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The map label for this gene is adk [H]

Identifier: 86610047

GI number: 86610047

Start: 2710266

End: 2710847

Strand: Direct

Name: adk [H]

Synonym: CYB_2616

Alternate gene names: 86610047

Gene position: 2710266-2710847 (Clockwise)

Preceding gene: 86610046

Following gene: 86610048

Centisome position: 88.96

GC content: 61.17

Gene sequence:

>582_bases
GTGCCGAGGTTGATCTTTCTGGGGCCGCCGGGGGCGGGCAAAGGTACACAGGCGGAGCGGCTGGCGGCCATTTACCACAC
GCCCAAAATTTCCACAGGCGATCTGTTGCGGGCCGAGGTGAAAGCCCAAACGCCCCTGGGGTGCCAGGCCAAGGTTTACA
TGGATGCGGGAGAGCTGGTGCCTGACGAGGTGCTGATCGGAATGGTGAAGGGGCAGTTGCAGCAGTCTCCGGAGCAGGGT
TGGATCCTGGATGGATTTCCTCGCACCTTAGCCCAGGCAGAAGCCTTGGAAGAGCTGCTGCAAGAGCTGGGACAAGATTA
CGACTACGTCCTCAACTTGGAGGTGCCGGATGAGGTGGTGGTGGCCCGGCTGCTGGCCCGGGGCAAGGAACAGGGGCGCA
GCGATGATGCGGATCGGTCGGTGATTCTCAAGCGTCTGGAGGTCTATCGGCAGCAGACGGCTCCCCTGATCGATTTTTAT
GAGGCCAAGGGGCGCTTGCAGCGGGTCAACGGCAACCAGCCGATGGAATCCGTACAGGAACATCTGCAGGCTCTTTTGGA
AGGCTTCAGGAGGACGGCGTGA

Upstream 100 bases:

>100_bases
CGACCTCGCTACTGATTTTGGTGGGGGTGGCGATCGAGACCTCCAAGCAGATCCAGACTTATGTCATCTCACAACGCTAC
GAAGGGATGGTCAAACAGTA

Downstream 100 bases:

>100_bases
TCAGAGCAGGAGCTGGAAATCCCTCCCAGCGGCGGGGCATGCAGCTTATTGAGATCAAATCTCGCCGCGAAGTGGAGAAA
ATGCGGCGGGCCGGTCGGGT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase [H]

Number of amino acids: Translated: 193; Mature: 192

Protein sequence:

>193_residues
MPRLIFLGPPGAGKGTQAERLAAIYHTPKISTGDLLRAEVKAQTPLGCQAKVYMDAGELVPDEVLIGMVKGQLQQSPEQG
WILDGFPRTLAQAEALEELLQELGQDYDYVLNLEVPDEVVVARLLARGKEQGRSDDADRSVILKRLEVYRQQTAPLIDFY
EAKGRLQRVNGNQPMESVQEHLQALLEGFRRTA

Sequences:

>Translated_193_residues
MPRLIFLGPPGAGKGTQAERLAAIYHTPKISTGDLLRAEVKAQTPLGCQAKVYMDAGELVPDEVLIGMVKGQLQQSPEQG
WILDGFPRTLAQAEALEELLQELGQDYDYVLNLEVPDEVVVARLLARGKEQGRSDDADRSVILKRLEVYRQQTAPLIDFY
EAKGRLQRVNGNQPMESVQEHLQALLEGFRRTA
>Mature_192_residues
PRLIFLGPPGAGKGTQAERLAAIYHTPKISTGDLLRAEVKAQTPLGCQAKVYMDAGELVPDEVLIGMVKGQLQQSPEQGW
ILDGFPRTLAQAEALEELLQELGQDYDYVLNLEVPDEVVVARLLARGKEQGRSDDADRSVILKRLEVYRQQTAPLIDFYE
AKGRLQRVNGNQPMESVQEHLQALLEGFRRTA

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth [H]

