVQPGDYVNTGSNLINVVPLPRVYVIANYKETQLRRVRPGQRVTIVADTFSGQTLKGEVE
CCCCCCCCCCCCCEEEEECCCEEEEEECCCHHHHHHCCCCCEEEEEEECCCCCEEECHHH
RISPASGSQFALLPPDNATGNFTKVVQRIPVRIQFAPGQPLLERLLPGMSVTTRIHADDG
CCCCCCCCEEEEECCCCCCCHHHHHHHHCCEEEEECCCHHHHHHHCCCCEEEEEEECCCC
PVGDHVDSAHR
CCCCCCCCCCC
>Mature Secondary Structure 
SDDRGQAGSASQSGAWRRLAIPLLAVSAAVAFTIVATLRWDAWIGSRAVQTTDDAYVRA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHH
QITQLSSRVAGAVKTVAVDDFQRVKAGDLLIQIDPADYIAQVEQAEAAVAGAEAALDNLA
HHHHHHHHHHHHHHEEEHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHH
NQIDLQNATIEQAEAQSVSAQALEVEAQQEDQRQQALVRTEAGTVQKFQQAVAAYAKAKA
HHHCCCCCHHHHHHHHHHHHHHHEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
DVRAAIAVVAAQRQQMAVLAGTRQQLTATLHGAKATLDAAKLRLGYTRIVAPFDGVASER
HHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCHHHHHHHHHHHCCEEEECCCCCCCCCC
QVQPGDYVNTGSNLINVVPLPRVYVIANYKETQLRRVRPGQRVTIVADTFSGQTLKGEVE
CCCCCCCCCCCCCEEEEECCCEEEEEECCCHHHHHHCCCCCEEEEEEECCCCCEEECHHH
RISPASGSQFALLPPDNATGNFTKVVQRIPVRIQFAPGQPLLERLLPGMSVTTRIHADDG
CCCCCCCCEEEEECCCCCCCHHHHHHHHCCEEEEECCCHHHHHHHCCCCEEEEEEECCCC
PVGDHVDSAHR
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]