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI7524346, Length=217, Percent_Identity=33.6405529953917, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI4502013, Length=217, Percent_Identity=33.6405529953917, Blast_Score=126, Evalue=1e-29,
Organism=Homo sapiens, GI19923437, Length=212, Percent_Identity=34.9056603773585, Blast_Score=122, Evalue=3e-28,
Organism=Homo sapiens, GI4502011, Length=190, Percent_Identity=37.3684210526316, Blast_Score=117, Evalue=6e-27,
Organism=Homo sapiens, GI7706497, Length=193, Percent_Identity=32.1243523316062, Blast_Score=110, Evalue=6e-25,
Organism=Homo sapiens, GI310110345, Length=197, Percent_Identity=31.9796954314721, Blast_Score=107, Evalue=5e-24,
Organism=Homo sapiens, GI53832003, Length=197, Percent_Identity=31.9796954314721, Blast_Score=107, Evalue=5e-24,
Organism=Homo sapiens, GI8051579, Length=197, Percent_Identity=31.9796954314721, Blast_Score=107, Evalue=5e-24,
Organism=Homo sapiens, GI53832001, Length=197, Percent_Identity=31.9796954314721, Blast_Score=107, Evalue=5e-24,
Organism=Homo sapiens, GI28144899, Length=182, Percent_Identity=34.0659340659341, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI28144897, Length=182, Percent_Identity=34.0659340659341, Blast_Score=96, Evalue=3e-20,
Organism=Homo sapiens, GI22749187, Length=128, Percent_Identity=35.15625, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI209915597, Length=187, Percent_Identity=26.7379679144385, Blast_Score=72, Evalue=4e-13,
Organism=Escherichia coli, GI1786680, Length=216, Percent_Identity=40.2777777777778, Blast_Score=144, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17567503, Length=181, Percent_Identity=39.2265193370166, Blast_Score=137, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI17552384, Length=215, Percent_Identity=36.7441860465116, Blast_Score=136, Evalue=7e-33,
Organism=Caenorhabditis elegans, GI17533833, Length=196, Percent_Identity=31.6326530612245, Blast_Score=101, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17550688, Length=185, Percent_Identity=34.0540540540541, Blast_Score=97, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17537943, Length=220, Percent_Identity=26.8181818181818, Blast_Score=70, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI25147457, Length=182, Percent_Identity=25.2747252747253, Blast_Score=67, Evalue=5e-12,
Organism=Saccharomyces cerevisiae, GI6320432, Length=204, Percent_Identity=37.7450980392157, Blast_Score=141, Evalue=5e-35,
Organism=Saccharomyces cerevisiae, GI6322828, Length=184, Percent_Identity=34.2391304347826, Blast_Score=116, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6321018, Length=195, Percent_Identity=33.8461538461538, Blast_Score=109, Evalue=3e-25,
Organism=Drosophila melanogaster, GI22026816, Length=212, Percent_Identity=34.9056603773585, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI17737899, Length=200, Percent_Identity=34, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI24645822, Length=200, Percent_Identity=34, Blast_Score=107, Evalue=4e-24,
Organism=Drosophila melanogaster, GI221459597, Length=188, Percent_Identity=30.8510638297872, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21356893, Length=188, Percent_Identity=30.8510638297872, Blast_Score=105, Evalue=2e-23,
Organism=Drosophila melanogaster, GI24663208, Length=166, Percent_Identity=29.5180722891566, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI17647141, Length=166, Percent_Identity=29.5180722891566, Blast_Score=84, Evalue=5e-17,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006259
- InterPro:   IPR000850 [H]

Pfam domain/function: PF00406 ADK [H]

EC number: =2.7.4.3 [H]

Molecular weight: Translated: 21451; Mature: 21320

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRLIFLGPPGAGKGTQAERLAAIYHTPKISTGDLLRAEVKAQTPLGCQAKVYMDAGELV
CCCEEEECCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCC
PDEVLIGMVKGQLQQSPEQGWILDGFPRTLAQAEALEELLQELGQDYDYVLNLEVPDEVV
HHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHH
VARLLARGKEQGRSDDADRSVILKRLEVYRQQTAPLIDFYEAKGRLQRVNGNQPMESVQE
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEECCCCCCHHHHHH
HLQALLEGFRRTA
HHHHHHHHHHCCC
>Mature Secondary Structure 
PRLIFLGPPGAGKGTQAERLAAIYHTPKISTGDLLRAEVKAQTPLGCQAKVYMDAGELV
CCEEEECCCCCCCCCHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCC
PDEVLIGMVKGQLQQSPEQGWILDGFPRTLAQAEALEELLQELGQDYDYVLNLEVPDEVV
HHHHHHHHHHHHHHCCCCCCCEECCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCHHHH
VARLLARGKEQGRSDDADRSVILKRLEVYRQQTAPLIDFYEAKGRLQRVNGNQPMESVQE
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEECCCCCCHHHHHH
HLQALLEGFRRTA
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA